Events Research Articles

Sucessão familiar no meio rural – uma análise com base em os Buddenbrook de Thomas Mann

Na atualidade a sucessão familiar no meio rural ainda é um assunto que demanda estudos para elucidar a problemática que a cerca, mesmo com a ressignificação e a construção de novos padrões sociais. O presente trabalho tem como objetivo realizar uma análise no romance “Os Buddenbrook – Decadência de Uma Família”, correlacionando com as características encontradas nos dias atuais e os possíveis processos que podem levam ao sucesso ou ao fracasso da sucessão. Nos caminhos metodológicos foram realizadas pesquisas bibliográficas e documentais com caráter qualitativo, visando o aprofundamento sobre a sucessão familiar e todas as bases e pilares que a compõe. A pesquisa qualitativa aqui realizada é direcionada para a validação do objeto de estudo apresentado. Por consequência após análise dos acontecimentos contidos na ficção foi possível enfatizar que a sucessão familiar deve ser vista como um processo e não como um evento, sendo necessária a formação de sucessores e não somente de herdeiros. É necessário viabilizar processos de formações dos filhos e filhas, objetivando a aquisição de conhecimentos que possam serem utilizados na liderança das propriedades rurais e, consequentemente, na perpetuação dos negócios familiares. Os entraves apresentados no romance podem ser facilmente encontrados em espaços rurais no Brasil. Com base na obra de Thomas Mann, os temas abordados puderam ser discutidos, e constatou-se que as relações familiares formam os pilares na construção do sucessor, cabendo principalmente ao patriarca a tarefa de determinar a melhor forma de planejamento.

Variation of homologous recombination in Populus tomentosa with different genotypes.

Homologous recombination is an important source of biological genetic variation. Limited by detection methods, there are only a few reports on the homologous recombination in high plants and its product - heteroduplex DNA (hDNA). In the present study, applying the strategy of detecting hDNA by constructing populations from inhibited post-meiotic segregation, two hybrid triploid populations were constructed from two maternal parents inPopulus tomentosa by inhibiting post-meiotic segregation. One hundred and ten simple sequence repeat (SSR) markers were used to study the occurrence and variation of hDNA on nine chromosomes inP. tomentosa with different genotypes. The results showed that the frequencies of hDNA between two female parents inP. tomentosa ranged from 8.5% to 87.2%. The hDNA frequency was positively correlated to the distance from the centromere, but the average hDNA frequency on a chromosome had no correlation with the chromosome length. One to 3 times recombination events were detected on most chromosomes, and only a few four- or five-times recombination events were detected. The overall frequencies of hDNA on the same chromosome in two genotypic individuals were roughly similar, while the hDNA frequencies varied greatly at specific SSR loci. Compared withTacamahaca poplar hybrid,P. pseudo-simonii × P. nigra 'Zheyin3#', detection of homologous recombination times and the frequency and location of hDNA were largely different. This study is the first to describe the characteristics and variations of homologous recombination inP. tomentosa with two different genotypes, which will provide valuable insights for exploring the characteristics and variations of homologous recombination among interspecies and intraspecies in higher plant.

Spatial Planning for Urban Resilience in the Face of the Flood Risk: Institutional Actions, Opportunities and Challenges

The research was inspired by the increasing impact of extreme weather events and changing climate patterns on flood-prone regions and cities, and the consequent human and economic costs. Despite global efforts for flood resilience and climate adaptation involving climate analysts, economists, social scientists, politicians, hydrological engineers, spatial planners, and policymakers, it is only partially clear how best to construct resilience measures and implement concrete initiatives. The complexity of institutions is a key factor that is often neglected, and which needs further investigation. The thesis examines the institutional arrangements that determine the role of spatial planning in managing flood risk, through an in-depth case study of Guangzhou, one of the most vulnerable cities in China and globally. The thesis employs theories of historical institutionalism, planning procedure and planning tools, policy framing and collaborative governance, to explore the mechanisms and factors that influence the creative planning and design process. Content analysis, GIS-based mapping, stakeholder analysis and TOWS analysis are used to investigate data from official policy documents, grey literature, geo-information data and interview scripts. The findings indicate that institutional arrangements, such as long-established planning traditions, formal planning procedures and tools, policy framing patterns and contextual organisational factors, determine spatial planning’s role in managing flood risk. They do this through (1) the extent of the changeability of an established planning system towards expanded flood resilience measures; (2) the performance of cross-level communication and boundary-spanning work between planning and water management; (3) the legal framework that planners and hydrological engineers follow; and (4) the capacities of planning and water management institutions to work on flood issues. This research shows how to apply knowledge from policy science, political science, institutional science and administration, to analyse the nature of the planning process in tackling the urgent challenge of flood risk and climate change.

La cultura urbana como espectáculo: la experiencia de modernidad en la Exposición Internacional de Barcelona 1929

Este artículo propone una mirada renovada sobre la Exposición Internacional de Barcelona 1929 a través de su cultura material y visual, los pabellones comerciales, sus atracciones y la configuración de su espacio para analizar cómo el diseño del evento se interrelaciona con varias dinámicas inscritas en la cultura urbana y a la experiencia de modernidad. Veremos así la centralidad que cobran las experiencias sensitivas, cómo el régimen visual del evento se relaciona con la circulación de saberes en el siglo XIX o que vínculos establece el consumo con la creación de nuevos espacios urbanos, nuevas formas de entretenimiento y estilos modernos como el Art Déco. El objetivo será visualizar el alcance del evento de 1929 en la concreción de culturas urbanas asociadas a la irrupción de la sociedad de consumo que se intuyeron en 1888.

Abstract PS2-18: Circulating tumor DNA (ctDNA) mutation (mut) profile in relation to paboclicib (pal) efficacy in hormone receptor positive (HR+) and HER2 negative (HER2-) metastatic breast cancer (MBC)

Abstract Background: Cyclin-dependent kinases 4 and 6 inhibitors (CDK4/6i) are now standard of care (SOC) for pts with HR+/HER2- MBC. However, aside from HR positivity, there are no biomarkers for pt selection. Although mutations (muts) in genes such as RB1, FAT1, or FGFR, are associated with CDK4/6i resistance, they are rare events in HR+/HER2- MBC. The goal of this study is to examine the ctDNA mut profile, and the impact of commonly mutated genes (ESR1, TP53 and PIK3CA) on progression free survival (PFS) in pts received pal as SOC in a real world experience. Methods: Chart review was performed for pts with HR+/HER2- MBC who received pal and ctDNA Guardant360® (G360) testing between 01/2015 and 06/2020 at Siteman Cancer Center. The Kaplan-Meier method was used to generate time-to-event curves with calculated mPFS. A stratified log-rank test was used for all comparisons with P-values reported. Hazard ratios (HRs) and associated 95% confidence intervals (CI) were calculated with a stratified Cox proportional-hazards model. Results: Among the 73 pts identified, median age was 61.5 years (range 33.7-83.3). 15 (20.5%) pts received pal as 1st-line, 22 (30.1%) pts as 2nd-line, and 36 (49.3%) pts as 3rd-line and beyond. All 73 pts had muts by G360. Top 3 mutated genes are PIK3CA (n=25, 34.2%), TP53 (n=20, 27.4%) and ESR1 (n=17, 23.3%), followed by GATA3 (n=12, 16.4%) and MYC (n=6, 8.2%). For association analysis with PFS, 17 pts were excluded from further analysis due to having had multiple interim therapies between G360 testing and pal therapy, leaving 56 pts who had G360 immediately prior to pal (n=11), during pal (n=13), at progressive disease (PD) on pal (n=20), or had 1 additional therapy after PD on pal (n=12). Among the 56 pts, the median age on pal was 62.8 years (36.6-78.4). Median duration on pal was 7.7 months (mo). Pal was received as 1st-line in 14 (25.0%), 2nd-line in 17 (30.4%) and 3rd-line plus in 25 (44.6%) pts. Muts in PIK3CA, TP53 and ESR1, were identified in 18 (32.1%), 16 (28.6%), and 13 (23.2%) pts, respectively, with rates similar to the entire 73-pt cohort. Among 13 ESR1 mutant pts, 7 had letrozole and 6 had fulvestrant as pal’s endocrine partner. Concurrent muts in 2 of 3 genes were observed in 11 (19.6%) pts (6 with PIK3CA and TP53, and 5 with ESR1 and TP53). The mPFS was 7.4 and 12.6 mo (p=0.03) in pts with or without PIK3CA mut, 7.9 and 12.8 mo (p=0.85) with or without ESR1 mut, and 16.0 and 13.3 mo (p=0.46), with or without TP53 mut, respectively. mPFS for pts with concurrent muts in 2 of the 3 genes was 7.4 mo, compared to 11.7 mo and 13.3 mo in pts with 1 or no mut in these 3 genes (p=0.46). In multivariate analysis that included age, visceral mets and line of therapy, the HRs for PFS were <1 for pts without mut in PIK3CA or ESR1 (Table 1). Pts with 1-5 and 6-10 mut were 26% and 36% less likely to have PD compared to pts with >10 muts, respectively. Conclusions: In this retrospective real world experience, ctDNA muts in PIK3CA and ESR1 as well as higher number of muts in ctDNA were associated with worse outcome in pts received pal. Although several studies have shown CDK4/6i benefit regardless of PIK3CA or ESR1 mut status, our data indicates that muts in these genes render worse prognosis on CDK4/6i and supports PIK3CA and ESR1 muts as driver events in HR+ MBC. PI3Ki or novel ER targeted agents are combined with CDK4/6i in clinical trials and results are eagerly awaited. In addition, further study for pts with higher ctDNA mut number is warranted. Multivariate Cox Proportional Hazards Regression Model on PFSVariablesPFSHR (95% CI)P-valueESR1 (non-mut vs. mut)0.64 (0.26-1.56)0.32TP53 (non-mut vs. mut)1.70 (0.80-3.60)0.16PIK3CA (non-mut vs. mut)0.42 (0.17-1.02)0.06Age (<65 vs. >=65 yo)0.92 (0.45-1.87)0.81No. Lines of pal (1st- vs. 3rd-line)0.61 (0.25-1.48)0.28No. Lines of pal (2nd- vs. 3rd-line)0.46 (0.20-1.04)0.06No. of muts (1-5 vs. >10)0.74 (0.24-2.33)0.61No. of muts (6-10 vs. >10)0.64 (0.20-2.07)0.46Visceral mets (no vs. yes)1.25 (0.52-2.98)0.61 Citation Format: Jing Xi, Nusayba Bagegni, Foluso Ademuyiwa, Ashley Frith, Rama Suresh, Anna Roshal, Caron Rigden, Leonel Hernandez-Aya, Lindsay Peterson, Mateusz Opyrchal, Katherine Clifton, Katherine Weilbaecher, Ron Bose, Cynthia Ma. Circulating tumor DNA (ctDNA) mutation (mut) profile in relation to paboclicib (pal) efficacy in hormone receptor positive (HR+) and HER2 negative (HER2-) metastatic breast cancer (MBC) [abstract]. In: Proceedings of the 2020 San Antonio Breast Cancer Virtual Symposium; 2020 Dec 8-11; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2021;81(4 Suppl):Abstract nr PS2-18.

Issues and Events

Issues and Events

Events

Events

The Hybrid USERN 2020 Congress: New Standards for Events in Practice

The article's abstract is not available.

Kreuzfahrtterminal Warnemünde: Abfertigung, kommunale Nutzung, Landmark

AbstractDie steigenden Schiffsanläufe und Passagierzahlen in Rostock‐Warnemünde, einem der bedeutendsten Standorte für den Kreuzfahrttourismus im Ostseeraum, erforderten eine Erweiterung und Modernisierung der Infrastruktur. Das neue Cruise‐Terminal wurde 2020 eröffnet. Trotz der in diesem Jahr geringeren Auslastung durch die weltweite Corona‐Pandemie bleibt die Nachfrage und Prognose für den Ostseeraum hoch. Die Gestaltung des Gebäudes folgt den Anforderungen der unterschiedlichen Nutzungen im Jahresverlauf als EU‐Außengrenze und kommunaler Veranstaltungsraum. Die Windlasten waren aufgrund der exponierten Lage in unmittelbarer Küstennähe sowie durch die Position der Schiffe im Bezug zum Gebäude versuchsgestützt zu ermitteln. Der gewünschte repräsentative Charakter des Gebäudes, kombiniert mit einer komplizierten Gründungssituation, erzeugt ein außergewöhnliches Tragwerk in Stahlbauweise. In diesem Beitrag wird detailliert auf die anspruchsvolle Tragwerksplanung eingegangen.

A snapshot of reef conditions in North Ari Atoll (Maldives) following the 2016 bleaching event and Acanthaster planci outbreak

Coral reefs are degrading worldwide. This study explored the benthic community structure (biotic and abiotic benthic cover and coral composition) at three islands (Rasdhoo, Maayafushi and Vihamaafaru) in the central Maldivian archipelago, 2 years after the 2016 El Nino–Southern Oscillation (ENSO) and the associated mass-bleaching events. Hence, we assessed benthic cover on the same GPS sites and depth (10m) of a subset of reefs that had been previously studied. The islands represent a range of management categories and oceanic influence. Average live coral cover in 2018 was lowest on Maayafushi reefs (0.65±0.41%), a resort island with minimal exposure to oceanic influence. At Rasdhoo, a community island with south-eastern oceanic exposure, live coral cover was 14.70±3.20% and 90% of the colonies were less than 20cm in diameter. At Vihamaafaru, an uninhabited island with oceanic exposure from the west, reefs assessed had a live coral cover of 17.9±6.80%, Acropora spp. remained the dominant taxa, and 35% of colonies were 20cm or greater in diameter. This evident trend, in variation of live coral cover and size of the coral colonies, among the three island settings indicates the greatest potential for recovery of coral cover on reefs with more exposure to oceanic influence.

Cultural Change in the Construction Industry The Role of Project Alliance Organizational Culture

Project alliances are a contemporary approach for managing complex construction projects. In order to succeed, they require establishment of trust and collaborative ways of working, calling for fundamental changes in the behaviors and values among organizational members taking part in them. The increasing use of project alliancing may therefore influence the underlying values, norms and regulations within the construction sector, and hence contribute to the cultural change within the construction industry by large. The purpose of this paper is to elaborate the understanding of the cultural change that is produced by the use of project alliances, focused on collaborative behaviors. The research particularly develops knowledge on the mechanisms through which the use of project alliances may shape the industry culture. Data were collected from the Finnish construction sector, where alliance projects are increasingly popular. Central industry representatives were interviewed, and data content analysed. The findings reveal that industry level cultural change related to project alliances is a continuously evolving process and an outcome of change events and purposeful cultural change work at multiple levels including individuals, organizations, networks and construction industry. The results therefore draw attention to the role of multi-level interactions in advancing cultural change, which has to date received limited attention. The findings on the role of individuals’ career paths and trajectories are also novel, as they implicate that individual level movement and cultural orientation may play a more significant role in cultural change dynamics within project-based industries than has been acknowledged

Assessment of climate change impact on high flows in a watershed characterized by flood regulating reservoirs

A climate-induced extreme flow event such as flooding is one of the most devastating natural hazards, which can significantly damage human lives and properties. This study examined the effects of climate change on the high flow conditions in the Great Miami River Watershed in Ohio under two emission scenarios (RCP 4.5 and RCP 8.5). Streamflow for the 21st century was simulated by utilizing a watershed model - SWAT (Soil and Water Assessment Tool) and 10 different climate outputs from the Coupled Model Intercomparison Project phase 5 (CMIP5). The future streamflow was divided into three equal periods: 2016-2043 (early century), 2044-2071 (mid-century), and 2072-2099 (late century) and independently analyzed to compare high flows of respective intervals with baseline periods (1988-2015). The analysis predicted that 7-day, 10-year high-flow (7Q10) would increase by 38% under RCP 4.5 and 44% under RCP 8.5. Similarly, the annual peak flows for study periods were predicted to increase by 26% under RCP 4.5 and 38% under RCP 8.5 from the base period. However, the analysis demonstrated an erratic response for monthly peaks indicating that the peak flow would increase in summer months - May and July to October. Meanwhile, the result did not show any significant increase during the winter season, especially from November to April. The analysis of the four major dams located in the watershed showed that the dam’s peak discharges increase in January, May, and September. Even though increasing peaks were projected in September for the 21st century, the monthly peaks from the watershed outlet were found to be lowest in September as compared to other months. The frequency of future flooding compared to the historical record was found to be increasing in the mid-century under RCP 4.5 and the late century under RCP 8.5. As the future flood is projected to increase, this study finds the reasonable impact of climate change on flood regulating reservoirs/dams in monthly flows. However, daily high flows (90th percentile flow) would be increasing significantly (44% to 250%) under RCP 8.5. Keywords: climate change, high flows, SWAT, Great Miami River Watershed, flood regulating reservoir, assessment DOI: 10.25165/j.ijabe.20211401.5883 Citation: Shrestha S, Sharma S. Assessment of climate change impact on high flows in a watershed characterized by flood regulating reservoirs. Int J Agric & Biol Eng, 2021; 14(1): 178–191.

The fear of flying and the competitiveness of a return to service of the Boeing 737 MAX

Fear of flying has no direct relationship with actual airline or aircraft safety. For those afraid of flying, the choice of an airline ticket and the related airplane is expected to be an important issue. This article uses a methodology to simulate the experience of purchasing unlabeled airline tickets to investigate whether individuals who are afraid of flying unconsciously change their choice depending on the ticket parameters. The Boeing 737 MAX, which became notorious for being grounded due to two recent accidents, was randomly assigned to airline tickets. This aircraft was compared with eight competing alternatives. The results demonstrate that in the event of a return to service, the passenger preference for this aircraft would be low comparable to that for competing modern airplanes that are less known to the North American public. Nonetheless, Boeing products continue to instill a sense of safety and trust in those afraid of flying.

Issues and Events

Issues and Events

Profound Hypoxemia From Right Ventricular Failure Following Acute Type A Aortic Dissection

Acute aortic dissection is a catastrophic event with high mortality rate if left untreated. Complications of aortic dissection are fairly common, and some of them increase mortality rates further, necessitating early diagnosis and treatment. We present a case of Stanford type A aortic dissection with an uncommon complication of right ventricular failure, which resulted in a rare presentation of persistent hypoxemia despite intubation and maximal ventilatory support. Other common causes of hypoxemia were ruled out and this was eventually attributed to the aortic dissection and emergency surgery was arranged for the patient. Our case can help to increase the awareness of such a potential association, which should be considered in future similar clinical situations, thus minimizing any delay in management. J Med Cases. 2021;12(4):145-148 doi: https://doi.org/10.14740/jmc3652

Resilient or not: boundary-spanning in innovation focused MNEs during global crises

Purpose: The purpose of this paper is to provide a critical perspective on whether the boundary-spanner model and consequently complex disaggregated intra-MNE value chain activities are crisis resilient Design/methodology/approach: The paper is a conceptual theory development based on literature integration and phenomenological juxtaposing Findings: The need for boundary-spanning in assisting dispersed new and complex knowledge creation activities – which can hardly be replicated in virtual collaboration spaces alone – will endure if not even grow This requires deeper understanding of boundary spanning in the context of the globally dispersed MNE Increased location diversification engendered by COVID-19 implies a greater need for the boundary spanning function, not less Research limitations/implications: Regarding future research, the crisis provides a unique opportunity for taking a closer look at the formation, nurturing and resilience of interdependence, particularly behavioural interdependence and the actions and characteristics of individuals associated with [boundary spanning] actions Specific research questions should focus on the boundary-spanning model in the virtual space;the characteristics and effects of temporality and the boundary-spanning model, the specific actions of boundary spanners during unforeseen events and the empirical testing of the relationships developed in Table 1 Practical implications: For practitioners, I suggest avoiding compromising structural interdependence with defaulting on top-down hierarchical approaches during crises;and while doing so, not paying attention to the effects of such actions on behavioural interdependence and its champions (i e global boundary spanners) Such interference likely results in sub-optimal global collaboration outcomes and innovation, characterized by fundamentally recursive processes involving creativity, failure, reconfiguring, sensemaking and improvisation Social implications: TBC Originality/value: The author develops a critical perspective to assess the crisis-resilience of the boundary-spanning model In so doing, I juxtapose two contemporary views on the persistence or fading of the global MNE model, and hence, the future need for a socio-behavioural managerial function – like boundary-spanning – connecting dispersed MNE activities The authors provide numerous avenues for advancing extant research on boundary-spanning in MNEs © 2021, Emerald Publishing Limited

Extraction of optimal time-varying mean of non-stationary wind speeds based on empirical mode decomposition

The time-varying mean (TVM) component of non-stationary wind speeds is commonly extracted utilizing empirical mode decomposition (EMD) in practice, whereas the accuracy of the extracted TVM is difficult to be quantified. To deal with this problem, this paper proposes an approach to identify and extract the optimal TVM from several TVM results obtained by the EMD. It is suggested that the optimal TVM of a 10-min time history of wind speeds should meet both the following conditions: (1) the probability density function (PDF) of fluctuating wind component agrees well with the modified Gaussian function (MGF). At this stage, a coefficient p is newly defined as an evaluation index to quantify the correlation between PDF and MGF. The smaller the p is, the better the derived TVM is; (2) the number of local maxima of obtained optimal TVM within a 10-min time interval is less than 6. The proposed approach is validated by a numerical example, and it is also adopted to extract the optimal TVM from the field measurement records of wind speeds collected during a sandstorm event.

Advice on Selecting a Site For Out‐of‐Town Events

Advice on Selecting a Site For Out‐of‐Town Events

Middle and long-term follow-up of 101 children with giant coronary artery aneurysm of Kawasaki disease

Objective: To summarize the clinical features, middle-and long-term prognosis of Kawasaki disease (KD) with giant coronary artery aneurysm (GCAA). Methods: In this retrospective cohort study, a cross-sectional analysis was conducted on 101 KD children with GCAA in the KD with GCAA database established by Beijing Children's Hospital, Capital Medical University in 2004. GCAA was diagnosed as coronary artery absolute lumen diameter ≥8.0 mm. All patients were followed up regularly. The endpoint was the time of last follow-up or the death time. T test or χ2 test was used for comparison between groups. Results: A total of 101 KD children with GCAA were enrolled, including 82 males (81.2%) and 19 females (18.8%). The age of disease onset was 2.5 (1.0, 4.5) years. The follow-up duration was 4.5 (2.7, 7.5) years, with a longest of 19 years. All children received routine treatment with aspirin and warfarin, and clopidogrel was added in severe cases. At the end of follow-up, 13 cases (12.9%) had cardiac enlargement, 11 cases (10.9%) developed heart failure, 13 cases (12.9%) experienced myocardial infarction, 2 cases (2.0%) underwent coronary artery bypass graft and 6 cases (5.9%) died. A total of 170 coronary arteries were involved, including 24 (14.1%) GCAAs on the main trunk of left coronary artery, 10 (5.9%) GCAAs on left circumflex, 57 (33.5%) GCAAs on left anterior descending, 78 (45.9%) GCAAs on the middle segments of right coronary artery, and 1 (0.6%) GCAA in the distal segments of right coronary artery. Eleven cases (10.9%) recovered with the coronary artery absolute lumen diameter of all GCAAs below 4.0 mm. Among 170 branches with GCAAs, 28 (16.5%) regressed below 4.0 mm. No significant difference was found in the regression rates between right and left GCAA (18.7% (17/91) vs. 13.9% (11/79), χ²=2.473, P=0.116). There was no statistically significant difference in retraction between unilateral GCAA and bilateral GCAA (16.1% (9/56) vs. 4.4% (2/45), χ2=2.381, P=0.123). Conclusions: GCAA of KD occurred more common in the middle segments of right and left anterior descending coronary arteries. The incidence of adverse cardiac events and the mortality rate in children with GCAA complicated with KD was high. Their long-term prognosis was poor.

Place and date – Event – Details

Place and date – Event – Details