This study is conducted to determine the normal blood parameter values in bird of Collared Dove (Streptopelia decaocto) and the effect of probiotic (Chunchine.Geyao® :China) and antibiotic (Tilmicosin phosphate-Tilmivap® :Jordan) on body weight, hematology and biochemical values in these birds. Forty apparently healthy adults of both sexes Collared dove were selected randomly and assigned into four equal groups (n=10) as A, B, C and D groups. Group A was considered as control group fed on a balanced ration, group B fed with the addition of 1.5 gm probiotic/liter drinking water, group C fed with 0.3ml antibiotic/liter drinking water and group D were fed with 1.5gm probiotic and 0.3 ml antibiotic/liter drinking water respectively during the 35 day of experimental period. The results showed that there is no significant differences in the heterophil, lymphocyte, heterophil/lymphocyte ratio, total serum cholesterol, ALT and in different treated groups. The present findings suggest that supplementation of Probiotic has significant effects on some hematology and biochemical parameters of Collared Dove (Streptopelia decaocto) compared to antibiotic supplementation.