Problem setting. The innovativeness of changes in Industry 4.0 systems involves not only comprehensive digitalization and automation of production processes and management, but also solutions to issues of environmental protection and a closed production cycle. The circular economy and Industry 4.0 are interrelated topics and require additional research. Analysis of recent researches and publications. An in-depth study of many components of Industry 4.0 was conducted by Zadorozhnij G.V. The peculiarities of the relationship between the circular economy and Industry 4.0 and sustainable development were dealt with Hennemann Hilario da Silva, T. and Sehnem, S., Di Maria E., De Marchi V., Galeazzo A., Tang Y. M., Hallioui A. et al. Hnap A. studied the prospects for the development of circular Industry 4.0 until 2030. Target of the research is to determine the general principles of potential innovative changes of Industry 4.0 in the conditions of European integration under the influence of the circular economy. Article’s main body. The article examines the role and significance of the circular economy and Industry 4.0 processes, which are gaining particular importance in relation to the level of costs and the effectiveness of the changes that may occur. The problem lies in the parallel development of changes in the circular economy and Industry 4.0, which must be combined. Analysis of recent studies has shown that the circular economy and the concepts of Industry 4.0 together influence sustainable development. An essential characteristic of the changes taking place under the influence of Industry 4.0 is the increase in the impact of changes in the circular economy and the formation of the environmental factor. Prospective programs for the transition to a circular economy using Industry 4.0 technologies are potential application strategies in specific fields of research. According to the data of various studies in different countries, evidence of the relationship between these topics has been obtained. The European Commission considers the transition from Industry 4.0 to Industry 5.0 as a direction that strengthens the importance of European industry and is a key direction of economic and social change, it should lead the digital and environmental transition. In the article, a Google Trends search was made for the topics «circular economy», «Industry 4.0», 2Industry 5.0» for the time period of the last 12 months (as of March 5, 2023) all over the world, Ukraine, some EU countries, with the selection of an average level of interest in these topics The average level of interest in the topic of the circular economy in the world is much higher than in the topic of Industry 4.0. Similar to the world indicators of the country of Italy, while in Ukraine the ratio is similar, but at a much lower level. Ukraine is close to Poland, but the trends are opposite, in Ukraine the demand for the circular economy prevails, and in Poland for Industry 4.0. Only two countries, Germany and Italy, have a demand for Industry 5.0. Conclusions and prospects for the development. The conducted studies showed that in Ukraine at the state level, programs should be formed to increase attention to both Industry 4.0 and the circular economy. Taking into account the tasks of European integration, the process of informing about the tasks of the EU for the development of Industry 5.0 should begin. The European experience should be used at the national level in Ukraine to stimulate the development of the foundations of the circular economy in industry for the recovery of the Ukrainian economy.