For the mitigation of severe accidents, the European Pressurized Water Reactor (EPR) has adopted and improved the defense-in-depth approaches of its predecessors, the French “N4” and the German “Konvoi” plants. Beyond the corresponding evolutionary changes, the EPR includes a new, 4th level of defense-in-depth that is aimed at limiting the consequences of a postulated severe accident with core melting. It involves a strengthening of the confinement function and the avoidance of large early releases. The latter requires the prevention of scenarios and events that can result in high loads on the containment, e.g., a failure of the Reactor Pressure Vessel (RPV) at high internal pressure. This is achieved by dedicated design measures. The paper gives an short overview of the general concept and the strategies for: primary circuit depressurization, H 2 mitigation and the avoidance of energetic Fuel Coolant Interactions (FCIs). It then describes, in detail, the conceptual solution for the stabilization and long-term cooling of the molten core. The EPR melt retention strategy supports itself on the use of an ex-vessel core catcher located in a compartment lateral to the pit. The related spatial and functional separation isolates the core catcher from the various loads during RPV failure and, at the same time, avoids risks resulting from an unintended initiation of the system during power operation. Within the core catcher, the melt will be passively flooded with water from the Internal Refueling Water Storage Tank (IRWST). Due to the effective cooling of the melt from all sides a stable state will be reached within hours and complete solidification of the melt is achieved after a few days. The core catcher can optionally be supplied by the Containment Heat Removal System (CHRS). In this active mode of operation, the water levels inside spreading compartment and reactor pit rise and the pools become subcooled, so further steaming is avoided. This results in a depressurization of the containment in the long-term.