The study on nursing care for patients with iron-deficiency anemia in the ICU underscores the relevance of this common and potentially serious condition, caused by insufficient iron levels in the body. This deficiency hampers hemoglobin production, resulting in symptoms such as fatigue, weakness, and difficulty concentrating. Factors such as blood loss, dietary iron deficiency, and underlying conditions contribute to the development of iron-deficiency anemia, especially in critically ill patients in the ICU. The research reviewed biochemical data for anemia in the ICU and highlighted the importance of nursing care in this context. Increased oxygen demand due to physiological stress can exacerbate symptoms of iron-deficiency anemia in critically ill patients, leading to severe complications and prolonged hospitalization. The literature review addressed the methodology used to identify best care practices, including searching electronic databases and analyzing institutional protocols. The discussion of results underscored the severity of iron-deficiency anemia in the ICU, emphasizing the need for effective interventions to improve clinical outcomes. The results and discussions highlighted the crucial role of nursing in caring for patients with iron-deficiency anemia in the ICU. From early symptom detection to appropriate treatment administration, the nursing team plays a crucial role in patient recovery. Challenges such as constant monitoring, iron supplementation administration, and blood transfusions were discussed, emphasizing the need for continuous education and specialized training of the healthcare team. Finally, the concluding remarks emphasized the importance of a coordinated and continuous approach in managing iron-deficiency anemia in the ICU. The implementation of evidence-based practices, along with continuous team training, is essential for providing high-quality care and improving outcomes for patients.