You have accessJournal of UrologyProstate Cancer: Basic Research IV1 Apr 2015MP61-02 COPY NUMBER VARIATION OF GSTT1 AND GSTM1 AND THE RISK OF PROSTATE CANCER IN A CARIBBEAN POPULATION OF AFRICAN DESCENT Laurent Brureau, Elise Emeville, Cedric Broquere, Severine Ferdinand, Pascal Blanchet, Luc Multigner, and Marc Romana Laurent BrureauLaurent Brureau More articles by this author , Elise EmevilleElise Emeville More articles by this author , Cedric BroquereCedric Broquere More articles by this author , Severine FerdinandSeverine Ferdinand More articles by this author , Pascal BlanchetPascal Blanchet More articles by this author , Luc MultignerLuc Multigner More articles by this author , and Marc RomanaMarc Romana More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.2183AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Deletions of the glutathione S-transferase genes M1 and T1 (GSTM1 and GSTT1) have been studied as potential risk factors for prostate cancer. Conflicting results have been obtained. Moreover, most such studies could not discriminate heterozygous from homozygous carriers of the non-deleted alleles. We investigated whether copy number variation (CNV) of the GSTM1 and/or GSTT1 genes contribute to the risk of prostate cancer in the Caribbean population of African descent of Guadeloupe. METHODS In a population-based case-control study, we compared 629 prostate cancer patients and 622 control subjects. Logistic regression was used to estimate adjusted odds ratios (OR) and 95% confidence intervals (CI). Exact copy numbers of GSTM1 and GSTT1 were determined by real-time PCR. RESULTS A higher copy number of GSTM1 was marginally associated with prostate cancer risk. Men with 2 and 3 or more GSTT1 genes were at higher risk of prostate cancer (OR: 1.55, 95% CI: 1.11-2.16 and OR: 4.89, 95% CI: 1.71-13.99, respectively; P(trend)<0.001). Men with 3, 4 and 5 or more copies of both GSTM1 and GSTT1 genes were at higher risk of prostate cancer (OR: 2.18, 95% CI: 1.21-3.91, OR: 3.24, 95% CI: 1.63-6.46, and OR: 5.77, 95% CI: 1.40-23.84, respectively; P(trend)<0.001). CONCLUSIONS Copy number of GSTT1 and combined GSTM1/GSTT1 appear to be associated with prostate cancer risk in our population study with gene dose relationship. Our results support the hypothesis that variations in copy number of GSTT1 modulate the risk of prostate cancer. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e747 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Laurent Brureau More articles by this author Elise Emeville More articles by this author Cedric Broquere More articles by this author Severine Ferdinand More articles by this author Pascal Blanchet More articles by this author Luc Multigner More articles by this author Marc Romana More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...