Evolution Of System Research Articles

On the Re-Creation of Protoribosome Analogues in the Lab.

The evolution of the translation system is a fundamental issue in the quest for the origin of life. A feasible evolutionary scenario necessitates the autonomous emergence of a protoribosome capable of catalyzing the synthesis of the initial peptides. The peptidyl transferase center (PTC) region in the modern ribosomal large subunit is believed to retain a vestige of such a prebiotic non-coded protoribosome, which would have self-assembled from random RNA chains, catalyzed peptide bond formation between arbitrary amino acids, and produced short peptides. Recently, three research groups experimentally demonstrated that several distinct dimeric constructs of protoribosome analogues, derived predicated on the approximate 2-fold rotational symmetry inherent in the PTC region, possess the ability to spontaneously fold, dimerize, and catalyze the formation of peptide bonds and of short peptides. These dimers are examined, aiming at retrieving information concerned with the characteristics of a prebiotic protoribosome. The analysis suggests preconditions for the laboratory re-creation of credible protoribosome analogues, including the preference of a heterodimer protoribosome, contradicting the common belief in the precedence of homodimers. Additionally, it derives a dynamic process which possibly played a role in the spontaneous production of the first bio-catalyzed peptides in the prebiotic world.

Capitella teleta gets left out: possible evolutionary shift causes loss of left tissues rather than increased neural tissue from dominant-negative BMPR1

BackgroundThe evolution of central nervous systems (CNSs) is a fascinating and complex topic; further work is needed to understand the genetic and developmental homology between organisms with a CNS. Research into a limited number of species suggests that CNSs may be homologous across Bilateria. This hypothesis is based in part on similar functions of BMP signaling in establishing fates along the dorsal-ventral (D-V) axis, including limiting neural specification to one ectodermal region. From an evolutionary-developmental perspective, the best way to understand a system is to explore it in a wide range of organisms to create a full picture.MethodsHere, we expand our understanding of BMP signaling in Spiralia, the third major clade of bilaterians, by examining phenotypes after expression of a dominant-negative BMP Receptor 1 and after knock-down of the putative BMP antagonist Chordin-like using CRISPR/Cas9 gene editing in the annelid Capitella teleta (Pleistoannelida).ResultsEctopic expression of the dominant-negative Ct-BMPR1 did not increase CNS tissue or alter overall D-V axis formation in the trunk. Instead, we observed a unique asymmetrical phenotype: a distinct loss of left tissues, including the left eye, brain, foregut, and trunk mesoderm. Adding ectopic BMP4 early during cleavage stages reversed the dominant-negative Ct-BMPR1 phenotype, leading to a similar loss or reduction of right tissues instead. Surprisingly, a similar asymmetrical loss of left tissues was evident from CRISPR knock-down of Ct-Chordin-like but concentrated in the trunk rather than the episphere.ConclusionsOur data highlight a novel asymmetrical phenotype, giving us further insight into the complicated story of BMP’s developmental role. We further solidify the hypothesis that the function of BMP signaling during the establishment of the D-V axis and CNS is fundamentally different in at least Pleistoannelida, possibly in Spiralia, and is not required for nervous system delimitation in this group.

Evolutionary Tripartite Game Model in the Coal Mine Risk-Hazard Double Pre-Control and Management in China

The classification, investigation, and management of the safety risk (namely, risk-hazard double pre-control management mechanism) in coal mines were introduced into a behavioral evolution game to assess the decision-making processes of coal mine workers, regulators, and supervisors. A tripartite game tree and a revenue perception matrix were constructed, and the evolutionary stability strategy (ESS) achieved by the evolutionary system under different conditions was obtained according to the replication dynamic equation (RD). The numerical simulation of the evolution game was conducted in MATLAB, which verified the influence of various parameters on the behaviors adopted by all parties. The results show: (1) When the safety, regulatory, and supervisory costs are high, the average expected value of mine workers, regulators, and supervisors to choose safety behaviors is low, so they adopt an unsafe behavior. By contrast, reducing costs can encourage the adoption of safety behaviors. (2) When the punishment for accident losses caused by unsafe behavior and the lack of regulations and supervision is higher than 50% of the initial state, the actors in the tripartite game are more inclined to avoid risks when facing cost losses in the short term, which can lead them to choose a safety behavior. (3) When the actors in the tripartite game face different accident probabilities and accident loss, with the severity of the accident increasing to 80% of the initial state, mine workers and regulators gradually adopt safety and regulation behaviors, and supervisors quickly adopt supervision methods.

Emergence and evolution of standardization systems in medical biology laboratories

Abstract Introduction The history of standardization relating to the activities of medical laboratories traces the development of quality system standards in the world, and their evolution. Content In this study, we have included the key benchmarks that represent the stages of the quality system’s evolution in recent decades. Accreditation of medical laboratories has become compulsory in most countries, regarding national or international standards. International acknowledgment of the effectiveness of the results delivered to the many stakeholders, particularly patients and prescribers, is conferred through the use of standards. Summary The ISO 15189 standard represents the latest and most specific international standards for medical laboratories of all types. Outlook More research is necessary to study if laboratory practices reflect the evolution of standards within the medical laboratory field.

Sub-6 GHz beamforming with low-cost software-defined radio: Design, testing, and performance evaluation

The rapid evolution of mobile communication systems has led to the introduction of novel technologies and techniques that address existing challenges, such as interference caused by multiple users and transmission through the millimetre-wave band. In this paper, we present a novel approach that utilises a low-cost software defined radio (SDR) unit to enable transmitting and receiving beamforming in the sub-6 GHz band. We provide a detailed account of the underlying concepts and background of beamforming and SDR, outline the design of multiple components, and report on the comprehensive testing and verification of a real-life prototype using over-the-air (OTA) methods. Our results demonstrate that the proposed approach achieves outstanding performance, with measurements of bit error rate (BER) that outperform existing solutions. In summary, this work contributes to the ongoing efforts to enhance mobile communication systems by providing an innovative, high-performance solution that is cost-effective and reliable using SDR technology in the sub-6 GHz band.

Enhancing PAPR reduction efficiency in MIMO-OFDM systems via selective mapping and metaheuristic algorithms

The relentless evolution of communication systems, driven by the demands of 5G and the impending 6G networks, necessitates heightened data rates and spectral efficiency. orthogonal frequency division multiplexing (OFDM), a form of multicarrier modulation employed in multi-input multi-output (MIMO) systems, stands as a pivotal technology. Yet, OFDM grapples with challenges, notably the peak-to-average power ratio (PAPR) issue. Selective mapping (SLM) has been a favored technique for mitigating PAPR in OFDM, albeit challenged by computational complexities in its pursuit of discovering optimal phase factors. This paper pioneers a transformative approach by integrating metaheuristic algorithms genetic algorithm (GA), particle swarm optimization (PSO), and the innovative fireworks algorithm (FWA) into SLM for PAPR reduction while minimizing computational complexity. Simulation results not only affirm the efficacy of SLM-based techniques but also spotlight the potential of metaheuristic algorithms in addressing PAPR challenges in modern communication systems. The study transcends single-antenna systems, extending to MIMO-OFDM systems based on WiMAX standards, validating the efficacy of these techniques in multi-antenna configurations. Crucially, the FWA, proposed for the first time in this paper, emerges as a robust candidate, striking an enviable balance between computational efficiency and performance, achieving a notable PAPR reduction with a favorable search number.

Diagenetic history and porosity evolution of the Middle Permian clastic-carbonate mixed system, Indus Basin, Pakistan: Implications for reservoir development

This study deals with unraveling the diagenesis-induced porosity evolution in a mixed clastic-carbonate sequence of the Middle Permian Indus Basin, Pakistan. Multiple data sets including outcrop, petrography, cathodoluminescence, scanning electron microscopy (SEM), mineralogy, and geochemical isotopic compositions were integrated to establish a link between porosity evolution and diagenesis. The spatial thickness and facies variations of the strata at outcrop scale are inherently controlled by the underlying bathymetry of the basin with deepening westward trend. The low values of δ18O of the target strata, relative to average values of the Permian carbonate, hints to diagenetic alteration in the strata. The data sets used in this study reveal modification of the strata in four environments, that is, i) early marine diagenesis indicated by micritization, pervasive dolomitization and isopachous fibrous cements, followed by ii) meteoric dissolution, and iii) shallow burial diagenetic processes including the precipitation of blocky cement, compaction of skeletal and non-skeletal allochems, and stylolites, and iv) a deep burial environment, characterized by pressure solution, and micro-fractures. The clastic intervals host subangular to subrounded quartz grains, floating textures, and almost complete absence of deleterious clay minerals, consequently resulting in the preservation of primary porosity. The primary porosity of carbonate intervals is preserved in the form of intercrystalline and intracrystalline porosity. The secondary porosity evolved through various diagenetic phases in the form of fractures and dissolution. The diagenetic solution mediated by organic matter in carbonates may have experienced both bacterial decomposition and thermochemical sulfate reduction, precipitating sulfides within the pores. The plug porosity/permeability analyses generally suggest high porosity in the siliciclastic unit, and carbonates with wackestone fabric while lower values were observed for the inner shelf pure carbonate facies. However, both intervals show very low permeability values probably due to isolated moldic pores and intense micritization. Therefore, clastic intervals may provide an opportunity to serve as a moderate reservoir; however, the carbonate intervals possess very low permeability values and could generally be considered as low-moderate reservoir potential.

Drainage reorganization and divide migration driven by basin subsidence: An example from the Micang Shan, outskirts of eastern Tibet and its implications for Cenozoic evolution of the Yangtze River

AbstractThe Cenozoic India‐Asia collision has elevated the Tibetan Plateau and produced large strike‐slip faults in the interior and margins of the plateau, which profoundly influenced drainage reorganization and divide migration in Asia. Recent studies have revealed that the drainage divides between the major rivers in and around the Tibetan Plateau have been migrating for tens of millions of years, due to tectonic and/or climatic disturbance or river capture events. Drainage‐divide stability analysis can provide new, independent insights into the Cenozoic evolution of the river systems. In this study, we focus on the Hanzhong Basin and the adjacent Micang Shan (Shan means Mountain(s)) at the tail of the Qingchuan strike‐slip fault in the outskirts of eastern Tibet. We investigated the stability of the Micang Shan drainage divide, which separates the Han and Jialing rivers (two major tributaries of the Yangtze River), using two methods—χ‐plot and Gilbert metrics. The results show that most segments of the Micang Shan drainage divide are either moving south or stable. We further calculated the predicted stable divide location and identified the abandoned river channels and residual planation surfaces. Based on these analyses, we suggest that (1) the migration of the Micang Shan drainage divide is driven by the tectonic subsidence of the Hanzhong Basin; and (2) the upper reaches of the Han River flowed southward to the Sichuan Basin before basin subsidence. This study supports the hypothesis that the Palaeo‐Middle Yangtze River and its tributaries primarily flowed southward. Moreover, the flow direction of the Middle Yangtze River has been, and still is, transitioning from southward to eastward. The change in river network flow direction is driven by regional block tilting towards the east, surface deformation from strike‐slip faulting, regional extension east of the Tibetan Plateau and/or increased influence from the summer monsoon.

Enhancing sustainability: Exploring the evolution and dynamics of the grassland social-ecological system in Inner Mongolia over the past 260a

Understanding the intricate relationship between social-ecological systems (SES) coupling and long-term regional sustainable development is critical for effective management strategies. While recent research has predominantly focused on human-earth coupling, there is a dearth of knowledge concerning the transition of grassland SES from one regime to another and the underlying drivers. This study employs a comprehensive SES framework to identify and analyze interactions within typical pastoral areas of Inner Mongolia, aiming to shed light on the evolution of the grassland SES over the past centuries. Our research defines five distinct evolutionary phases in the grassland SES since the mid-Qing Dynasty. Each phase is characterized by unique social and ecological features, providing a nuanced understanding of the system's dynamics. We establish empirical links between the phases and their driving forces and impacts by assessing the main changes between these periods. Specifically, our findings reveal instances of negative cross-scale effects emerging during the evolution process. We observe that unreasonable resource utilization and an inability to curb ecological degradation may lead to unsustainable traps, posing challenges to long-term sustainability. To illustrate, during the transition from Phase 3 to Phase 4 in the late 19th century, a shift towards sedentary pastoralism led to increased land degradation due to intensified grazing practices. This unsustainable trajectory highlights the importance of adaptive management strategies to mitigate such negative consequences. This study contributes insights into the social and ecological management of grassland pastoral areas in China and for global analogous regions. By addressing the identified phases and their associated challenges, our research provides a foundation for crafting sustainable policies and practices to ensure the resilience of grassland SES in diverse geographical contexts.

Multi-Agent Distributed Optimal Control for Tracking Large-Scale Multi-Target Systems in Dynamic Environments.

This article considers the problem of motion coordination for a multiagent (MA) network whose goal is to track a large-scale multitarget (MT) system in a region populated by dynamic obstacles. We first characterize a density path which corresponds to the expected evolution of the macroscopic state of the MT system, which is represented by the probability density function (PDF) of a time-varying Gaussian mixture (GM). We compute this density path by using an adaptive optimal control method which accounts for the distribution of the (possibly moving) obstacles over the environment described by a time-varying obstacle map function. We show that each target of the MT system can find microscopic inputs that can collectively realize the density path while guaranteeing obstacle avoidance at all times. Subsequently, we propose a Voronoi distributed motion coordination algorithm which determines the individual microscopic control inputs of each agent of the MA network so that the latter can track the MT system while avoiding collisions with obstacles and their teammates. The proposed algorithm relies on a distributed move-to-centroid control law in which the density over the Voronoi cell of each agent is determined by the estimated macroscopic state evolution of the MT system. Finally, simulation results are presented to showcase the effectiveness of our proposed approach.

Relative Occurrence Rate between Hot and Cold Jupiters as an Indicator to Probe Planet Migration

We propose a second-order statistic parameter ε, the relative occurrence rate between hot Jupiters (HJs) and cold Jupiters (CJs) (ε = η HJ/η CJ), to probe the migration of gas giants. Since the planet occurrence rate is the combined outcome of the formation and migration processes, a joint analysis of HJ and CJ frequency may shed light on the dynamical evolution of giant planet systems. We first investigate the behavior of ε as the stellar mass changes observationally. Based on the occurrence rate measurements of HJs (η HJ) from the Transiting Exoplanet Survey Satellite survey and CJs (η CJ) from the California Legacy Survey, we find a tentative trend (97% confidence) that ε drops when the stellar mass rises from 0.8 to 1.4 M ⊙, which can be explained by different giant planet growth and disk migration timescales around different stars. We carry out planetesimal and pebble accretion simulations, both of which can reproduce the results of η HJ, η CJ, and ε. Our findings indicate that the classical core accretion + disk migration model can explain the observed decreasing trend of ε. We propose two ways to increase the significance of the trend and verify the anticorrelation. Future works are required to better constrain ε, especially for M dwarfs and for more massive stars.

Reducing Road Mishaps: A CNN Model for Driver Fatigue Detection

Over the last few decades, there have been substantial developments in a variety of domains, including computer science, artificial intelligence, and machine learning, which has accelerated the evolution and application of intelligent systems in specific areas such as transportation. One way these systems are used in transportation is through fatigue detection, and to enable this technology, Convolutional Neural Networks serve as the foundation on which this system is built. CNNs are frequently employed in computer vision applications because they can automatically extract pertinent features from input data without the need for manual feature engineering. This CNN-based fatigue detection system was built in-order to address the repercussions of fatigued driving by monitoring the driver’s facial features in real-time so as to predict the fatigue levels and send out an alert to restore the driver’s alertness level so as to reduce road mishap. The system relies on visual input from a camera, which sends this input to a fatigue detection program installed on a Raspberry Pi microprocessor and sends out via alerts via a display and audio alerts via a piezoelectric buzzer. The model shows excellent performance, consistently achieving high accuracy, peaking at 97.34% on the 64th epoch, and consistently maintaining high validation accuracy, reaching 96.02% in the 67th epoch, indicating its ability to function effectively.

Planetary Paleomagnetic Intensity Recording Fidelity Test Using a Synthetic Lava

AbstractMeteorite paleomagnetism is fundamental to understanding planetary dynamo processes and the evolution of the early Solar System. However, due to the extraterrestrial and ancient origins of meteorites, their paleomagnetic recording fidelity remains uncertain, which can be tested from a planetary sample formed in a known field. On Earth, historic lavas are used to examine paleomagnetic recording fidelity through the Thellier‐series experiment and other paleointensity methods, which can produce paleointensity estimates to test against the known field strength. But natural terrestrial rocks have different magnetic mineralogy from planetary samples, so they cannot faithfully infer the recording fidelity of meteorites. Here, we used an iron‐particle‐bearing sample from the Syracuse University Lava Project (SULP), which is analogous to the lunar basalts and howardite‐eucrite‐diogenite meteorites and forms in the present‐day Earth's field, to investigate the recording fidelity of these meteorites. No remanence has been identified in the high coercivity range with alternating field (AF) demagnetization due to the sample's low coercivity and AF noise, which produces underestimated paleointensities. Two accurate thermal paleointensities indicate that we may acquire accurate paleointensities from non‐ideal multidomain (MD) iron grains with the Thellier‐Coe and RESET methods, but the success rate is low due to the MD effect and thermal alteration in the experiments. Our results imply that MD iron‐bearing meteorites have the potential to provide accurate paleointensities that can be used to constrain planetary processes.

A multi-methodological approach to record dynamics and timescales of the plumbing system of Zaro (Ischia Island, Italy)

Determining the time spans of processes related to the assembly of eruptible magma at active volcanoes is fundamental to understand magma chamber dynamics and assess volcanic hazard. This information can be recorded in the chemical zoning of crystals. Nevertheless, this kind of study is still poorly employed for the active volcanoes of the Neapolitan area (Southern Italy), in particular, for Ischia island where the risk is extremely high and this information can provide the basis for probabilistic volcanic hazard assessment. For these reasons, we acquired chemical composition on clinopyroxene crystals erupted at Ischia during the Zaro eruption (6.6 ± 2.2 ka) and performed numerical simulations of the input of mafic magma into a trachytic reservoir, in order to investigate various aspects of pre-eruptive dynamics occurring at different timescales. This event emplaced a ~ 0.1 km3 lava complex, in which the main trachytic lava flows host abundant mafic to felsic enclaves. Previous petrological investigation suggested that mafic magma(s) mixed/mingled with a trachytic one, before the eruption. In this work, the clinopyroxene zoning patterns depict the growth of crystals in different magmatic environments, recording sequential changes occurred in the plumbing system before the eruption. The evolution of the plumbing system involved a hierarchy of timescales: a few hours for magma mingling caused by mafic recharge(s) and likely occurred multiple times over a decade during which a dominant magmatic environment was sustained before the eruption. Such timescales must be considered in volcanic hazard assessment at Ischia and similar active volcanoes in densely populated areas.

JWST/NIRCam Detection of the Fomalhaut C Debris Disk in Scattered Light

Observations of debris disks offer important insights into the formation and evolution of planetary systems. Though M dwarfs make up approximately 80% of nearby stars, very few M dwarf debris disks have been studied in detail—making it unclear how or if the information gleaned from studying debris disks around more massive stars extends to the more abundant M dwarf systems. We report the first scattered-light detection of the debris disk around the M4 star Fomalhaut C using JWST's Near Infrared Camera (NIRCam; 3.6 and 4.4 μm). This result adds to the prior sample of only four M dwarf debris disks with detections in scattered light and marks the latest spectral type and oldest star among them. The size and orientation of the disk in these data are generally consistent with the prior Atacama Large Millimeter/submillimeter Array submillimeter detection. Though no companions are identified, these data provide strong constraints on their presence—with sensitivity sufficient to recover sub-Saturn mass objects in the vicinity of the disk. This result illustrates the unique capability of JWST to uncover elusive M dwarf debris disks in scattered light and lays the groundwork for deeper studies of such objects in the 2–5 μm regime.

Lower crustal control in the iron isotope systematics of plutonic xenoliths from Adak Island, Central Aleutians, with implications for arc magma geochemistry

We present bulk-rock and mineral Fe isotope data of ultramafic to mafic xenoliths and basaltic to andesitic lavas from Adagdak Volcano (Adak Island, Central Aleutians) to study the effects of early differentiation on the Fe isotopic evolution of island arc basalts and their crystallization products. The Fe isotope composition of ultramafic cumulate xenoliths increases from dunite (δ56Fe = –0.09 to –0.02 ‰) to clinopyroxenite (δ56Fe = +0.06 to +0.09 ‰), consistent with higher modal proportions of clinopyroxene (δ56Fe = –0.05 to +0.11 ‰) relative to olivine (δ56Fe = –0.10 to +0.06 ‰) in the latter. Mid-crustal cumulate amphibole gabbro and hornblendite cumulates also record heavier Fe isotope compositions (δ56Fe = +0.04 to +0.08 ‰) due to the abundance of isotopically heavy amphibole (δ56Fe = +0.07 to +0.09 ‰) and magnetite (δ56Fe = +0.11 to +0.13 ‰) in these rocks. High inter-mineral fractionations observed in spinel-olivine and spinel-clinopyroxene pairs (Δ56Fespl-ol = +0.12 to +0.28 and Δ56Fespl-cpx = +0.06 to +0.19) suggest that spinel is not recording equilibrium crystallization conditions for the ultramafic assemblages, likely due to subsolidus Fe-Mg exchange. Our data also include Fe isotope measurements of one mantle dunite (δ56Fe = +0.03 ± 0.05 ‰). Five Adagdak lavas, spanning from basalts to andesites, yield a narrow range of δ56Fe between +0.03 and +0.06 ‰. Our results highlight the potential of amphibole in driving the Fe isotope depletion trends observed in many erupted arc lavas, as amphibole hosts 28–99 % of the FeOT budget in the amphibole gabbro and hornblendite cumulates. This is also supported by single-crystal synchrotron Mössbauer spectroscopy of two amphibole grains, the first from an amphibole gabbro and the second from a hornblendite, which yield Fe3+/ΣFe ratios of 0.55 ± 0.06 and 0.58 ± 0.02, respectively. Water content and hydrogen isotope compositions determined by secondary-ion mass spectrometry from the same amphibole grains indicate partial dehydrogenation. Using Rayleigh fractionation modeling to account for oxidation during post-crystallization dehydrogenation, we calculate magmatic Fe3+/ΣFe ratios of 0.41 ± 0.04 for the amphibole gabbro and 0.30 ± 0.05 for the hornblendite. These data are then used to estimate an appropriate Fe force constant for Adagdak amphibole and quantitatively evaluate the effects of amphibole fractionation. Through a fractional crystallization model, we show how arc melts may experience periods of increasing δ56Fe during olivine-dominated fractionation, followed by decreasing δ56Fe once magnetite and amphibole saturate as cumulate phases. Notably, this dichotomy between fractionation of isotopically light versus heavy cumulate assemblages and its effects on the Fe isotope evolution of arc magmas is not captured by the Adagdak lava record, highlighting the utility of cumulates in chronicling the early isotopic evolution of magmatic systems.

A Non‐Magnetized Chondrite Parent Body Revealed by Paleomagnetic Investigation of LL6 Chondrite NWA 14180

AbstractMagnetic records from meteorites provide valuable information about the formation and evolution of the solar system and planets. The parent planetesimals of chondrites are typically considered to be undifferentiated based on their primary chemical composition and texture. However, recent paleomagnetic investigations of various chondrites indicate that they carry a primary remanence generated by a dynamo, suggesting partial differentiation of their parent planetesimals. The presence of a dynamo within the parent planetesimal of LL chondrites remains uncertain due to the ambiguous origin of the remanent magnetism. Here, we report petrographic, paleomagnetic, and rock magnetic properties for the novel LL6 chondrite NWA 14180. The high metamorphic temperature experienced by NWA 14180 could have removed the pre‐accretionary remanence. The fusion crust baked‐contact test suggests that NWA 14180 preserves primary magnetic information about its parent body. Alternating field demagnetization results from interior subsamples reveal distinct low‐ and medium‐coercivity components that may represent a viscous remanent magnetization acquired in the geomagnetic field. No natural remanent magnetization was unblocked in the high coercivity range, implying that NWA 14180 cooled in zero‐field conditions. Therefore, we suggest that the parent body of NWA 14180 did not have a dynamo. Furthermore, this result suggests that the LL chondrite parent planetesimal accreted later and was smaller in size than other chondrite classes.

Crystal plasticity finite element method investigation of normal tensile deformation anisotropy in rolled pure titanium sheet

Industrial pure titanium with hexagonal close-packed (HCP) crystal structure has a high degree of anisotropy at room temperature. On the mesoscopic scale, this is due to the rolling texture presented by its crystal orientation. Tensile tests were performed on smooth specimens with five angles in the first quadrant at room temperature, and the central deformation region and fracture region were characterized using EBSD and SEM, respectively. The modified Salem anisotropic hardening model is incorporated into the crystal plasticity finite element method (CPFEM) framework in the form of incremental hardening to describe the initial strength and hardening increment evolution of each deformation system of pure titanium. Both slip dislocation and twinning mechanisms are considered in the CPFEM simulation. Three models with different meshing strategies are used to simulate the tensile conditions to capture the evolution of macro and micro variables of pure titanium sheet. The results show that there are anisotropy in stress-strain, system activity, cumulative shear strain, crystal orientation, twin volume fraction, stress triaxiality and Lode parameter. The purpose of this paper is to explore the anisotropy of macro-meso variables in different directions before damage occurs, so as to provide reference for the subsequent construction of related damage models.

Acid-Activated TAT Peptide-Modified Biomimetic Boron Nitride Nanoparticles for Enhanced Targeted Codelivery of Doxorubicin and Indocyanine Green: A Synergistic Cancer Photothermal and Chemotherapeutic Approach.

The evolution of nano-drug delivery systems addresses the limitations of conventional cancer treatments with stimulus-responsive nanomaterial-based delivery systems presenting temporal and spatial advantages. Among various nanomaterials, boron nitride nanoparticles (BNNs) demonstrate significant potential in drug delivery and cancer treatment, providing a high drug loading capacity, multifunctionality, and low toxicity. However, the challenge lies in augmenting nanomaterial accumulation exclusively within tumors while preserving healthy tissues. To address this, we introduce a novel approach involving cancer cell membrane-functionalized BNNs (CM-BIDdT) for the codelivery of doxorubicin (Dox) and indocyanine green to treat homologous tumor. The cancer cell membrane biomimetic CM-BIDdT nanoparticles possess highly efficient homologous targeting capabilities toward tumor cells. The surface modification with acylated TAT peptides (dTAT) further enhances the nanoparticle intracellular accumulation. Consequently, CM-BIDdT nanoparticles, responsive to the acidic tumor microenvironment, hydrolyze amide bonds, activate the transmembrane penetrating function, and achieve precise targeting with substantial accumulation at the tumor site. Additionally, the photothermal effect of CM-BIDdT under laser irradiation not only kills cells through thermal ablation but also destroys the membrane on the surface of the nanoparticles, facilitating Dox release. Therefore, the fabricated CM-BIDdT nanoparticles orchestrate chemo-photothermal combination therapy and effectively inhibit tumor growth with minimal adverse effects, holding promise as a new modality for synergistic cancer treatment.

Modern Industrial Policy and the World Trade Organization

This article surveys the economics of industrial policy as it relates to the World Trade Organization (WTO). Motivated by concern that the modern use of industrial policy is emerging in ways that threaten cooperation in the international trading system, the article begins with the basic historical economic framework for tying industrial policy to underlying market failures. It then introduces the dominant economic understanding of the role played by the WTO, examining the WTO's rules on subsidies (and thus industrial policy), the unease with the evolution of the trading system's subsidy rules, gaps in knowledge, and important data and measurement shortcomings. The main part of the article examines four areas in which modern industrial policy operates differently and has become especially important for the trading system: China, supply chain resilience, supply chain responsiveness, and climate change. The article identifies the evidence to date, open questions, and potential paths forward for economic research to help inform policymakers’ efforts to restore international economic cooperation in trade and industrial policy.