Artificial Neural Networks (ANN) demonstrate a compelling application of AI in predicting student performance, a critical aspect for both students and educators. Accurate forecasting of student achievements enables educators to monitor progress effectively, allowing educational institutions to optimize outcomes and improve student results. This study focuses on leveraging ANN for predictive analytics in student performance. Through a detailed evaluation of transfer functions, optimizers, learning rates, and momentum values, the model achieves an impressive 98% accuracy with specific configurations: a learning rate of 0.005, momentum of 0.7, Sigmoid transfer function, and SGD optimizer. Additionally, the study performs a comparative analysis of various Machine Learning Algorithms, including ANN, Support Vector Machines (SVM), K-Nearest Neighbors (KNN), Decision Trees (DT), Naive Bayes (NB), and Logistic Regression (LR). Using data from 689 B.Tech students at IP University, the analysis reveals that ANN outperforms other algorithms with an accuracy of 97%. This high accuracy demonstrates the potential of ANN in educational settings, providing a valuable tool for educators to enhance student performance and outcomes.