Evaluation Of Balance Research Articles

Evaluation of Oxidative Stress Levels and Dynamic Thiol-disulfide Balance in Patients with Retinopathy of Prematurity

Purpose The aim of this study is to evaluate both dynamic thiol-disulfide homeostasis and oxidative stress (OS) levels in patients with retinopathy of prematurity (ROP). Methods A total of 129 infants of <34 weeks gestational age were enrolled in the present study. The thiol-disulfide homeostasis was determined by using the new, cost-effective and fully automated colorimetric method. Total antioxidant status (TAS), Total oxidant status (TOS) and Oxidative stress index (OSI) levels were evaluated. Results We found serum TAS levels were lower while serum TOS and OSI levels were significantly higher in patients with ROP compare to the without ROP group (p < .05). However, native, total and disulfide values were not statistically significant between the groups (p > .05). In addition, we also evaluated the native, total and disulfide levels in patients with ROP according to grades and no statistically significant results were found (p > .05). Low birth weight (p = .001), gestational age (p = .001) and 5-min Apgar score were significantly lower in the ROP group. Conclusion This study revealed that dynamic thiol-disulfide homeostasis was changed in patients with ROP. Increased TOS and decreased TAS levels may be associated with functional reduction of the antioxidant system due to increased OS. This indicate that ROP patients are highly sensitive to OS. The dynamic thiol-disulfide homeostasis may conduce to the pathophysiological mechanism and disease follow-up in patients with ROP. The results of this study show that ROP patients are highly sensitive to oxidative stress.

Evaluation of the Medical Resource Allocation: Evidence from China.

Medical resource allocation is an increasingly crucial issue. It is vital to understand residents' (people living in the local area) evaluation of it. This study explores residents' evaluation of medical resource allocation and its determinants with the dimensions of medical resource adequacy, balance, publicness, and accessibility. We used data from the China General Social Survey (CGSS). Binary logistic regression models were constructed from the four dimensions separately, and we compared the differences among them. The study's results showed that accessibility and publicness are the highest and lowest dimensions of residents' evaluation, respectively. The high evaluation of social equity may be a positive contributor to a higher evaluation of publicness and accessibility. The central region residents had the lowest evaluation of adequacy (OR = 0.697, p = 0.010) and balance (OR = 0.642, p = 0.008). To sum up, perceived social equity, social trust, and social class are crucial factors. Based on the results, the government should strengthen the supervision of the medical market, increase financial support for the health field in the central region, and establish a multi-level medical security system that may help optimize the allocation.

Design and application of a novel direct light-driven thermogravimetric analyzer

Thermogravimetric analysis is one of the evaluation means widely used to characterize thermoinduced chemical reaction and mass variation processes. However, the emergence of photothermal characteristics research makes traditional thermogravimetric analysis unable to meet the requirements. Therefore, a novel direct light-driven thermogravimetric analyzer is designed for fast photothermal integrated pyrolysis weight loss measurement based on the principle of high temperature measurement under light flux. The photothermal conversion characteristics are studied by analyzing the calcination progress of the blackened calcium carbonate particles. At the same time, the error and uncertainty analysis of the instrument is carried out. Compared with the conventional thermogravimetric electric heating approach, the direct light-driven thermogravimeter provides the same environment as the actual solar photothermal capture and utilization scenarios and enables getting deep insights into the mechanism of the photothermal conversion and chemical reaction kinetics involved which are consistent with the real solar-thermal energy applications. Its unique photothermal integrated design is also valuable for the composition analysis, kinetic analysis or evaluation of solid-gas balance of the materials, which provides an important analysis method for solar photothermal conversion.

Development and evaluation of force balance based functions for dust detachment from bulk particles stressed by fluid flow

Development and evaluation of force balance based functions for dust detachment from bulk particles stressed by fluid flow

A public data set of walking full-body kinematics and kinetics in individuals with Parkinson's disease.

To our knowledge, there is no Parkinson's disease (PD) gait biomechanics data sets available to the public. This study aimed to create a public data set of 26 idiopathic individuals with PD who walked overground on ON and OFF medication. Their upper extremity, trunk, lower extremity, and pelvis kinematics were measured using a three-dimensional motion-capture system (Raptor-4; Motion Analysis). The external forces were collected using force plates. The results include raw and processed kinematic and kinetic data in c3d and ASCII files in different file formats. In addition, a metadata file containing demographic, anthropometric, and clinical data is provided. The following clinical scales were employed: Unified Parkinson's disease rating scale motor aspects of experiences of daily living and motor score, Hoehn & Yahr, New Freezing of Gait Questionnaire, Montreal Cognitive Assessment, Mini Balance Evaluation Systems Tests, Fall Efficacy Scale-International-FES-I, Stroop test, and Trail Making Test A and B. All data are available at Figshare (https://figshare.com/articles/dataset/A_dataset_of_overground_walking_full-body_kinematics_and_kinetics_in_individuals_with_Parkinson_s_disease/14896881). This is the first public data set containing a three-dimensional full-body gait analysis of individuals with PD under the ON and OFF medication. It is expected to contribute so that different research groups worldwide have access to reference data and a better understanding of the effects of medication on gait.

A new device for assessment and training the human balance and coordination: Marmara Balance and Education System (MarBES).

Balance and coordination are important for performing activities of daily living. Balance and coordination assessment and training are used by physiotherapists in many different rehabilitation areas. Marmara Balance and Education System (MarBES) is a device developed to evaluate and improve balance and coordination. To examine the test-retest reliability of the MarBES device. Double-leg and single-leg (eyes open-closed) tests were applied to healthy young adult participants for balance testing on the MarBES device. Weight data is estimated from pressure sensors located in 4 different corners and a score is calculated with computer software for the individual's center of gravity (center of pressure X, Y) and the amount of deviation from the center for each axis. Weight transfer to the target surface was measured for assessment of the participants' coordination performance. Participants rested for 10min and all measurements were repeated by the same evaluator. The obtained data were recorded and the reliability of the measurements was evaluated with Spearman's rho correlation analysis. A total of 40 healthy young individuals (28 female) with a mean age of 21years were included. The balance assessments with MarBES showed moderate to good reliability (ICC: 0.535-0.903). The coordination assessment results showed moderate to good reliability (ICC: 0.575-0.712). Objective evaluation of balance and coordination parameters is very important in rehabilitation. Results of the study showed that the MarBES device developed by the researchers is a reliable method for the evaluation of balance and coordination in healthy young individuals.

Ammonia Recovery from Livestock Manure Digestate through an Air-Bubble Stripping Reactor: Evaluation of Performance and Energy Balance

The recovery of livestock manure, rich in nutrients, as fertilizer in agriculture, could pose the risk of an excessive load of nitrogen on the soil. Ammonia stripping is one of the available technologies for reducing the amount of nitrogen in the digestate obtained by the anaerobic digestion of manure. The study investigated the performance and energy consumption of a full-scale ammonia-stripping plant, equipped with a bubble reactor and working without the use of any alkaline reagent under semi-batch conditions. Stripping tests were conducted on the liquid fraction of the digestate, studying the current and optimized operative conditions of the plant. The main variables influencing the process were pH, temperature, airflow, and feed characteristics. In the experimental tests, the pH spontaneously increased to 10, without dosing basifying agents. Higher temperatures favoured the stripping process, the higher tested value being 68 °C. The airflow was kept equal to 15 Nm3 h−1 m−3digestate in the pre-stripping and to 60 Nm3 h−1 m−3digestate in the stripping reactors, during all tests. The energy requirement was completely satisfied by the CHP (combined heat and power) unit fed with the biogas produced by manure digestion. Results showed anaerobic digestion coupled with stripping to be a suitable solution for removing up to 81% of the ammonium with neither external energy input nor reagent dosage.

Water use and soil water balance of Mediterranean tree crops assessed with the SIMDualKc model in orchards of southern Portugal

Orchards consist of complex agricultural systems, with a variety of characteristics (planting density, tree height, training system, canopy cover, irrigation method, interrow management) influencing crop evapotranspiration (ETc). Thus, irrigation water management requires finding crop coefficients (Kc) that represent the characteristics of local orchards, evidencing the need for site specific data. The main objective of this study was to derive the Kc of almond, olive, citrus, and pomegranate orchards in Alentejo, southern Portugal, wherein they became dominant over the last decade. Monitoring was carried out in nine orchards, which management decisions were performed by the farmers. The ETc was estimated from the soil water balance computed for each orchard using the FAO56 dual-Kc approach with the SIMDualKc model. The model successfully simulated the soil water contents measured in the various fields along two growing seasons, with root mean square error values lower than 0.005 m3 m−3 and modeling efficiencies from 0.363 to 0.782. The estimated basal crop coefficients (Kcb) for the initial, mid- and end-seasons were respectively 0.22, 0.58, and 0.50 for almond; 0.32–0.33, 0.35–0.36, and 0.33–0.34 for olive; 0.40, 0.40–41, and 0.40–0.41 for citrus; and 0.24, 0.60, and 0.52 for pomegranate. Small variations in olive and citrus Kcb values were found to be related to differences in the fraction of the ground covered by trees’ canopies and tree height. The single Kc values, which included the component relative to soil evaporation, were also estimated. Furthermore, evaluation of the soil water balance in the nine case studies showed salinity effects in one almond orchard, mild irrigation water deficits in olive systems, and large non-consumptive water use in citrus and pomegranate orchards. These results evidence the need for better management of orchards irrigation water in the region, and the current study provides for reliable information on the Kc of tree crops to support improving the management of local orchard systems and the preservation of soil and water resources. Aimed at these resources and the sustainability of their use, simulated alternative irrigation schedules were performed, which identified possible water savings of 20 mm in case of olives, up to 855 mm for citrus.

Balancing new technology: Virtual reality for balance measurement case report.

Falling and the inability to maintain balance are the second leading cause of unintentional injury deaths globally. There are a number of chronic and acute conditions characterized by balance difficulties, including neurological diseases, and sport injuries. Therefore, methods to monitor and quantify balance are critical for clinical decision-making regarding risk management and balance rehabilitation. New advances in virtual reality (VR) technology has identified VR as a novel therapeutic platform. VRSway is a VR application that uses sensors attached to a virtual reality headset, and handheld remote controllers for measurement and analysis of postural stability by measuring changes in spatial location relative to the center of mass and calculates various postural stability indexes. This case report evaluates balance measures in 2 healthy participants with no previous history of balance disorders using the VRSway software application and compares to output generated by the current gold standard of balance measurement, force platform technology. The primary objective of this case study was to validate the VRSway stability score for evaluation of balance. Here, we present posturography measures of the VRSway in comparison with force plate readouts in 2 healthy participants. Body Sway measurements were recorded simultaneously in both the force plate and VRSway systems. Data calculated by proprietary software is highly correlative to the data generated by force plates for each of the following measurements for participant-1 and participant-2, respectively: Sway index (r1 = 0.985, P < .001; r2 = 0.970, P < .001), total displacement (r1 = 0.982, P < .001; r2 = 0.935, P < .001), center of pressure mean velocity (r1 = 0.982, P < .001; r2 = 0.935, P < .001), ellipse radius 1 (r1 = 0.979, P < .001; r2 = 0.965, P < .001), ellipse radius 2 (r1 = 0.982, P < .001; r2 = 0.969, P < .001), and ellipse area (r1 = 0.983, P < .001; r2 = 0.969, P < .001). Data from this case study suggest that VRSway measurements are highly correlated with output from force plate technology posing that VRSway is a novel approach to evaluate balance measures with VR. More research is required to understand possible uses of VR-based use for balance measurement in a larger and more diverse cohort.

Balance and Fall Risk Assessment in Community-Dwelling Older Adults after Recovery from COVID-19: A Cross-Sectional Study.

SARS-CoV-2 atypical symptoms in older persons include falls, confusion, dizziness, and unusual weariness. Falls and their consequences are among the most prevalent causes of disability among older adults, significantly lowering quality of life and resulting in the loss of independence as well as impaired psychosocial functioning. The study purpose was to examine the impact of the SARS-CoV-2 infectious disease on balance in community-dwelling older adults. Sixty-four older adults aged ≥ 60 years from both sexes, 31 treated for SARS-CoV-2 infection and 33 matched normal controls participated in the study. The Biodex Stability System (BSS) and Berg Balance Scale (BBS) were used for evaluation of balance and fall risk. The correlation between the Biodex overall stability index and the Berg Balance Scale score was investigated. When compared to controls, the SARS-CoV-2 group had significantly higher values of the Biodex overall stability index (OSI) (p = 0.011), anterior-posterior stability index (APSI) (p = 0.013), mediolateral stability index (MLSI) (p = 0.018), and fall risk index (FRI) (p = 0.008), as well as statistically lower scores on the Berg balance scale (p = 0.003). A moderate negative correlation was found between the two assessment tools in the SARS-CoV-2 group. Balance impairment and an increased risk of falling are among the outcomes of SARS-CoV-2 in community-dwelling older adults.

Movement Balance Evaluation for Basketball Training Through Multi-Source Sensors

Balance ability is the basic sports quality of athletes. For basketball players, balance training includes take-off, turning, confrontation, shooting, landing, and other links. If the players have good balance ability, they can effectively prevent sports injury and competition interference and improve the performance of basketball competition. This paper adopts the acceleration signals from multi-source sensors to evaluate movement balance for basketball training. First, acceleration signals are collected by acceleration sensors to depict the basketball player's actions. Second, the hidden Markov model is used to describe the change or transfer of different states during player's actions. Third, the acceleration signal and observation sequence from hidden Markov are used to determine whether the player is under imbalance state. The effectiveness is evaluated on a private dataset.

Balance assessment tools and their psychometric properties among individuals post-stroke: a systematic review

Background and purpose Balance assessment following stroke is a significant part of the rehabilitation program. The Berg Balance Scale (BBS), the Postural Assessment Scale for Stroke (PASS) and the Balance Evaluation Systems Test (BESTest) are multi-item balance scales commonly used for assessing balance for people post-stroke. The purpose of our systematic review is to identify and appraise the literature on the psychometric properties of these balance measures (BBS, PASS and BESTest) in studies involving people post-stroke. Methods A comprehensive electronic literature search was performed in five databases PubMed, CINAHL, Embase, Scopus and Web of Science; in addition to hand searching of relevant references. Two independent reviewers screened the literature search results to include studies that were: written in the English language and published in peer-reviewed journals; participants were adults (>18 years) and had a diagnosis of stroke; Balance of participants was assessed using one (or more) of the following measures: BBS, PASS, BESTest or a shortened version of these measures; and the study reported at least one psychometric property for the balance measure. Two independent reviewers extracted the data using a standardized form. Quality of included studies was assessed using a critical appraisal tool. Results A total of 65 studies met our inclusion criteria and were included in our review. The majority of studies reported on the psychometric properties of the BBS, followed by the PASS and then the BESTest. Results of the critical appraisal scale showed that the overall quality of studies was good. A variety of psychometric properties were reported, with validity being the most reported property followed by reliability. Discussion The BBS, BESTest and PASS and their variants show overall excellent psychometric properties when used among people post-stroke. However, further research is needed to investigate the responsiveness of these measures following rehabilitation programs.

Biomechanical Research Methods Used in Acrobatic Gymnastics: A Systematic Review

The biomechanical analysis of Acrobatic Gymnastics elements has not been extensively explored in scientific research to date. Due to the increased challenge of implementing experimental protocols and collecting data from multiple individuals, it is required to develop strategies that allow a safe, valid and reproducible methodology. This work aims to collect information and systematically analyze the biomechanical approach in Acrobatic Gymnastics to date. A search was conducted in the Web of Science, Scopus, EBSCO, PubMed and ISBS databases. After the selection and quality-control phases, fourteen documents were included. The results revealed that the biomechanical research in Acrobatics has been focused on balance evaluation, in which the force plate and the center of pressure are the most used instrument and variable, respectively. Research has been focused on kinetics evaluation. Kinematics analysis of pair/group elements would provide scientific answers to unresolved problems, considering that Gymnastics provides almost limitless possibilities to study human motion. Researchers should focus on the type of element, difficulty degree, main characteristics, relationship between the instrument and floor surface specificity and safety conditions. We encourage gymnastics clubs and coaches to establish networks with biomechanics laboratories, allowing to bridge the gap between research and practice.

Effects of climate change and agricultural expansion on groundwater storage in the Amur River Basin

Since the 1990s, the climate in the Amur River Basin (ARB) has changed, and large-scale wetlands in the region have been reclaimed for paddy fields. The study of the influence of climate change and agricultural expansion on groundwater storage is of great significance to the evaluation of regional water resource balance and the promotion of ecological protection and agricultural development. In this work, the groundwater storage anomaly (GWSA) in the ARB and its drivers were analyzed for the period 2003–2016 using Gravity Recovery and Climate Experiment (GRACE) satellite data, a Global Land Data Assimilation System model, and in situ observations of groundwater levels. Results indicated that 1) the GWSA in the ARB increased at a rate of 2.0–2.4 mm/yr from 2003 to 2016; the GWSA in the upper reaches of the ARB increased, whereas the GWSA in the middle and lower reaches decreased during the study period. 2) The GWSA in the middle and lower reaches of the ARB was greatly influenced by temperature (Tmp) and evapotranspiration (ET). Tmp was positively correlated with GWSA, whereas ET was negatively correlated with GWSA (p &amp;lt; 0.05). 3) Extreme rainfall had a delayed effect on groundwater recharge. Wetland degradation and agricultural development were the main factors causing the decrease of the GWSA in the middle and lower reaches of the ARB. In summary, temperature and evapotranspiration affect groundwater storage by regulating the water–heat balance, wetland reclamation reduces the regional storage capacity, and the irrigation required for reclaimed farmland is the main source of groundwater loss.

Evaluation of thiol disulfide balance in adolescents with vitamin B12 deficiency

BackgroundVitamin B12 is an important vitamin for metabolism and affects many mechanisms in the body including neuronal migration, DNA synthesis, neurotransmitter synthesis, brain and cognitive development. Increased oxidative stress in the body leads to the damage of the child development, but also plays a crucial role in the pathogenesis of many diseases encountered in the childhood period. Our aim is to investigate whether or not B12 deficiency is associated with dynamic thiol/disulfide homeostasis in adolescent patients.MethodsThis is a case-controlled observational study consisting of 45 adolescent patients with vitamin b12 deficiency and a control group consisting of 45 healthy adolescent. Patients between 11 and 18 ages who applied to the outpatient clinic for the first time with one of the complaints of headache were selected due to their decreased school performance, dizziness, and fatigue. Hemogram, vitamin B12, homocysteine levels and oxidative stress parameters such as native and total thiol disulfide levels and ratios of disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol were measured from the patients.ResultsVitamin B12 level was found to be significantly lower in vitamin B12 deficiency group (p < 0.001). The serum disulfide level was found to be 27.5 ± 8.38 in the case group and 20.5 ± 8.36 in the control group (p < 0.001). In the multiple linear regression analysis, it was determined that the independent variables of native thiol, homocysteine and disulfide levels effected of vitamin B12 levels (p < 0.001, p < 0.001, p < 0.005 respectively; R2 = 0.62).ConclusionThe results obtained in terms of the effect of vitamin B12 deficiency on oxidative stress in adolescents are remarkable. The increase in oxidative stress parameters in the patient group may also suggest that oxidative stress plays a vital role in vitamin B12 deficiency in adolescence.

Clustered Associations between Musculoskeletal Fitness Tests and Functional Movement Screen in Physically Active Men.

Functional Movement Screen (FMS) is a tool used to assess fundamental movement patterns. There are relationships between musculoskeletal fitness (MSF) and a FMS. However, there is limited data regarding the multidimensional associations between these two constructs. This study is aimed at investigating the associations and detailed structures of FMS components and MSF components and identifying a deeper detailed structure of their relations to physical fitness. The study sample included 114 physically active men with an average body height of 1.81 ± 0.07 (cm), body weight of 80.61 ± 9.49 (kg), and a BMI of 24.65 ± 2.46 (kg/m2). Each participant performed a FMS test, sit-and-reach (S&R) test, sit-ups (ABS) evaluation, balance evaluation on an AMTI platform, handgrip strength (HG) testing, and standing broad jump (SBJ) ability. The Kendall's Tau correlation was performed to identify simple associations between FMS and MSF. Cluster analysis was used to determine the multidimensional nature of the relationships. In the vast majority, a positive correlation was observed suggesting that a high level of MSF improved FMS test results. A cluster analysis revealed 4 separate clusters. Shoulder mobility (SM) was identified as a single cluster. A strong similarity was observed between SBJ and trunk stability push-up (TSPU) forming a second cluster. This cluster joined to another consisting of the S&R test and active straight leg raise (ASLR) test. The last cluster consisted of HG and hurdle step (HS). These results confirmed that FMS and MSF tests measure the same constructs-a foundation for an individual's motor coordination, muscle strength, postural stability, and dynamic balance. This knowledge could be helpful in effectively enhancing physical performance based on combining similar constructs to accelerate the achievement of established goals.

Update of Rehabilitation in Huntington's Disease: Narrative Review.

Huntington's disease (HD) is a neurodegenerative disease that has motor dysfunction, predominantly chorea, cognitive impairment, and psychiatric disturbances as symptoms. Treatment is directed to reduce the severity of symptoms, although there are few studies and no clinical guidelines for rehabilitation in HD. Therefore, this review aimed to establish an effective rehabilitation approach for HD according to the stage of the disease. In the early stage of HD, the motor symptoms are mild, and psychological symptoms occur. Treatment in this period should focus on aerobic and resistance exercises, task-specific training, secondary prevention education, cognitive training, and psychological management. In the middle stage of HD, the motor symptoms are more severe. Task-specific rehabilitation approaches, education for the patient and caregiver, functional respiratory exercises, activities of daily living training, multidisciplinary and multimodal daycare rehabilitation are helpful to patients in this stage. At the late stage of HD, most patients need complete support for activity of daily living. Mobility and balance evaluation and prevention strategies should be focused on for safety, and respiratory exercises and physical exercise to prevent complications in patients with severely impaired mobility should be considered based on the patient's condition. Programmed rehabilitation management based on the stage of the disease is effective for patients with HD.

Ethical perspectives and police science: Using Social Contract Theory as an analytical framework for evaluating police legitimacy

Abstract It has recently been argued that ethical/moral considerations could be better integrated into the science of policing. The present study picks up the gauntlet and examines if a central normative theory of government authority—Social Contract Theory—can contribute to our understanding of police legitimacy. Building on five constraints on police authority derived from Social Contract Theory, the present study examines the relationship between citizen views of police compliance with the social contract while enforcing COVID-19 regulations, and of police legitimacy. A community survey carried out in Israel reveals that public evaluations of the appropriate balance between liberty, safety, and police authority, have a significant, independent correlation with legitimacy, surpassed only by views of procedural justice. These findings have implications for the theory, practice, and future study of police legitimacy, but more generally demonstrate the utility of theoretical–philosophical theories and concepts concerned with ethics for contemporary research questions in policing.

Immunohistochemical and histochemical analysis of the rat skin after local electron irradiation.

Skin cancer is the most frequently diagnosed type of cancer among all malignant neoplasms. The decrease in mitotic activity and the death of intact keratinocytes arise due to the constantly renewing epithelium being highly sensitive to ionizing radiation. The aim of the study is immunohistochemical evaluation of the proliferative-apoptotic balance of keratinocytes, the fibrous component of the skin, and the expression of pro-inflammatory and anti-inflammatory cytokines after single or fractional local electron irradiation. Wistar rats (n = 80) were taken from the ITM&B Vivarium (Sechenov University) and divided into groups: I-control, which were injected with saline; and experimental groups, local electron irradiation at doses: II-8 Gy (single), III-40 Gy (single), IV-summary dose 78 Gy (fractional; 13 Gy per day for 6 days). We performed histological analysis, histochemical analysis using Masson, safranine, and picrosirius red staining, immunohistochemical (Ki-67, caspase-3, p53, types I and III collagens, IL-1, IL-6, IL-4, and IL-10) and morphometric analysis of skin fragments of the outer surface of the thigh, irradiated in accordance with the design of the experiment. The early and delayed effects of local electron irradiation at different doses were studied. After local electron irradiation, dose-dependent morphological changes in the skin of the experimental groups were observed: violation of the histoarchitectonics of the skin confirmed by morphological and morphometric analysis, the proliferation of connective tissue according to the results of histochemical and immunohistochemical studies with signs of the radiation-induced skin fibrosis development, an increase in the levels of pro- and anti-inflammatory cytokines. We observed the most pronounced signs of radiation-induced skin damage in the group of fractional irradiation after 3 months. 8 Gy and 40 Gy single local electron irradiation leads to a shift in the proliferative-apoptotic balance of keratinocytes toward their apoptosis, which activity is directly correlated with the dose of ionizing radiation, and 78 Gy in fractions leads to partial desquamation of the epithelium and inflammatory infiltration. In addition, after 3 months a significant increase in the expression of type I and III collagen fibers and the development of radiation-induced skin fibrosis takes place against the background of 78 Gy fractional local electron irradiation.

Acid-Base.

In clinical medicine, evaluation of acid-base balance can be a valuable diagnostic and monitoring tool. Blood gas machines need very small volumes of blood and provide immediate results, making them ideal for use in the emergency room and intensive care setting. This review outlines the stepwise approach to assessment of acid-base balance in dogs, common causes of acid-base abnormalities, and the general approach to treatment.