Excellent Response Research Articles

Therapeutic Potential of MDMA- and Psychedelic-Assisted Psychotherapy for Adolescent Depression and Trauma.

There is a mental health crisis affecting youth, and the utility of existing treatments is often limited by lack of effectiveness and tolerability. The aim of this review is to report on outcomes of clinical trials for psilocybin-assisted psychotherapy for adults with depression and MDMA-assisted psychotherapy for adults with post-traumatic stress disorder (PTSD) and discuss recommendations for exploring these treatments in adolescent populations. There have been encouraging data supporting the use of psilocybin-assisted psychotherapy for depression, including previously treatment-resistant symptoms. MDMA-assisted psychotherapy is showing similar promise in treating PTSD, with excellent response and remission rates that appear durable. However, no studies have looked at the use of these treatments in younger patients. The safety and efficacy of psychedelic- and MDMA-assisted psychotherapies should be investigated in adolescents, especially considering the burden of untreated and undertreated psychiatric illness in youth, and the benefits of a potentially earlier, more effective, and more tolerable recovery process. Research and implementation should be tailored to the needs of this population, and equity and access should be considered at every stage. In this novel and rapidly evolving landscape, the psychiatric community is encouraged to advocate for safe, appropriate, and inclusive inquiry into, and application and scaling of these treatment models in adolescent patients.

Superior Capacitive Energy Storage at High Temperature of All-Organic Aromatic Polymer via Enhancing Conjugate Angle between Benzene Rings.

High-temperature polymer capacitors with superior energy storage density are considerable and desirable components in advanced power pulse, electrical, and energy conversion systems. However, due to the π-π conjugated benzene ring structure, carriers migrate through polyimide (PI) chains, reducing discharge energy density (Ue) and charge-discharge efficiency (η) at high temperature. Here, the ether (-O-) and isopropylidene (-C(CH3)2-) groups are purposefully introduced into the position between the benzene rings to increase the conjugate angle in PI chains, and spatial folded chains are designed to impede charge transport at high temperature. The experimental results show both surface charge dissipation rate and leakage current decrease at 150 °C when (-C(CH3)2-) groups increase, indicating that deep traps that hinder charge transport are introduced in the chains. Hence, the breakdown strength of the designed polymer (BAPP+BPADA) significantly increases, and its Ue and η reach 3.87 J/cm3 and 90% at 150 °C, 2.74-times the energy density of the pristine PI film. Simultaneously, the BAPP+BPADA film exhibits excellent discharge response and cycling charge-discharge stability, which have the potential to be applied in functional devices under extreme conditions. The work performs a superior energy storage all-organic film and offers a strategy that regulates the chains' spatial topological structure for future aromatic polymers for high-temperature energy storage.

Design of a High-Voltage Miniaturized Control System for Macro Fiber Composites Actuators

Macro Fiber Composites (MFCs) exhibit significant potential in active control applications. These include vibration control for unmanned aerial vehicle wings and helicopter rotors. However, the high-voltage drive requirements of MFCs present challenges. The miniaturization of the controller is a mandatory condition in order not to affect the overall space utilization. Thus, this paper presents a specialized miniaturized high-voltage control system designed specifically for MFC actuators. The proposed system employs a mixed analog-digital modulation method (ADM). This method precisely regulates a discontinuous conduction mode flyback switch-mode power supply operating in current mode. The system achieves an adjustable high-voltage output range of -500 V to 1500 V. The mixed control system consists of several components. These include a switching power supply, a voltage divider circuit, a bleeder circuit, and a digital controller. Additionally, this high-voltage control system integrates with a Simulink software environment. The system is compact and lightweight. It also features high load capacity, high power, and excellent dynamic response. Moreover, it offers real-time control capabilities. Experimental validation on a high-aspect-ratio wing demonstrates that this control system achieves a vibration reduction effect of 65%. The miniaturized control system provides a valuable research base for vibration control studies.

Outcomes of Postchemoradiotherapy Watch-and-Wait Strategy in Patients With Rectal Cancer: A 20-Year, Single-Center Study.

The watch-and-wait (WW) strategy is a nonsurgical alternative for patients with rectal cancer exhibiting an excellent response to chemoradiotherapy. Studies on the WW strategy have primarily investigated 5-year oncological outcomes; few have focused on longer-term outcomes or the optimal patient selection approach for this therapeutic strategy. This retrospective study enrolled patients with locally advanced rectal adenocarcinoma who had achieved complete response after chemoradiotherapy. Patients who achieved pathological complete response were categorized into a control group (n = 95) and those who achieved clinical complete response and were managed using the WW strategy were categorized into a case group (n = 33). Kaplan-Meier estimates were calculated for the between-group comparison of survival. The median follow-up duration was 89 months. Compared with the control group, the case group exhibited improved long-term sphincter preservation, particularly for low-lying tumors (p = 0.032), and inferior nonlocal-regrowth disease-free survival (p = 0.007). Within the case group, patients achieving a complete response by positron emission tomography exhibited 5-year survival rates similar to those achieving a complete endoscopic response. The WW strategy is associated with improved sphincter preservation but worse nonlocal-regrowth disease-free survival. The potential of PET in patient selection for this strategy deserves further investigation.

The Emerging of 2D Layer‐Blocked Frameworks

Blocked copolymers are a versatile and powerful class of materials, and their properties can be modified by carefully designing the molecular architecture. Their ability to self‐assemble into nanoscale structures and the multifunctionality make them invaluable in advanced materials science, nanotechnology, and biomedical engineering. Compared to traditional blocked copolymer morphologies such as linear, cyclic, and branched, 2D layer‐blocked frameworks provide materials with clear structure, permanent porosity, favorable chemical and thermal stability, larger surface area, ultra‐high carrier mobility, efficient charge separation and migration, and excellent photoexcitation response. In this concept article, we summarized the design concepts and state‐of‐the‐art strategies for the construction of 2D layer‐blocked frameworks and reviewed the development of some 2D‐like blocked frameworks and their applications in semiconductor, catalysis, energy storage, etc. Finally, we also outlook for the challenges of these materials in preparation and applications across different research fields.

2D Flower-like CdS@Co/Mo-MOF as Co-Reaction Accelerator of g-C3N4-Based Electrochemiluminescence Sensor for Chlorpromazine Hydrochloride

In this study, we have proposed an electrochemiluminescence (ECL) signal amplification system which is based on two-dimensional (2D) flower-like CdS@Co/Mo-MOF composites as a co-reaction accelerator of the g-C3N4/S2O82− system for ultrasensitive detection of chlorpromazine hydrochloride (CPH). Specifically, the 2D flower-like Co/Mo-MOF with mesoporous alleviated the aggregation of CdS NPs while simultaneously fostering reactant-active site contact and improving the reactant–product transport rate. This allowed the material to act as a novel co-reaction accelerator, speeding up the transformation of the S2O82− into SO4•− and enhancing the cathodic ECL emission of g-C3N4. Moreover, the signal probe which was synthesized by coupling the 2D CdS@Co/Mo-MOF and graphitic carbon nitride (g-C3N4) achieved the generation of SO4•− in situ and reduced energy loss. The results confirmed that the ECL signal was enhanced 6.2-fold and stabilized by CdS@Co/Mo-MOF. Based on the extremely strong quenching effect of chlorpromazine hydrochloride (CPH) on this system, a “signal-off” type sensor was constructed. The sensor demonstrated excellent sensitivity and linear response to CPH concentrations ranging from 1 pmol L−1 to 100 μmol L−1, with a low detection limit of 0.4 pmol L−1 (S/N = 3).

Early downmodulation of tumor glycolysis predicts response to fasting-mimicking diet in triple-negative breast cancer patients.

In preclinical experiments, cyclic fasting-mimicking diets (FMDs) showed broad anticancer effects in combination with chemotherapy. Among different tumor types, triple-negative breast cancer (TNBC) is exquisitely sensitive to FMD. However, the antitumor activity and efficacy of cyclic FMD in TNBC patients remain unclear. Here, we show that a severely calorie-restricted, triweekly, 5-day FMD regimen results in excellent pathologic complete response (pCR) rates (primary endpoint) and long-term clinical outcomes (secondary endpoints) when combined with preoperative chemotherapy in 30 patients with early-stage TNBC enrolled in the phase 2 trial BREAKFAST. Bulk and single-cell RNA sequencing analysis revealed that highly glycolytic cancer cells, myeloid cells, and pericytes from tumors achieving pCR undergo a significant, early downmodulation of pathways related to glycolysis and pyruvate metabolism. Our findings pave the wave for conducting larger clinical trials to investigate the efficacy of cyclic FMD in early-stage TNBC patients and to validate early changes of intratumor glycolysis as a predictor of clinical benefit from nutrient restriction. This study was registered at Clinicaltrials.gov (NCT04248998).

Layer symmetry and irradiation dominate the oxidation capability of birnessite on biogenic isoprene

The climate-active gas isoprene (C5H8) is one of the most abundant biogenic volatile organic compounds (VOCs). Soil is one of the significant sinks for isoprene, yet the role played by the naturally abundant birnessite in the soil surface layer during the oxidation of isoprene remains largely unknown. This study investigates the reactions of isoprene with triclinic and hexagonal birnessite on the Earth's surface environments. Hexagonal birnessite exhibits a superior oxidation capacity than triclinic birnessite, rapidly oxidizing isoprene. The transformation of birnessite from triclinic to hexagonal increases the number of interlayer Mn(III) octahedra, which creates numerous sites for isoprene oxidation. In-situ DRIFTS and DFT calculations indicate that abundant electrophilic active species on the surface of hexagonal birnessite, such as interlayer Mn(III) octahedra and 1O2, oxidize isoprene by attacking conjugated double bonds. Furthermore, birnessite exhibits excellent photoelectric response and photothermal effects, enabling sunlight irradiation under natural conditions to accelerate the oxidation of isoprene by birnessite. The findings of this study elucidates the critical role of birnessite in the oxidation of isoprene and shed light on the fate of isoprene in soil minerals.

Electromechanical properties of different phases in ferroelectric crystals regulated by variously oriented electric fields

Electric fields offer a convenient and tunable way to induce phase transitions for regulating the electromechanical properties of ferroelectrics. However, regulating the electromechanical properties by using electric fields in various directions for different ferroelectric phases has yet to be systematically investigated, especially for lead-free material KNbO3. Based on the nonlinear thermodynamics analysis, the electric field-temperature phase diagrams of KNbO3 single crystals under different electric field directions (E[001], E[011], E[111]) have been constructed, along with the electric-field-induced electromechanical responses. The results show that the phase diagrams are markedly different under different electric field directions. Specifically, the electric field-temperature phase diagram appears as a "line"-shaped phase boundary under E[001], while it appears as a "U"-shaped phase boundary under E[011], and an arrowhead-shaped phase boundary under E[111]. It is also found that there are excellent electromechanical responses near both "U"-shaped and arrowhead-shaped phase boundaries due to the significant alterations in polarization slopes near the phase boundaries, offering an alternative pathway to regulate and enhance the electromechanical properties in ferroelectrics.

Numerical study on dynamic response characteristics of proton exchange membrane water electrolyzer under transient loading

Under dynamic operating conditions, the proton exchange membrane water electrolyzers are prone to voltage overshoot, resulting in fluctuations under transient operation. In this paper, a three-dimensional, two-phase, non-isothermal model is developed to investigate the role of various factors on the dynamic response characteristics of electrolyzers. The results demonstrate that the overshoot phenomenon can be significantly mitigated by using a linear loading strategy and a multi-step loading strategy compared to a step loading strategy. Meanwhile, the effect of the flow field structure was examined, revealing that single-serpentine flow field exhibited excellent dynamic response performance. Additionally, calculated through multiple evaluation methods, it was found that the effect of loading magnitude was significantly greater than that of the other factors, including temperature, flow field structure and anode porous transport layer porosity. Finally, under combined variable load conditions, research revealed that whereas single-serpentine flow field shown benefits regarding dynamic response and energy dissipation.

Highly sensitive and Durable crack structures on Flexible, Friction-Resistant substrates

Flexible sensors using crack-sensitive structures have garnered significant interest due to their exceptional sensitivity stemming from crack disconnection and reconnection mechanisms. However, studies on the sensor’s crack size is imperative, as cracks are typically regarded as defective or harmful in real-life applications. In this study, a new multi-layer configuration (PDMS/Ecoflex)/CNT/PET/(PDMS/Ecoflex) is employed to create piezoresistive pressure sensors with reduced crack size labelled crack free, demonstrating extensive linearity and exceptional sensor responsiveness. The crack size on the conductive layer was significantly reduced using Cetyl Trimethyl Ammonium Bromide cationic surfactant. PDMS/Ecoflex (PE) blend matrix was shown to have an outstanding mechanical and tribological properties compared to PDMS and Ecoflex alone achieving flexibility of up to 500 %, decreasing friction by 56 %, and enhancing wear resistance. The crack-free sensors exhibited a linearity of 0.99, high sensitivity (GF = 132), and low response time (19 ms). Furthermore, crack-free pressure sensors exhibit distinct characteristics such as low detection limits, rapid response/recovery, negligible hysteresis, excellent dynamic response (over 1000 cycles), and exceptional long-term durability. the cracked-free sensor was compared to a standard crack-based sensor to analyze the crack appearance and mechanism on the overall performance and application including health monitoring and various body movement detection.

ChatGPT vs human expertise in the context of IT recruitment

This study aims to address the gap in understanding the extent to which AI can replace human technical interviewers in the recruitment process. It investigates the potential of a Large Language Models, specifically ChatGPT, Google Gemini and Mistral, in assessing candidates’ competencies in Information Technology (IT) compared to evaluations made by human experts. The experiment involved three experienced DevOps specialists who assessed the written responses of 21 candidates to ten industry-relevant questions; each limited to 500 characters. The evaluation was conducted using a simple yet effective −2 to 2 scale, with −2 indicating a negative assessment for incorrect answers, 0 for ambiguous or incomplete answers, and 2 for excellent responses. The same set of responses was then evaluated by LLMs, adhering to the identical criteria and scale. This comparative analysis aims to determine the reliability and accuracy of AI in replicating expert human judgement in IT recruitment. The study’s findings, backed by the Fleiss kappa test, show that human reviewers are not perfectly aligned in their judgement. On the other hand, the AI tool also lacks consistency, as the consequent repetition of the same review request may result in a different decision. The results are anticipated to contribute to the ongoing discourse on AI-assisted decision-making and its practical applications in human resource management and recruitment.

Constructing micro-region networks in expanded graphite for bi-directional high thermal conductivity of thermoplastic polymer composite

Thermoplastic polymers have limited application in thermal management due to its low thermal conductivity (TC). Adding high TC fillers and hot-pressing process can effectively improve in-plane TC. However, single filler orientation limits through-plane heat transfer and most of polymer-based composites have low through-plane TC (<10 W/m·K). The preparation of polymer-based composites with bi-directional high thermal conductivity is still a great challenge. In this work, a novel maleic anhydride (MA) modified nano Al2O3 (M−Al2O3)/expanded graphite (EG)/PVDF composite (MAE/P) with bi-directional high thermal conductivity was prepared by a melt self-adsorption and hot-pressing method, where the EG was used for constructing the main thermal conductive network and the M−Al2O3 was embedded in EG 3D structure to build micro-region network to greatly increase the out-plane thermal conductivity (TC) of the composite. Results show that the through-plane and in-plane TC of the MAE/P were 13.78 W/m·K and 102.24 W/m·K (50 wt% filler content), respectively. The finite element simulation computation of microstructure also amply demonstrates the effectiveness of enhancing TC by gap filling. Research shows that the key to achieving bi-directional high thermal conductivity is that more phonon transmissionpathways were constructed along vertical direction when M−Al2O3 is embedded. Moreover, the MAE/P also indicates excellent thermal infrared response capability, electromagnetic interference shielding (87.22 dB at 70 wt% filler content) and mechanics performance (over 130 MPa bending strength at 50 wt% filler content). This work provides a new method to greatly enhance bi-directional TC of thermoplastic polymer-based composites.

Efficient Estimation and Response Variable Selection in Sparse Partial Envelope Model

In this paper, we propose a sparse partial envelope model that performs response variable selection efficiently under the partial envelope model. We discuss its theoretical properties including consistency, an oracle property and the asymptotic distribution of the sparse partial envelope estimator. A large-sample situation and high-dimensional situation are both considered. Numerical experiments demonstrate that the sparse partial envelope estimator has excellent response variable selection performance both in the large-sample situation and the high-dimensional situation. Moreover, simulation studies and real data analysis suggest that the sparse partial envelope estimator has a much more competitive performance than the standard estimator, the oracle partial envelope estimator, the active partial envelope estimator and the sparse envelope estimator, whether it is in the large-sample situation or the high-dimensional situation.

Prediction of Pollutant Emissions from a Low-Speed Marine Engine Based on Harris Hawks Optimization and Lightgbm

With the rapid development of data science, machine learning has been widely applied to research on pollutant emission prediction in internal combustion engines due to its excellent responsiveness and generalization ability. This article introduces Lightgbm (LGB), which belongs to ensemble learning, to predict the pollutant emissions from a low-speed two-stroke marine engine. The dataset used to train LGB was derived from a one-dimensional performance simulation model of the engine, which was rigorously verified for its reliability by experimental data. To further improve the forecast performance of the LGB model, we used Harris Hawks Optimization (HHO) to automatically optimize the hyperparameters of the model, and finally, we analyzed the importance of the model features. The results show that changes in engine control parameters have significant influences on NOx and soot emissions from the engine, which can serve as the basis for the selection of the LGB model features; the LGB model was able to accurately predict pollutant concentrations from the engine with much higher accuracy than a single decision tree (DT) model; combining with HHO, the predictive ability of the LGB model was significantly improved, such as for the validation set prediction results, the mean absolute error (MAE) was reduced by about 20%, the mean squared error (MSE) was reduced by about 30%, and the coefficient of determination (R2) was increased by about 0.005; and the importance analysis of the model features indicated that the combustion condition of the fuel was highly correlated with the generation of the pollutants, and the fuel injection phases can be adjusted in practice to achieve highly efficient and low-emission processes of combustion. The results of this study can provide references for the development of a new generation of highly efficient and low-pollution marine engines.

A general strategy for enhancing the performance of Ga2O3-based self-powered solar-blind photodetectors through band structure engineering

Abstract The spectral response of Ga2O3 almost perfectly covers the 200~280 nm solar-blind ultraviolet wavelength range, making it an ideal semiconductor material for fabricating solar-blind ultraviolet photodetectors. However, due to the considerably deep valence band energy of Ga2O3 the construction of heterojunctions typically induces a significant valence band offset (EV). Herein, we present a band engineering approach to improve the performance of Ga2O3 bases photodetectors. This pronounced valence band barrier can strongly influence the transport of photo-generated charge carriers, especially the extraction of holes in the depletion region. By introducing nitrogen (N) during the growth process, we elevated the valence band of Ga2O3 by 0.43 eV. The organic high-molecular-weight material of PEDOT:PSS has been utilized in conjunction with Ga2O3 to construct heterojunction photodetectors. The photodetectors exhibit excellent self-powered characteristics, with responsivity, detectivity, and response time being nearly ten times higher than those of Ga2O3 photodetectors before band structure modulation. The investigation into modulating the band structure of Ga2O3 carried out in this study will lay the theoretical foundation and provide technical solutions for developing satisfactory self-powered photodetectors.

Our Experience in Treating Infantile Hemangioma: Prognostic Factors for Relapse After Propranolol Discontinuation.

Infantile hemangioma (IH) is a common benign tumor in infants. While most cases exhibit a self-limiting nature, some require medical treatment to avoid complications. Propranolol is the first-line therapy for IH, it has a high success rate, and is safe to use. Unfortunately, some patients might experience rebound growth after propranolol discontinuation. Currently, it is unclear which factors predict this phenomenon. This study aimed to identify factors affecting the rebound growth of IH after propranolol cessation. We also aimed to identify predictors for an excellent response to oral propranolol. We performed a retrospective cohort study using clinical data from all patients referred to our clinic with IH and placed on systemic oral propranolol between January 2009 to December 2023 in the dermatology outpatient clinic of Rambam Healthcare Campus. Out of a total of 552 patients with IH, 301 received oral propranolol for at least 6months. A relapse phenomenon was observed in 38 (12.6%) patients. We found a significant association between limb involvement and the least likelihood of hemangioma rebound (p < 0.001). An excellent response to oral propranolol was observed in 57.8% of patients. Younger age at initiation of oral propranolol was associated with an excellent response (p = 0.015). Also, IHs located on the limbs (67) showed a higher rate of excellent response to oral propranolol compared to other anatomical sites (p = 0.02). Interestingly, patients who were treated with a dose of 2mg/kg/day were associated with excellent response to treatment (p = 0.007). IHs located on the limbs demonstrated less rebound growth and a better treatment response. When oral propranolol was initiated earlier or when the target dose was 2mg/kg/day, there was a higher rate of excellent response to treatment.

Design of long‐wavelength infrared InAs/InAsSb type‐II superlattice avalanche photodetector with stepped grading layer

AbstractWeak response in long‐wavelength infrared (LWIR) detection has long been a perennial concern, significantly limiting the reliability of applications. Avalanche photodetectors (APDs) offer excellent responsivity but are plagued by high dark current during the multiplication process. Here, we propose a high‐performance type‐II superlattices (T2SLs) LWIR APD to address these issues. The low Auger recombination rate of the InAs/InAsSb T2SLs absorption layer is exploited to reduce the dark current initially. AlAsSb with a low k value is employed as the multiplication layer to suppress device noise while maintaining sufficient gain. To facilitate carrier transport, the conduction band discontinuity is optimized by inserting an InAs/AlSb T2SLs stepped grading layer between the absorption and multiplication layers. As a result, the device exhibits excellent photoresponse at 8.4 μm at 100 K and maintains a low dark current density of 5.48 × 10−2 A/cm2. Specifically, it achieves a maximum gain of 366, a responsivity of 650 A/W, and a quantum efficiency of 26.28% under breakdown voltage. This design offers a promising solution for the advancement of LWIR detection.

Bottom‐up Synthesis of Piezoelectric Covalent Triazine‐based Nanotube for Hydrogen Peroxide Production from Water and Air

Carbon nanotubes (CNTs) are nanoscale tubular materials with superior mechanical strength and electronic properties. However, the conventional CNTs are inherently non‐piezoelectric, mainly due to the lack of polar structures with pure carbon elements. The direct synthesis of fully conjugated and polarized organic nanotubes with desired piezoelectric properties remains a challenge. Herein, we report the bottom‐up synthesis of a new type of covalent triazine‐based nanotube (CTN‐1) as a novel piezoelectric material. The CTN‐1 comprises of high surface area, nitrogen‐rich and fully conjugated structure, which provides a series of merits for piezoelectric catalytic processes. These structural features combined with one‐dimensional tubular morphology endow CTN‐1 with excellent mechanical stimuli response and thus displaying prominent piezoelectric properties via pronounced nanocurvature effect. We further show that the CTN‐1 enables the efficient synthesis of H2O2 from water in the air via mechanical energy conversion, with an excellent piezocatalytic H2O2 evolution rate of 4115 μmol g‐1 h‐1, which exceeds all other reported piezoelectric materials. The piezocatalysis by the CTN‐1 can be practically integrated into a self‐Fenton system, which exhibits excellent pollutant degradation capability. This work demonstrates the enormous potential of a new type of piezoelectric synthetic nanotube from organic frameworks for the in‐situ synthesis valuable chemicals.

Bottom-up Synthesis of Piezoelectric Covalent Triazine-based Nanotube for Hydrogen Peroxide Production from Water and Air.

Carbon nanotubes (CNTs) are nanoscale tubular materials with superior mechanical strength and electronic properties. However, the conventional CNTs are inherently non-piezoelectric, mainly due to the lack of polar structures with pure carbon elements. The direct synthesis of fully conjugated and polarized organic nanotubes with desired piezoelectric properties remains a challenge. Herein, we report the bottom-up synthesis of a new type of covalent triazine-based nanotube (CTN-1) as a novel piezoelectric material. The CTN-1 comprises of high surface area, nitrogen-rich and fully conjugated structure, which provides a series of merits for piezoelectric catalytic processes. These structural features combined with one-dimensional tubular morphology endow CTN-1 with excellent mechanical stimuli response and thus displaying prominent piezoelectric properties via pronounced nanocurvature effect. We further show that the CTN-1 enables the efficient synthesis of H2O2 from water in the air via mechanical energy conversion, with an excellent piezocatalytic H2O2 evolution rate of 4115 μmol g-1 h-1, which exceeds all other reported piezoelectric materials. The piezocatalysis by the CTN-1 can be practically integrated into a self-Fenton system, which exhibits excellent pollutant degradation capability. This work demonstrates the enormous potential of a new type of piezoelectric synthetic nanotube from organic frameworks for the in-situ synthesis valuable chemicals.