Abstract Esophageal cancer typically requires multimodal treatment, with neoadjuvant chemotherapy and radiation followed by esophagectomy, which has helped improve the 5-year survival of this disease. Short-term quality of life (QOL) has been previously evaluated in patients who have undergone esophagectomy. As survival rates improve and patients are living longer after having multimodal therapy, there exists a need to better understand how long-term QOL is impacted after esophagectomy. A single-center cross-sectional QOL study was performed on a cohort of patients who underwent esophagectomy for esophageal cancer (2010–2017) with a post-operative survival period of at least four years. Patients who met inclusion criteria were contacted by phone in 2021–2022 to complete the European Organisation for Research and Treatment of Cancer (EORTC) OES-30 and OES-18 questionnaires, after standardization of interviews via a telephone script. Descriptive statistics were performed. One hundred and fifty-five patients met inclusion criteria, and 64 (41.3%) completed the QOL questionnaires. Mean age was 64 years, the majority were white (98.4%) men (82.3%), and 82% underwent preoperative chemoradiation treatment. All patients underwent a minimally invasive surgical approach. At the time of QOL surveillance, the mean time from operation was 6.9 years. The median global QOL score in this population was 79.2 (Max 100). The population had median reported severity scores for dysphagia (100), reflux (33.3) trouble eating (16.7), and pain (11.1) (Max 100). A median score of 0 was found for all other esophageal symptom categories. In patients surviving at least four years from esophagectomy for esophageal cancer, symptom severity scored highest for dysphagia. Elevated severity scores were also seen in descending order for reflux, difficulty eating, and pain. Despite these continued symptoms, long-term overall QOL remained high for this population after esophagectomy.