Everyday Quality Research Articles

Dog owners and preventative healthcare: knowledge level, interest, and impact on perceptions of veterinarians’ trustworthiness and empathy

Abstract OBJECTIVE Gain a better understanding of dog owners’ knowledge and interest level for 13 preventative healthcare (PHC) topics. Examine the potential predictive value of owners’ satisfaction with how their veterinarian communicates about PHC topics and perceived veterinarian-related trust and empathy and frequency of PHC veterinary visits. METHODS An electronic survey was created in Qualtrics and distributed to dog owners within the US via a link offered in Prolific, an open online marketplace whereby respondents receive small monetary compensation for completing surveys. RESULTS A total of 738 participants completed the survey, all of whom were dog owners living in the US. Owners reported knowing the most about the importance of mental engagement, how to assess their dog’s everyday quality of life, vaccines, and parasites. Owners were most interested in learning more about how to assess their dog’s everyday quality of life, importance of mental enrichment, diseases related to their dog’s breed, and senior care. Veterinarians were the primary source of information for 13 of 14 topics. Owners’ satisfaction with how PHC information is discussed was a significant predictor for perceived veterinarian empathy and trustworthiness, as well as frequency of PHC visits. CONCLUSIONS Dog owners understand the value of PHC and look to their veterinarian for this information. Satisfaction with PHC dissemination predicts owners’ views of their veterinarian’s trustworthiness and empathy. CLINICAL RELEVANCE Dissemination of PHC information can improve animal health and well-being not only directly but also indirectly through its impact on owners’ perceptions of their veterinarian.

The health and quality of life of dental workers in jordan during COVID-19: A cross-sectional study.

Dental team members are susceptible to high mental and physical stress levels, which could have increased during the Coronavirus disease 2019 (COVID-19). This study aimed to evaluate Jordanian dental workers' health-related quality of life (HRQoL) and determine its predictors during the COVID-19 Pandemic. This was a cross-sectional survey study conducted on dental team members, namely; Dentists, dental Assistants, and Dental Technicians. The survey questionnaire was composed of questions related to stress during COVID-19, a short-form survey of 12 items (SF-12), a Depression, Anxiety, and Stress scale (DASS-21), and a Nordic musculoskeletal disorder questionnaire (NMQ). Descriptive analyses were used to describe the main outcome measures, and multiple variable regression analysis was conducted to identify the quality of life predictors. Participants' HRQoL measured by SF-12 showed a mean±SD score of 67.1±17.19 for the physical component and 54.51±20.27 for the mental component. The Nordic scale showed symptoms of lower back pain as 63.9% over 12 months, 32% over 12 months' functional limitation symptoms, and 45% in 7 days The regression model was found strong for our study with 53.8% variations (r2 = 0.538, F = 43.739, P < 0.001) in health-related quality of life. Our study concluded that the level of HRQoL among Jordanian dental specialists during COVID-19 was observed to impact levels of physical and mental well-being which negatively influence the quality of life. Predictive factors like depression, stress, anxiety, musculoskeletal health, and individual everyday quality of life significantly affect the HRQoL of dental specialists.

UK Stakeholder Perspectives on Surrogate Endpoints in Cancer, and the Potential for UK Real-World Datasets to Validate Their Use in Decision-Making.

Duration of overall survival in patients with cancer has lengthened due to earlier detection and improved treatments. However, these improvements have created challenges in assessing the impact of newer treatments, particularly those used early in the treatment pathway. As overall survival remains most decision-makers' preferred primary endpoint, therapeutic innovations may take a long time to be introduced into clinical practice. Moreover, it is difficult to extrapolate findings to heterogeneous populations and address the concerns of patients wishing to evaluate everyday quality and extension of life. There is growing interest in the use of surrogate or interim endpoints to demonstrate robust treatment effects sooner than is possible with measurement of overall survival. It is hoped that they could speed up patients' access to new drugs, combinations, and sequences, and inform treatment decision-making. However, while surrogate endpoints have been used by regulators for drug approvals, this has occurred on a case-by-case basis. Evidence standards are yet to be clearly defined for acceptability in health technology appraisals or to shape clinical practice. This article considers the relevance of the use of surrogate endpoints in cancer in the UK context, and explores whether collection and analysis of real-world UK data and evidence might contribute to validation.

Analytical Method Development and Validation for Simultaneous Estimation of Memantine and Donepezil in Pharmaceutical Dosage form by RP-HPLC

A simple, precise and accurate method was developed for the simultaneous estimation of memantine and donepezil. The chromatogram was performed with a Thermo scientific C18 (150 x 4.6mm, 5µm). At a flow rate of 1ml/min, mobile phase used is 70:30% v/v mixture of buffer pH 4.5 and ACN. The best detection wave length for memantine and donepezil was at 265nm. The retention time was 2.325 and 3.088minutes. Assay results of 100.87 percent and 99.31 percent, %RSD values are below 2 and linearity R2 values are 0.999 for both the drugs. The strategy appears to have been compact and worth, and it is proper for everyday Quality Control Estimates in Industry sections since Maintenance Times are Diminishing and that Gathered Code was reducing. Thus, the developed method was validated according to 1CH guidelines for routine analysis of the sample.

Contested Spaces and Everyday Peace Politics in Northern Ireland

Abstract In 2022, the United Kingdom downgraded the security threat in Northern Ireland from “severe” to “substantial”, first set in 2010. The latter means that an attack is likely but not highly likely. For many analysts and political observers, the twenty-five years of peace that followed the signing of the Belfast/Good Friday Agreement (B/GFA) though interspersed with periods of political stalemate, have led to an overall external sense the conflict has ended. This downgrading of the security threat in Northern Ireland appears to confirm this sense of a settled peace. Still, the type of peace that has been achieved, and particularly the political dynamics regarding contentious spatial issues, continue to shape the quality of peace experienced by the local population. In turn, it is precisely this everyday quality of peace that reflects the real success, or failure, of various peacebuilding efforts as such practices produce the empirical evidence of sustainable reconciliation or continue sectarian divisions in a post-conflict space.

Assessing the quality of nursing clinical placement: Aquantitative cross-sectional study.

To evaluate the quality of nursing clinical placement among nursing students. This is a descriptive cross-sectional study. Two hundred eighty two nursing student completed self-administered, online questionnaires. The questionnaire assessed participants' socio-demographic data, and the quality of their clinical placement. The students had a high mean score for the overall satisfaction of their clinical training placement with high mean score for the item of "patient safety was fundamental to the work of the units" and the item of "I anticipate being able to apply my learning from this placement," while the lowest mean score was related to "This placement was a good learning environment" and "Staff were willing to work with students." Patient or Public Contribution: Quality of clinical placement is critical for improving the everyday quality of care for patients who are in desperate need of caregivers with professional knowledge and skills.

The main principles of designing public spaces in Germany on the example of the city of Hannover

In Germany, public space and its use are thought to be full of conflicts: festivalization vs. everyday quality, advertising vs. urban design, commerce vs. culture, drivers vs. strollers, demonstrators vs. tourists, private use vs. general accessibility, spontaneous, temporary appropriation vs. permanent order, and design&#x0D; The often conflicting expectations – also of women and men or old and young people – about public space are an expression of the increasingly heterogeneous nature of urban society. In terms of design, the pendulum swings between nostalgic kitsch, cool modern design and aesthetic neglect.&#x0D; In recent years, the pressure and overload of private and public advertising, road and information signs, retail and restaurant furniture and telecommunications equipment have increased. The generally accepted indicator, the agreement about what quality of form is in public space, seems to be largely lost.&#x0D; Too often only the city center is seen as a public space in need of planning and political attention. Main roads or district and district centers are lost from sight, let alone commercial areas. Demographic changes, a smaller, older and brighter urban population make new demands on public space, as a place where different cultures and increasingly differentiated lifestyles meet, as a place for the integration of urban society.&#x0D; So there is a need for action. It is not about uniform rules for the use and design of public spaces, nor about the illusion of ideal and consistent planning. Rather, it is about criteria of social and aesthetic quality, about what is appropriate in each city and each district, which should be developed and discussed in dialogue with residents, users and the public.

DEVELOPMENT, OPTIMIZATION AND VALIDATION OF HPLC METHOD FOR ASSAY AND DISSOLUTION TESTING OF FUROSEMIDE TABLET FORMULATION UTILIZING DESIGN OF EXPERIMENT APPROACH

A robust HPLC method was developed and validated for the quantitative estimation of furosemide tablet and dissolution testing. The optimization of chromatographic conditions (% organic phase, flow rate and pH of aqueous phase) was done using the Box-Behnken experimental design. The creation of a reliable HPLC technique utilised the design of experiments methodology effectively. The furosemide peak was found to have a Rt value of 4.86 min under the optimal HPLC settings, which included a C18 (250 mm 4.6 mm, 5 m) column and a methanol: aqueous solution of formic acid buffer (0.2 % V/V, pH 2.5) as mobile phase.The optimized method was validated according to ICH Q2(R1) guideline. Using a fractional factorial design with six chromatographic components, the robustness of the approach was evaluated. The results showed that a multivariant approach was successfully used to improve a reliable HPLC technique for everyday quality monitoring of furosemide in tablet formulations

Addressing Gender-Related Inequality in Continence Care

Addressing Gender-Related Inequality in Continence Care

THE MAIN PRINCIPLES OF DESIGNING PUBLIC SPACES IN GERMANY ON THE EXAMPLE OF THE CITY OF HANNOVER

In Germany, public space and its use are thought to be full of conflicts: festivalization vs. everyday quality, advertising vs. urban design, commerce vs. culture, drivers vs. strollers, demonstrators vs. tourists, private use vs. general accessibility, spontaneous, temporary appropriation vs. permanent order, and design&#x0D; The often conflicting expectations – also of women and men or old and young people – about public space are an expression of the increasingly heterogeneous nature of urban society. In terms of design, the pendulum swings between nostalgic kitsch, cool modern design and aesthetic neglect.&#x0D; In recent years, the pressure and overload of private and public advertising, road and information signs, retail and restaurant furniture and telecommunications equipment have increased. The generally accepted indicator, the agreement about what quality of form is in public space, seems to be largely lost. &#x0D; Too often only the city center is seen as a public space in need of planning and political attention. Main roads or district and district centers are lost from sight, let alone commercial areas. Demographic changes, a smaller, older and brighter urban population make new demands on public space, as a place where different cultures and increasingly differentiated lifestyles meet, as a place for the integration of urban society.&#x0D; So there is a need for action. It is not about uniform rules for the use and design of public spaces, nor about the illusion of ideal and consistent planning. Rather, it is about criteria of social and aesthetic quality, about what is appropriate in each city and each district, which should be developed and discussed in dialogue with residents, users and the public.

A National Survey on Patient Satisfaction and Use Trends with Revaree, a Hyaluronic Acid Suppository, for Vaginal Dryness

ABSTRACT Introduction During menopause, many women experience vaginal atrophy symptoms including vaginal dryness, burning, stinging, and dyspareunia. Revaree is a non-drug, hormone-free vaginal insert containing hyaluronic acid. Clinical evidence supports the use of hyaluronic acid to reduce vaginal dryness, vaginal itching and burning, and dyspareunia. Objective A national survey study was conducted to affirm results previously reported from controlled clinical trials and to investigate the trends of this product across multiple variables. This study gathered information on the real-world experiences of women, including the use of Revaree and its effect on symptom relief including vaginal dryness, quality of life, and satisfaction. Methods An optional, rolling online survey was emailed to patients who had been taking Revaree for time periods ranging from less than one month to more than one year. Survey data was collected from 3,080 patients between March 2019 and October 2021. A 5-point Likert scale was used to assess patient satisfaction. During the initial 9 months of enrollment, patients received no compensation. To increase enrollment, after the initial 9 months, patients were compensated with a $5 gift card for completing the survey. Results An analysis of survey findings showed that of patients taking Revaree (n=total applicable responses per question): 83% responded that Revaree reduced vaginal dryness (n=3,050); 73% responded that Revaree reduced vaginal burning (n=2,315); 77% responded that Revaree reduced vaginal irritation (n=2,644); 66% responded that Revaree reduced pain during sex (n=2,576); 69% responded that Revaree made sex more comfortable (n=2,617); 66% responded that Revaree improved intimacy with partners (n=2,617); and 72% responded that Revaree improved quality of life (n=2,933). Furthermore, 79% responded that Revaree is easy to insert (n=3,000); 69% responded that Revaree is non-messy (n=3,023); 80% responded that the insert formulation makes Revaree convenient to use (n=2,997); and 60% responded that Revaree makes everyday activities more comfortable (n=2,677). No differences in efficacy (e.g., improvements in vaginal dryness, vaginal burning, and vaginal irritation) were detected when the data were analyzed by user age (age range: 24 – 84). Additionally, no decrease in efficacy was detected with use over time. Of the 3,080 women, 58% reported that they first saw an improvement with Revaree within 2 weeks and 85% reported that they first saw an improvement with Revaree within 8 weeks. Overall, 79% of women reported satisfaction with Revaree (n=3,007); 92% of women would recommend Revaree to friends or family (n=3,079); and 96% plan to continue using Revaree (n=3,079). Conclusions This survey study demonstrated high levels of relief from vaginal atrophy symptoms across a wide age range with the use of Revaree. A majority of women saw great improvement in symptoms within the first month, with continued or higher levels of improvement with continued use. These findings confirm the objective findings of previously published randomized, controlled studies on Revaree's main ingredient, hyaluronic acid. Together, the results of this study support the use of Revaree to alleviate vaginal atrophy symptoms, enhance comfort during intimacy, and improve everyday quality of life. Disclosure Yes, this is sponsored by industry/sponsor: JDS Therapeutics Clarification Industry initiated, executed and funded study Any of the authors act as a consultant, employee or shareholder of an industry for: JDS Therapeutics

A case report on the efficacy of a short-term physiotherapy intervention strategy in the initial stages of Multiple Sclerosis

Multiple sclerosis is a chronic autoimmune progressive disease of demyelination of the central nervous system with subsequent axonal damage. The symptoms are due to loss of oligodendrocytes, but CNS diseased effects are often controlled through rehabilitation. The goal of this study is to see if early physiotherapy rehabilitation combined with immunosuppressants can suppress and minimize symptoms while also slowing down the illness process from the first day of hospitalization to six weeks, which normally causes the patient's condition to deteriorate. The patient is required to follow the physiotherapy guidelines for a period of six weeks. Based on their symptoms, the patient's interventions were gradually increased each week. The functional independence measure (FIM) and the Short Form survey-12 were used to assess the patient's everyday quality of life in the first week and then again in the seventh week (SF-12).There is a variation in the value of outcome measures after the 7th re-assessment. The FIM level has risen from 3-moderate assistance with assistance to 6-modified independence without assistance. The SF-12 physical score improved significantly from 48.020307 to 56.57706, whereas the SF-12 mental score changed just slightly. Multiple sclerosis disease impairment is mostly caused by disease progression, but it can also be exacerbated by decreased physical activity, which causes muscle weakness, limited range of motion, and stiffness. Exercise and training have demonstrated improvement of the above-mentioned deteriorations in multiple sclerosis patients

Outcome of short‐term physiotherapy intervention program on early stage of multiple sclerosis ‐ A case report

INTRODUCTIONMultiple sclerosis is a chronic autoimmune progressive disease of demyelination of central nervous system with subsequent axonal damage. The symptoms are due to central nervous system lesions resulting from loss of oligodendrocytes, which myelinates CNS leading to tingling and numbness of limbs and reactive gliosis with no cure for the disease. But CNS diseased effects are often controlled through rehabilitation.OBJECTIVE OF THE STUDYThe aim of this study is to observe the importance of early physiotherapy rehabilitation along with immunosuppressants to suppress and reduce the symptoms and slows down the disease process beginning from the initial day of hospitalization to six weeks which causes progression in the patient reducing the incapacity and improves functional measures and quality of life in multiple sclerosis patients. Muscle weakness, and spasticity, balance and coordination can be improved through stretching and strengthening exercises.METHODPatient strictly followed intervention for a period of six weeks under the supervision of Physiotherapist. Intervention includes strengthening, aerobic conditioning, flexibility exercises, coordination exercise, balance exercises, gait training using assistive devices, sensory, functional, bowel and bladder control training. Interventions were gradually progressed up to the patient every week according to their symptoms. Patient was assessed in 1st and 7th week using the outcome measures namely Functional independence measure (FIM) and Short Form survey‐12 (SF‐12) assessing the impact of health on patient’s everyday quality of life.RESULTSAfter the 7th week re‐assessment, it has been shown there is a difference in the value of outcome measures. FIM level has improved from 3‐moderate assistance with helper to 6‐modified independence without helper. SF‐12 physical score showed marked improvement from 48.020307 to 56.57706 while SF‐12 mental score change showed very minor change.CONCLUSIONMultiple sclerosis disease impairment is primarily a consequence of disease progress, but it can be aggravated by reduced physical activity leading to muscle weakness, decreased ROM, spasticity. Exercise and training have been shown to improve the above said deteriorations in multiple sclerosis patients and certainly can be alleviated.Score through FIM and Health survey scale are tabulated as follows Outcome measure Preintervention Postintervention FIM, Functional Independent Measure (in scales) 3‐‐ Moderate Assistance(&gt;= 50%): Helper‐Modified Dependance 6‐‐ Modified, Independence (Device): No Helper SF‐12, Quality of life measure PCS‐12 (Physical Score): 48.020307 MCS‐12 (Mental Score): 59.04606 PCS‐12 (Physical Score): 56.57706 MCS‐12 (Mental Score): 60.75781

A resource-oriented intervention addressing balance in everyday activities and quality of life in people with advanced cancer: protocol for a feasibility study

BackgroundPeople with advanced cancer need to balance their resources and energy in order to experience enjoyment and quality of life in the time they have left. A resource-oriented intervention is developed targeting these aspects. The present protocol presents a feasibility study of this resource-oriented intervention in people with advanced cancer.MethodsA feasibility study with a repeated-measurement design without a control group will be conducted at the research clinic of REHPA, the Danish Knowledge Center for Rehabilitation and Palliative Care. Data will be gathered at baseline, during and after a 5-day residential stay, after 6 weeks, during a 2-day follow-up stay and after 12 weeks. In total, 20–25 home-living adults (≥ 18 years) with advanced cancer reporting needs in everyday life will be recruited. The intervention consists of workshops and engagement in physical and creative everyday activities provided by a multidisciplinary team.Outcome measures are quality of life, physical function and fatigue, which will be assessed using the European Organisation for Research and Treatment of Cancer Quality-of-Life Questionnaire Core-30. Balance in everyday activities will be assessed using the Occupational Balance Questionnaire.Feasibility data will also be collected regarding (1) fidelity, (2) adherence, (3) dose and (4) reach and mechanisms of impact. For exploration of mechanism of impact, participant observations and focus group interviews will be used.DiscussionThis study presents a new approach in rehabilitation and palliative care aimed at supporting people with advanced cancer; instead of identification of problems, the present resource-oriented palliative rehabilitation intervention will target people’s resources, enhancing balance in everyday activities and underpinning enjoyment and quality of life. The results from the feasibility study can inform ways in which to support the everyday life of people with advanced cancer and thus have potential to improve their quality of life. The long-term perspectives are to evaluate the intervention in terms of effect, process and cost-effectiveness. This will provide evidence to adjust the content of rehabilitation and palliative care for this group of people.Trial registrationNCT04772690Name of the registry: Balance, Activity and Quality of Life (BAL)Date of registry: February 26, 2021

A Digital Screening System for Alzheimer Disease Based on a Neuropsychological Test and a Convolutional Neural Network: System Development and Validation.

BackgroundAlzheimer disease (AD) and other types of dementia are now considered one of the world’s most pressing health problems for aging people worldwide. It was the seventh-leading cause of death, globally, in 2019. With a growing number of patients with dementia and increasing costs for treatment and care, early detection of the disease at the stage of mild cognitive impairment (MCI) will prevent the rapid progression of dementia. In addition to reducing the physical and psychological stress of patients’ caregivers in the long term, it will also improve the everyday quality of life of patients.ObjectiveThe aim of this study was to design a digital screening system to discriminate between patients with MCI and AD and healthy controls (HCs), based on the Rey-Osterrieth Complex Figure (ROCF) neuropsychological test.MethodsThe study took place at National Taiwan University between 2018 and 2019. In order to develop the system, pretraining was performed using, and features were extracted from, an open sketch data set using a data-driven deep learning approach through a convolutional neural network. Later, the learned features were transferred to our collected data set to further train the classifier. The first data set was collected using pen and paper for the traditional method. The second data set used a tablet and smart pen for data collection. The system’s performance was then evaluated using the data sets.ResultsThe performance of the designed system when using the data set that was collected using the traditional pen and paper method resulted in a mean area under the receiver operating characteristic curve (AUROC) of 0.913 (SD 0.004) when distinguishing between patients with MCI and HCs. On the other hand, when discriminating between patients with AD and HCs, the mean AUROC was 0.950 (SD 0.003) when using the data set that was collected using the digitalized method.ConclusionsThe automatic ROCF test scoring system that we designed showed satisfying results for differentiating between patients with AD and MCI and HCs. Comparatively, our proposed network architecture provided better performance than our previous work, which did not include data augmentation and dropout techniques. In addition, it also performed better than other existing network architectures, such as AlexNet and Sketch-a-Net, with transfer learning techniques. The proposed system can be incorporated with other tests to assist clinicians in the early diagnosis of AD and to reduce the physical and mental burden on patients’ family and friends.

Aesthetics for everyday quality: one way to enrich healthcare improvement debates

In this paper we seek to illuminate the importance of aesthetics for healthcare quality and encourage more explicit discussion of aesthetics in healthcare improvement scholarship and practice. We hope to...

Attachment Style Differences in the Affective Experience of Chronic Pain in Osteoarthritis

Lifespan psychological and life course sociological perspectives have long acknowledged that individual functioning is shaped by historical and socio-cultural contexts. Secular increases favoring later-born cohorts are widely documented for general well-being (among older adults). However, little is known about secular trends in short-term fluctuations in daily affective well-being and whether historical changes have occurred in young, middle-aged, and older adults alike. To examine these questions, we compared data from two independent national samples of the NSDE survey obtained 18 years apart (1995/96 vs. 2013/14) and identified case-matched cohorts (per cohort, n = 782, aged = 23–75 years) based on age and gender. We additionally examine the role of economic and health resources for cohort differences in affective variability. Results revealed that later-born cohorts report higher variability in daily negative affect than did those 18 years ago. In contrast, no cohort differences emerged in variability in daily positive affect. We conclude from our national US sample that secular trends in affect variability do not generalize unanimously to different timescales across adulthood. We discuss possible underlying mechanisms and practical implications.

Machine learning in orthodontics: Challenges and perspectives.

Artificial intelligence (AI) applications have significantly improved our everyday quality of life. The last decade has witnessed the emergence of up-and-coming applications in the field of dentistry. It is hopeful that AI, especially machine learning (ML), due to its powerful capacity for image processing and decision support systems, will find extensive application in orthodontics in the future. We performed a comprehensive literature review of the latest studies on the application of ML in orthodontic procedures, including diagnosis, decision-making and treatment. Machine learning models have been found to perform similar to or with even higher accuracy than humans in landmark identification, skeletal classification, bone age prediction, and tooth segmentation. Meanwhile, compared to human experts, ML algorithms allow for high agreement and stability in orthodontic decision-making procedures and treatment effect evaluation. However, current research on ML raises important questions regarding its interpretability and dataset sample reliability. Therefore, more collaboration between orthodontic professionals and technicians is urged to achieve a positive symbiosis between AI and the clinic.

Disease Related Morbidity and Quality of Life Impairment in Patients with Single Sided Deafness.

Patients with single sided-deafness (SSD) have hearing deficits amounting to a handicap to their everyday quality of life and are likely to suffer serious social challenges. There is a significant gap in the "disability" aspect of SSD in literature. The study was undertaken to compare the quality of life of SSD patients in various domains with normal hearing individuals. 51 patients of SSD with pure sensorineural hearing loss with impaired ear having a pure tone average of more than or equal to 70dB was compared with 50 subjects with normal hearing sensitivity. Pure tone audiometric testing and the english version of Speech, Spatial and Qualities of Hearing Scale (SSQ) were used to enumerate subjective advantage. Total average SSQ score across domains in patients (6.6 ± 1.2) was significantly poorer in comparison to the control group (8.4 ± 0.9). Based on SSQ, patients with SSD experience hearing disability in comparison to the control group (p < 0.01). The ratings of all the items in the SSQ subdomains were higher in the reference group than in the patient group. Individuals with single sided-deafness experience significant auditory disability in all the three domains of speech, spatial & qualities of hearing. Therefore, these patients should be strongly counselled for currently available treatment options.

Whatis the impact of post-radical prostatectomy urinary incontinence on everyday quality of life? Linking Pad usage and International Consultation on Incontinence Questionnaire Short-Form (ICIQ-SF) for a COMBined definition (PICOMB definition).

To identify the definition for urinary continence (UC) after radical prostatectomy (RP) which reflects best patients' perception of quality of life (QoL). Continence was prospectively assessed in 634 patients, 12 months after RP using the International Consultation on Incontinence Questionnaire Short-Form (ICIQ-SF) and the number of pads employed in a 24-hour period (pad usage). We used the one-way ANOVA technique with posthoc pairwise comparisons according to Scheffé's method (homogeneous subsets) for assessing the degree of QoL deficit related to urinary incontinence (UI). The continence prevalence is 64.4%, 74.1%, 88.3%, and 35.8% using "0 pads," "1 safety pad," "1 pad," and "ICIQ score 0" definitions, respectively. Pad usage is moderately strongly associated with ICIQ 1, 2, and 3 (ρ = 0.744, 0.677, and 0.711, respectively; p < 0.001). Concordance between classical UC definitions is acceptable between "0 pads-ICIQ score 0" (K = 0.466), but poor for "1 safety pad" and "1 pad" (K = 0.326 and 0.137, respectively). Patients with "0 pad usage" have better QoL related to urine leakage than patients with "1 safety pad" or "1 pad" (1.41 vs. 2.44 and 3.11, respectively; p < 0.05). There were no significant differences found regarding QoL between patients with ICIQ score 0 and ICIQ score 2 (1.01 vs. 1.63; p = 0.63). Pad usage and the ICIQ-SF's answers provide useful information. We propose a combined definition (0 pads and ICIQ score ≤2) as it is the definition with the least impact on daily QoL.