Ethylenediamine Research Articles

Highly Sensitive Diethylamine Detection at Room Temperature Using g-C3N4 Nanosheets Decorated with CuO Hollow Polyhedral Structures.

Chemiresistive-based metal oxide semiconductor (MOS) gas sensors are widely used in gas sensing due to their advantageous properties. Graphitic carbon nitride (g-C3N4) and metal oxide heterostructure materials can improve charge transport properties, selectivity, and sensitivity in MOS gas sensor materials. Herein, for the first time, CuO hollow polyhedral structures (HPSs) were synthesized via a hydrothermal technique and annealed at different temperatures, with the 400 °C annealed (CuO-400 HPSs) demonstrating remarkable sensing capabilities for diethylamine (DEA) gas at room temperature (RT). The x-g-C3N4 nanosheets were decorated with CuO HPSs in varying amounts (x = 0.8, 1.8, 2.1, and 3.1 wt %) and then annealed at 400 °C for x-g-C3N4-CuO-400 hollow polyhedral heterostructures (HPHSs). Indeed, among the synthesized samples, the 1.8%-g-C3N4-CuO-400 HPHSs have a higher sensitivity to DEA (resistance change in gas (Rg) and air (Ra); Rg/Ra= 65 @ 20 ppm), a low detection limit (Rg/Ra= 6 @ 500 ppb), wide dynamic response (Rg/Ra= 190 @ 80 ppm), strong stability (30 days), and 21.6 times higher sensitivity than pure CuO at RT toward 20 ppm of DEA. The exceptional gas-sensing behavior can be attributed to various factors, including controlled annealing conditions that result in the formation of well-defined structures and greater porosity, efficient charge transfer properties resulting from an optimized ratio of g-C3N4 to CuO in HPHSs, an abundance of defects, unsaturated Cu sites, and synergistic effects. The study presents a universal strategy for generating sensitive and selective g-C3N4-based composite materials for low-temperature gas sensors.

Hydrogen-rich syngas upgrading via CO2 adsorption by amine-functionalized Cu-BTC: the effect of different amines.

Syngas produced from supercritical water gasification typically contain a high amount of CO2 along with H2. In order to improve the quality of syngas, amine-functionalized copper benzene-1,3,5-tricarboxylate (Cu-BTC) was synthesized as an effective adsorbent for selective removal of CO2 from syngas to increase the concentration of H2. The amines used in this study included monoethanolamine (MEA), ethylenediamine (EDA), and polyethyleneimine (PEI). The fundamental physicochemical character of adsorbents, CO2 adsorption capacity, and CO2/H2 selectivity were analyzed. The physicochemical characterization indicated that the structure of amine-functionalized Cu-BTC was partially damaged, which resulted in a decrease in specific surface area and pore volume. On the other hand, the enlarged pore size was beneficial for the mass transfer of gas in the adsorbent. Among these adsorbents, Cu-BTC/PEI exhibited the maximum CO2 adsorption capacity of 3.83mmol/g and the highest CO2/H2 selectivity of 19.74. It was found that the adsorption pressure is the most significant factor for the CO2 adsorption capacity. Lower temperature and higher pressure were favored for CO2 adsorption capacity and CO2/H2 selectivity, so physical adsorption by Cu-BTC played a dominant role. Moreover, Cu-BTC/PEI can be well-regenerated with stable adsorption efficiency after five consecutive cycles. These findings suggested that Cu-BTC/PEI could be a promising alternative adsorbent for CO2 capture from syngas.

Effects of anticoagulant (EDTA and Heparin) on blood of goat.

Blood is an important tool for accurate diagnosis of disease, forensic investigation, and hematological analysis. However this phenomenon can be thwarted occasionally if appropriate anticoagulant with storage times is not maintained properly. This research aims to compare and explore the effect of anticoagulants (such as ethylene diamine tetra acetic acid and heparin) and storage time on the hematological parameters in indigenous goats. Twenty goats were enrolled and raised for this purpose. Bloods were collected into two different tubes containing EDTA and heparin and analyzed immediately to evaluate the basal value. All tubes were divided into two aliquots and stored at 4°C and 25°C and were analyzed again at the 24th and 48th hours of collection. The statistical analysis of this result showed that there was no significant difference (P>0.05) in the anticoagulant’s effect on the hematological parameters. RBC, Hb, PCV, MCV, MCH, MCHC, total WBC, and Platelets except ESR decreased gradually along with the storage time of up to 48 hours compared to the basal value. The hematological parameters were reduced more significantly (P<0.05) when stored at 250C rather than 4°C indicating that the parameters remain in better condition in refrigeration. The samples should be stored at 4°C rather than room temperature and be used within 24 hours because the storage time modify the analyzed results. These findings demonstrate that both of the anticoagulants (EDTA and Heparin) show reliable results, therefore it can be used to store blood samples for any diagnostic purpose. Res. Agric. Livest. Fish. Vol. 11, No. 1, April 2024: 1-10

Recycling of Polydicyclopentadiene Enabled with N-Coordinated Boronic Bonds.

In this contribution, we reported the transformation of polydicyclopentadiene (PDCPD) from thermoset into vitrimer. First, two N-coordinated diboronic diols were successfully synthesized via the reaction of N,N,N-tri(2-hydroxyethyl)amine and/or N,N,N",N"-tetrakis(2-hydroxyethyl)ethylene diamine with 4-(hydroxymethyl) phenylboronic acid and then they were transformed into two N-coordinated cyclic boronic diacrylates. The latter two dienes carrying electron-withdrawing substituents were used for the ring opening insertion metathesis copolymerization (ROIMP) of dicyclopentadiene to afford the crosslinked PDCPD. In the crosslinked PDCPD networks, N-coordinated cyclic boronic bonds were integrated. It was found that the as-obtained PDCPD networks displayed the excellent reprocessing properties. In the meantime, the fracture toughness was significantly improved. Owing to the inclusion of N-coordinated cyclic boronic ester bonds, the modified PDCPDs had the thermal stability much superior to plain PDCPD. The results reported in this work demonstrated that PDCPD can successfully be transformed into the vitrimers via the introduction of N-coordinated cyclic boronic ester bonds. This article is protected by copyright. All rights reserved.

Fluorescence behaviors of perylene-dispersed super engineering plastic films

We attempted to manufacture films in which fluorescent dye is dispersed using engineering plastic as a matrix which has high heat and chemical resistance as well as excellent mechanical performance. In this study, films containing highly dispersed perylene in colorless and transparent aromatic polyamide (PA) and polyimide (PI) were manufactured. The perylene-dispersed PA film emitted strong blue light with a maximum fluorescence at 457 nm. On the other hand, the perylene-dispersed PI film showed significant fluorescence quenching with its maximum fluorescence wavelength significantly red-shifted to 546 nm. The perylene-dispersed PI film treated with ethylene diamine at 80 °C showed strong blue fluorescence, and when the film was further heated at 200 °C, the fluorescence was quenched. These films are expected to be applied as back light unit or color conversion layer for OLED and Micro LED due to their excellent physical properties.

Evaluation of the effect of aminophylline on inflammatory parameters in COVID-19 patients with acute respiratory distress syndrome

Background: In Acute respiratory distress syndrome (ARDS), invasion and activation of pro- and anti-inflammatory mediators and cytokines result in oxidative damage to the lung tissue. Aminophylline is a combination of theophylline and ethyl diamine, has anti-inflammatory, bronchodilator, ROS inhibitor effects, and stimulates surfactant release. Mortality of ARDS in COVID-19 patients is high; aminophylline is expected to reduce the incidence of mortality. Information regarding the use of aminophylline in COVID-19 patients with ARDS is still limited. Objective: To evaluate the efficacy of aminophylline in inflammatory parameters in COVID-19 patients with ARDS. Methods: It was a retrospective cohort observational study at the Universitas Airlangga Hospital. Samples were hospitalised COVID-19 patients with ARDS who received a loading dose of 240-480 mg and a maintenance dose of 720-960 mg aminophylline. The primary outcomes were improved C-reactive protein (CRP), IL-6, lymphocytes, neutrophils, and Neutrophil-lymphocyte ratio (NLR), which were measured before and after administration of aminophylline with a duration of therapy of 1-5 days. Result: A total of 50 patients with ARDS were enrolled in the study. Lymphocyte and CRP decreased (p = 0.002; p = 0.128). IL-6, neutrophil, and NLR increased (p = 0.255; p = 0.064; p = 0.005). Conclusion: It can be concluded that the administration of aminophylline has not improved inflammatory parameters.

Cryo-storage of porcine hides at the industrial scale for tissue engineering and regenerative medicine application

BACKGROUND: The industrial scale cryo-storage of raw tissue materials requires a robust, low-cost and easy-to-operate method that can facilitate the down-stream process. OBJECTIVE: The study was aimed to develop the multifunctional protective solutions (MPS) for transportation at ambient conditions and also subsequent cryo-storage below −20°C of raw porcine hides for tissue engineering and regenerative medicine. MATERIALS AND METHODS: Protective solutions with antimicrobial activity and proteinase-inhibiting activity were developed and tested for its efficacy in preserving the extracellular matrix of porcine dermis from microbial spoilage, proteolytic degradation, freeze damage and excessive dehydration during shipping and cryo-storage. The MPSs contained phosphate-buffered saline with ethylene diamine tetra acetic acid (EDTA) added as chelator and proteinase inhibitor, as well as glycerol or maltodextrin (M180) as cryoprotectants. RESULTS: MPSs prepared with EDTA and glycerol or M180 had significant antimicrobial activity and proteinase-inhibiting activity during the period of shipping and handling. Glycerol and M180 prevented eutectic salt precipitation and excessive freeze dehydration upon cryo-storage of porcine hides. Without glycerol or M180, hides could be freeze-dehydrated to the low hydration at ˜0.4 g/g dw, and formed irreversible plications after freezing. A critical hydration (0.8˜0.9 g/g dw) was observed for the extracellular matrix of porcine dermis, and dehydration to a lower level could impose enormous stress and potential damage. The soaking of porcine hides in MPSs decreased water content as glycerol and M180 entered into dermis. Upon equilibration, the glycerol content in the tissue was about 94% of the incubating glycerol solution, but the M180 content in the tissue was only about 50% of the incubating M180 solution, indicating that M180 did not get into the entire aqueous domain within dermis. MPSs reduced ice formation and increased the unfrozen water content of porcine raw hides upon cryo-storage. CONCLUSION: MPSs prepared with EDTA and glycerol or M180 have antimicrobial activity and proteinase-inhibiting activity, which can be used for transportation and cryo-storage of raw hides at the industrial scale. Glycerol at 7.5% w/v and M180 at 20% w/v were sufficient to prevent freeze damage and excessive freeze dehydration.

Sustainable chitosan/polyvinyl alcohol composite film integrated with sulfur-modified montmorillonite for active food packaging applications

Sulfur-functionalized montmorillonite (S-MMT), which has strong antioxidant and antibacterial activities, was prepared by forming a sulfur-amine complex using ethylenediamine (EDA). S-MMT was added to the chitosan/polyvinyl alcohol (Chi/PVA) blend polymer to develop an active food packaging film. The composite film, especially 4 wt% S-MMT-added Chi/PVA film (Chi/PVA/S-MMT4%), showed significant increases in tensile strength (∼25.1 %), elongation at the break (∼94.1 %), and UV-blocking ability (98.2 % UV-A and 100 % UV-B) compared to the neat Chi/PVA film. The Chi/PVA/S-MMT4% film also exhibited remarkable antioxidant properties (100 % ABTS and 65.4 % DPPH scavenging activity) and potent antibacterial activity (stopped the growth of L. monocytogenes and E. coli). Chicken packaged in the composite film showed a significant reduction in quality changes, including appearance, pH, thiobarbituric acid reactive substances (TBARS), and total viable colonies (TVC) over 20 days of storage. Multifunctional Chi/PVA/S-MMT films have high potential in active food packaging applications.

Assessment of the ability of Pseudomonas aeruginosa and Staphylococcus aureus to create biofilms during wound healing in a rat model treated with carboxymethyl cellulose/carboxymethyl chitosan hydrogel containing EDTA.

The primary objective of this study was to develop a carboxymethyl cellulose (CMC) and carboxymethyl chitosan (CMCS) hydrogel containing ethylene diamine tetra acetic acid (EDTA) as the materials for wound healing. CMC and CMCS solutions were prepared with a concentration of 4% (w/v). These solutions were made using normal saline serum with a concentration of 0.5% (v/v). Additionally, EDTA with the concentrations of 0.01%, 0.05%, 0.1%, 0.5%, 1%, and 2% (w/v) was included in the prepared polymer solution. The analysis of the hydrogels revealed that they possess porous structures with interconnected pores, with average in size 88.71 ± 5.93 μm. The hydrogels exhibited a swelling capacity of up to 60% of their initial weight within 24 h, as indicated by the weight loss and swelling measurements. The antibacterial experiments showed that the formulated CMC/CMCS/EDTA 0.5% hydrogel inhibited the growth of Staphylococcus aureus and Pseudomonas aeruginosa. Moreover, the produced hydrogels were haemocompatible and biocompatible. At the last stage, the evaluation of wound healing in the animal model demonstrated that the use of the produced hydrogels significantly improved the process of wound healing. Finally, the findings substantiated the effectiveness of the formulated hydrogels as the materials for promoting wound healing and antibacterial agents.

Comparison of heavy metal contaminants removal using EDTA and Cyanex 302 as chelating agents for supercritical CO2-based soil remediation

Supercritical CO2-based soil remediation technology has become one new method with its advantages of high efficiency, environmental protection, and no secondary pollution. In this study, experiments on a kilogram-scale experimental system have been conducted under different pressures, temperatures, processing times, etc. A wide range of parameter conditions (∼75 °C, ∼40 MPa, ∼40 min) have been tested to explore parameter effects on the removal efficiencies (RE) of metal contaminants: lead, chromium, and arsenic. Comparisons between Cyanex 302 and Ethylene Diamine Tetraacetic Acid (EDTA) as chelators have been conducted: (1) Both Cyanex 302 and EDTA show significant role in promoting the soil remediation process under supercritical CO2 remediation process. Additionally, the removal efficiency of EDTA for the three metals is generally lower than that of Cyanex 302 under the same operating conditions. (2) Cyanex 302 exhibits selectivity for metals. For Cyanex 302, the RE of both lead (Pb) and arsenic (As) was quite high (>93 %), while the removal efficiency of chromium (Cr) showed an obvious regularity with the increase of temperature, pressure and processing time, from 37 % to 83 %. (3) For EDTA cases, the RE of lead (Pb), chromium (Cr) and arsenic (As) showed different trends: the lowest removal efficiency found to be 48 %, 15 %, 28 % at 20 MPa, 35 °C, 20 min conditions, respectively; and the highest of 83 %, 63 %, 64 %, respectively, at 30 MPa, 55 °C conditions. EDTA cases showed different results for all three metals: the influence of temperature on removal efficiency is most obvious, while the influence of processing time on efficiency is neglectable.

A systematic approach for screening green entrainers combining the environmental-health-safety indexes and separation performance

Here we propose a new approach for extractive distillation (ED) process design, integrating environmental-health-safety (EHS) indexes as early as during the entrainer screening phase. Typically, safety and environmental factors are addressed later in the design process, often during optimization or in a sequential evaluation after cost-based optimization. However, in this study, we propose for the early incorporation of EHS considerations during the entrainer screening phase. This involves assessing the entrainer suitability using traditional metrics alongside additional EHS criteria, such as lethal dose (LD50) and flash point. Two azeotropic mixtures, i.e., tetrahydrofuran (THF)/ethanol (EtOH) and THF/methanol (MeOH), are chosen to exemplify our proposed methodology. Among the 1432 screened entrainers, the top 10 entrainers were identified based on separation index. These candidates were then subjected to further evaluation based on EHS criteria. Ethylenediamine (EDA) emerged as the optimal choice for the separation of THF/MeOH and THF/EtOH mixtures, demonstrating commendable EHS performance. Both separation processes were successfully simulated using Aspen Plus, which confirms the validity and suitability of the screened entrainer.

Excess properties and intermolecular interactions of 2-methoxyethanol + ethylenediamine binary system: Density, viscosity, spectral analyses, computational chemistry, and CO2 absorption property

To examine the fundamental physicochemical properties as well as intermolecular interactions for the 2-methoxyethanol (EGME) (1) + ethylenediamine (EDA) (2) binary system, this work systemically measured the density (ρ) and viscosity (η) values of the binary system with various mole ratios at P = 100.5 kPa and T = (298.15–318.15) K with the growth gap of 5 K. The as-measured values of the pure substances were compared with literature data. Multiple semi-empirical formulas were used to fit ρ and η values, and the absolute average deviations (AAD%) were calculated. After that, the excess molar volume (VmE), partial molar volume (V¯), apparent molar volume (Vφ), viscosity deviation (Δη), excess activation of Gibbs free energy (ΔG∗E), and several thermodynamic properties of the binary system were systemically analyzed. According to analysis results, it has been proven that the interaction exists between EGME and EDA molecules. And then, excess properties were fitted to the Redlich-Kister equation using multi-parametric nonlinear regression analyses, and standard deviations (σ) were calculated. In addition, based on various characterization methods including Raman, ultraviolet (UV), and nuclear magnetic resonance hydrogen (1H NMR) spectral analyses and density functional theory (DFT) calculation results, it is demonstrated that there is intermolecular hydrogen bonds in EGME (1) + EDA (2) binary system as the form of –OH⋯NH2–, which was consistent with the existence forms of intermolecular hydrogen bonds in different alcohol-amine systems from references. Finally, CO2 absorption capacity by pure EDA, pure EGME, and the EGME (1) + EDA (2) binary system were severally determined.

Rapid and sensitive determination of trace Cd in carbonate samples using direct solid sampling electrothermal vaporization atomic absorption spectrometry

The accurate determination of cadmium (Cd) hosted and accumulated in sedimentary carbonate remains challenging due to its low concentration (ng·g−1) and complex matrix. Conventional methods, such as inductively coupled plasma mass spectrometry (ICP-MS) and graphite furnace atomic absorption spectrometry (GF-AAS), which typically rely on liquid sampling and sample digestion, are tedious, labor-intensive and time-consuming. In this study, a rapid and sensitive method for the direct determination of carbonate-hosted Cd was developed based on solid sampling electrothermal atomic absorption spectrometry (SS-ETV-AAS). This method eliminates the need of acid digestion procedure, allowing the entire analysis, including sample preparation, to be completed within 10 min. To minimize the carbonate matrix effect, ethylene diamine tetra acetic acid disodium salt (EDTA-2Na) was proposed as matrix modifier to facilitate the release of Cd, enabling fast and accurate determination of trace Cd in carbonate samples. Under optimized conditions, the Cd detection limits was found to be as low as 0.17 ng·g−1, and repeatability (relative standard deviation, RSD) was better than 8 % (n = 7). The accuracy of the proposed SS-ETV-AAS was verified by analyzing five carbonate certified reference materials (GBW07127, GBW07129, GBW07130, GBW07135 and JDo-1), two soil certified reference materials (GBW07404a, GBW07405), as well as several actual carbonate samples. All these results demonstrate that the proposed SS-ETV-AAS method provides a simple, rapid and sensitive approach for measuring trace Cd in carbonates.

Structural and tribological studies on the interaction of porcine gastric mucin with non- and cationic-modified β-lactoglobulins

β-lactoglobulin (BLG) is the major whey protein with negative charges at neutral pH in aqueous media. Thus, the interaction with mucins, the major polyanionic component of mucus, is very weak due to the electrostatic repulsion between them. The present study postulates that cationization of BLG molecules may reverse the interaction characteristics between BLG and mucin from repulsive to associative. To this end, cationic-modified BLGs were prepared by grafting positively charged ethylenediamine (EDA) moieties into the negatively charged carboxyl groups on the aspartic and glutamic acid residues and compared with non-modified BLG upon mixing with porcine gastric mucin (PGM). To characterize the structural and conformational features of PGM, non/cationized BLGs, and their mixtures, various spectroscopic approaches, including zeta potential, dynamic light scattering (DLS), and circular dichroism (CD) spectroscopy were employed. Importantly, we have taken surface adsorption with optical waveguide lightmode spectroscopy (OWLS), and tribological properties with pin-on-disk tribometry at the sliding interface as the key approaches to determine the interaction nature between them as mixing PGM with polycations can lead to synergistic lubrication at the nonpolar substrate in neutral aqueous media as a result of an electrostatic association. All the spectroscopic studies and a substantial improvement in lubricity collectively supported a tenacious and associative interaction between PGM and cationized BLGs, but not between PGM and non-modified BLG. This study demonstrates a unique and successful approach to intensify the interaction between BLG and mucins, which is meaningful for a broad range of disciplines, including food science, macromolecular interactions, and biolubrication etc.

Ethylenediamine-functionalized metal-organic frameworks for applications of electrochemical supercapacitors as an additive

In this study, the impact of incorporating ethylenediamine (ED)-functionalized metal-organic frameworks (MOFs) on enhancing the electrochemical performance of polypyrrole(PPy)-based conducting polymers as supercapacitor electrode materials was investigated. The stability of terephthalic acid-containing MOFs in different environments, including exposure to acids, relies on the specific metal ions and ligands utilized in their construction. In this research, ED treatment was chosen for its resistance to acid attack. Unlike the post-synthetic modifications observed in previous literature regarding ED-modified MOF5, this study introduces a unique approach where ED is directly integrated into the framework in a single step. The resulting materials, referred to as ED-MOF, were employed in creating a novel composite material concurrently with polypyrrole, designed for use as electrode materials in supercapacitor applications. The optimal loading in the electrochemical preparation of polypyrrole-based conducting polymers was determined using cyclic voltammetry and electrochemical impedance spectroscopy techniques. Areal capacitance for the resulting electrodes was evaluated through cyclic charge-discharge experiments. The areal capacitance of the ED-ZnMOF/1@/PPy/PGE electrode was found to be 575.2 mF.cm−2 at a charge/discharge current density of 1 mA.cm−2. This research underscores the potential advantages of combining conducting polymers and metal-organic frameworks in supercapacitors, as well as other electrochemical systems.

Deviation of Root Canal Curvature Using Three Types of Rotary Instruments: An In Vitro Study

One of the essential requirements for a successful endodontic treatment is efficient cleaning and shaping. Since its introduction, the nickel-titanium rotary system has gained popularity due to its elasticity and suppleness in the creation of curved root canals. To assess the deviation in root canal curvature in severely curved root canals following three different rotary file system preparations. Thirty-six human permanent mandibular first molars were chosen and stored in regular saline after being newly extracted with the curve mesial root. To standardize length at 13 mm, the mesial roots were separated from the tooth and the crown was removed. The three groups of teeth were A, B, and C. Groups A, B, and C were equipped with rotary variable taper instruments, reciprocating variable taper instruments, and rotary constant taper control memory instruments, respectively, in their mesio buccal canals. The instruments were never pressed apically; instead, they were employed in the canal with a constant, gentle passive movement. With frequent and copious irrigation using 5.25% sodium hypochlorite solution and 17% ethylene diamine tetra acetic acid, all canals were shaped and cleansed. To assess the curvature deviation, periapical radiographs were taken both before and after preparation. By using the Schneider method to measure the pre- and post-instrument canal curvatures, the deviation was found. The Wilcoxon test was employed for numerous pairwise comparisons across distinct groups, and the Kruskal-Wallis test was used to conduct statistical analysis among three groups. The p-value of less than 0.05 was deemed statistically significant. Compared to groups A and B, group C had the least variation of canal curvature. The current study concludes that a 4% rotating constant taper control memory instrument works better than a rotary variable taper instrument or a reciprocating variable taper instrument for shaping a curved canal.

Green Catalytic Synthesis of Ethylenediamine from Ethylene Glycol and Monoethanolamine: A Review.

Ethylenediamine (EDA) is a crucial chemical raw material and fine chemical intermediate. Compared with the industrial approach of ammonolysis of 1,2-dichloroethane, the catalytic amination of ethylene glycol (EG) is an economical and environmentally benign route that will be the future trend for EDA synthesis. Herein, we systemically review the recent progress in direct and indirect catalytic conversion of EG to EDA. Furthermore, different types of catalysts are discussed: (i) supported metal and multimetallic catalysts, (ii) solid acid catalysts, and (iii) other active catalysts (e.g., ionic liquids and metal complexes). Finally, we conclude with the frontiers and future prospects of the catalytic synthesis of EDA from EG and monoethanolamine, providing readers a snapshot of this field.

Role of low-molecular-weight organic compounds on photochemical formation of Mn(III)-ligands in aqueous systems: Implications for BPA removal

Aqueous trivalent manganese [Mn(III)], an important reactive intermediate, is ubiquitous in natural surface water containing humic acid (HA). However, the effect of low-molecular-weight organic acids (LMWOAs) on the formation, stability and reactivity of Mn(III) intermediate is still unknown. In this study, six LMWOAs, including oxalic acid (Oxa), salicylic acid (Sal), catechol (Cat), caffeic acid (Caf), gallic acid (Gal) and ethylene diamine tetraacetic acid (EDTA), were selected to investigate the effects of LMWOAs on the degradation of BPA induced by in situ formed Mn(III)-L in the HA/Mn(II) system under light irradiation. The chromophoric constituents of HA could absorb light radiation and generate superoxide radical to promote the oxidation of Mn(II) to form Mn(III), which was further involved in transformation of BPA. Our results implied that different LMWOAs did significantly impact on Mn(III) production and its degradation of BPA due to their different functional group. EDTA, Oxa and Sal extensively increased the Mn(III) concentration from 50 to 100 μM compared to the system without LMWOAs, following the order of EDTA > Oxa > Sal, and also enhanced the degradation of BPA with the similar patterns. In contrast, Cat, Caf and Gal had an inhibitory effect on the formation of Mn(III), which is likely because they consumed the superoxide radicals generated from irradiated HA, resulting in the inhibition of Mn(II) oxidation and further BPA removal. The product identification and theoretical calculation indicated that a single electron transfer process occurred between Mn(III)-L and BPA, forming BPA radicals and subsequent self-coupling products. Our results demonstrated that the LMWOAs with different structures could alter the cycling process of Mn via complexation and redox reactions, which would provide new implications for the removal of organic pollutants in surface water.

Effect of EDTA with porous balloon on calcified lesion: An atherosclerotic cadaver study.

Ethylene diamine tetra-acetic acid (EDTA) is a chelating agent used to dissolve calcium deposits but evidence in decalcifying atherosclerotic lesions is limited. We assessed the feasibility and efficacy of EDTA delivered via porous balloon to target calcified lesions in cadaveric below-the-knee (BTK) arteries. Using porcine carotid arteries, EDTA concentration was measured in the arterial wall and outside the artery at the 0-, 0.5-, 4-, and 24-h circulation after the injection through a porous balloon. In cadaver BTK samples, the proximal and distal anterior tibial artery (ATA) and distal posterior tibial artery (PTA) were studied. EDTA-2Na/H2O or EDTA-3Na/H2O were administrated using a porous balloon, then circulated for 6 h for EDTA-3Na/H2O and 24 h for EDTA-2Na/H2O and EDTA-3Na/H2O. Micro-CT imaging of the artery segments before and after the circulation and cross-sectional analyses were performed to evaluate calcium burden. In the porcine carotid study, EDTA was delivered through a porous balloon present in the arterial wall and was retained there for 24 h. In BTK arteries, cross-sectional analyses of micro-CT revealed a significant decrease in the calcium area in the distal ATA segment under 24-h circulation with EDTA-2Na/H2O and in the distal ATA segment under 24-h circulation with EDTA-3Na/H2O. The proximal ATA segment under 6-h circulation with EDTA-3Na/H2O showed no significant change in any parameters of calcium CONCLUSION: EDTA-3Na/H2O or EDTA-2Na/H2O with longer circulation times resulted in greater calcium reduction in atherosclerotic lesion. EDTA may have a potential therapeutic option for the treatment of atherosclerotic calcified lesions.

An Ultrathin Solid Electrolyte for High‐Energy Lithium Metal Batteries

AbstractSolid‐state electrolytes (SSEs) are key to unlocking the potential of lithium metal batteries (LMBs), but their high thickness (>100 µm) due to poor mechanical properties limits energy density improvements. Herein, an ultrathin (≈5 µm) polymer SSE with a high Young's modulus (10.6 GPa), made from a polyvinylidene fluoride‐hexafluoropropylene (PVDF‐HFP) matrix and an ethylene diamine tetraacetic acid (EDTA) additive is proposed. By virtue of the electron‐donating property, EDTA induces the conformation transformation of PVDF‐HFP, enhancing the mechanical strength by a fine‐grain strengthening mechanism. In addition, PVDF‐HFP with cis‐conformation shortens the pathway for Li+, promotes the Li+ dissociation and immobilizes the anions of lithium salt, thus increasing the ionic conductivity (2.47 × 10−4 S cm−1) and transfer number (0.59) of the electrolyte. Moreover, the electrolyte also possesses a wide voltage window (4.7 V) and good heat/flame resistance. The half cells and full cells with the electrolytes show good cycling and rate performance. Notably, a pouch cell based on the electrolyte exhibits impressive energy densities of 516 Wh kg−1 and 1520 Wh L−1 (excluding packages), showing great potential for practical use in LMBs.