The author analyzes subregional projects that could add dynamics to the process of European integration in the situation of substantial conceptual and institutional crisis of the European Union what directly affects the efficience of implementation of the EU projects (Eastern Partnership). Here the aurhor means reload and activation of the Organization for Democracy and Economic Development GUAM and conceptualization the Baltic-Black See Union as isntitutional instruments of sub-regional stability in the context of deep crisis of Euroipean security. The consequences of sub-regional instutitutionalization for the EU and its prograns will be complex and multi-dimention. Firstly, there will be the rise of stability and security on the EU eastern flank as a compensation for its non-sufficient security elements as well as NATO low readiness for Russian threat. As soon as activation of Russian neo-imperial revisionism seriously undermines the EU Eastern Partnership Program and hampers the integration of the post-soviet states into the European and Euro-Atlantic in stitutions, establishment of both above-mentioned institutions will give a serious integration impuls for the European civilization and acceleration of the appearance of new wave of the EU members. The other result of institution building will be development of transport and logistic infastructure in the context of the implementationa bilateral EU-China trans continental projects resulting the growth of the EU poterntial as a leading global economic and political player. It is proved that ODED-GUAM and the Baltic-Black Sea Union could become substantial factors of the support of the European Union in whole and its Eastern Partnership Program particularly in case substantial work is being made by the interested states. But the main precondition of the activation pf sub-regional projects is political will and startegic interests of western elites.
 Keywords: European Union, EU Eastern Partnership, Organization for Democracy and Economic Development GUAM, Baltic-Black Sea Union, subregional integration.