Registration Of Events Research Articles

Revenue Trend Analysis of Bharatpur Metropolitan City (BMC), Nepal

The present study aims to explore a comprehensive analysis of the revenue trends with special focus on the case of Bharatpur Metropolitan City. The study adopts a quantitative research design, employing document analysis, and an observation checklist. This study presents findings over the last 13 years 2067 to 2079, focusing on three key headings: Tax related to Land and Property, Service fee and Tariff and Dividend tax. Tax related to Land and Property encompasses taxes such as property tax, Malpot tax, business tax, house rent tax and homeland registration tax it exhibited the most substantial growth. Service fee and tariff represent the total sum of service fees and tariff, including fees for Building permits, event registration, and fines, relationship certification, education fees, electricity fees and parking fees. This variable showed initial growth but also experienced fluctuations. Dividend tax includes vehicle tax, entertainment tax, and advertising tax, showing modest yet steady growth, despite having the smallest contribution, it displayed consistent growth. The study underscores the diverse contributions of these revenue sources, emphasizing the need for strategic planning to stabilize and enhance the financial health of BMC by optimizing each revenue stream’s potential.

Evaluation of nurse practitioners' extended scope of practice in a regional hospital emergency department in tropical Australia.

There is very little literature examining the workload and impact of nurse practitioners (NPs) working in emergency departments (ED) in regional and rural Australia. The aim of this paper was to review the ED NPs scope of practice in the ED discharge stream and patient outcomes at Cairns Hospital over a 7-month period. This retrospective study examined the ED electronic medical record between 14 May 2019 and 31 December 2019. Cases managed by ED NPs, referrals, procedures performed, representations and disposition data were collected. Adverse events were sought from the Qld Health adverse events register (Riskman), the department complaints register and the ED M&M meeting minutes. A total of 1443 patients were treated by NPs, with ages ranging from 0 to 98 years (median 40 years). Australasian Triage Score (ATS) 3 cases made up 30% of the workload. Other than ATS 3 cases, time to being seen was better than the general department. There were very few unexpected representations, complaints or adverse events. This study supports the view that NPs working in a regional emergency department can safely manage a variety of patients outside a fast-track model, with a wide age range and a variety of triage categories and diagnoses. We believe this has important implications for the provision of emergency care, especially in regional and rural Australia.

Integrated coastal vulnerability index for coastal flooding: A case study of the Croatian coast

The combination of accelerated urbanization and tourism-related activities, along with frequent coastal flooding, has generated pressure on the coastline of the Republic of Croatia (RH). In this paper, an integrated coastal vulnerability model (ICVI) for coastal flooding was developed. The ICVI was generated using a GIS multicriteria approach and derived from two sub-indices: the physical vulnerability index (CVIN) and the socio-economic vulnerability index (CVIS). In total, 30 criteria were used in the derivation of the ICVI, with twelve contributing to CVIS and eighteen to CVIN. The ICVI model is represented as a line divided into smaller segments, each segment indicating ICVI vulnerability levels ranging from 1 (very low) to 5 (very high). The accuracy of CVIN was evaluated using 159 geocoded coastal flood locations obtained from various websites and the official register of Hrvatske Vode flood events from 2008 to 2023. More than 80% of geocoded flood locations are situated in areas with very high (5) or high (4) CVIN. Furthermore, out of 32 settlements with officially registered flood events, 90.6% of them are located in areas with very high or high ICVI. Since all data used in the ICVI derivation were acquired from open-source databases and a user-friendly GIS-MCDA toolbox was utilized, this paper presents a cost-effective approach to modeling integrated coastal vulnerability. This model can guide decision-makers and provide them with new insights for implementing an effective integrated coastal zone management strategy.

Development and evaluation of an interactive information system in technical assistance and rural extension

The state of Espírito Santo has a wide diversification of rural activities, such as family agribusinesses and activities related to rural tourism. However, diagnosing the rural zone presents some challenges, such as the difficulty of access and location, long distances, and excessive costs, combined with the scarcity of human and financial resources inherent to public services. In this sense, it is necessary to restructure the communication and technical assistance and rural extension model established by public institutions to reinforce the trend towards the use of Information and Communication Technology (ICT) tools and the implementation of concepts such as e-government (e-Gov). In this context, we propose an interactive computational tool, focusing on diagnosing, planning, and addressing the different current demands the rural sector presents. To achieve this, we have developed a consulting and data analysis system that also employs artificial intelligence concepts, aiming to increase the efficiency and quality of public services in rural areas. The proposed system is called Agrolegal Ater Digital and includes functionalities such as registration, diagnosis, virtual library, event registration, news, and funding opportunities. The objective is to facilitate access to information for rural entrepreneurs regarding the public services offered and to increase the speed of communication with public agents. The results obtained through the conducted diagnoses are promising, with good acceptance from the test group regarding the proposed tool and the use of information technology in addressing requests in rural areas.

Analysis of conditions related to diabetic foot in the pre and post COVID-19 pandemic in Brazil

With the COVID-19 pandemic, an exacerbation of hospitalizations due to diabetic foot was noted in Brazil, which was due to the loss of access to primary health care by the population, especially the most economically disadvantaged in a country with a vast continental extension and very unequal, economically. We carried out an observational, retrospective and descriptive analysis of hospital data on hospitalization for diabetic foot treatment, using SIH/SUS and DataSUS between 2015 and 2023. Mortality, length of stay, costs, nature of care and demographic distribution of procedures were analyzed. During the period, 196,523 hospitalizations were recorded for the treatment of complicated diabetic foot. In addition, 5,711 cases of deaths were associated with a fatality rate of 0.54%. In relation to financial expenditure, the Northeast Region stood out with the highest expenditure rate. The most socially vulnerable regions had higher hospitalization and mortality rates, although there was little change in financial resources during the pre- and post-pandemic period. This situation highlights the need to promote greater regional equity in indicators and access to health to minimize preventable problems such as UPD. Situations such as the one experienced in the COVID-19 pandemic served to highlight the shortcomings of the country's health system and how the health-disease process is strongly linked to local socioeconomic conditions, making it necessary to promote collective health measures aimed at minimizing disparities regions in Brazilian territory. The lack of data collected by the health event registration system in the country constitutes a limitation in the present study, which makes us suggest greater rigor and diversity in the collection of information in order to better translate the reality of the data presented here.

Mapping the ‘lifelong journey’ of physical literacy: a biographical assessment method for the physical activity and health context

ABSTRACT Physical literacy (PL) describes individuals’ unique relationship with physical activity by integrating physical, cognitive, affective, and social aspects. The person-centered concept highlights a ‘lifelong journey’ for each individual and postulates beneficial effects on biopsychosocial health. Despite extensive suggestions on how to assess the concept, no instrument has so far sufficiently aligned with these ‘individual journeys’ for PL. Therefore, the goal of this conceptual article is to introduce the biographical PL mapping (BMAP-PL) as a purposive, flexible, and paradigmatically open method for the broad physical activity and health context. Intending to provoke individual narratives by plotting domain-driven courses across the lifespan, the BMAP-PL involves four sequential phases guided by a trained facilitator: (a) introduction and overview; (b) personalization and registration of life events; (c) evaluation and biographical visualization of PL dimensions; (d) final overview. The idiosyncratic courses can undergo both qualitative and quantitative analysis, including a potential for synthetic integration. Qualitative analyses can span the identification of life events, transition phenomena, domain-differential analyses, and inter-individual patterns via narrative analysis, thematic analysis, typological analysis, or the grounded theory approach. We suggest quantitative analyses with descriptive and inferential statistical potential on the intra-individual, inter-individual, and group/population level. Given the profound cognitive engagement with the complex behavior of physical activity, BMAP-PL allows for a smooth transition to interventional endeavors (e.g. self-exploration of identity facets, prospective projections, goal setting). The application of the method has value for both research and practice but is based on requirements on the personal and atmospheric level. Emphasizing the need to complement the conceptual ideas through empirical data, we conclude by outlining an agenda for future activities.

Efficacy of a new generation topical retinoid in the treatment of patients with moderate to severe acne on the face and trunk

BACKGROUND: The extreme prevalence of acne, long-term course and multifactorial pathogenesis necessitate the development of new drugs and treatment methods aimed at increasing efficiency and achieving clinical effects in the shortest possible time. This article presents data from two international clinical studies to determine the effectiveness and safety of trifarotene 50 µg/g (0.005%) cream in the treatment of patients with moderate acne on the face and trunk. AIM: To evaluate the safety and effectiveness of trifarotene cream, 0.005%, a new topical retinoid, for moderate acne of the face and trunk. MATERIALS AND METHODS: Two international, double-blind, randomized, placebo (vehicle) controlled, 12-week phase III studies screened 2817 and randomized 2420 patients 9 years of age and over. The effectiveness of the drug was assessed based on the registration of the number of patients who achieved the effect of "clear" or "almost clear" skin condition and an improvement of ≥2 points in terms of IGA on the facial skin and PGA on the truncal skin during 12 weeks of treatment, as well as by calculating the change in absolute number of inflammatory and non-inflammatory acne elements relatively to the initial level. The safety of therapy was assessed based on the registration of adverse events, local tolerability (the formation and severity of retinoic dermatitis), abnormalities in vital signs and the results of standard laboratory tests. RESULTS: The onset of effect of trifarotene versus that of its vehicle was rapid, with significant reductions in both inflammatory and noninflammatory lesion counts seen as early as 1 week after treatment on the face and as early as 2 weeks after treatment on the trunk. In both studies, at week 12 the facial success rates according to IGA and PGA and change in inflammatory and noninflammatory lesion counts (both absolute and percentage) were all highly significant (p 0.001) in favor of trifarotene when compared with the vehicle and the formation of the “almost clear” and “clean” effect was registered in the vast majority of patients, who used cream with 0.005% trifarotene. CONCLUSION: The results of the study demonstrated the pronounced clinical effectiveness of trifarotene cream 0.005% in the treatment of patients with moderate acne on the skin of the face and trunk.

O-086 Risk of serious adverse event after fertility preservation procedures: a comparison of cancer and non-cancer patients

Abstract Study question Do cancer patients have a higher risk of serious adverse event associated to fertility preservation procedures compared to non-cancer patients ? Summary answer No increased risk of adverse event after fertility preservation procedures was identified in cancer patients compared to non-cancer patients undergoing fertility preservation for other indications. What is known already Current recommendations encourage a prompt and exhaustive discussion on the different techniques of fertility preservation that can be performed in cancer patients of reproductive age prior to cancer treatments. Although cryopreservation of mature oocytes and/or embryos is the technique of reference in the absence of contraindication, ovarian stimulation and subsequent oocyte retrieval are associated to complications. Cancer patients might present an additional risk given tumoral hypervascularity and proinflammatory environment, as well as possible immune or coagulation disorders. However, whether cancer patients have an increased risk of serious adverse event associated to fertility preservation procedures compared to non-cancer patients remains unknown. Study design, size, duration A bicentric, retrospective study between January 1st, 2014 and December 31st, 2021. Participants/materials, setting, methods All women undergoing fertility preservation procedures by oocyte and/or embryo cryopreservation after controlled ovarian stimulation or in vitro maturation.The main endpoint was the occurrence of a serious adverse event (hospitalization for ovarian hyperstimulation syndrome, hemorrhage, infection, thromboembolic event, ovarian torsion, acute urine retention or death) in cancer patients compared to non-cancer patients undergoing fertility procedures. Main results and the role of chance A total of 4476 cycles (n = 3180 patients) were included, of which 3761 after controlled ovarian stimulation and 715 in vitro maturation cycles. Among the 4476 cycles, 1678 were performed in an oncological context (n = 1546 cancer patients) and 2798 were fertility preservation cycles for an indication other than cancer (n = 1634 patients). A total of 29 serious adverse events associated to fertility preservation procedures were registered, of which 17 intraperitoneal hemorrhages, 8 cases of ovarian hyperstimulation syndrome, 3 cases of infection and 1 case of acute urine retention. The risk of serious adverse event associated to fertility preservation procedures was not significantly different between cancer patients and non-cancer patients (0.36% vs. 0.82%, respectively, P = 0.06). Young age (P = 0.002), a higher number of oocytes retrieved (P = 0.006) and a higher number of oocytes vitrified (P = 0.002) were significantly associated to the risk of presenting a serious adverse event after fertility preservation. Limitations, reasons for caution Although rates of serious adverse events in our study are similar to that reported in previous literature and that the declaration and registration of any serious adverse event is mandatory according to French legislation, it is possible that not all serious adverse events were declared and registered. Wider implications of the findings Given the trend of delaying parenthood and the improved survival rates after cancer treatments, these findings are of particular importance, emphasizing the safety of performing fertility preservation procedures for cancer patients of reproductive age who might have a pregnancy desire after cancer treatment. Trial registration number not applicable

Non-invasive quantitative assessment of induced component displacement can safely and accurately diagnose tibial component loosening in patients: A prospective diagnostic study.

Aseptic loosening often requires major, expensiveand invasive revision surgery. Current diagnostic modalities merely show indirect signs of loosening. A recent proof of concept study proposed a non-invasive technique for the quantitative and visual assessment of implant movement as a diagnostic aid for tibial component loosening. The primary research question addressed is whether this novel diagnostic modality can safely and effectively aid the diagnosis of aseptic loosening. This clinical study included patients suspected of aseptic total knee arthroplasty (TKA) loosening listed for revision surgery and asymptomatic patients. Safety was evaluated using a numerical rating scale (NRS) for discomfort and by registration of adverse events. Feasibility was assessed by recording the duration and ease of the procedure. Intra- and interrater reliability were evaluated. In symptomatic patients, diagnostic accuracy metrics were evaluated with intra-operative assessment as a reference test. In total, 34 symptomatic and 38 asymptomatic knees with a TKA were analysed. The medianNRSfor discomfort during loading was 6 (interquartile range [IQR]: 3.75-7.00) in symptomatic patients and 2 (IQR: 1.00-3.00) in asymptomatic patients. No adverse events were reported. The majority of users found the use of the loading device easy. The median time spent in the computed tomography roomwas 9 min(IQR: 8.00-11.00). Excellent to good intra- and interrater reliabilities were achieved. Diagnostic accuracy analysis resulted in a sensitivity of 0.91 (95% confidence interval [CI]: 0.72-0.97) and a specificity of 0.72 (95% CI: 0.43-0.90). The proposed diagnostic method is safe, feasible, reliableand accurate in aiding the diagnosis of aseptic tibial component loosening. Level II.

Pembangunan Sistem Pengelolaan Event Atma Jaya Yogyakarta Menggunakan React dan .Net5 Berbasis Web dan Mobile

Atma Jaya Yogyakarta University until today, has had its own system to disseminate information to its students and staff, but in terms of event management, the system owned has not met the most important needs of its users. The purpose of this research is to design and build a web and mobile-based event management system using the ASP .Net Core 5 framework and the React Native framework so that it can be used in the Atma Jaya Yogyakarta University environment. The research was conducted through several methods, namely observation, literature study, and system development. In addition, application testing was carried out by distributing questionnaires to 29 respondents who participated on the participant page and 4 respondents on the admin page. After going through the process of designing, building, and testing applications, this research succeeded in building an event management application at Atma Jaya Yogyakarta University with the name UAJY Events. With the construction of the UAJY Events application, management, registration and search for events organized in the university environment can be done more efficiently.

First detailed calculation of atmospheric neutrino foregrounds to the diffuse supernova neutrino background in Super-Kamiokande

The diffuse supernova neutrino background (DSNB)—a probe of the core-collapse mechanism and the cosmic star-formation history—has not been detected, but its discovery may be imminent. A significant obstacle for DSNB detection in Super-Kamiokande (Super-K) is detector backgrounds, especially due to atmospheric neutrinos (more precisely, these are foregrounds), which are not sufficiently understood. We perform the first detailed theoretical calculations of these foregrounds in the range 16–90 MeV in detected electron energy, taking into account several physical and detector effects, quantifying uncertainties, and comparing our predictions to the 15.9 live time years of pre-gadolinium data from Super-K stages I–IV. We show that our modeling reasonably reproduces this low-energy data as well as the usual high-energy atmospheric-neutrino data. To accelerate progress on detecting the DSNB, we outline key actions to be taken in future theoretical and experimental work. In a forthcoming paper, we use our modeling to detail how low-energy atmospheric-neutrino events register in Super-K and suggest new cuts to reduce their impact. Published by the American Physical Society 2024

EventPro – Application for Events

Abstract: In recent years, the event management landscape has undergone a profound transformation, driven by the emergence of event apps that have played a pivotal role in this evolution. This abstract delves into the concept of event apps, shedding light on their transformative impact and their potential to revolutionize the entire event lifecycle, encompassing planning, execution, and the overall event experience. Event apps are specialized software applications tailored to streamline the comprehensive event management process. Leveraging the widespread adoption of smartphones and the connectivity of the internet, these digital tools provide a seamless, enhanced event experience for attendees, organizers, and stakeholders. A prominent advantage of event apps is their capacity to simplify the event registration and ticketing process. Attendees can swiftly and conveniently register for events, select sessions, and make payments, effectively reducing the administrative workload for event organizers. Furthermore, event apps offer an array of features, including personalized schedules, interactive maps, and real-time notifications, ensuring attendees can effortlessly navigate events and stay informed about the latest updates. Beyond convenience, event apps foster valuable networking interactions among participants. They facilitate connections, meeting scheduling, and the exchange of contact information, opportunities that might have been challenging to achieve in a traditional event setting. They track attendee engagement, preferences, and behaviors, equipping organizers with insights to tailor future events for maximum impact. Additionally, event apps enable real-time communication, simplifying logistics management and responses to unexpected changes or challenges. As technology continues to advance, the potential for event apps to further revolutionize event planning, execution, and overall experiences is virtually limitless.

Radiopharmaceuticals Adverse Events Management.

Radiopharmaceuticals are radioactive compounds used for diagnostic or therapeutic purposes which are most often administered intravenously. Adverse events that may induce both adverse reactions and drug-to-drug interactions with changes in expected biodistribution, potentially affecting patient safety and diagnostic accuracy. Adverse reactions are relatively rare due to the small doses and under-reporting is the norm. The aim of this study is to increase awareness of the need to report in order to create protocols for the management of such adverse events among professionals in a Nuclear Medicine Department. A reporting system was established a decade ago through an electronic form to enhance adverse event registration. The radiopharmacist collects data for further communication with National Health authorities and develops an annual report with recommendations on the management of these adverse events. A total of 128 reports were collected, including 65 cases of extravasations, 18 adverse reactions, and 45 drug interactions. Over the years, reporting has been increasing, adverse reactions occurred at a higher incidence than reported in the literature, and each anomalous biodistribution was analysed for possible drug interaction. The annual reports have been used to develop a local guideline for the management of adverse reactions and recommendations for discontinuation of treatment to avoid interactions with radiopharmaceuticals. The recognition of adverse events associated with radiopharmaceuticals is increasing, underlining the need for vigilant reporting and improved management strategies. An efficient reporting system promotes awareness of possible interactions between radiopharmaceuticals and other medicines and their potential adverse reactions to enhance patient safety.

Pentraxin-3: Possibilities and perspectives for using the biomarker in patients with previous COVID-19

Objective: to determine the potential prognostic value of serum biomarkers in relation to the development of adverse cardiovascular events in patients who have undergone COVID-19. Material and methods. The prospective study involved 114 patients hospitalized with confirmed COVID-19. In addition to standard examinations, blood samples were taken from patients on the day of hospitalization to determine the level of serum cardiovascular biomarkers, including pentaxin-3 (РТХЗ). The patients were monitored for 366 [365; 380] days after discharge from the COVID hospital with registration of major adverse cardiovascular events (MACE) developed in patients. Results. During follow-up, MACE was noted in 19 patients (16.7%), including 2 deaths (1.8%) from cardiovascular causes. The incidence of MACE was higher in patients with higher concentrations of РТХЗ (odds ratio — OR 1.28, 95% confidence interval — Cl 1.13-1.45; p<0,001), interleukin 6 (OR 1.01, 95% Cl 1.0-1.02; p=0.048), D-dimer (OR 2.05, 95% Cl 1.16-3.6; p=0.019), lactate dehydrogenase (OR 1.08, 95% Cl 1.03-1.13; p<0.001), creatine phosphokinase-MB (OR 1.19, 95% Cl 1.02-1.39; p=0.001). The concentration of PTX3>3.1 ng/ml predicted the development of MACE with a sensitivity of 94.0% and a specificity of 82.1% (AUC 0.885; p<0.001). Conclusion. Serum biomarkers, in particular РТХЗ, may be used to predict the development of MACE in the long-term follow-up of patients who have undergone COVID-19.

Prediction of cardiovascular risk in patients with hepatocellular carcinoma receiving anti-angiogenic drugs: lessons from sorafenib

Antiangiogenics are associated with an increased risk of major adverse cardiac and cerebrovascular events (MACE). The identification of at-risk subjects is relevant in the case of hepatocellular carcinoma (HCC), for which anti-angiogenic TKIs and bevacizumab are used in first and subsequent lines of therapy, to select alternative drugs for patients with excessive risk. We verified the ability to predict MACE in sorafenib-treated patients of the 2022 European Society of Cardiology (ESC-2022) score for anti-angiogenics and the recently proposed CARDIOSOR score. A retrospective analysis was conducted of prospectively collected data of the ARPES and ITA.LI.CA databases. All patients received sorafenib for unresectable HCC from 2008 to 2018. Baseline information to calculate the ESC-2022 and CARDIOSOR scores and registration of evolutive events (including MACE) were available for all patients. The predictive ability of both scores was verified using competing risk regressions and tests for goodness of fit. This study included 843 patients (median follow-up 11.3 months). Thirty-four (4.0%) patients presented a MACE. The four-tier ESC-2022 classification showed a progressive risk increase for every class (cumulative risk 1.7%, 2.7%, 4.3%, and 15.0% in the low, medium, high, and high-risk tiers, respectively). The dichotomous CARDIOSOR scale identified a high-risk group with a fourfold increased risk of MACE (sHR 4.66, p = 0.010; cumulative risk 3.8% and 16.4%). ESC-2022 showed a better goodness of fit compared to the CARDIOSOR score [C-index 0.671 (0.583–0.758) vs 0.562 (0.501–0.634), p = 0.021], but this gap was eliminated using the linear version of CARDIOSOR. Both the ESC-2022 and CARDIOSOR scores discriminated patients at increased risk for MACE. The use of these scores in clinical practice should be encouraged, since therapeutic measures can mitigate the cardiovascular risk.

Development of Event Management System in Professional Organization of Indonesian Professional Assessors Association (IASPRO) Using User Centered Design Method

An organization usually has events that need to be publicized to the wider community. The Indonesian Professional Assessors Association (IASPRO) only uses social media to publicize events such as seminars, workshops, or other events that are held. As a result, many organizational members or potential participants do not know that the event is being held or are even confused about registering and finding out what the participant quota for the event is. To make it easier for potential participants, a system is needed to organize event publication and registration. Therefore, an event management system is created, namely a web-based application with a User-centered Design approach. The use of the User-centered Design method aims to produce a system that suits the needs and comfort of the user. At the testing stage, the author uses the System Usability Scale method to evaluate the system interface, and black box testing to measure software functionality and ensure the software meets user needs. Test results using the System Usability Scale obtained an Acceptability range value of 81.67 with Grade A, with these results it is certain that users are satisfied with the current interface design.
 Keywords: system, event management, UCD, web-based,; organization

Modern Challenges of Event Tourism and Business, Organizational Needs

Event tourism is one of the growing and high-income directions of the tourism industry, event tourism is characterized by a variety of content, function and purpose, events that are held around the world have a high social, economic, cultural, historical, sports, business industrial significance. The mentioned article analyzes the course of event tourism, its scope and organizational needs and the relevance of event management. The method of literature review is used for the research. The article discusses the social positive and negative effects of event tourism on the environment, economy and society, as well as the social role in the process of employment and labor market formation. Event management, which is systematically used in event tourism, is new compared to other tourism sectors and is constantly experiencing progress along with the increased demand and need. The research showed that the most important problematic aspect in the process of planning and conducting events is the lack of professional staff and the absence of necessary competencies. Also, the research found that time management is a problem, The respondents have different attitudes towards the digital systems of budgeting, registration and identification of events.

Register for the dental events of 2024

Register for the dental events of 2024

Register for the dental events of 2024.

Register for the dental events of 2024.

Validation of a novel web-based application for hepatic arterial infusion floxuridine dosing.

15 Background: Hepatic arterial infusion (HAI) floxuridine (FUDR) dosing is a complex, multifactorial process with weight-based dosing dependent on the fold change of aspartate aminotransferase, alkaline phosphatase, and total bilirubin relative to reference values from preceding cycles and compounded over time. Given the complexity of dosing calculations and lack of experience with this treatment in community centers, HAI is typically administered only at tertiary oncology centers with limited access for rural disadvantaged patients. We developed an online tool to automate the dosing of FUDR to broaden safe and effective administration of HAI. Methods: The FUDR dosing algorithm developed at Memorial Sloan Kettering Cancer Center was digitalized as eDoseHAI, a novel multi-layer architecture web application tool featuring JavaScript (front-end), C# RESTful API (back-end) and Azure SQL server (data storage with Splunk data lake event registration). To validate this tool, manual dosing from patients who received ≥1 dose of HAI FUDR at our institution 6/2020-8/2023 was retrospectively compared to app-based dosing. Mismatch between app-based dosing and historical manual dosing was designated as dosing errors, excluding intentional adjustments based on physician discretion. Results: Internal validity was tested by entering records into eDoseHAI from 54 patients who received a total of 370 FUDR cycles (median 6; range 1-19). Ten patients (18.5%) were found to have unintentional dosing errors (e.g., delayed dose reductions) during treatment, impacting 52 cycles (14.1%). The median cycle at first error was 3 (range 2-6), impacting a median of 5 cycles (range 3-12). Dosing errors occurred in only 11.1% of the 45 patients supervised by a senior HAI physician, compared to 55.6% of the 9 patients supervised by three less experienced HAI physicians. Dosing accuracy improved over time; among the 14 patients on active HAI therapy, only 1 had an identified dosing error. eDoseHAI was able to reliably and accurately calculate dosing for all patients. Conclusions: HAI FUDR dosing is nuanced and complex, such that dosing errors occurred even with senior HAI oncologists. eDoseHAI is a web-based application tool designed to improve accuracy and thus safety of HAI dosing. We plan to further validate eDoseHAI using external data from an international HAI consortium, and to conduct a phase II clinical trial in which our team supervises FUDR dosing by community oncologists using eDoseHAI's supervisory mode with a goal to disseminate HAI therapy to disadvantaged rural patients who lack access.