The 122 patients with liver cirrhosis (LC) were examined. The markers of HBV, HDV and HCV have been revealed in 82% patients with LC. The first place in LC etiological structure takes chronic liver diseases with HCV markers. More severe clinical course of LC with HBV/HCV, HBV/HDV/HCV markers combinations, LC with active replication of HBV and LC D have been observed. More favorable clinical course of LC with HCV markers and HBV seroconversion markers have been observed.