The article considers foreign experience in the state spatial development strategy in concord with regional clusters, as well as the impact of clusters on the growth of economies of the states and the regions therein. The study sets the goal of identifying the opportunity to implement foreign experience in support of territorial clusters at realization of the Strategy of Spatial Development of Russia. The research is based on conceptual approaches of foreign and Russian scientists in the sphere. Particular stress is made on the specifics of strategic planning systems in the European Union member states; explicitation of the notion of ‘clusters’ and ‘cluster initiatives’; specific nature of operations of specialized cluster organizations and agencies of regional development; experience of support and development of cluster entities in the USA and Canada; actual cluster policies under the strategy of spatial development; defining the role of observatories of spatial development and the cluster observatories in Europe and the USA. The conclusion is made that the implementation of foreign experience in Russia is viable with allowance for national economic policy and with regard of ‘smart specialization’ when every Russian region with its unique resource capacity employs its own development potential. For that end it is necessary to update the regional strategies of socio-economic development, territorial planning patterns, cluster policies in line with the new Strategy of Spatial Development of Russia for the period as far as 2025; invigorate the formation of centers of cluster development in all RF member territories to interact with the regional authorities, develop regional infrastructure for cluster support and start monitoring of cluster support policies; regard the opportunities to build a network of regional observatories of spatial development at Russian flagship universities; initiate the databases integration process; proceed with forming the Russian interactive cluster map