AbstractEuropa's long‐term habitability depends on thermodynamics—modulated by tidal evolution—and geochemical pathways that define chemical and energy inventories for use by putative biology. Hydrogen produced from the reaction of water and rock during serpentinization is one potential source of metabolic energy. Here, we demonstrate how thermally modulated volumetric changes to Europa's ice shell, ocean, and fluid‐accessible rocky mantle influence oceanic salinity and serpentinization rates in Europa's interior. During periods of steady cooling, hydrogen flux into the ocean remains relatively constant because of the continuous propagation of thermal cracking into the rocky mantle regardless of ocean composition. However, during periods of fluctuating heat production driven by changes in orbital eccentricity, modulation of the ice shell volume, and consequently the salinity and water activity of the ocean, alters the serpentinization rate. In parallel, the extent of fracturing within the seafloor varies, changing the volume of reactable rock available. Our results show that the stability of serpentinization reactions on Europa over time highly depends on the thermal‐orbital evolution and oceanic salt content. The variability in the hydrogen production rate is significant across potential orbital histories, varying by up to 15 orders of magnitude for the lowest salinity and most kosmotropic ocean conditions, such as dilute MgSO4 compositions. We also show that this variability decreases with increasing ocean salinity and more chaotropic compositions, such as a concentrated NaCl ocean. These results suggest new ways that ocean composition and water activity are essential to stable habitable conditions in ocean worlds.