Background: Cognitive impairment is a common condition in chronic heart failure (CHF), and is a marker of poor outcome and disability. Although the cause of this condition is not clear, previous studies have shown that mental status could improve with medical treatment, however there is little information about the effect of betablockers on cognitive function of CHF patients. Aims and Methods: To evaluate the influence on cognitive function of chronic use of betablockers (defined as >3 months of therapy with this drugs), 77 consecutive patients followed in our nurse-led HF clinic underwent clinical and psychosocial examination, blood chemistry, echocardiography, and mini mental state examination (MMSE). Patients with chronic use of betablockers were designed as group A and patients with less than 3 months or no use were designed as group B. Results: Baseline characteristics were: mean age 69.5±8.8 years, 56% were men, 44% had NYHA functional class III-IV, impaired left ventricular ejection fraction was present in 75% and heart failure etiology was ischemic in 50% of patients, mental status evaluation was abnormal (MMSE 70% low risk of having abnormal cognitive function. Conclusions: Chronic use of betablockers is associated with better cognitive function in patients with CHF, the high rate of prescription of these drugs and early detection of cognitive impairment should be fundamental tasks in HF units.