Excellent Self-healing Properties Research Articles

First-Aid Hydrogel Wound Dressing with Reliable Hemostatic and Antibacterial Capability for Traumatic Injuries.

First-aid for severe traumatic injuries in the battlefield or pre-hospital environment, especially for skin defects or visceral rupture, remains a substantial medical challenge even in the context of the rapidly evolving modern medical technology. Hydrogel-based biomaterials are highly anticipated for excellent biocompatibility and bio-functional designability. Yet, inadequate mechanical and bio-adhesion properties limit their clinical application. To address these challenges, a kind of multifunctional hydrogel wound dressing is developed with the collective multi-crosslinking advantages of dynamic covalent bonds, metal-catechol chelation, and hydrogen bonds. The mussel-inspired design and zinc oxide-enhanced cohesion strategy collaboratively reinforce the hydrogel's bio-adhesion in bloody or humoral environments. The pH-sensitive coordinate Zn2+ -catechol bond and dynamic Schiff base with reversible breakage and reformation equip the hydrogel dressing with excellent self-healing and on-demand removal properties. In vivo evaluation in a rat ventricular perforation model and Methicillin-resistant Staphylococcus aureus (MRSA)-infected full-thickness skin defect model reveal excellent hemostatic, antibacterial and pro-healing effectiveness of the hydrogel dressing, demonstrating its great potential in dealing with severe bleeding and infected full-thickness skin wounds.

Low-temperature self-healing polyurethane adhesives via dual synergetic crosslinking strategy

Abstract Damage to polymer adhesives is one of the most common reasons for structural integrity damage of composite solid propellants. The introduction of self-repairing technology into the adhesive is expected to solve this problem. However, at low temperatures, the self-repairing and mechanical properties of the materials are greatly impaired, thereby limiting the application of self-repairing adhesives in composite solid propellants. In this study, based on the dual synergistic crosslinking strategy, a polyurethane adhesive exhibiting excellent self-healing and mechanical properties at low temperatures was successfully prepared. The adhesive exhibited high self-repairing efficiency and ultra-long elongation at break at low temperatures. Specifically, at a low temperature of −40°C, the self-repair efficiency was over 70% and the elongation at break was over 1,400%, which were much higher than the results of the control group. Moreover, the strength was comparable to that of the control group. This polyurethane adhesive shows excellent self-healing and mechanical properties at low temperatures and is expected to provide the strong self-healing ability and mechanical properties for composite solid propellants, alleviating the problem of structural integrity damage.

Fabrication of graphene oxide-modified self-healing microcapsules for Cardanol-based epoxy anti-corrosion coatings

In this paper, graphene oxide (GO) modified microcapsules have been developed for use in self-healing Cardanol-based epoxy anti-corrosion coatings on steel substrates. The microcapsules had a polymethyl methacrylate (PMMA) shell, covered with aminated GO flakes and contained either of the two complementary healing agents mixed with nanosized GO flakes. One set of capsules contained epoxidized nanosized GO and Cardanol-based epoxy resin, while the other contained aminated nanosized GO and Cardanol-based amine curing agent. The microcapsules had a narrow size distribution with a peak value of 4 μm. The Cardanol-based coatings containing various fractions of up to 20 wt% microcapsules in their stoichiometric ratio showed excellent anti-corrosion and self-healing properties. FT-IR, XPS, AFM, and Raman spectroscopy were used to characterize the size and chemical composition of the GO. Optical microscopy and SEM were used for morphological characterization. Double cantilever test upon bulk samples showed an excellent load transfer across the fracture plane after only 1 day curing at room temperature. The anti-corrosion properties of the Cardanol-based coating containing the two-component microcapsules were tested using electrochemical impedance spectroscopy (EIS). It was found that, after 60-day immersion in 3.5 wt% NaCl solution, the low-frequency impedance modulus |Z|0.01Hz of the Cardanol-based coating containing GO-modified microcapsules was three orders of magnitude higher than that of the systems with capsules without GO. After scratching the coating containing 20 wt% GO-modified microcapsules and exposing it to an aqueous 3.5 wt% NaCl solution, the |Z|0.01Hz of the Cardanol-based coating returned over a period of 7 days to the original value.

Seamlessly Adhesive Bionic Periosteum Patches Via Filling Microcracks for Defective Bone Healing.

Current artificial designs of the periosteum focus on osteogenic or angiogenic properties, while ignoring the filling and integration with bone microcracks, which trigger a prolonged excessive inflammatory reaction and lead to failure of bone regeneration. In this study, seamless adhesive biomimetic periosteum patches (HABP/Sr-PLA) were prepared to fill microcracks in defective bone via interfacial self-assembly induced by Sr ions mediated metal-ligand interactions among pamidronate disodium-modified hyaluronic acid (HAPD), black phosphorus (BP), and hydrophilic polylactic acid (PLA). In vitro, HABP/Sr-PLA exhibited excellent self-healing properties, seamlessly filled bone microcracks, and significantly enhanced osteogenesis and angiogenesis. Furthermore, in a rat cranial defect model, HABP/Sr-PLA was demonstrated to significantly promote the formation of blood vessels and new bone under mild 808 nm photothermal stimulation (42.8 °C), and the highest protein expression of CD31 and OPN was five times higher than that of the control group and other groups. Therefore, the proposed seamless microcrack-filled bionic periosteum patch is a promising clinical strategy for promoting bone repair.

A high-performance, full-degradable bioinspired newspaper-based composite enhanced by borate ester bonds

Sustainable construction materials with high performance serve as an important role in our dairy life. However, constructing strong, green and cost-effective structural materials from waste feedstocks is still challenging. Inspired by the borate chemistry in natural plant cell walls, a high-performance, full-degradable and multifunctional newspaper (NP)-based laminated composite was successfully fabricated by boric acid (BA) and poly(vinyl alcohol) (PVA) via borate ester bonds and hydrogen bonds under simple hot-pressing process. Owing to the strong covalent borate ester bonds and abundant hydrogen bonds crosslinking, the resultant b-NP/PVA/BA composite exhibited outstanding tensile strength (147.83 ± 1.60 MPa), elongation at break (15.43 ± 0.56%) and toughness (17.80 ± 0.78 MJ/m3), which exceeded most wood-based composites and all reported NP-based composites. The b-NP/PVA/BA composite also showed excellent self-healing property and could be biodegraded completely within 4 months in soil. Furthermore, the obtained composite was useful for panel overlayers due to its excellent mechanical enhancement effect, antimildew and healthy properties. Notably, the cost-effective and green raw materials, as well as the facile and eco-friendly preparation, offered a competitive strategy to develop high-performance and full-biodegradable composites from waste resources, which can be extensively utilized in the fields of building, furniture and packaging.

Highly Stretchable, Ultra-Sensitive, and Self-Healable Multifunctional Flexible Conductive Hydrogel Sensor for Motion Detection and Information Transmission.

Self-healable flexible sensing materials are extensively investigated for their potential use in human motion detection, healthcare monitoring, and other fields. However, the existing self-healable flexible sensing materials have limited their application in real life due to the weak stability of the conductive network and the difficulty in balancing stretchability and self-healing performances. In this paper, a flexible sensor with skin-like properties was prepared by composing a polymer composite hydrogel with a multiple network structure consisting of polyaniline, polyvinyl alcohol, chitosan, and phytic acid. The composite hydrogel was tested and proved to own high mechanical properties (stretchability ≈ 565%, strength ≈ 1.4 MPa), good electrical conductivity (0.214 S cm-1), excellent self-healing properties (>99% healing efficiency in a 4 h healing period), and antibacterial properties. It had high sensitivity and a wide sensing range for strain and pressure, making it possible to manufacture multifunctional flexible sensors with comprehensive performance exceeding that of most flexible sensing materials. Notably, this polymer composite hydrogel can be manufactured in a large area and at a low cost, which is beneficial for its further application in many fields.

Photochromic Polyurethane Coatings with Cross-Linked Structure and Self-Healing Behavior Based on the FRET Effect.

Intelligent fluorescent coatings have received widespread attention in the encryption technique field such as anti-counterfeit, while the traditional fluorescent coatings are easy to be damaged by external force. In this study, the fluorescent and self-healing anti-counterfeit coatings are prepared after rational molecular design. Two polymers containing fluorescent groups, including polyurethane containing the anthracene (AN) side group and polyimide containing the naphthalenediimide (NDI) structure are synthesized to realize multiple color changes with fluorescence through simply blending. Due to the overlapping fluorescence spectra of the groups, enabling the fluorescence resonance energy transfer effect (FRET), the coating with different group ratios exhibits tunable fluorescence under the same excitation light, providing diverse patterns. Moreover, due to the reversible photo-crosslinking and thermal de-dimerization properties of anthracene, the recording, erasure, and rewriting of the surface pattern can be realized, and the fluorescent anti-counterfeit coatings exhibit excellent self-healing properties after cross-linking due to the FRET effect, which solves the problem of poor healing and ensures the stability and integrity. The fluorescent coating with cross-linked structure and self-healing behavior based on the FRET effect greatly expands the functional applications of traditional polyurethane materials.

Durable self-healing coating system based on pH-responsive core-shell nanostructures

A critical access to high-efficiency anti-corrosion coatings is adding pH-responsive nanocontainers encapsulated with corrosion inhibitors into epoxy resin as it endows the composite coating with significant active long-term corrosion protection. Here, two self-healing coating systems (I-PBZ-EP and II-PBZ-EP) were constructed based on epoxy coating (EP) and benzotriazole-loaded zeolitic imidazolate framework (ZIF-8) encapsulated with polydopamine (PDA) by one-pot and two-pot methods, respectively. Electrochemical impedance spectroscopy (EIS) investigation shows that the low-frequency impedance modulus value (|Z|0.01Hz) of I-PBZ-EP still reaches 2.16 × 1010 Ω·cm2 which is the highest among all the coatings after 35 d of immersion. |Z|0.01Hz of the scratched I-PBZ-EP is 1.10 × 105 Ω·cm2 after 13 h of immersion in 3.5 wt% NaCl solution, which far surpasses |Z|0.01Hz of the scratched II-PBZ-EP, exhibiting its excellent self-healing properties. This is because I-PBZ can release more benzotriazole (BTA) (22.5 mg/L and 13.4 mg/L) than II-PBZ (15.8 mg/L and 9.4 mg/L) under acidic and basic conditions to repair the micro-defects. In short, by changing the loading mode of corrosion inhibitors, I-PBZ-EP with a simpler synthesis method manages to provide the long-term anticorrosion protection for the carbon steel substrate.

Development of PEG-grafted-lignosulfonate/cationic-polyelectrolyte/poly(acrylic acid) complex and evaluation of its toughness, self-healing property, and internal physical structure

A lignosulfonate-derived material was prepared by complexing polyethylene glycol (PEG)-grafted lignosulfonate (LS-g-PEG) with a cationic polyelectrolyte (PDADMACl). The mechanical property of this LS-g-PEG/PDADMACl complex was similar to those of the conventional unmodified-LS/PDADMACl complex, however, the addition of poly(acrylic acid) (PAAc) improved the toughness of the LS-g-PEG complex more than seven-fold at the optimal composition (from 0.7 to 5.2 MJ/m3). This increase in toughness upon PAAc addition was not observed in the conventional unmodified-LS/PDADMACl complex and it was attributed to the synergistic effect of plasticization by the amorphous PEG component, as well as the formation of a rigid polyelectrolyte complex. In addition to better strain and toughness than other reported lignosulfonate-derived materials, the LS-g-PEG/PDADMACl/PAAc complex displayed a humidity-induced self-healing property; complete healing of mechanical properties was observed under optimal conditions. These good toughness and excellent self-healing properties may broaden the applications of lignin-derived materials as highly durable and damage-resistant materials.

Spider-web inspired self-healing, adhesive, injectable conductive hydrogel for human motion monitoring and shape recognition

Conductive hydrogels have received significant attention in fabricating wearable strain sensors, electronic skins, and human-machine interface applications, but suffer the poor cycling capacity and hard to be applied in complex sensing applications. Herein a spider web-inspired poly (stearyl methacrylate-co-acrylic acid) and polyvinyl alcohol interpenetrating network conductive hydrogel was synthesized via one-step in-situ polymerization to address these challenges aforementioned. The as-obtained hydrogels exhibit good mechanical strength (111 kPa stress), high stretchability (1029% strain), strong adhesiveness, high conductivity, injectability, and rapid self-healing performance (the healing efficiency of 87.3% at room temperature within 4 h). Attributing to excellent self-healing properties, the hydrogels were easily reprocessed four times at room temperature without losing their intrinsic characteristics. Additionally, high strain sensitivity (GF = 4.28 in the wide strain-sensing range 1–500%) and real time monitoring large/tiny human motions have been also realized. Most importantly, a assembled sensing array has been demonstrated via the injectable behaviour to detect the mass and contact shape of the target We believe that this study will definitely broaden the practical applications of a new generation of hydrogel-based wearable strain sensor.

Construction of self-healable and recyclable waterborne polyurethane-MOF membrane for adsorption of dye wastewater based on solvent etching deposition method

The treatment of dye wastewater by combining metal–organic framework (MOF) and polymer adsorbent membranes has attracted extensive attention. However, most of the polymer/MOF composite will encounter problems such as the poor compatibility, the holes of MOF are easily blocked by polymer chains, moreover, the study about the self-healable and recycle properties have never been done. To fill this gap, this research puts forward a novel solvent etching deposition method, combining waterborne polyurethane containing dynamic disulfide bonds (WPU-SS) with MOF (UiO-66-NH2) to prepare a self-healable and recyclable adsorption membrane (WPU-SS-MOF). The results show that WPU-SS-MOF membrane has excellent mechanical and self-healing properties, the tensile strength and elongation at break of WPU-SS-MOF membrane are 5.16 MPa and 1117.1%, respectively, and the self-healing efficiency can reach 96.1%. The adsorption experiments results show that WPU-SS-MOF has excellent adsorption and recycling capacity for the anionic dyes of methyl orange (MO) and Congo red (CR), and the removal efficiency remained above 80% after 5 cycles. In summary, this is the first time to combine the function of adsorption of MOF with WPU-SS by a solvent etching deposition method, which provides vast application foreground for dye wastewater treatment.

Alginate/polyacrylamide host-guest supramolecular hydrogels with enhanced adhesion

Although injectable hydrogels with minimally invasive delivery have garnered significant interest, their potential applications have been restricted by a singular property. In this study, a supramolecular hydrogel system with improved adhesion was constructed through host-guest interactions between alginate and polyacrylamide. The maximum tensile adhesion strength between the β-cyclodextrin and dopamine-grafted alginate/adamantane-grafted polyacrylamide (Alg-βCD-DA/PAAm-Ad, namely AβCDPA) hydrogels and pigskin reached 19.2 kPa, which was 76 % stronger than the non-catechol-based control hydrogel (β-cyclodextrin-grafted alginate/adamantane-grafted polyacrylamide, Alg-βCD/PAAm-Ad). Moreover, the hydrogels demonstrated excellent self-healing, shear-thinning, and injectable properties. The required pressure to extrude the AβCDPA2 hydrogel from a 16G needle at a rate of 2.0 mL/min was 67.4 N. As the polymer concentration and adamantane substitution degree increased, the hydrogels exhibited higher modulus, stronger network structure, and lower swelling ratio and degradation rate. Encapsulating and culturing cells within these hydrogels demonstrated good cytocompatibility. Therefore, this hydrogel can serve as a viscosity extender or bioadhesive, and as a carrier material to deliver encapsulated therapeutic substances into the body through minimally invasive injection methods.

Mixed Conductive, Injectable, and Fluorescent Supramolecular Eutectogel Composites.

Eutectogels are an emerging family of soft ionic materials alternative to ionic liquid gels and organogels, offering fresh perspectives for designing functional dynamic platforms in water-free environments. Herein, the first example of mixed ionic and electronic conducting supramolecular eutectogel compositesis reported. A fluorescent glutamic acid-derived low-molecular-weight gelator (LMWG) was found to self-assemble into nanofibrillar networks in deep eutectic solvents (DES)/ poly(3,4-ethylenedioxythiophene) (PEDOT): chondroitin sulfate dispersions. These dynamic materials displayed excellent injectability and self-healing properties, high ionic conductivity (up to 10-2 S cm-1), good biocompatibility, and fluorescence imaging ability. This set of features turns the mixed conducting supramolecular eutectogels into promising adaptive materials for bioimaging and electrostimulation applications.

Self-Healable Conductive Hydrogels with High Stretchability and Ultralow Hysteresis for Soft Electronics.

Stretchable sensors based on conductive hydrogels have attracted considerable attention for wearable electronics. However, their practical applications have been limited by the low sensitivity, high hysteresis, and long response times of the hydrogels. In this study, we developed high-performance poly(vinyl alcohol) (PVA)/poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) based hydrogels post-treated with NaCl, which showed excellent mechanical properties, fast electrical response, and ultralow hysteresis properties. The hydrogels also demonstrated excellent self-healing properties with electrical and mechanical properties comparable to those of the original hydrogel and more than 150% elongation at break after the self-healing process. The high performance of the optimized hydrogels was attributed to the enhanced intermolecular forces between the PVA matrix and PEDOT:PSS, the favorable conformational change of the PEDOT chains, and an increase in localized charges in the hydrogel networks. The hydrogel sensors were capable of tracking large human motion and subtle muscle action in real time with high sensitivity, a fast response time (0.88 s), and low power consumption (<180 μW). Moreover, the sensor was able to monitor human respiration due to chemical changes in the hydrogel. These highly robust, stretchable, conductive, and self-healing PVA/PEDOT:PSS hydrogels, therefore, show great application potential as wearable sensors for monitoring human activity.

On-Demand Dissociable Antibacterial Self-Healing Hydrogel with Rapid Arginine-Related Biosynthesis Capacity to Promote Full-Thickness Bacteria-Infected Wound Healing

Developing a self-healing hydrogel wound dressing with intrinsic antibacterial and on-demand dissociable properties is highly desired yet challenging in clinician applications to enhance angiogenesis and collagen growth for rapid wound healing. Herein, we present a thermoresponsive self-healing hydrogel dressing with intrinsic antimicrobial property based on a poly(N-isopropylacrylamide)-derived ABA triblock copolymer (TNOTN) and an aldehyde β-cyclodextrin (ACD) for rapid healing of full-thickness infected wounds. The prepared TNOTN–ACD hydrogel exhibits excellent thermal responsiveness with a well-defined thermal-induced sol–gel transition, allowing in situ gelling and on-demand removal of wound dressing via temperature switch. Meanwhile, the dynamic Schiff base bonds formed between TNOTN and ACD endow the hydrogel with excellent self-healing properties, which can maintain structural integrity for constant and effective antibacterial performance. Meanwhile, TNOTN–ACD hydrogels have good antibacterial properties against both S. aureus and E. coli, as well as good biocompatibility and hemocompatibility. More importantly, in vivo spatial metabolomics revealed that the TNOTN–ACD hydrogel dressing could accelerate angiogenesis and collagen deposition via the arginine-related biosynthesis pathways, thereby effectively promoting wound closure in a full-thickness bacteria-infected skin defect.

A Transparent, and Self-Healable Strain-Sensor E-Skin Based on Polyurethane Membrane with Silver Nanowires

Electronic skin (E-skin) is increasingly utilized in modern society, yet current E-skin technology suffers from issues, such as opacity, hardness, and fragility. To address these challenges, a novel E-skin was developed using polyurethane (PU) as the matrix material and silver nanowires (AgNWs) as the sensing material. By leveraging the small degree of microphase separation and lack of crystallization in the PU, combined with the appropriate length–diameter ratio of the AgNWs, the resulting E-skin exhibited a visible light transmittance of 75%. The E-skin also showed excellent self-healing properties (83.63% efficiency in the third repair) and mechanical properties (with almost no degradation after 60 tensile cycles) due to the reversible dynamic cross-linking network within the PU. The synergistic effect of PU and AgNWs resulted in exceptional sensing performance for the E-skin, with a gauge factor of 46 (when ε = 10%). Moreover, the E-skin demonstrated signal stability during human joint motion monitoring and successfully identified different movement states, highlighting its potential for diverse applications. This research presents a simple yet effective approach for producing transparent, durable, and stable E-skin.

Preparation and Biomedical Applications of Cucurbit[n]uril-Based Supramolecular Hydrogels.

The cucurbit[n]uril supramolecular hydrogels are driven by weak intermolecular interactions, of which exhibit good stimuli responsiveness and excellent self-healing properties. According to the composition of the gelling factor, supramolecular hydrogels comprise Q[n]-cross-linked small molecules and Q[n]-cross-linked polymers. According to different driving forces, hydrogels are driven by the outer-surface interaction, the host-guest inclusion interaction, and the host-guest exclusion interaction. Host-guest interactions are widely used in the construction of self-healing hydrogels, which can spontaneously recover after being damaged, thereby prolonging their service life. The smart Q[n]s-based supramolecular hydrogel composed is a kind of adjustable and low-toxicity soft material. By designing the structure of the hydrogel or modifying the fluorescent properties, etc., it can be widely used in biomedicine. In this review, we mainly focus on the preparation of Q[n]-based hydrogels and their biomedical applications including cell encapsulation for biocatalysis, biosensors for high sensitivity, 3D printing for potential tissue engineering, drug release for sustained delivery, and interfacial adhesion for self-healing materials. In addition, we also presented the current challenges and prospects in this field.

Development and characteristics of multifunctional ultra-lightweight engineered cementitious composites incorporating cenospheres and PE fibre

Ultra-lightweight, high ductility, high strength, and multi-functionality are recent development trends in concrete. This study proposed a design concept of multifunctional ultra-lightweight engineered cementitious composites (ULW-ECCs) without functional fillers using fly ash cenosphere (FAC) and polyethylene (PE) fibre, which has heat insulation, self-sensing, and self-healing functions. The mechanical (tension, compression, flexure) and corresponding self-sensing properties under monotonic and cyclic loading, self-healing, thermal conductivity, and thermal effusivity properties were examined. The ULW-ECCs were developed based on the maximum packing density of the matrix, which showed high pseudo-strain-hardening indices and had an apparent density of 1055–1333 (Oven-dry density: 946–1261) kg/m3, compressive strength of 36–58 MPa, and a tensile strain capacity of 4%–8% under standard curing condition. With the use of FAC with a highly stiff shell, the ULW-ECCs show high strength and high thermal insulation properties. ULW-ECCs incorporating FAC show excellent self-sensing properties without any conductive fillers under compression, bending and tension. The electromechanical behaviour was consistent and repeatable during cyclic and monotonic loading processes, and a microstructure model was used to explain the self-sensing mechanism. The cement paste in the matrix can form a 3D-like honeycomb structure because a large number of FACs evenly divide the cement paste, which shows sensitive self-sensing ability. Additionally, the multiple micro-cracks of ULW-ECCs show excellent self-healing properties. Optical microscope and SEM analyses of ULW-ECC were used to explain the results. The developed multifunctional ULW-ECCs without functional fillers would be a promising material for sustainable development.

Design of anti-mildew smart microcapsules with chitosan as encapsulant for advanced electronic packaging epoxy coating

Moisture protection, anti-mildew and anti-corrosion are essential to guarantee the normal service of electronic devices. Although the epoxy holds great potential for electronic packaging, its inferior anti-corrosive performance and anti-mildew capability significantly affect the lifespan of the coating and thus impede further technological advances in electronic devices. To address this concern, herein, we fabricate environmental-friendly anti-mildew smart microcapsules (MCs) by encapsulating benzotriazole (BTA) loaded halloysite clay nanotubes (HNTs) with chitosan (CTS). The coating presents superior anti-mildew property with 5 wt% MCs addition. Furthermore, the charge transfer resistance (Rct) of T2 copper beneath the coating is three orders of magnitude larger after 35 days' immersion, which confirms a significantly promoted anti-corrosive performance for the coating. Moreover, mechanism study shows that such enhanced corrosion protective performance of proposed coating benefits from an excellent self-healing property enabled by a sustainable release of BTA with water and dual-pH sensitivity as well as effective adsorption of BTA on metal surface. It is further uncovered that the release rate of BTA is simultaneously determined by solubility of BTA, acid pH sensitivity of CTS and interaction between BTA and CTS. In addition, mechanical properties of coatings are enhanced with the tensile strength and elongation significantly increased, while the wet adhesion force (72 h) is also enlarged from 4.03 MPa to 7.22 MPa. Such a delicate design of environmental-friendly anti-mildew smart MCs not only enhances the corrosion protective property and the anti-mildew performance of the electronic packaging coatings, but also can facilitate the fabrication of other multifunctional organic coatings by utilizing multifunctional inhibitor or polyelectrolytes.

Salvianolic-Acid-B-Loaded HA Self-Healing Hydrogel Promotes Diabetic Wound Healing through Promotion of Anti-Inflammation and Angiogenesis.

Inflammatory dysfunction and angiogenesis inhibition are two main factors leading to the delayed healing of diabetic wounds. Hydrogels with anti-inflammatory and angiogenesis-promoting effects have been considered as promising wound care materials. Herein, a salvianolic acid B (SAB)-loaded hyaluronic acid (HA) self-healing hydrogel (HA/SAB) with anti-inflammatory and pro-angiogenesis capacities for diabetic wound healing is reported. The HA hydrogel was prepared via the covalent cross-linking of aldehyde groups in oxidized HA (OHA) and hydrazide groups in adipic dihydrazide (ADH)-modified HA (HA-ADH) with the formation of reversible acylhydrazone bonds. The obtained HA hydrogel exhibited multiple favorable properties such as porous structures, excellent self-healing properties, a sustainable release capacity of SAB, as well as excellent cytocompatibility. In addition, the effects of the SAB-loaded HA self-healing hydrogel were investigated via a full-thickness skin defect model using diabetic rats. The HA/SAB hydrogel showed enhanced skin regeneration effects with accelerated wound closure, shorter remaining dermal space length, thicker granulation tissue formation, and more collagen deposition. Furthermore, reduced inflammatory response and enhanced vascularization were found with HA/SAB2.5 hydrogel-treated wounds, indicating that the hydrogel promotes diabetic wound healing through the promotion of anti-inflammation and angiogenesis. Our results suggest that the fabricated SAB-loaded HA self-healing hydrogel is promising as a wound dressing for the treatment of diabetic wounds.