The tectonic and tectonostratigaphic evolution of foreland basins and related Tertiary depressions are the key to investigate deformation history and the uplifting of the continental lithosphere of the Alpine–Pyrenean Orogeny. The northern part of the Duero basin is the foreland basin of the Cantabrian Mountains, which are, in turn, the western part of the Pyrenean Orogen. We have studied the western sharp end of the Duero foreland basin, and its relation to the Tertiary deposits of the NW Iberian Peninsula and the topography evolution. In order to propose a coherent tectonic and tectonosedimentary model that could explain all Tertiary deposits, we have analysed the depositional environment, stratigraphic sequences, paleocurrents and established a correlation of the main outcrops. Besides, a detailed structural mapping of the Alpine structures that limit and affect the main Tertiary outcrops has been carried out. The Tertiary deposits of the NW Iberian Peninsula depressions are affected and fragmented by Alpine structures that limit their extensions and locations. The stratigraphic succession is similar in the NW Tertiary outcrops; they are mainly terrigenous and carbonated continental deposits formed by assemblage of alluvial fans developed at the mountains front, in arid or semiarid conditions. Three formations can be identified in the main depressions: Toral Fm, Santalla Fm and Médulas Fm. The NW Tertiary outcrops were the western deposits of the Duero foreland basin that surrounded the lateral termination of the Pyrenean Orogen. These deposits were fragmented and eroded by the subsequent uplift of the Galaico–Leoneses Mountains and the NE–SW strike-slip faults activity (broken foreland basin). Only the latest stages of some of these outcrops can be considered as intramontane basins as traditionally have been interpreted. The sedimentation started in the northeast (Oviedo–Infiesto) during the Eocene and migrated to the west (As Pontes) during the Late Oligocene–Early Miocene times. Meanwhile, southern areas were far away from the tectonic activity (El Bierzo, O Barco, Monforte, Sarria depressions).