ABSTRACT Rights-based climate change litigation has become central to advancing mitigation ambition across the globe. This article analyses trends in legal argumentation in such litigation at the supranational level and identifies two principal arguments commonly employed by litigants: the adverse effects of climate change on human health or culture. The study reveals that claims based on the European Convention on Human Rights (ECHR) almost exclusively engage with health-based arguments, while culture-based arguments are more prevalent in cases brought under the International Covenant on Civil and Political Rights and the American Convention on Human Rights. Various factors are explored to elucidate the reason for this distinction, including the types of applicants, the absence of an explicit right to culture in the ECHR, the European Court of Human Rights’ earlier environmental jurisprudence, and perceptions of justiciability. In doing so, the analysis sheds light on the potential implications of the differing approaches to rights-based climate change litigation before the European Court of Human Rights. This includes the Court’s landmark judgment in Verein KlimaSeniorinnen and others v Switzerland as well as implications for future cases. This research offers critical insights on the strategic direction of rights-based climate change litigation, including its possible limitations.