The ultimate dream of unification models consists in combining both gauge and Yukawa couplings into one unified coupling. This is achieved by using a supersymmetric exceptional E6 gauge symmetry together with asymptotic unification in compact five-dimensional space-time. The ultraviolet fixed point requires exactly three fermion generations: one in the bulk, and the two light ones localised on the SO(10) boundary in order to cancel gauge anomalies. A second option allows to preserve baryon number and to lower the compactification scale down to the typical scales of the intermediate Pati-Salam gauge theory.