In this paper, a plate counter-flow dew-point evaporative cooling system was designed with a nanoporous membrane covered on the surface of the wet channel for enhancement of heat and mass transfer. First, the operating principle of this device and theoretical analysis of nanoporous membrane evaporation were discussed in detail. Then, the impacts of several operating parameters on cooling performance, mainly including inlet air temperature, humidity, velocity, and the effect of utilizing the membrane, were investigated in trials. It was found that the cooling performance can be improved by using membrane significantly. In the dry channel, the maximum temperature decrease can reach 12.5 °C. At a high inlet air temperature, the product air can be dropped to a lower temperature, contributing to a more significant heat transfer process. Lower humidity, on the other hand, resulted in a reduced product air temperature and a lower cooling efficiency. Under the condition of 50% humidity, the wet-bulb efficiency and dew-point efficiency were 1.09 and 0.79, respectively. With the inlet air velocity increasing from 1.5 m/s to 2 m/s, the outlet air temperature would rise, and the wet-bulb efficiency and dew-point efficiency would decrease. To achieve better cooling performance, inlet air velocity ought to be limited to a low speed.