ABSTRACT Background: The most malignant skin tumors of the head are dominated by epithelial cancers, particularly basal cell carcinomas, followed by squamous cell carcinomas and melanomas. Herein, we present a case series of malignant skin cancers in the cephalic region. We address their epidemiological, clinical, histological, and therapeutic profiles in our context. Materials and Methods: This was a prospective study conducted for descriptive purposes on cases of skin cancer, including melanoma, squamous cell carcinoma, and basal cell carcinoma, followed at the dermatology department of CHU Hassan II Fez between June 2017 and December 2021. Results: We collected a total of 260 patients with different types of skin cancer. 147 cases (57%) were in the cephalic location: 56% presented squamous cell carcinoma, followed by melanoma (22%) and basal cell carcinoma (21%). Conclusion: The early detection of skin cancer is essential to reduce the functional morbidity and mortality associated with these tumors, especially in these cephalic locations. Key words: Cutaneous tumors, Cephalic region, Early diagnosis