Sustainable design often requires highly efficient building performance evaluations. This study proposed a hybrid model combining multivariate regression modelling (MRM) and machine learning modelling (MLM) for the rapid prediction of interior temperatures affected by heat pipe thermal diodes and solar cavities based on experimental data. A heat pipe thermal diode can promote unidirectional heat transmission from the solar cavity on the south side of our newly built experimental house to the indoor environment to increase the interior temperature and reduce the heating load in cold climates. Experimental data were collected and then imported, cleaned, and split according to MRM and MLM requirements, respectively. In MRM, linear multivariate formulas were generated according to the thermal diode's two different working conditions. In MLM, a machine-learning model was created and trained using the experimental data. The results our hybrid model produced were comprehensively evaluated via R-square, statistical discrepancies, and complex MRM analyses. The similarity between the prediction and experimental results clearly demonstrates our model's accuracy and efficiency. This research was an original attempt to integrate emerging computational tools and provide a means to perform highly efficient quantitative analysis of indoor thermal environments for environmental studies and sustainable designs in the early stages.