Cycle Events Research Articles

Entinostat in patients with relapsed or refractory abdominal neuroendocrine tumors.

Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are rare neoplasms with an increasing annual incidence and prevalence. Many are metastatic at presentation or recur following surgical resection and require systemic therapy, for which somatostatin analogs such as octreotide or lanreotide comprise typical first-line therapies. Nonetheless, treatment options remain limited. Epigenetic processes such as histone modifications have been implicated in malignant transformation and progression. In this study, we evaluated the anti-proliferative effects of a histone deacetylase (HDAC) inhibitor, entinostat, which was computationally predicted to show anti-cancer activity, as confirmed in in vitro and in vivo models of GEP-NETs. This was a phase II study to evaluate the efficacy and safety of entinostat in patients with relapsed or refractory abdominal NETs. The primary objective was to estimate the objective response rate to entinostat. Additionally, with each patient as his/her own control we estimated the rates of tumor growth prior to enrollment on study and while receiving entinostat. Patients received 5 mg entinostat weekly until disease progression or intolerable toxicity. The dose could be changed to 10 mg biweekly for patients who did not experience grade ≥ 2 treatment-related adverse events (AEs) in cycle 1, but was primarily administered at the starting 5 mg weekly dose. The study enrolled only 5 patients due to early termination by the drug sponsor. The first patient that enrolled had advanced disease and died within days of enrollment before follow-up imaging due to a grade 5 AE unrelated to study treatment and was considered non-evaluable. Best RECIST response for the remaining 4 patients was stable disease (SD) with time on study of 154+, 243, 574, and 741 days. With each patient as his/her own control, rates of tumor growth on entinostat were markedly reduced with rates 17%, 20%, 33%, and 68% of the rates prior to enrollment on study. Toxicities possibly or definitely related to entinostat included grade 2/3 neutrophil count decrease [2/4 (50%)/ 2/4 (50%)], grade 3 hypophosphatemia [1/4, (25%)], grade 1/2 fatigue [1/4 (25%)/ 2/4 (50%)], and other self-limiting grade 1/2 AEs. In the treatment of relapsed or refractory abdominal NETs, entinostat 5 mg weekly led to prolonged SD and reduced the rate of tumor growth by 32% to 83% with an acceptable safety profile (ClinicalTrials.gov Identifier: NCT03211988).

Dynamics of Mood Swings during Menstrual Cycles between Physically active and Inactive Adolescents: A Tripura-based Study

The menstrual cycle is an important biological process in women that is associated with a range of physical symptoms that can shape how women think, feel, and participate in daily life activities. This study employed a qualitative survey design to investigate the effect of physical activity and menstrual cycle on mood variability in adolescents. Purposively, 40 participants from Tripura University (n=20, physically active and n=20 Inactive) completed the Brunel mood scale questionnaire that explored menstrual cycle events: anger, tension, depression, fatigue, confusion, happiness and calmness. The participants’ response was further analysed descriptively through percentage analysis and differences between physically active and inactive students were assessed using the Mann Whitney-U test. The descriptive results depicted a mean rank of 16.20 and 24.80 of mood swing among Physically Active Students and Physically Inactive students respectively which shows a higher mood swing in inactive women. The significant difference was observed between physically active students and physically inactive students (two groups as U-value was 114.000 which was smaller than the critical value i.e., 127). Persons involved in physical activity have less chance of mood swing compared to sedentary people. In addition, the study concluded that regular moderate exercise helps reduce factors that enhance mood swing during the menstrual cycle.

Syringeable Near-Infrared Light-Activated In Situ Immunogenic Hydrogel Boosts the Cancer-Immunity Cycle to Enhance Anticancer Immunity.

Effective anticancer immunity depends on properly activating multiple stepwise events in the cancer-immunity cycle. An immunologically "cold" tumor microenvironment (TME) engenders immune evasion and refractoriness to conventional checkpoint blockade immunotherapy. Here, we combine nanoparticle formulations and an in situ formed hydrogel scaffold to treat accessible tumors locally and to stimulate systemic immunity against metastatic tumor lesions. The nanoparticles encapsulate poly(ε-caprolactone)-derived cytotoxic chemotherapy and adjuvant of Toll-like receptor 7/8 through a reactive oxygen species (ROS)-cleavable linker that can be self-activated by the coassembled neighboring photosensitizer following near-infrared (NIR) laser irradiation. Further development results in syringeable, NIR light-responsive, and immunogenic hydrogel (iGEL) that can be implanted peritumorally and deposited into the tumor surgical bed. Upon NIR laser irradiation, the generated ROS induces iGEL degradation and bond cleavage in the polymer-drug conjugates, triggering the immunogenic cell death cascade in cancer cells and spontaneously releasing encapsulated agents to rewire the cancer-immunity cycle. Notably, upon application in multiple preclinical models of melanoma and triple-negative breast cancer, which are aggressive and refractory to conventional immunotherapy, iGEL induces durable remission of established tumors, extends postsurgical tumor-free survival, and inhibits metastatic burden. The result of this study is a locally administrable immunogenic hydrogel for triggering host systemic immunity to improve immunotherapeutic efficacy with minimal off-target side effects.

Dynamical complexity in microscale disk-wind systems

Context. Powerful winds at accretion-disk scales have been observed in the past 20 years in many active galactic nuclei (AGN). These are the so-called ultrafast outflows (UFOs). Outflows are intimately related to mass accretion through the conservation of angular momentum, and they are therefore a key ingredient of most accretion disk models around black holes (BHs). At the same time, nuclear winds and outflows can provide the feedback that regulates the joint BH and galaxy growth. Aims. We reconsidered UFO observations in the framework of disk-wind scenarios, both magnetohydrodynamic disk winds and radiatively driven winds. Methods. We studied the statistical properties of observed UFOs from the literature and derived the distribution functions of the ratio ω̄ of the mass-outflow and -inflow rates and the ratio λw of the mass-outflow and the Eddington accretion rates. We studied the links between ω̄ and λw and the Eddington ratio λ = Lbol/LEdd. We derived the typical wind-activity history in our sources by assuming that it can be statistically described by population functions. Results. We find that the distribution functions of ω̄ and λw can be described as power laws above some thresholds, suggesting that there may be many wind subevents for each major wind event in each AGN activity cycle, which is a fractal behavior. We then introduced a simple cellular automaton to investigate how the dynamical properties of an idealized disk-wind system change following the introduction of simple feedback rules. We find that without feedback, the system is overcritical. Conversely, when feedback is present, regardless of whether it is magnetic or radiation driven, the system can be driven toward a self-organized critical state. Conclusions. Our results corroborate the hypothesis that AGN feedback is a necessary key ingredient in disk-wind systems, and following this, in shaping the coevolution of galaxies and supermassive BHs.

Remote path-following control for a holonomic Mecanum-wheeled robot in a resource-efficient networked control system

This paper introduces a novel resource-efficient control structure for remote path-following control of autonomous vehicles based on a comprehensive combination of Kalman filtering, non-uniform dual-rate sampling, periodic event-triggered communication, and prediction-based and packet-based control techniques. An essential component of the control solution is a non-uniform dual-rate extended Kalman filter (NUDREKF), which includes an h-step ahead prediction stage. The prediction error of the NUDREKF is ensured to be exponentially mean-square bounded. The algorithmic implementation of the filter is straightforward and triggered by periodic event conditions. The main goal of the approach is to achieve efficient usage of resources in a wireless networked control system (WNCS), while maintaining satisfactory path-following behavior for the vehicle (a holonomic Mecanum-wheeled robot). The proposal is additionally capable of coping with typical drawbacks of WNCS such as time-varying delays, and packet dropouts and disorder. A Simscape Multibody simulation application reveals reductions of up to 93% in resource usage compared to a nominal time-triggered control solution. The simulation results are experimentally validated in the holonomic Mecanum-wheeled robotic platform.

The efficacy and safety of apatinib combined with S-1 for advanced gastric cancer: A systematic review and meta-analysis.

Advanced gastric cancer (AGC) that does not respond to first-line therapy poses a challenge to clinical management. The objective of this study was to compare the efficacy and safety of apatinib combined with S-1 in second-line and above treatment of AGC. Cochrane Library, Science Direct, EMBASE, PubMed, and CNKI were searched for randomized controlled trial until August 2023. Only patients who met "Standardized Diagnosis and Treatment Guide for Gastric Cancer" were included in the study. The accurate data and distinguishing between follow-up time and drug dose were extracted to reduce heterogeneity and the risk of bias of the included trials was evaluated according to the Cochrane Handbook. Finally, the survival benefit of the treatment was evaluated based on clinical response rate, survival period, biochemical index, and adverse event occurrence in the trial. The meta-analysis included 29 randomized controlled trials involving 2149 participants. Statistically significant increases in clinical effective rate (odds ratios = 2.61, 95% confidence interval [2.13-3.20], P < .00001) and disease control rate (odds ratios = 3.16, 95% confidence interval [2.54-3.94], P < .00001) were found when apatinib combined with S-1, and also had obvious advantages in reducing tumor markers and regulating immune factors. In addition, apatinib combined with S-1 significantly increased the risk of hypertension but reduced damage to liver function, while the improvement of other adverse events was not pronounced. Apatinib combined with S-1 is more effective and safe for second-line and above treatment of AGC. This study minimized the conclusion bias caused by the basic data sources, but more high-quality studies are still needed to validate these conclusions.

#1431 Risk factors of adverse cardiovascular events in the early postoperative period in kidney transplant recipients

Abstract Background and Aims Kidney transplantation improves quality of life and increases life expectancy in patients with Stage 5 Chronic Kidney Disease. However, the frequency of adverse cardiovascular events in the postoperative period remains high and reduces the effectiveness of transplantation. The aim was to study the incidence of cardiovascular risk factors in the preoperative period in kidney transplant recipients with adverse cardiovascular events in the early postoperative period. Method The study included 51 kidney transplant recipients whose age was 46.1 ± 4.6 years. 12 (23.5%) recipients had adverse cardiovascular events (acute myocardial infarction, unstable angina, rhythm disturbance, complicated hypertensive crisis) in the early postoperative period. 39 (76.5%) recipients with uncomplicated postoperative period formed the comparison group. The study groups were comparable by gender and age. Results Traditional cardiovascular risk factors were assessed. The study groups had comparable rates of arterial hypertension, obesity, hyperglycemia, dyslipidemia and smoking in the preoperative period and graft function in the postoperative period. The study groups didn't have significant differences in the incidence of anemia and hemoglobin blood concentration. But the erythropoietin blood level in the preoperative period in recipients with adverse cardiovascular events was higher—38.5 (23.5-155.0) mU/mL versus 16.0 (10.0-32.0) mU/mL, p &amp;lt; 0.01, and hypererythropoietinemia was diagnosed more often—58.3% (n = 7) versus 25.6% (n = 10), p &amp;lt; 0.05, than in patients without cardiovascular events. The incidence of elevated interleukin-6 blood level in the preoperative period was higher in recipients with adverse cardiovascular events—25.0% (n = 3) versus 5.1% (n = 2), p &amp;lt; 0.05. At the same time C-reactive protein levels and white blood cell counts were not significantly different. Recipients with adverse cardiovascular events had a lower left ventricular ejection fraction—59.5 ± 10.6% versus 65.6 ± 7.1%, p &amp;lt; 0.05, and a higher incidence of left ventricular diastolic dysfunction in the preoperative period—75.0% (n = 9) versus 35.9% (n = 14), p &amp;lt; 0.05, than in recipients without cardiovascular complications. Conclusion Kidney transplant recipients with adverse cardiovascular events in the early postoperative period had a higher incidence of left ventricular diastolic dysfunction, increased blood levels of erythropoietin and interleukin-6 and a lower left ventricular ejection fraction before transplantation than recipients with an uncomplicated postoperative period.

#1396 Anxiety level in kidney transplant recipients with adverse cardiovascular events

Abstract Background and Aims Kidney transplantation is the most cardioprotective method of renal replacement therapy and it has a positive effect on the psycho-emotional state of patients. However, kidney transplant recipients have a higher cardiovascular risk and a higher prevalence of anxiety and depression than people in the general population. The aim of the study was assessment of anxiety levels and the quality of life of kidney transplant recipients preceding adverse cardiovascular events. Method The study included 154 kidney transplant recipients. 54 (35.1%) of them had adverse cardiovascular events (acute coronary syndrome, complicated hypertensive crisis or rhythm disturbance) for three years of observation. The comparison group was 100 (64.9%) recipients without cardiovascular complications during the observation period. The study groups were comparable by age, gender, graft function and traditional cardiovascular risk factors. Results The average level of situational anxiety of kidney transplant recipients was 39 ± 7, the level of personal anxiety—43 ± 8. The structure was dominated by recipients with moderate personal anxiety—55.2% (n = 85) and moderate situational anxiety—66.9% (n = 103). However, the proportion of persons with high personal anxiety was quite high—40.9% (n = 63). The structure of anxiety levels had no significant differences depending on subsequent cardiovascular complications. Nevertheless, kidney transplantation recipients with adverse cardiovascular events had higher previous level of situational anxiety than recipients without cardiovascular events—41 ± 7 versus 38 ± 7, p &amp;lt; 0.05. During the study kidney transplant recipients were asked to rate their quality of life on a scale of 1 to 10. Recipients with subsequent adverse cardiovascular events had a lower subjective quality of life than recipients without cardiovascular complications—7 (6-8) versus 8 (7-8), p &amp;lt; 0.01. Conclusion Based on the study it was found that recipients with adverse cardiovascular events in the late postoperative period are characterized by a higher level of situational anxiety and a lower quality of life before these complications.

Effect of Anchoring Dynamics on Proton-Coupled Electron Transfer in the Ru(bda) Coordination Oligomer on a Graphitic Surface.

The oligomeric ruthenium-based water oxidation catalyst, Ru(bda), is known to be experimentally anchored on graphitic surfaces through CH-π stacking interactions between the auxiliary bda ([2,2'-bipyridine]-6,6'-dicarboxylate) ligand bonded to ruthenium and the hexagonal rings of the surface. This anchoring provides control over their molecular coverage and enables efficient catalysis of water oxidation to dioxygen. The oligomeric nature of the molecule offers multiple anchoring sites at the surface, greatly enhancing the overall stability of the hybrid catalyst-graphitic surface anode through dynamic bonding. However, the impact of this dynamic anchoring on the overall catalytic mechanism is still a topic of debate. In this study, a crucial proton-coupled electron transfer event in the catalytic cycle is investigated using DFT-based molecular dynamics simulations plus metadynamics. The CH-π stacking anchoring plays a critical role not only in stabilizing this hybrid system but also in facilitating the proton-coupled electron transfer event with possible vibronic couplings between the anchoring bonds motion and charge fluctuations at the catalyst - graphitic surface interface. Furthermore, this computational investigation displays the presence of a quartet spin state intermediate that can lead to the experimentally observed and thermodynamically more stable doublet spin state.

Cyclical ‘wetting’ phenomenon in the source region of Yellow River under long-term trends from 1956 to 2022

Study regionthe source region of the Yellow River (SRYB) Study focusDue to environmental changes, the drying and wetting processes have become increasingly intricate, and it is uncertain whether the wetting phenomenon in the SRYB indicates a long-term trend or a temporary cyclic event. This study utilized monthly streamflow and precipitation records from 1956 to 2022 to calculate hydrological and meteorological-dryness/wetness, represented by the standardized streamflow and precipitation indices, respectively. This study used detrended, wavelet, and cross-wavelet methods to investigate dry-wet variability and identified the atmospheric circulation phenomena driving the dryness/wetness and cyclical changes in the region. New hydro-meteorological insights for the SRYB(i) The SRYB showed an overall fluctuating wetting trend, which intensified after 2000. (ii) There were notable oscillatory cycles at 3–5 years, 10–12 years, and approximately 20–25 years in both hydrological and meteorological dry-wet variability. (iii) Transitions from dry to wet conditions had no significant link to short-term cycles (e.g., 3–5 years), but were linked to decadal cycles (e.g., 20–25 years). (iv) Spring and winter precipitation and streamflow dominated the interannual dry-wet variability. (v) The ENSO, AMO, and PDO influenced short-term cyclic fluctuations, while the AO and PDO influenced decadal cyclic fluctuations. This indicates that the wetting trend follows a cyclic pattern, and the intensification since 2000 is consistent with a decadal cyclic signal.

Activating Iterative Revolutions of the Cancer-Immunity Cycle in Hypoxic Tumors with a Smart Nano-Regulator.

The activation of sequential events in the cancer-immunity cycle (CIC) is crucial for achieving effective antitumor immunity. However, formidable challenges, such as innate and adaptive immune resistance, along with the off-target adverse effects of nonselective immunomodulators, persist. In this study, a tumor-selective nano-regulator named PNBJQ has been presented, focusing on targeting two nonredundant immune nodes: inducing immunogenic cancer cell death and abrogating immune resistance to fully activate endogenous tumor immunity. PNBJQ is obtained by encapsulating the immunomodulating agent JQ1 within a self-assembling system formed by linking a Type-I photosensitizer to polyethylene glycol through a hypoxia-sensitive azo bond. Benefiting from the Type-I photosensitive mechanism, PNBJQ triggers the immunogenic cell death of hypoxic tumors under near-infrared (NIR)light irradiation. This process resolves innate immune resistance by stimulating sufficient cytotoxic T-lymphocytes. Simultaneously, PNBJQ smartly responds to the hypoxic tumor microenvironment for precise drug delivery, adeptly addressing adaptive immune resistance by using JQ1 to downregulate programmed death ligand 1 (PD-L1) and sustaining the response of cytotoxic T lymphocytes. The activatable synergic photoimmunotherapy promotes an immune-promoting tumor microenvironment by activating an iterative revolution of the CIC, which remarkably eradicates established hypoxic tumors and suppresses distal lesions under low light dose irradiation.

The observed evolution of sub‐daily to multi‐day heavy precipitation in Switzerland

AbstractHeavy precipitation is a major natural hazard in the Alps. Understanding the possible changes due to climate change is a prerequisite for effective climate adaptation and protection. In this study, we revisit the long‐term (1901–2023) evolution of daily and multi‐day heavy precipitation intensity and frequency, discuss trends for sub‐daily to multi‐day events in the recent period 1981–2023 and investigate elevation dependencies in the complex topography of Switzerland. We analyze station measurements from MeteoSwiss' dense operational network covering the whole country and a wide range of elevation levels. We find that daily maximum precipitation and the frequency of precipitation events exceeding the 99th all‐day percentile have increased since 1901 with a peak in the 1980s and decreases thereafter. For the recent period 1981–2023, positive trends in summer heavy precipitation intensity are detected for short (10‐min to 3‐h) events, but no changes are found for the frequency of these moderate extreme events. For longer (1‐ to 5‐day) events on the other hand, decreases in intensity and frequency are found, especially for the winter half‐year. We hypothesize that the opposing trends on the centennial (1901–2023) vs. decadal (1981–2023) time scales are caused by the interaction between thermodynamics, reflecting the primary influence of human‐induced climate change, and the internal variability of atmospheric dynamics. Moreover, we observe a small negative elevation dependency of the daily long‐term trends up to 2300 m above sea level. For the 1981–2023 trends, no strong elevation dependencies are found for sub‐daily events. For daily events, we find small opposing negative summer and positive winter elevation dependencies for both intensities and frequencies. The reason for these tendencies remains unclear. Our results underscore the need to further investigate the interplay between climate change, internal variability of large‐scale dynamics and elevation to better understand heavy precipitation variability in the complex Alpine terrain.

Dynamic characterization of water hammer in gangue fly ash slurry pipelines during valve closure

In the process of coal-filling mining, the gangue fly-ash slurry (GFS) needs to be transported over a long distance to reach the gobs. The abrupt closure of the valve during the transportation of GFS can result in a water hammer that significantly endangers the stability and safety of the pipeline transport system. To study the fluctuations in pressure induced by abrupt closure of the valve, experiments on the rheological parameters of gangue-coal ash slurry were conducted. Transient numerical simulations were carried out using the computational fluid dynamics method for various valve closing times. The results indicate that, with the increase of slurry concentration, the yield stress of the slurry significantly increases. When the concentration exceeds 76%, the increase in yield stress reaches 38.4% and 35.1%, respectively. Upon valve closure, the internal pressure of the slurry in the pipeline exhibits periodic dynamic oscillations. As the duration of valve closure increases, the frequency of periodic water hammer events decreases. The maximum water hammer pressure caused by valve closure decreases with the increasing distance between the valve and the closure point. At the same time, the intensity of maximum water hammer pressure fluctuations increases with the increase in slurry concentration and flow velocity in the pipeline. The results can provide references for water hammer protection and pipeline selection during the transportation of backfill slurry in mining.

Assessment of dynamical downscaling performance over cordex east Asia using MPAS-A global variable resolution model: climatology, seasonal cycle, and extreme events

Assessment of dynamical downscaling performance over cordex east Asia using MPAS-A global variable resolution model: climatology, seasonal cycle, and extreme events

Insights from Chilean NCDs Hospitalization Data during COVID-19.

The COVID-19 pandemic has affected the lifestyles of people of all ages, conditions and occupations. Social distance, remote working, changes in diet and a lack of physical activity have directly and indirectly affected many aspects of mental and physical health, particularly in patients with many comorbidities and non-communicable diseases (NCDs). In our paper, we analyzed COVID-19 hospitalized and non-hospitalized cases according to comorbidities to assess the average monthly percentage change (AMPC) and monthly percentage change (MPC) using open access data from the Chilean Ministry of Science, Technology, Knowledge and Innovation. As expected, the infection mainly affected patients with comorbidities, including cardiovascular risk factors. The hospitalized cases with obesity and chronic lung disease increased throughout the period of June 2020-August 2021 (AMPC = ↑20.8 and ↑19.4%, respectively, p < 0.05), as did all the non-hospitalized cases with comorbidities throughout the period (AMPC = ↑15.6 to ↑30.3 [p < 0.05]). The increases in hospitalizations and non-hospitalizations with comorbidities may be associated with physical inactivity. A healthy lifestyle with regular physical activity may have had a protective effect on the COVID-19 severity and related events in the post-pandemic period, especially for the NCD population.

Pediatric obstructive sleep apnea: a prospective observational study of respiratory events in the immediate recovery period after adenotonsillectomy

BackgroundAdenotonsillectomy is often curative for pediatric obstructive sleep apnea, yet children remain at high risk of respiratory complications in the postoperative period. We sought to determine the incidence and risk factors for respiratory depression and airway obstruction, as well as clinically apparent respiratory events in the post-anesthesia care unit (PACU) in high-risk children after adenotonsillectomy. MethodsIn this prospective cohort study, we enrolled 60 high-risk children having adenotonsillectomy. Our primary outcome was respiratory depression and airway obstruction in the PACU measured using a noninvasive respiratory volume monitor (RVM) and defined by episodes of predicted minute ventilation less than 40% for at least 2 min. We measured clinically apparent respiratory events using continuous observation by trained study staff. ResultsThe median (range) age of our sample was 4 years (1, 16) and 27 (45%) were female. Black and Hispanic race children comprised 80% (n = 48) of our cohort. Thirty-nine (65%) had at least one episode of PACU respiratory depression or airway obstruction measured using the RVM, while only 21 (35%) had clinically apparent respiratory events. Poisson regression demonstrated the following associations with an increase in episodes of respiratory depression and airway obstruction: BMI Z-score less than −1 (estimate 3.91; [95%CI 1.49–10.23]), BMI Z-score 1–2 (estimate 2.04; [1.20–3.48]), and two or more comorbidities (estimate 1.96; [1.11–3.46]). ConclusionsRespiratory volume monitoring in the immediate postoperative period after pediatric high-risk adenotonsillectomy identifies impaired ventilation more frequently than is clinically apparent.

CDK4/6 activity is required during G2 arrest to prevent stress-induced endoreplication.

Cell cycle events are coordinated by cyclin-dependent kinases (CDKs) to ensure robust cell division. CDK4/6 and CDK2 regulate the growth 1 (G1) to synthesis (S) phase transition of the cell cycle by responding to mitogen signaling, promoting E2F transcription and inhibition of the anaphase-promoting complex. We found that this mechanism was still required in G2-arrested cells to prevent cell cycle exit after the S phase. This mechanism revealed a role for CDK4/6 in maintaining the G2 state, challenging the notion that the cell cycle is irreversible and that cells do not require mitogens after passing the restriction point. Exit from G2 occurred during ribotoxic stress and was actively mediated by stress-activated protein kinases. Upon relief of stress, a significant fraction of cells underwent a second round of DNA replication that led to whole-genome doubling.

A Nonstationary Stochastic Rainfall Generator Conditioned on Global Climate Models for Design Flood Analyses in the Mississippi and Other Large River Basins

AbstractExisting stochastic rainfall generators (SRGs) are typically limited to relatively small domains due to spatial stationarity assumptions, hindering their usefulness for flood studies in large basins. This study proposes StormLab, an SRG that simulates precipitation events at 6‐hr and 0.03° resolution in the Mississippi River Basin (MRB). The model focuses on winter and spring storms caused by water vapor transport from the Gulf of Mexico—the key flood‐generating storm type in the basin. The model generates anisotropic spatiotemporal noise fields that replicate local precipitation structures from observed data. The noise is transformed into precipitation through parametric distributions conditioned on large‐scale atmospheric fields from a climate model, reflecting spatial and temporal nonstationarity. StormLab can produce multiple realizations that reflect the uncertainty in fine‐scale precipitation arising from a specific large‐scale atmospheric environment. Model parameters were fitted monthly from December–May, based on storms identified from 1979 to 2021 ERA5 reanalysis data and Analysis of Record for Calibration (AORC) precipitation. StormLab then generated 1,000 synthetic years of precipitation events based on 10 CESM2 ensemble simulations. Empirical return levels of simulated annual maxima agree well with AORC data and show an overall increase in 1‐ to 500‐year events in the future period (2022–2050). To our knowledge, this is the first SRG simulating nonstationary, anisotropic high‐resolution precipitation over continental‐scale river basins, demonstrating the value of conditioning such stochastic models on large‐scale atmospheric variables. StormLab provides a wide range of extreme precipitation scenarios for design floods in the MRB and can be further extended to other large river basins.

Early Clinical Results for a New Self-Organizing Hybrid Fabric in Congenital Cardiac Surgery

BackgroundWe have developed a new hybrid warp-knit fabric for induction of in situ tissue regeneration that has shown appropriate antideterioration properties and expandability in preclinical studies. This study was performed to assess the clinical efficacy and safety of this fabric in the early postoperative period after congenital cardiac surgery. MethodsThe fabric comprises biodegradable (complete degradation period, 2-3 years) and nonbiodegradable yarns coated with cross-linked gelatin. A multicenter single-arm 3-year study was conducted. The primary end point for regulatory approval was the surgical success rate without death or reintervention related to fabric failure at 1 year after surgery. Secondary end points included the incidence of material-related secondary lesions. ResultsThe fabric was implanted at 41 sites (pulmonary artery, n = 18; right ventricular outflow tract, n = 12; atrial septum, n = 7; and ventricular septum, n = 4) in 34 patients of median age 1 year 11 months (range, 4 months-58 years). The surgical success rate was 100%. There were no abnormal findings for the fabric on echocardiography and no serious adverse events in a median follow-up period of 40 months (range, 36-55 months), other than 3 stenotic lesions that were due to the surgical procedure. These results permitted regulatory approval for use of the fabric in Japan. ConclusionsThe new fabric promoting tissue self-organization through a novel technology showed acceptable efficacy and safety in the early postoperative period after congenital cardiac surgery.

MCSA-based fault diagnosis for rotary parts in servo motion system: Approach and experimental study

Motor current signature analysis (MCSA), as a non-invasive diagnostic method, is robust to environmental noise and of less sensor cost than vibration-based monitoring. Although large amount of progress has been achieved, little attention is paid to the MCSA-based diagnosis task in the Servo motion systems (SMS). An approach using Park vector demodulation, comb filtering and the ensemble empirical mode decomposition (EEMD) is proposed for cyclic fault event detection in this paper. Experiment studies reveal that the MCSA approach could extract the fault signature under extremely low-speed or noisy working condition, which has potential in the scenarios where the accelerometers placement is limited or affected by interferences.