A Casson fluid is the most suitable rheological model for blood and other non-Newtonian fluids. Casson fluids hold yield-stress and have great significance in biomechanics and polymer industries. In this analysis, a numerical simulation of non-coaxial rotation of a Casson fluid over a circular disc was estimated. The influence of thermal radiation, second-order chemical reactions, buoyancy, and heat source on a Casson fluid above a rotating frame was studied. The time evolution of secondary and primary velocities, solute particles, and energy contours were also examined. A magnetic flux of varying intensity was applied to the fluid flow. A nonlinear sequence of partial differential equations was used to describe the phenomenon. The modeled equations were reduced to a non-dimensional set of ordinary differential equations (ODEs) using similarity replacement. The obtained sets of ODEs were further simulated using the parametric continuation method (PCM). The impact of physical constraints on energy, concentration, and velocity profiles are presented through figures and tables. It should be noted that the effect of the Casson fluid coefficient, the Grashof number, and the magnetic field reduces the fluid’s primary velocity contour. The mass transfer field decreases with the action of constructive chemical reactions, but is augmented by the effects of destructive chemical reactions. The accelerating trend in Schmidt number lowers the mass profile, while it is enhanced by increasing values of activation energy and Soret number.