Abstract Appropriate simulation set parameters are the precondition to obtain accurate results; while the simulation results are affected by multiple factors, it is thus crucial to investigate the sensibility of different factors. This paper first analyses the application situation of numerical simulation software in the field of geotechnical engineering and finds that Fast Lagrangian analysis of continua in three dimensions (FLAC3D) has been widely used on roadways or tunnels. Then, taking the roadway excavation process as the engineering background, FLAC3D was used to create 171 schemes of different simulation parameters and analyze the influence of different factors on the simulation results. The findings show that there is a considerable difference in the degree of effect of different parameters on the simulation results. Most of the factors have a remarkable effect on the numerical simulation results (displacement and stress), and only some factors (parameter uniformity and density) have almost no effect on the results. Meanwhile, the trend of displacement and stress is opposite in most cases. In addition, some neglected factors can also have a considerable effect on the simulation results, such as the zone amount; therefore, it is necessary to avoid the variation of nonstudy factors as possible when carrying out the numerical simulation. This study may significantly assist concerned engineers and technicians in developing a more organized and thorough grasp of the impacts of various parameters on simulation outcomes.