A 65-year-old femal patient complained mainly of "an exposed bone that appeared after tooth extractions performed eight months earlier". Her medical history revealed breast cancer and lung metastasis, undergoing treatment with chemotherapy, radiotherapy, and Zoledronate. Intraoral examination revealed necrotic bone in the mandible with the presence of exudate. Panoramic radiographs demonstrated evidence of a radiopaque image, suggestive of bone necrosis involving the region of lower incisors and extensive area of bone sequestration spread across the body of the mandible to the region of pre-molars. Treatment included 0.12% chlorhexidine digluconate mouth rinses, antibiotic therapy, laser therapy, and hyperbaric oxygen therapy before and after surgery. Surgery was performed using vibrating tips connected to a high power ultrasonic (piezo) device, and the necrotic bone which was sent for histological analysis. The patient received followed up for two years, presenting good general health and no sign of bone exposure. A 65-year-old femal patient complained mainly of "an exposed bone that appeared after tooth extractions performed eight months earlier". Her medical history revealed breast cancer and lung metastasis, undergoing treatment with chemotherapy, radiotherapy, and Zoledronate. Intraoral examination revealed necrotic bone in the mandible with the presence of exudate. Panoramic radiographs demonstrated evidence of a radiopaque image, suggestive of bone necrosis involving the region of lower incisors and extensive area of bone sequestration spread across the body of the mandible to the region of pre-molars. Treatment included 0.12% chlorhexidine digluconate mouth rinses, antibiotic therapy, laser therapy, and hyperbaric oxygen therapy before and after surgery. Surgery was performed using vibrating tips connected to a high power ultrasonic (piezo) device, and the necrotic bone which was sent for histological analysis. The patient received followed up for two years, presenting good general health and no sign of bone exposure.