Markov chain Monte Carlo (MCMC) allows one to generate dependent replicates from a posterior distribution for effectively any Bayesian hierarchical model. However, MCMC can produce a significant computational burden. This motivates us to consider finding expressions of the posterior distribution that are computationally straightforward to obtain independent replicates from directly. We focus on a broad class of Bayesian hierarchical models for spatially dependent data, which are often modeled via a latent Gaussian process (LGP). First, we derive a new class of distributions referred to as the generalized conjugate multivariate (GCM) distribution. The GCM distribution’s theoretical development follows that of the conjugate multivariate (CM) distribution with two main differences: the GCM allows for latent Gaussian process assumptions, and the GCM explicitly accounts for hyperparameters through marginalization. The development of GCM is needed to obtain independent replicates directly from the exact posterior distribution, which has an efficient regression form. Hence, we refer to our method as Exact Posterior Regression (EPR). Simulation studies with weakly stationary spatial processes and spatial basis function expansions are provided. We provide an analysis of poverty incidence from the U.S. Census Bureau, and an analysis of high-dimensional remote sensing data. Supplementary materials for this article are available online.