Objective To explore the evaluation and application of the Omaha system in the self-management of patients with central venous catheter (PICC) via peripheral venous implantation. Methods A total of 100 patients with PICC catheterization in the blood department of the hospital were selected and divided into the intervention group and the control group according to the voluntary principle, 50 patients of each group.The control group was taught and followed up after conventional catheterization.The intervention group was given systematic care of Omaha.The self-management ability of the two groups was observed 3 days before catheterization, 1 day before discharge and 2 weeks after discharge. Results The scores of self-management ability of the two groups were compared 3 days before catheterization, and the difference was no statistically significant(P>0.05). Compared with the control group, the self-management score of the routine catheterization observation, compliance to maintenance, catheter management confidence, exception handling, movement with the tube, daily life with the tube in the intervention group were increased after continued intervention with the Omaha system, 1 day before discharge and 2 weeks after discharge, and the differences were statistically significant (P<0.05). Conclusions The application of the Omaha system in the self-management of PICC patients has improved the self-management ability of patients in general and helped to improve the quality of life of patients with PICC. Key words: Omaha systems; Patients with PICC; Self-management ability