Evaluation Of Immediate Release Tablets Research Articles

Formulation and evaluation of immediate release tablet of risperidone

The main objective of the present investigation was to formulate Risperidone immediate release tablet. Risperidone, an antipsychotic drug mainly act as a D2 and 5HT2A receptor antagonist. Superdisintegrants agents like kollidon and citric acid were used and compressed into tablet by direct compression method. Risperidone is mainly used to treat schizophrenia bipolar disorder. The six formulations having different concentration of superdisintegrants were prepared and formulation blend was examined for angle of repose, bulk density tapped density and compressibility. The tablet were evaluated for various parameters like hardness, thickness, friability, weight variation, disintegration time and invitro dissolution time, all the parameter were found within limits.

Formulation and Evaluation of Immediate release Tablets of Dasatinib using Croscarmelose Sodium

The objective of the present study was to develop an immediate release tablet of Dasatinib using different concentrations of cross carmelose sodium (CCS) as superdisintegrant with a view to gain rapid disintegration in gastric pH for treatment of chronic myeloid leukemia (CML) and acute myeloid leukemia (AML).Five different formulations of Dasatinib immediate release tablets were prepared using wet granulation method. Different pre compression and post compression characterization of tablet was carried out. In vitro drug release studies were carried out in USP II paddle type dissolution apparatus for different formulation and the batch containing 5% CCS gave maximum amount of drug release of 99.14%.Drug and excipients compatibility studies were carried out through FTIR spectroscopy. FTIR spectroscopy studies reveled that there is no interaction between drug and different excipients used in formulation. Short term stability studies (at 40±2oC/75±5% RH) on the best formulation indicated that there no significant changes in drug content.

FORMULATION DEVELOPMENT AND EVALUATION OF EFAVIRENZ AND LAMIVUDINE IMMEDIATE RELEASE TABLETS: A COMBINATION THERAPY

The present study outlines a systematic approach for Formulation and Evaluation of Immediate release Tablets of lamivudine an d Efavirenz. The objective of this regimen is, to delay disease progression, to incr ease the duration of survival by achieving maximal and prolonged suppression of HIV repli cation, to restor e and preserve immunological function. Combination therapy is more effective and has less chances of developing resistance th an monotherapy. To achiev e this goal various prototype formulation trials were taken and evaluated with respect to the various quality control tests s uch as Thickness, hardness, weight variation, dissolution, disintegration, hardness and assay. The formula was finalized by compari ng the Invitro dissolution profile with that of the Marketed Tablets. The invitro release study was performed in 2%SLS in purified water upto30 min. Among all the formulations, formulation F5 release profile was good as compared to the marketed products. S tability studies (40±2oC/75±5%RH) for 2 months indicated that no characteristics changes in formulation. There was no chemical interaction between drug and excipients .

Formulation and evaluation of immediate release tablet using response surface methodology

The purpose of the present work was to develop an optimized immediate release tablet for hypertensive patients using amlodipine besylate as a model drug candidate by optimization technique to produce the intended benefits. A 32 factorial design was employed in formulating immediate release tablet.The independent variables selected were superdisintegrants such as sodium starch glycolate and in addition to that, effect of microcrystalline cellulose was studied. The dependent variables considered for study was DT and DP60. The tablets prepared were evaluated for thickness, uniformity of weight, hardness, friability, wetting time, in vitro disintegration time, and in vitro drug release study. The response surface plots differentiate the results between the independent and dependent variables. Apart from fulfilling all official and other specifications, the tablets exhibited higher rate of release.

Formulation and evaluation of immediate release tablet using response surface methodology

Formulation and evaluation of immediate release tablet using response surface methodology