Historical Events Research Articles

Suleiman Al-Nabulsi and His Position on Arab Nationalist Causes

This study addressed the position of Suleiman Al-Nabulsi on many Arab and national causes, as Al-Nabulsi is considered one of the men of Jordan had a prominent role in the Jordanian and Arab political life. His life reflected to a large extent the reality of political life and its interactions in the Jordanian arena and the Arab world at large ,this study aims to underline Al-Nabulsi ’s position regarding all causes at Jordanian and Arab national levels , such as the Palestinian situation, Arab unity, the Algerian revolution, the Baghdad Pact, the tripartite aggression against Egypt and other Jordanian and national causes, in addition to clarifying Al-Nabulsi ’s philosophy of national loyalty, which stems from principle of Arab existence unity. he is one of the prime ministers in Jordan who did not limit nationalism just at Jordan’s level , besides his role in the social reform that aims to attain more of democracy and opposition to foreign mandates which he considered as a form of colonialism (Al-Mousa, 1986, p. 57), and therefore it was natural that this philosophy will be in conflict with the philosophy of the state which aims to maintain its entity and independence ,the descriptive historical method was used that relies on the historical events as they appeared in their sources ,and to apply critical approach and analyze them in a scientific ,rational and neutral objectivity far from prejudice .the study reached many conclusions some of which are :the national philosophy of Al-Nabulsi that transcends the political and geographical boundaries of Jordan ,because he upholds the high values and ideals in his calculations ,and in fact he tried to subject reality to those values , also President Nasser’s ideas regarding unity has a great impact on his personality ,so he experienced a conflict between the loyalty to the country ,and the loyalty to Arab nationalism by president Nasser ,so naturally he saw no conflict between the two loyalties to the country on the one hand and the larger Arab nationalism on the other hand (Al-Mousa 1986 ,P 58 ), but the two loyalties complimented each other and he defended this concept until the last day of his life.

HISTORY AND CONSTITUTIONALISM OF THE GRAND DUCHY OF LUXEMBOURG: BRIEF NOTES - DOI: 10.12818/P.0304-2340.2024v85p223

The text provides a brief and general approach to the formation history of Luxembourg, emphasizing the constitutional landscape of the country, presented in three sections. The first one highlights the historical and formal events that lead to modern Luxembourg. In the second, the more important constitutional moments in the XIX century are exposed, with commentaries regarding the Constitutions of 1841, 1848, 1856, and 1868. In the third, the political and constitutional reforms of the XX century, considering the I and II World Wars, are commented upon, with the intention to expose some of the main characteristics of the Grand-Duché, such as its openness to the international sphere, constitutional actions for the integration of Europe, and the main normative diploma that shows the compromise with Human and Fundamental rights, considering specific dynamics of the relations of the powers of the state.

Modeling the Bioenergetics and Life History Traits of Chironomus riparius–Consequences of Food Limitation

Chironomids have a number of characteristics that make them a useful group for investigating the impact of environmental and chemical stressors on their life cycle stages. It is crucial to first understand sensitivities to environmental factors and provide a basis for interpreting the results of toxicity tests. We focused on Chironomus riparius–one of the most studied species in aquatic toxicity tests—to understand the changes during the larval stage under conditions of food abundance and limitation. We developed a model based on Dynamic Energy Budget (DEB) theory, a framework to capture the entire life cycle of an individual under varying food and temperature conditions. Available information from this study and the literature pointed out that the first three larval instars are immature and the fourth larval instar is mature, during which the organism saves, in two phases, energy for essential processes occurring during the subsequent non-feeding stages. The model can successfully predict the observed prolonged fourth instar duration under food limitation, the times of life history events (e.g., pupation and emergence), and egg production. This model has the potential to be integrated with toxicokinetic–toxicodynamic models to study the effects of toxicants on a variety of biological traits.

The evolution and causes of the change in the demographic model of Russia. Message 1. General assessment of historical, medical, social and demographic events

The demographic situation in different periods was determined by the general patterns of childbearing, epidemics and the state of society. In Russia, even against the background of great upheavals, population growth has been observed for several centuries with a high birth rate, which exceeded the total mortality rate. Epidemics, wars and political events of the twentieth century, as well as the change of priorities in the 1990s, left their mark and led to a decrease in the population. This analytical review is devoted to the evolutionary changes in the Russian population model. The main historical, medical, social and demographic events that dynamically affect the demographic situation in our country are considered. Special attention is paid to the factors influencing the decline in the population in the country, which must be taken into account when planning and implementing state and territorial programs to stimulate the birth rate, taking into account the main political and economic changes.

Exploring and Researching “Guizhou Village Super League”

The fame of “Guizhou Village Super League” in 2023 is a phenomenal event in Chinese history. “Guizhou Village Super League” is not only a competition, but also a cultural exchange opportunity that integrates Chinese rural culture and world football culture. This article takes “Guizhou Village Super League” as the research object and uses the method of literature review to objectively study the development and impact of Guizhou village supermarkets. Research has found that the main reason for the explosive popularity of “Guizhou Village Super League” is the widespread dissemination of short video platforms. The fresh element of countryside plus football has aroused the public’s curiosity and aroused widespread concern on the Internet. The support of the local government has also expanded the influence of “Guizhou Village Super League”. Finally, the persistent efforts of the local people and their love for sports are also essential. The fame of”Guizhou Village Super League” proves the feasibility of combining Chinese rural culture with modern popular culture. In the current era of Internet media, it seems to be a very effective way to improve the poverty situation in China’s rural areas and promote China’s local culture by taking the integration of Chinese traditional culture and world popular culture as the media for China’s rural areas to go global.

Formation of historical memory of the first independence period in Latvia in the Perestroika years, 1987–1990

The author analyses the evolution of a new historical narrative in Latvia during the era of Perestroika, a period marked by the emergence of numerous public initiatives springing from political and social movements. One of the key initiatives was the restoration of the memory of ‘forgotten pages of history’, namely events and individuals who had been erased from the historical record in the Soviet Union for ideological reasons. Given that the restoration of state sovereignty was a central objective of this period, the “revival” of commemorative dates related to the history of the Republic of Latvia’s first independence (1918–1940) was a logical consequence of the search for one’s roots. A number of historical events were not only integrated into the collective memory but also referenced in political documents designed to reinstate national sovereignty. One of the primary objectives of this process was to construct a new historical narrative that would assert continuity and legal identity between the Republic of Latvia of the interwar period and the one that emerged in the late Soviet era, seeking to secede from the USSR and regain its lost independence. The formulation of the doctrine of national continuity entailed, on the one hand, the pursuit of reference points that would serve as the basis for a new state and national identity, and, on the other hand, encompassed a public discourse on the “black pages” of history, reflecting the aspiration to overcome the challenging historical legacy associated with the loss of independence in 1940 and to establish a framework for legitimate international relations.

Violence and apocalyptic notions in Mark 13

Mark 13 is famously known as the most challenging text in the entire Markan gospel. In Mark 13:7–8, the Markan Jesus foretells a tumultuous period marked by wars, rumours of wars, nations in conflict and natural hazards, aligning with common motifs in apocalyptic literature. The language vividly depicts a world in upheaval, emphasising cosmic and earthly disturbances as harbingers of climactic historical moments. The destruction of the temple, announced in Mark 13:2, is subject to both literal and symbolic interpretations, with some associating it with the historical event of the Second Temple’s destruction in 70 CE and others perceiving it as a symbol of the end of an age. Approaching Mark 13 without being triggered by violent connotations is unthinkable. Hence, responsible interpretation is pivotal in addressing such potentially violent connotations, particularly considering contemporary world conflicts. Sensitivity, without compromising the truth of the message of Mark 13, is crucial when considering the text’s impact on war-torn communities. This applies both to a reading that simulates the possible intention of the text within the context in which the Gospel, according to Mark, originated and to a historically informed use of such a reading considering contemporary conflicts. This study aims to employ a historiographical hermeneutic as an investigative tool to contribute a plausible understanding of the present text and avoid utilising this text as proof to promote violence and wars today. Especially, when one considers the recent catastrophes: natural hazards, civil unrest and wars across the world. Some are quick to utilise the Olivet discourse to explain such gruesome activities.Contribution: This study contextualizes Mark 13 within the 1st century CE, focusing on the Second Temple’s destruction in 70 CE. It promotes a sensitive interpretation, avoiding justifications for contemporary violence, and highlights the text’s relevance by drawing parallels between its turmoil and current global conflicts, encouraging ethical reflection.

The distinctions between Chinese and Western literature

In today’s globalization, the communication between Chinese and western literature is becoming more and more frequent, and the influence between them is also deepening. However, although mixed in some aspects, Chinese and Western literature still maintains its own characteristics and charm. Through the discussion of the differences between Chinese and Western literature, we can better understand the diversity of different cultures, promote cross-cultural dialogue and understanding, and enrich the spiritual world of human beings. This paper discusses the differences between Chinese and Western literature in various aspects, including communication mode, communication medium, development time, cycle, content and core ideas. Through the combination of historical events and objective development laws, this paper explores the influence of literature on economic and political development. This paper discusses in detail the relationship between literature and national and social development and how various social factors affect literature development, both of which restrict each other and cooperate with each other.

SPYGLASS. V. Spatially and Temporally Structured Star-forming Environments in the Cepheus-Hercules Complex

Young associations record complete histories of star-forming events through their demographics and dynamics, and Gaia has greatly expanded our knowledge of these associations. We present the first structural and dynamical overview study of the Cep-Her Complex, which has recently emerged as the largest stellar population within 500 pc that still lacks substantial follow-up. We reveal that Cep-Her is not a singular association, but rather an amalgam of four, consisting of the older (τ > 100 Myr) open cluster Roslund 6, in addition to three dynamically coherent and highly substructured young associations that we focus on: Orpheus (25–40 Myr), Cinyras (28–43 Myr), and Cupavo (54–80 Myr). With 9552 ± 960 stars in Orpheus, 3872 ± 455 stars in Cinyras, and 8794 ± 1827 stars in Cupavo, all three are among the largest young associations within 500 pc, rivalling major associations like Sco-Cen. Our novel view of the ages and dynamics of these associations reveals evidence for sequential star formation in Cinyras, in addition to a multiorigin pattern of stellar dispersal in Orpheus that may hint to the presence of multiple clouds at formation. Dynamical simulations indicate that, while some embedded open clusters and central components of these associations are converging, they likely lack the mass necessary to capture one another and undergo hierarchical cluster assembly. Our results provide our first view of the complex star-forming environments that gave rise to the associations of Cep-Her, which will serve as important laboratories for future studies of star and planet formation.

Prevalence and clinical significance of left ventricular thrombus discovered by pathological examination in explanted hearts of patients with end-stage cardiomyopathy

Abstract Objective We sought to determine the prevalence of anatomic LV thrombus detected by pathological examination of explanted hearts in patients with end-stage cardiomyopathy (CM) who have undergone heart transplantation, and to examine the relationship between anatomic LV thrombus missed by cardiac imaging and thromboembolic events. Methods and results A total of consecutive 148 explanted hearts from patients (44 years; 80% were men) undergoing heart transplantation were examined. The most common etiology of end-stage heart failure was dilated CM (53%). Of 148 explanted hearts, LV thrombus was present in 19 patients/hearts (13%). Excluding patients with ischemic CM (n=7), LV thrombus was present in 8 DCMs (9%), 1 genetic associated with LV noncompaction (100%), 2 hypertrophic CM (25%), and 1 arrhythmogenic CM (14%). None of patients with cardiac sarcoidosis (n=5) had LV thrombus. Of these patients, 11 (58%) received anticoagulants with favorable numbers of time in therapeutic range. No patient in the cohort had history of thromboembolic event before heart transplantation. Only 11 patients (26 %) with pathological evidence of LV thrombus had LV thrombus detected by previous echocardiograms (median time difference from echocardiogram to heart transplantation = 170 days). Six of 19 patients with anatomic LV thrombus had undergone cardiac MRI; LV thrombus had been detected in 2 patients (33%). The most common site of missed LV thrombus was LV cavity (where thrombi did not attach to any particular LV endocardial surface) followed by LV apex (Figure). Conclusion The prevalence of LV thrombus found by pathological examination in end-stage heart diseases was 13 % despite anticoagulation in most patients. However, the presence of these thrombi did not cause any serious thromboembolic events. Anatomic LV thrombi were missed by echocardiography/cardiac MRI in approximately 70% of patients. Genetic associated LV noncompaction and HCM were the most 2 prevalent CMs with anatomic thrombi, while none of patients with cardiac sarcoidosis had evidence of LV thrombus. Further study in thromboembolic milieu involving endocardial surface in specific type of CM may be needed.

Temporal trends in initiation of oral anticoagulants and stroke-free survival among elderly and very elderly patients with new onset atrial fibrillation - a 20-year perspective.

Abstract Background Oral anticoagulants (OACs) significantly reduce the risk of ischemic stroke in patients with atrial fibrillation (AF). However, evidence regarding efficacy of OACs are lacking in the very elderly patients. Aim To examine temporal trends in initiation of OACs and five-year stroke-free survival in the very elderly patients with new onset AF over a time span of 20 years. Methods From the Danish nationwide registries, we identified patients ≥ 65 years of age with new onset AF from 1999 to 2018. The index date was defined as the day of AF diagnosis for outpatients and as the day of discharge for inpatients. Patients with a prescription of OAC, history of bleeding events, or history of stroke/transient ischemic attack prior to index were excluded. Patients were divided into two age groups based on their age at index: 1) 65-84 years (elderly); and 2) ≥ 85 years (very elderly). Patients were further divided into four calendar year groups from 1999-2018, based on the year of inclusion. We investigated the initiation of OACs and calculated the absolute five-year probability of stroke-free survival in both age groups. Results We included 167,122 patients with new-onset AF between January 1st, 1999, and December 31st, 2018. Among the patients, 23.1 % were aged 85 years or older, 48 % were male and 80.5 % had a CHA2DS2-VASc score equivalent to 2 or higher for men and 3 or higher for women. Initiation of OACs increased in both age groups after the guideline implementation of DOACs in 2010 (Figure 1). In the elderly age group, the proportion of patients receiving OACs increased from 50% in 2010 to almost 90% in 2018. In the very elderly age group, the proportion increased from 25% in 2010 to almost 90% in 2018. The probability of the five-year stroke-free survival improved by approximately 15% from 1999 to 2018 in the elderly age group, with no significant changes in the very elderly age group. Conclusion The proportion of elderly AF patients receiving OAC has increased markedly in the last 20 years. Even so, stroke-free survival remains the same among the very elderly patients.Five-year stroke-free survival

Incidence of atrial fibrillation detected by an insertable cardiac monitor in a large real-world cohort of heart failure patients with reduced and preserved ejection fraction

Abstract Background Subcutaneous implantable cardiac monitors (ICM) have the capability to detect atrial fibrillation (AF) episodes with high degree of accuracy [1]. Objective We investigated the incidence of AF in patients implanted with an ICM and a clinical history of heart failure (HF) with reduced or preserved left ventricular ejection fraction (LVEF). Methods Patients with history of HF admissions who were implanted with an ICM were identified from the aggregated and de-identified electronic health record (EHR) database during 2007-2021. The device collected data were merged with the EHR data to create a de-identified database of real-world patients. Patients were included if they had ≥180 days of device follow-up. ICMs detect AF based on incoherence of RR intervals and absence of single p-wave between two R-waves [1]. All ICM detected AF episodes stored with at least 30 seconds of ECG at onset were adjudicated using an artificial intelligence (AI) model. The AI model was previously trained and validated using over 60K manually adjudicated episodes and was shown to have an accuracy of over 97% [2]. ICM detected AF episodes with AI model based true probability of AF ≥ 0.9 was analyzed. The Kaplan-Meier incidence curves for AF incidence as a function of episode duration, clinical history of AF, and LVEF are reported. Results A total of 1020 LINQ ICM patients with history of HF admission prior to implant were identified from the deidentified real-world dataset. LVEF was available in 889 (87%) patients, of whom 394 (44%) had EF <50%, and 495 (56%) had EF≥50%. NYHA class was available in 296 (29%) patients, of whom 39 (13%) were class I, 126 (43%) were class II, 112 (38%) were class III, and 19 (6%) were class IV. Patients had an average age of 68±13 years with 52% being males and had clinical history of hypertension in 95%, diabetes in 56%, coronary artery disease in 75%, AF in 57%, stroke/TIA in 51%, and renal dysfunction in 53%. A total of 911 patients with ≥180 days of follow-up (average follow-up of 25.8 months) were included. A total of 8407 episodes from 358 patients were classified by the AI model as true AF. The incidence of AF as a function of episode duration, clinical history of AF and reduced vs preserved LVEF are shown in Figures A, B, and C respectively. Incidence of AF, as detected by an ICM over 42 months of follow-up, was estimated to be 38% to 46% depending on AF episode duration. Estimated 42-month AF incidence was 23% in patients with no clinical history of AF. The 42-month AF incidence was 44% vs 47% in HF patients with reduced versus preserved LVEF. Conclusion Incidence of AF, as detected by an ICM over 3 years of follow-up, was estimated to be in close to half of ICM patients with history of HF events. Close to one fourth of the patients with no prior clinical history of AF had newly detected AF. AF incidence was similar in HF patients with preserved versus reduced LVEF in this real-world cohort.

Venous thrombo-embolic events as the probable cause of arterial ischemic event in patients with patent foramen ovale

Abstract Introduction The origin of the emboli involved in patent foramen ovale (PFO)-related embolic events remains mostly unknown. Purpose To evaluate the venous thrombo-embolic (VTE) origin of patients with PFO-related embolic event. Methods Patients planned for PFO closure for secondary prevention of PFO-related arterial embolic event had a systematic venous thrombo-embolic (VTE) risk evaluation that included : an extensive questionnaire on past history of VTE events, clinical situations at high risk of VTE including complicated hemorrhoids, prior saphenectomy or venous sclerosis, varicocele, intrapelvic tumor, pregnancy, surgery or prolonged travel or presence of hyperthrombotic state (i.e., thrombophilia, active cancer or covid) and an abdominopelvic magnetic resonance venography (MRV) evaluation to identify any intrapelvic venous disease. Results From July 2020 to May 2023, 366 consecutive patients (Median age 51 [42-58] years, 42.9% female) were prospectively included. A past medical VTE events, a high risk VTE situation, a hyperthrombotic state and a pelvic venous abnormality on MRV were present in 8.5% (95%CI 6.0-11.8), 22.7% (95%CI 18.7-27.2), 7.1% (95%CI 4.9-10.2), and 36.3% (95%CI 31.6-41.4), respectively, and 58.5% (95%CI 53.4-63.4) of the patients presented at least one of the previous conditions. MRV identified various undiagnosed pelvic venous abnormalities with 20.0% of pelvic varices, 9.8% of May-Thurner-Cockett and 7.4% of Nutcracker phenomenons (Figure 1). Imaging abnormalities were more frequent among younger patients (aOR 1.02 95%CI:1.00-1.04) and women (aOR 1.94 ; 95%CI:1.25-3.02). Conclusion A majority of patients undergoing PFO closure for secondary prevention have a potential VTE source of paradoxical emboli suggesting that VTE events is the probable cause of arterial ischemic event in these patients.

Refining risk stratification in hypertrophic cardiomyopathy: the role of late gadolinium enhancement and syncope in predicting adverse outcomes

Abstract Background The presence of late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (MRI) is recognized as a significant marker of myocardial fibrosis and a predictor of adverse outcomes in hypertrophic cardiomyopathy (HCM). Nevertheless, the specific quantity of LGE that correlates with poor outcomes is still under debate. Therefore, this study sought to assess the combined impact of LGE presence and a history of syncopal events and its association with clinical prognosis. Methods Between May 2018 and June 2023, a total of 230 HCM patients was prospectively enrolled at our Medical University, a tertiary referral center. The primary endpoint was a composite of new-onset ventricular tachycardia (VT), appropriate ICD therapy, and all-cause mortality. Results Median age of enrolled patients was 56 (IQR 44-64) years and 40% (n=94) were female. Median interventricular septal thickness (IVS) was 21 (IQR 18–25) mm and 43 % (n=84) had significant left ventricular outflow tract obstruction (LVOTO). Over a median follow-up of 3.2 years, 30 patients (13%) met the composite endpoint. These patients had a significantly higher LGE quantity compared to the non-event group (1.1 % vs. % 9.0, P=0.012). An LGE threshold of 5.2% was identified as an optimal predictor of the composite endpoint, with an area under the curve of 0.72, which increased to 0.77 when including at least one syncopal event in medical history. LGE > 5.2% and/or syncope were independently associated with adverse outcomes after multivariable adjustment (Adj HR 7.26 [95%CI 2.54-20.72]). Furthermore, NTproBNP and hsTnT were associated with the presence of LGE or syncope (OR for a 1-unit increase in standardized log-transformed biomarker NTproBNP 3.35 [95%CI 1.42-10.85]; hsTnT 3.48 [95%CI 1.48-10.24], respectively). Interestingly, typically used variables for risk stratification, such as age, IVS or LVOT were not significantly associated with these cardiac biomarkers. Conclusion An extent of LGE > 5.2% and the history of at least one syncope are associated with unfavorable clinical outcomes in HCM patients. These findings call for detailed MRI appraisal and suggest adopting a holistic approach to accurately identify high-risk patients.

Politics and city growth in Italy: Do connections matter?

AbstractIn this paper, I assess the existence of a political connection premium for Italian municipalities during the so-called “Second Republic” (1991–2011). The early 1990s witnessed a seminal event in Italian political history with the “Mani Pulite” (“Clean Hands”) investigation following the fall of the Berlin Wall. Subsequently, major political parties dissolved, culminating in a bipolar political landscape characterized by cyclical alternation between center-right and center-left factions (extending until at least 2011). Exploiting population data on small and medium-sized Italian municipalities between 1991 and 2011, I found that “politically connected” municipalities showed a population premium of about 2.5% compared to “non-politically connected” ones. The results are robust to NUTS-3 fixed effects, to a comprehensive set of controls, and to a full set of robustness checks. The relationship is confirmed using aggregate municipal income data as an additional proxy of local economic growth. Over and above this, social capital and the quality of local institutions seem to play a pivotal role in enabling the political connection. Election-related checks suggest the connection as two-way: using municipal data from the 2013 and 2018 general elections, I found that the treated municipalities depicted a higher turnout and fewer populist votes.

Subclinical myocardial fibrosis is almost ubiquitous in the hearts of older British persons: 'MyoFit46' cardiovascular sub-study of the NSHD

Abstract Background Unprecedented numbers are now surviving to older age, but little is known about the burden or pattern of myocardial fibrosis in the asymptomatic elderly population. Previous 1.5 Tesla (T) cardiovascular magnetic resonance (CMR) studies found a prevalence of unexpected infarct-pattern late gadolinium enhancement (LGE) of 17-20% above 75 years but less is known about non-infarct pattern scar in this group. We investigated the prevalence, patterns, and clinical predictors of left ventricular (LV) scar in a large asymptomatic older age cohort. Methods CMR with a single 3T magnet was performed on participants all born in the same week in March 1946, as part of the longest running continued surveillance birth cohort: the National Survey of Health and Development. LV short-axis stack LGE imaging was performed using a free-breathing motion-corrected balanced steady-state free precession sequence with phase-sensitive inversion-recovery. Two blinded observers independently recorded the prevalence, extent, and pattern of LGE per participant. Logistic regression was used to study the association between clinicodemographic parameters and LGE. Results 460 participants were prospectively recruited of which 406 completed CMR with LGE imaging (77.8 ± 0.1 years, 44% male). 341 (84%) demonstrated LGE affecting a mean of 2.1±1.2 myocardial segments per participant (Figure 1). The commonest pattern of LGE was inferior right ventricular insertion point (RVIP), observed in 66.9%. Other patterns included (Figure 2): Linear mid-wall (19.6%) of which 38% were located in the inferior/lateral walls; subepicardial (12.1%); subendocardial infarct-pattern (8.8%); patchy/diffuse (1.6%); embolic LGE (0.6%). Sub-analysis was performed comparing those without significant unexpected fibrosis (LGE–) vs those with focal fibrosis (LGE+, excluding RVIP and those participants with a known history of prior myocardial infarction). LGE+ participants were more likely to be female (71.7% vs 49.1%, p<0.001) or diabetic (11.3% vs 5.1%, p=0.05), had a higher body surface area (BSA, 1.9 vs 1.8 m2, p<0.001), weight (80.1 vs 72.8 kg, p<0.001), LV indexed end systolic volume (24.2 vs 20.4 ml/m2, p=0.001) and LV indexed mass (59.2 vs 55.4 g/m2, p<0.001), and a lower LV ejection fraction (67.9 vs 71.8%, p<0.001) In multivariable logistic regression: BSA, LV indexed mass, LV ejection fraction and diabetic status were independently associated with LGE+ status (odds ratios [95% confidence intervals]: 9.4 [0.7–3.8]; 1.0 [0.01–0.05]; 0.9 [-0.08--0.02]; and 2.5 [0.03–1.7] respectively, p<0.05). Conclusion Advanced PSIR MOCO LGE imaging at 3T reveals that the majority (84%) of asymptomatic British persons above the age of 75 harbour unexpected ‘subclinical’ focal fibrosis, with a substantial proportion of these scars consistent with probable historical myocarditis events. Further work will now explore the life-course determinants of this scar burden in the older age human heart.

A diagnosis of vascular ehlers-danlos syndrome in childhood: clinical and molecular features of 63 individuals

Abstract Background Vascular Ehlers-Danlos syndrome (vEDS) is a rare inherited connective tissue disorder characterised by generalised severe tissue friability and predominantly caused by pathogenic COL3A1 variants. Diagnosis of vEDS in childhood primarily occurs due to a positive family history and/or the occurrence of an early arterial or intestinal event. However, little has been reported on additional clinical characteristics and management in this population. Purpose This study aims to identify critical drivers of a childhood vEDS diagnosis in individuals diagnosed through a national EDS service. Methods 63 individuals (24 index, 31 females) with a clinical and genetic diagnosis of vEDS in childhood (< 18 years) were identified through a national EDS service, and childhood cardiovascular surveillance was conducted through joint inherited cardiovascular disease clinics. Results Diagnosis of vEDS in childhood occurred at a median age of 7 years (IQR 3-12) and was predominantly driven by positive family history of vEDS (55.5%). Clinical investigations were directly initiated by occurrence of a major clinical event in n=13 (20.6%), and a total of 17 major clinical events in childhood were recorded in 13 individuals. First events occurred at a median age of 11 years (IQR 0-13) and vascular events, though infrequent, occurred as early as the first year of life. In individuals who did not have a positive family history or major event, easy and/or excessive bruising was the most frequent cause for referral (60%). Conclusions This cohort provides further details of the clinical and genetic characteristics of children with vEDS and contributes new insight into drivers of vEDS diagnosis in childhood and the importance of long-term management, including paediatric cardiovascular surveillance.

Watery traces and absences: sensations and speculative histories of an ancient well and a carse landscape

This paper explores how mighty earth processes, aquatic agencies and human practical, political, religious, technological, commercial and environmental interventions have shaped and reshaped a now obscure Scottish holy well and the carse landscape to which it belongs. More specifically, I detail the historic pagan rituals, vigilant religious policing, romantic redesign and extensive terraforming that have informed the changing uses and symbolic associations of these watery realms, demonstrating how they testify to ceaselessly changing human-water relations. I explore how an awareness of particular historical events garnered from diverse texts can be supplemented with affective and sensory engagements with the non-human agencies, vestiges and absences of place. Together, they foster intimations and speculative imaginaries that conjure up speculative watery histories and conjectural futures.

THE CONTRIBUTION OF THE OIF IN POLITICAL MATTERS IN THE REPUBLIC OF CONGO FROM 1981 TO 2021

The Organization Internationale de la Francophonie (OIF) has played an important role in shaping the political landscape of the Republic of Congo over the four-decade timeframe. The study employed a historical and qualitative research approach, focusing on the analysis of political cooperation between the OIF and the Congo from 1981 to 2021. The research used a literature review to explore historical events, political reforms, and the impact of OIF's involvement in Congo's political landscape. The data were analyzed through thematic analysis, identifying key themes related to the political evolution of Congo, the organization's role in fostering democracy, peace, and human rights, and its outcomes of their collaboration. The analysis concludes that OIF has played a significant role in the promotion of democracy and peace in Congo through various initiatives.

Residential Mobility in Childhood and Union Dissolution Later in Life

The limited existing literature studying the effects of childhood residential mobility suggests that it influences a range of life outcomes, at least in young adulthood. Little is known about how the frequency of moving in childhood is related to later-life demographic behaviour in Europe. Drawing on residential and partnership histories from the Survey of Health, Ageing and Retirement in Europe (SHARE), this paper examines whether moving in childhood relates to union dissolution in adulthood. It empirically addresses two theoretical explanations underlying the potential association: First, according to the confounding hypothesis, effects of childhood residential mobility differ by family background and resources. Second, the family stress model suggests that the accumulated stress and conflicts associated with frequent residential mobility disrupt the family and child’s social ties, resulting in worse relationship skills in later life (mediation hypothesis). Applying discrete-time event history analysis to individuals born between 1945 and 1965 in Sweden, Denmark, and Finland, we find a significant association between childhood moves (prior to age 17) and adult union dissolution. The effect’s strength varies based on the number of childhood moves, demonstrating a clear gradient. Notably, adults with three or more childhood moves exhibit a 55% higher likelihood of union dissolution compared to non-movers. These associations persist even after accounting for childhood background factors, while family stress mediates the link partially. Our findings shed light on the role of spatial mobility in shaping demographic outcomes and underscore its potential contribution to the accumulation and reproduction of life disadvantages.