Event Abstract Back to Event NEUROPHYSIOLOGICAL CHARACTERIZATION OF CEREBELLO-THALAMO-CORTICAL CIRCUIT IN SWEDD PATIENTS. Tommaso Schirinzi1*, Francesco Di Lorenzo1, Viviana Ponzo2, Anna Rita Bentivoglio3, Antonio Pisani1 and Giacomo Koch2 1 Università di Roma Tor Vergata, Italy 2 IRCCS Fondazione Santa Lucia, Italy 3 Università Cattolica del Sacro Cuore, Italy Introduction: Patients with a clinical diagnosis of Parkinson’s Disease (PD) and normal dopaminergic functional imaging are called SWEDD (scans without evidence of dopaminergic deficit). One of the main clinical features of SWEDD is an asymmetric rest tremor poorly responsive to levodopa. Several evidence suggests that an abnormal activity in the Cerebello-Thalamo-Cortical (CTC) circuit is involved in the pathophysiology of tremor. In this study we provided a neurophysiological characterization of the CTC pathway of SWEDD patients in comparison to idiopathic PD patients and healthy subjects (HS). Materials and Methods: We enrolled 11 SWEDD patients, 8 PD patients and 6 HS. CTC circuit was investigated by a Cerebellar-Brain Inhibition (CBI) protocol and also by the after-effects on MEP amplitude of cerebellar Continuous-Theta-Burst-Stimulation (CTBS). Results: in SWEDD patients the CBI differed from PD patients but not from HS. Cerebellar CTBS induced long-lasting cortical inhibition of MEP amplitude in SWEDDs and HS but not in PD. Conclusions: SWEDD patients seem to have normal CTC pathway functioning compared to PD. This data may suggest that in SWEDD patients motor disturbances are unrelated to a CTC dysfunction. However, it must be pointed out that these findings may have been affected by the relatively small number of subjects, that warrants further additional investigations on larger sample groups. Keywords: swedd, Tremor, TMS, CBI, cerebello-cortical networks Conference: 5th Biennial Workshop on Dystonia: “Controversies in Dystonia and Parkinsonism” | Nobile Collegio Chimico Farmaceutico, Rome, May 29-30, 2015, Rome, Italy, 29 May - 30 May, 2015. Presentation Type: Poster presentation Topic: Pathophysiology of dystonia and parkinsonism Citation: Schirinzi T, Di Lorenzo F, Ponzo V, Bentivoglio A, Pisani A and Koch G (2015). NEUROPHYSIOLOGICAL CHARACTERIZATION OF CEREBELLO-THALAMO-CORTICAL CIRCUIT IN SWEDD PATIENTS.. Front. Neurol. Conference Abstract: 5th Biennial Workshop on Dystonia: “Controversies in Dystonia and Parkinsonism” | Nobile Collegio Chimico Farmaceutico, Rome, May 29-30, 2015. doi: 10.3389/conf.fneur.2015.57.00009 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 06 May 2015; Published Online: 08 May 2015. * Correspondence: MD. Tommaso Schirinzi, Università di Roma Tor Vergata, Rome, Italy, t.schirinzi@yahoo.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Tommaso Schirinzi Francesco Di Lorenzo Viviana Ponzo Anna Rita Bentivoglio Antonio Pisani Giacomo Koch Google Tommaso Schirinzi Francesco Di Lorenzo Viviana Ponzo Anna Rita Bentivoglio Antonio Pisani Giacomo Koch Google Scholar Tommaso Schirinzi Francesco Di Lorenzo Viviana Ponzo Anna Rita Bentivoglio Antonio Pisani Giacomo Koch PubMed Tommaso Schirinzi Francesco Di Lorenzo Viviana Ponzo Anna Rita Bentivoglio Antonio Pisani Giacomo Koch Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.