The evidence-based design (EBD) movement in architecture has been formed around notion that design of physical envi- ronment in healthcare facilities should be guided by empirical evidence that links design elements to healthcare outcomes (Hamilton, 2003; Ulrich et al., 2008). The outcomes targeted by EBD com- monly involve patient safety and related patient outcomes, but can also include staff such as productivity, satis- faction, and worker safety. Decades of EBD research and practice have shown that environmental design does indeed play a significant role in measures of care quality; however, it is important to remember that these qualities are not attributable solely to environmental design. The design of physical space is one component of a complex system that includes humans and technologies-which are also system components with their own set of design to consider-interacting within built environment. The qualities of interest to EBD (patient safety, outcomes, worker satisfaction, etc.) therefore should be considered as emergent proper- ties of entire system, viewed holistically, which depend not only on individual contributions of components but also on their complex interac- tions (e.g., Carayon et al., 2006).This systems-oriented perspective when evaluat- ing healthcare quality is one that is adopted by many emerging fields, including systems engineering and related fields of and (HFE). Indeed, in same way EBD might be consid- ered a form of systems engineering that emphasizes environmental component of healthcare sys- tem, HFE emphasizes studying and designing to support components of system. As for- mally defined by Internation- al Ergonomics Association (2000), HFE is the scientific discipline concerned with understanding of interactions among humans and other elements of a system, and profession that applies theoreti- cal principles, data and methods to design in order to optimize well-being and overall system performance. Central to HFE analysis is gaining an understanding of needs, abilities, and limita- tions of people and considering these in design of system components so that humans can perform work effectively, safely, and with adequate personal satisfaction.Traditionally, HFE has been divided into three domains of specialization: related to physical interaction, cognitive factors, and organizational (e.g., Wickens, Lee, Liu, & Gordon-Beck- er, 2004). The science of physical is often colloquially referred to as ergonomics (although formal definition of term does not exclu- sively apply to physical factors) and concerns topics such as anthropometry, biomechanics, metabol- ic processes of humans performing work, and design of workspaces to accommodate sizes, shapes, and physical work-producing abilities of workers. The specialization related to cog- nitive (often labeled as human factors to distinguish from physical ergonomics-although again, labels are not exclusive) is concerned with cognitive activities and functions such as percep- tion, attention, memory, decision making, problem solving, and learning. The study of organization- al factors-sometimes labeled as macroergonom- ics-considers social interactions among groups of people, including topics of communication and team dynamics; role of technology in support- ing these dynamics; and cultural influences on pat- terns in communication and team activities.Each of these three domains of specialization with- in HFE can complement EBD approaches to physical design of healthcare environments and thus further improve healthcare system. Most clearly, decisions about unit and/or room layout, and locations of equipment and supplies, can benefit from physical ergonomic assessment. For example, spaces between beds in intensive care units often are too small (Carayon & Alvarado, 2007); minimum inter-bed distance should allow comfortable access for larger care workers and also support workers' ability to interact with common equipment in space without disturb- ing neighboring patients. …