To explore the therapeutic effect of evidence-based nursing on the perioperative care of gastric cancer patients. 81 patients with gastric cancer hospitalized in our department from September 2018 to September 2019 were randomly divided into 40 experimental group and 40 control group; the control group used conventional nursing intervention and the experimental group used evidence-based nursing intervention to compare the surgical index, mental and emotional, clinical index, visual analogue scoring system score and complications of the two groups. The results showed that there were no statistically significant differences in intraoperative bleeding and operation time between the two groups, and the amount of intraoperative fluid replenishment was significantly lower in the experimental group than in the control group; after the nursing intervention, the Self-rating Anxiety Scale and Self-rating Depression Scale scores of the experimental group were lower than those of the control group at 1 d preoperatively and 3 d postoperatively (p<0.05); the Self-rating Anxiety Scale and Self-rating Depression Scale scores of the experimental group were lower than those of the control group at 6 h, 24 h and 72 h postoperatively (p<0.05). The visual analogue scoring system scores were all lower than those of the control group (p<0.05); the time of getting out of bed after surgery, the time of first postoperative exhaustion, the time of postoperative ureter extraction, the time of early feeding, the time of semi-liquid diet, and the time of postoperative hospitalization were all shorter in the experimental group than in the control group, and the costs were lower than those of the control group, and the differences were statistically significant (p<0.05). The comparison between groups was significantly different (p<0.05). The clinical application of evidencebased nursing care in the perioperative nursing coordination of gastric cancer radical surgery can not only reduce postoperative complications, but also shorten hospitalization time and help promote patients recovery, which is worth promoting.