Ethnic Heterogeneity Research Articles

Racially Informed Ethnic Heterogeneity in Asian American Intermarriage and Assimilation

Though racial integration of non-White minorities was initially considered unlikely, Asian Americans’ high rates of intermarriage with Whites suggest a new possibility. Recent research, however, reveals that Asian American intermarriage occurs in ethnically heterogeneous manners and further varies by spousal race and ethnicity. This study delves into the varied patterns of marital racial integration among Asian Americans, examining intermarriage data from the American Community Survey (ACS). In examining both interethnic and Asian-White interracial marriages, I find that Asian Americans continue to experience segmented assimilation in intermarriage, where their paths diverge by spousal race. Yet, ethnically heterogeneous understandings and experiences of one’s social position as “Asian” situate Asian Americans at varying distances from the mainstream White society, leading some Asian Americans to intermarry without having achieved acculturation or middle-class attributes. These findings challenge the presumed linear trajectory of minority incorporation, underscoring the pivotal role of race and racialization. This complexity further carries significant implications for broader American race relations

Artificial intelligence-enhanced electrocardiography predicts 10-year risk of atherosclerotic cardiovascular disease

Abstract Background The ACC/AHA pooled cohort equations (PCE) calculates the 10-year primary risk of atherosclerotic cardiovascular disease (ASCVD), an indication to initiate primary prevention statin therapy in international guidelines. The validity of PCE is limited by its overestimation of risk in high-risk cohorts and an ethnic heterogeneity. Electrocardiography (ECG) has not been incorporated in current ASCVD risk estimation tools. Artificial Intelligence (AI)-based models are capable to capture patterns that are informative for cardiovascular prognosis. Purpose We explored the predictive value of a discrete-time survival model in 10-year ASCVD risk in comparison to PCE. Methods We developed an AI-ECG model to predict the 10-year ASCVD risk in an unselected secondary care population from the USA comprised of 1,163,401 ECGs from 189,539 patients. Data was split into training/validation and hold-out test sets by patient ID. Our AI-ECG model uses deep learning with a residual convolutional neural network with a discrete-time survival loss function to output subject-specific survival curves, accounting for both time to event and censorship (i.e., loss to follow up). We compared the performance of out AI-ECG model using a subset of outpatient data (n=4590) of the BIDMC dataset to PCE and ASCVD risk factors including systolic blood pressure, total cholesterol, HDL cholesterol, hypertension, smoking history, diabetes mellitus, and ethnicity. Performances were evaluated using cox survival analysis. Our AI-ECG model was externally validated in the UKB Biobank (UKB), where we compared the performance of our AI-ECG model to predictions of existing AI-ECG models such as the Stanford Estimator of Electrocardiogram Risk (SEER) model. Results Our AI-ECG successfully predicted future ASCVD events in individuals (C-index 0.721 (0.719-0.723), 5-year AUC 0.761 (0.758-0.763), and differentiated between high and low risk group with an adjusted HR of 2.33 (2.26-2.41). Upon internal validation our AI-ECG model showed a superior performance (C-index 0.679 (0.651-0.708)) than PCE (0.605 (0.577-0.634)) and all risk factors combined (C index 0.642 (0.613-0.672)). When combining AI-ECG predictions with all risk factors, the model showed additional predictive value (0.686 (0.657-0.715)) (Figure 1). Our AI-ECG model showed modest predictive value within the UKB dataset (C-index 0.655 (0.637-0.673)), but significantly outperformed the SEER model (C-index 0.547 (0.527-0.567), p <0.0001 for comparison with AIRE). Conclusion We have shown the potential of AI-ECG models in predicting future ASCVD risks. AI-ECG models demonstrated accurate discrete time survival prediction and good classification performance superior to that of the SEER model, as well as PCE and ASCVD risk factors. . Accurate risk assessment of ASCVD may help prevent adverse events in high risk subjects and save unnecessary pharmacological interventios in low risk subjects.Figure 1

The impact of geopolitical processes in Bosnia and Herzegovina on urban development and cultural identity

The historical-geographical development of Bosnia and Herzegovina (BH) in the area of the fusion of Western and Eastern Christian civilizations and the Orient resulted in ethnic and religious heterogeneity, occasional political crises and ethnic conflicts that shaped the cultural identity and character of the entire development. BH was separated from the Yugoslav community in the conditions of the civil war. After the war in 1995, a complex administrative-territorial organization of the new state was established, based on the ethnic and religious affiliation of the population. At the same time, the transition of the socialist social system took place, as well as other geopolitical processes and social changes in the Western Balkans initiated by globalization. The paper focuses on cultural disintegration and changes in urban identity and development of cities through the analysis of the six largest urban centers as indicators of social changes in BH. The results of the analysis suggest that there has been a cultural differentiation of society, which is reflected in changes in the ethnic and religious structure of the population and their spatial distribution. Economic stagnation and depopulation of urban centers, as a consequence of the civil war and social reforms, were confirmed by a comparative analysis of statistical indicators of economic and demographic development. Cultural changes were determined by relevant scientific methods and approaches: historical-geographical method, comparative analysis of statistics of demographic indicators and changes in spatial distribution, ethnic and religious structure of the population, and economic changes by analysis of employment in sectors of the economy. The scientific results of previously published papers devoted to some of the mentioned problems, primarily economic development and population dynamics in BH and its large cities, were also taken into account. In this paper, social changes are observed through the cause-and-effect relationships of geopolitical and cultural processes (political, economic and cultural disintegration), social and economic reforms (ownership transition and deindustrialization) and their manifestations on cultural identity and the development of urban centers.

Phenotypic spectrum of iron-sulfur cluster assembly gene IBA57 mutations: c.286 T > C identified as a hotspot mutation in Chinese patients with a stable natural history.

Mutations in IBA57 disrupt iron-sulfur clusters maturation, causing a rare mitochondrial disease. Clinical manifestations vary from neonatal lethality to childhood-onset spastic paraparesis, yet the ethnic heterogeneity and natural history remain unclear, necessitating further exploration. This study aimed to delineate the genotype-phenotype correlation of IBA57 mutations by analyzing diverse clinical presentations. We report 11 Chinese patients and include literature-reported cases, totaling 61 patients enrolled for analysis. Clinical, neuroimaging, genetic, and disease progression information were collected. Among these, 46 presented as multiple mitochondrial dysfunctions syndrome 3 (MMDS3), with 58.7% originating from Chinese population. Based on disease course, we propose three clinical subtypes: neonatal, infant and childhood subtypes. Neonatal cases universally displayed hypotonia and respiratory distress at presentation, deceased within three months. Most infancy and childhood cases exhibited developmental regression and impaired motor function. Cavitating leukoencephalopathy was a typical neuroimaging finding in MMDS3 patients. The c.286 T > C mutation was reported in 85.2% of Chinese patients. A significantly lower mortality rate was observed compared to the non-Chinese group (P = 0.002), with a survival rate exceeding 90% at 5 years, indicating a relatively stable disease progression. Fifteen cases from three families manifested the spastic paraplegia 74 phenotype, demonstrating normal development before onset, with common clinical manifestations including spastic paraplegia (14/15), visual impairment (10/13), and peripheral neuropathy (9/13). In conclusion, this study indicates a hotspot mutation in Chinese and analyses the disease progression with different clinical subtypes.

Genetic associations and parent-of-origin effects of PVRL1 in non-syndromic cleft lip with or without cleft palate across multiple ethnic populations.

This study investigated the associations of PVRL1 gene variants with non-syndromic cleft lip with or without cleft palate (NSCL/P) by evaluating transmission distortion and parent-of-origin (POO) effects in multiple ethnic populations. We conducted allelic and genotypic transmission disequilibrium tests (TDT) on 10 single-nucleotide variants (SNVs) in PVRL1 using data from 142 Korean families with an affected child. POO effects were analyzed using the POO likelihood ratio test, comparing transmission rates of maternally and paternally inherited alleles. To assess generalizability and ethnic heterogeneity, we compared results from Korean families with data from the Center for Craniofacial and Dental Genetics, which included 2,226 individuals from 497 European and 245 Asian trios. TDT analysis identified significant over-transmission of the rs7940667 (G361V) C allele in Korean families (p=0.007), a finding replicated in both Asian (p=6.5×10-7) and European families (p=1.6×10-10). Eight SNVs showed strong TDT evidence in larger Asian and European datasets after multiple comparison corrections (p<0.0073). Of these, 4 SNVs (rs7940667, rs7103685, rs7129848, and rs4409845) showed particularly robust association (p<5×10-8). POO analysis revealed significant maternal over-transmission of the rs10790330-A allele in Korean families (p=0.044). This finding was replicated in European families (p=9.0×10-4). Additionally, 3 other SNVs, rs7129848 (p=0.001) and the linked SNVs rs3935406 and rs10892434 (p=0.025), exhibited maternal over-transmission in the validation datasets. Our findings provide robust evidence supporting the associations of PVRL1 variants with NSCL/P susceptibility. Further research is necessary to explore the potential clinical applications of these findings.

Social capital, social heterogeneity, and electoral turnout

AbstractAmong the many studied determinants of voting, we predict that i) increased social capital will be positively associated with turnout, while increased heterogeneity will be negatively associated; ii) both factors will work through their influence on the costs of information gathering and on the social norms of voting; and iii) that heterogeneity will interact with social capital in its association with turnout. We test these predictions at the extremely fine “meshblock” level by regressing New Zealand voter turnout in its 2017 national election on its 2013 census characteristics. We use roughly 40,000 meshblock volunteering rates to measure social capital, and heterogeneity based primarily on ethnic fragmentation. We find social capital is positively associated with voter turnout, while heterogeneity is negatively associated. We find robust evidence consistent with ethnic heterogeneity working through information costs and social norms, but less so social capital. We also find a robust interaction between social capital and heterogeneity in their association with turnout, consistent with ethnic heterogeneity raising bridging social capital that has a stronger association with turnout than in‐group bonding social capital.

Idiopathic Subglottic Stenosis in Non-Caucasian Women.

To characterize presentation, disease course, and treatment of idiopathic subglottic stenosis (iSGS) in non-Caucasian women and compare this cohort to the predominantly female, Caucasian patient cohorts identified in the literature. Retrospective review. Results are compared to systematic review of demographics. Multiple California institutions from 2008 to 2021. Patients with intubation within 2 years of disease or who met exclusion criteria listed in prior publications were excluded. A systematic review of iSGS patient demographics was also completed for comparison. Of 421 patients with iSGS, 58 self-identified as non-Caucasian women, with 50 ultimately included. Mean age of onset was 45.1 years old (95% confidence interval [CI], 41.5-48.8), and mean age at diagnosis was 47.2 years (95% CI, 43.6-50.7). Mean Charlson comorbidity index was 1.06 (n = 49, 95% CI, 0.69-1.44). At diagnosis, Cotton-Meyer severity scores (documented in n = 45) were Cotton-Myer (CM) I (28.9%), CM II (40%), and CM III (31.1%). Mean age at first endoscopic surgery was 47.7 (95% CI, 44.2-51.3) years. 64% experienced disease recurrence with a median of 11 months between their first and second surgery. Our systematic review identified 60 studies that reported demographic features in patients with iSGS. 95% of pooled patients were Caucasian, while other demographic features were similar to the current cohort. The non-Caucasian population, almost 14% of this Californian cohort, does not differ from the majority Caucasian population detailed in contemporary literature. This cohort supports the presence of some racial and ethnic heterogeneity in this disease population.

Parent perceptions of school relationships: Considerations of racial-ethnic differences and youth's peer victimization.

Literature has highlighted that social relationships at school are essential to school success, yet few studies have examined this construct from parents' perspectives. Even less research has explored perceptions of social relationships in the school among parents whose children are bullying victims and potential racial-ethnic differences in the perceptions. Using self-report data from 3,261 parents of middle and high school youth, this study used multilevel analyses in which parents were nested in their child's schools and examined parent perceptions of school relationships (including Child-School Connectedness, Parent-School Connectedness, School Outreach and Involvement, and Culture of Inclusiveness and Equity) in the context of youth victimization and whether these perceptions varied by the parent's racial-ethnic background. Results showed that compared with parents whose child was not a bullying victim (63.5%), those whose child was victimized (36.5%) had poorer perceptions of school relationships and that this difference was more pronounced in some racial-ethnic groups (e.g., Asian and Black) than in others (e.g., White, bi- or multiracial). These findings underscore the importance of addressing ethnic heterogeneity in how parents evaluate school-based social relationships in the context of peer bullying to effectively engage racial-ethnic minoritized parents of victimized youth in culturally responsive school bullying interventions. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Relationship quality in student-teacher-dyads: Comparing student and teacher determinants in multicultural classrooms

Teacher-student-relationship quality is associated with academic success and, among ethnic minority adolescents, it can promote positive intergroup relations. However, most research has studied student or teacher reports only and rarely accounted for ethnic classroom heterogeneity. This study investigated teacher-student-agreement on relationship quality in minority and majority student-teacher-dyads and tested predictors of relationship quality in adolescence. The sample comprised 309 minority (Mage = 12.99, SD = 1.30) and 200 majority adolescents (Mage = 13.50, SD = 1.56) and their 28 majority teachers (Mage = 45.82, SD = 11.50). Teachers reported higher relationship quality than students. Correlations in student-teacher-dyads were similar for minority and majority students. A better school climate, teachers’ awareness of social heterogeneity and culturally responsive teaching predicted relationship quality in student reports, whereas teaching enjoyment predicted relationship quality in teacher reports. In minority dyads, higher student socioeconomic status (SES) and lower levels of discrimination were additional predictors for relationship quality in both student and teacher reports. Findings suggest different processes in how minority and majority student-teacher-dyads evaluate relationship quality.

Ethnic fractionalization and income inequality: the case of Kazakhstan

Ethnic diversity has an impact on many areas of social life, which has led to an extensive layer of research on relationships in this area. Many authors have studied in detail the impact of ethnic diversity on conflicts, instability, domestic politics, other various social and cultural aspects. At the same time, the relationship between ethnic fractionalization and economic parameters remains insufficiently studied, which leaves a wide field for relevant research, especially at the level of individual countries, since most of the work is devoted to cross-country comparative analysis of the relevant parameters. One of the most actual problems in the context of ethnic heterogeneity is its relationship with income inequality. This article presents the results of a study of the relationship between ethnic diversity, estimated on the basis of the ethno-linguistic fractionalization (ELF) index, and two indicators of income inequality — the Gini coefficient and the inter-decile income share ratio (S90/S10). The analysis of this relationship was carried out on the example of one country — Kazakhstan — by comparing the corresponding indicators for seventeen regions. The results of the analysis showed the presence of a stable and noticeable relationship, expressed in the growth of income inequality as ethnic diversity grows in the regions of the country. It was revealed that in the most ethnically homogeneous regions, income inequality indicators are minimal, while in the most ethnically diverse regions they are much higher. A significant correlation was also found between ethnic fractionalization and indicators of income inequality. The results obtained are generally correspond to the results of a number of cross-country studies, but in the case of Kazakhstan they are more distinct, which can be interpreted as confirmation of the relationship between ethnic diversity and income inequality in general.

Alloimmunization and autoimmunization among multitransfused thalassemia and sickle cell disease patients

Blood transfusion is the mainstay for management of hemoglobinopathies, including thalassemia and sickle cell disease (SCD). Apart from other transfusion related adverse effects, immunization is a significant complication, particularly in multitransfused recipients. Alloimmunization rates vary widely, both in thalassemia and SCD patients. Alloimmunization complicates the management in form of hemolytic transfusion reactions, difficulty in finding compatible units, delays in transfusion and increasing costs. Exact pathogenesis and prevention modality have not been elucidated. Apart from antigenic differences, immunomodulatory effects and inflammation also play a role in pathogenesis. Ethnic heterogeneity between donors and recipients predisposes to higher alloimmunization.Transfusion management of hemoglobinopathies across the globe is fragmented, with different levels of care. Guidelines propose red cell antigen profiling, transfusion of leucoreduced red cells, preferably matched for Rh and Kell antigens, over and above ABO-D matching. For alloimmunized patients, corresponding antibody negative red cells need to be transfused. However, patients from different backgrounds are variably transfused with whole blood/red cells, which may or may not be leukoreduced. Prophylactic antigen matching reduces the risk of alloimmunization, however, has limitations. RH variants may not be picked up by phenotyping alone. Moreover, the approach of prophylactic antigen matching is expensive, labour intensive, time consuming and may cause delays in transfusions. There is limited, low quality evidence on best practices for transfusion management of SCD and thalassemia. The review analyses the magnitude of problem, factors contributing and modalities for prevention and management of immunization.

Examining the Etiology of Asian American Suicide in the United States.

Research highlights racial and ethnic disparities in suicide, but Asian American suicide receives very little attention in the literature. This is the first comprehensive, large-scale, nationally representative study of completed suicide among Asian Americans in the United States. Descriptive and multilevel regression techniques compared the risk factors for completed suicide across 227,786 Asian American, White, African American, Hispanic, and American Indian suicide decedents from 2003 to 2019. Results indicated that Asian American suicide decedents were significantly less likely than their counterparts to have several risk factors for suicide. Asian Americans were less likely to be male, uneducated, and unmarried. Asian Americans were less likely to use alcohol and drugs, to have mental health problems, and to die by firearm, relative to other suicide methods. Asian Americans were less likely to have a history of prior suicide attempts, to have intimate partner problems, and to have criminal legal problems. Conversely, Asian Americans were more likely to reside in places with higher levels of concentrated disadvantage, residential instability, racial and ethnic heterogeneity, and population density. The results underscore the need for race-specific suicide prevention strategies that, for Asian Americans in particular, take into account cultural values and barriers to help-seeking behavior.

Ethnic, Linguistic, and Religious Heterogeneity and Preferences for Public Goods and Redistribution in Latin America

One of the most prominent political-economic arguments is that heterogeneity undermines support for public goods and redistribution. Past research, however, has been mostly cross-sectional, used weak measures of heterogeneity, under-studied Latin America, and did not examine the multiple bases of heterogeneity. We assess negative (fractionalization and between-group inequality [BGI]) and positive (compensation) hypotheses with time-varying measures of ethnic, linguistic, and religious heterogeneity. We analyze four different preferences using up to six survey waves with over 200,000 Americas Barometer respondents across 24 Latin American and Caribbean countries. We estimate both fixed-effects models focusing on within-country variation and multilevel models focusing on between-country variation. Regardless of estimation technique, the prevailing pattern is statistical insignificance for both heterogeneity and BGI coefficients. The results largely contradict the fractionalization hypothesis, as only four of the 108 relevant heterogeneity coefficients are significantly negative. There is slightly more support for the BGI hypothesis, and especially ethnic BGI. Still, most BGI coefficients are insignificant and linguistic BGI is significantly positive in most models. The compensation hypothesis receives more support, as almost half of the heterogeneity coefficients are significantly positive. We conclude by cautioning against universal claims that heterogeneity undermines support for public goods and redistribution.

Effect of EVAR on International Ruptured AAA Mortality-Sex and Geographic Disparities.

Background: We sought to investigate the differential impact of EVAR (endovascular aneurysm repair) vis-à-vis OSR (open surgical repair) on ruptured AAA (abdominal aortic aneurysm) mortality by sex and geographically. Methods: We performed a retrospective study of administrative data on EVAR from state statistical agencies, vascular registries, and academic publications, as well as ruptured AAA mortality rates from the World Health Organization for 14 14 states across Australasia, East Asia, Europe, and North America. Results: Between 2011-2016, the proportion of treatment of ruptured AAAs by EVAR increased from 26.1 to 43.8 percent among females, and from 25.7 to 41.2 percent among males, and age-adjusted ruptured AAA mortality rates fell from 12.62 to 9.50 per million among females, and from 34.14 to 26.54 per million among males. The association of EVAR with reduced mortality was more than three times larger (2.2 vis-à-vis 0.6 percent of prevalence per 10 percentage point increase in EVAR) among females than males. The association of EVAR with reduced mortality was substantially larger (1.7 vis-à-vis 1.1 percent of prevalence per 10 percentage point increase in EVAR) among East Asian states than European+ states. Conclusions: The increasing adoption of EVAR coincided with a decrease in ruptured AAA mortality. The relationship between EVAR and mortality was more pronounced among females than males, and in East Asian than European+ states. Sex and ethnic heterogeneity should be further investigated.

The Genetic Markers of Knee Osteoarthritis in Women from Russia.

Osteoarthritis is a chronic progressive joint disease that clinically debuts at the stage of pronounced morphologic changes, which makes treatment difficult. In this regard, an important task is the study of genetic markers of the disease, which have not been definitively established, due to the clinical and ethnic heterogeneity of the studied populations. To find the genetic markers for the development of knee osteoarthritis (OA) in women from the Volga-Ural region of Russia, we conducted research in two stages using different genotyping methods, such as the restriction fragment length polymorphism (RFLP) measurement, TaqMan technology and competitive allele-specific PCR-KASPTM. In the first stage, we studied polymorphic variants of candidate genes (ACAN, ADAMTS5, CHST11, SOX9, COL1A1) for OA development. The association of the *27 allele of the VNTR locus of the ACAN gene was identified (OR = 1.6). In the second stage, we replicated the GWAS results (ASTN2, ALDH1A2, DVWA, CHST11, GNL3, NCOA3, FILIP/SENP1, MCF2L, GLT8D, DOT1L) for knee OA studies. The association of the *T allele of the rs7639618 locus of the DVWA gene was detected (OR = 1.54). Thus, the VNTR locus of ACAN and the rs7639618 locus of DVWA are risk factors for knee OA in women from the Volga-Ural region of Russia.

A Community-Based Prostate Cancer Screening and Education Program for Asian American Men in Medically Underserved Communities.

This study analyzed data from a community-based prostate cancer (PCa) education and screening program (Prostate Outreach Project; POP) to enhance PCa-related knowledge among medically underserved Asian American men. It also examined PCa screening history, clinical abnormalities based on prostate-specific antigen (PSA) tests and digital rectal examination (DRE) results, and follow-up and PCa diagnosis rates. Participants-521 Asian men (251 Vietnamese, 142 Chinese, and 128 South Asians)-were offered PCa screening using PSA tests and/or DRE and an educational session on PCa. Of these men, 277 completed PCa-related knowledge surveys before and after viewing an educational video. Significant between-group differences in PCa-related knowledge were found at pre-assessment (p < 0.001) but not at post-assessment (p = 0.11), at which time all groups showed improved PCa-related knowledge. Most participants (77.9%) had never received PCa screening, but Vietnamese men had the lowest previous screening rate (17.3%). Chinese men had elevated PSA values and the highest abnormal DRE rates. Of the 125 men with abnormal screening outcomes, only 15.2% had adequate follow-up. Of the 144 men diagnosed with PCa in POP, 11.1% were Asians (seven Chinese, six Vietnamese, and three South Asian). Despite the ethnic heterogeneity among Asian men, a community outreach program may successfully enhance their PCa-related knowledge.

Colorist Microaggressions and Brown Asian Americans: Implications for Behavioral Science

This article examines the manifestation of colorism toward Brown Asians through Microaggression Theory. Colorism has been defined as a stratification system based on skin tone, where those with the lightest skin tones are granted the most privileges, whereas those with the darkest are granted the least. Colorism impacts Asian Americans across domains, including education, employment, family relations, body image, and marital prospects. Brown Asians are particularly vulnerable to colorism and associated behaviors, as evidenced by the fact that South Asian countries house the largest skin bleaching markets. However, due to the historical aggregation of data on Asian American groups, research has traditionally focused on lighter-skinned East Asians, and experiences of darker-skinned Asians (i.e., South and Southeast Asians) remain largely obscured. This article describes the historical obscuring of colorism within Asian and American communities and utilizes Microaggression Theory to describe the potential manifestation of colorism toward Brown Asian communities. We propose five themes of colorist microaggressions Brown Asians may experience: (a) Invisibility &amp; Exclusion, and Authenticity (b) Assumptions of Beauty and Desirability, (c) Assumptions of Inferior Status or Intellect, (d) Assumptions of Deviance and Criminality, and (e) Internalized Microaggressions. Furthermore, we discuss additional considerations in studies of Brown Asian experiences, including cultural, historical, and ethnic heterogeneity, intersectionality, and experiences within organizations and institutions.

Ethnic heterogeneity and healthcare utilization: The mediating role of poverty in Ghana

AbstractsThe healthcare that a woman receives during pregnancy, at the time of delivery, and soon after delivery is imperative for the well-being and survival of both the mother and her child. Hence, understanding the factors that influence the utilization of healthcare around the period of birth is important for improving the health of the mother and her child as well as reducing maternal mortality. Although numerous studies have examined the factors that influence the utilization of healthcare around the period of birth, no study has considered the role of ethnic heterogeneity. This paper bridges a significant gap in the literature by reporting findings from the first study that examines the effect of ethnic heterogeneity on healthcare utilization in Ghana. The study utilized data from both the Demographic Health Survey and Ghana Population and Housing Census. Our estimates show that a unit increase in a heterogenous ethnic group lowers the likelihood of utilizing healthcare at the time of birth and after delivery via increasing household poverty.

Global carrier frequency and predicted genetic prevalence of patients with pathogenic sequence variants in autosomal recessive genetic neuromuscular diseases

Genetic neuromuscular diseases are clinically and genetically heterogeneous genetic disorders that primarily affect the peripheral nerves, muscles, and neuromuscular junctions. This study aimed to identify pathogenic variants, calculate carrier frequency, and predict the genetic prevalence of autosomal recessive neuromuscular diseases (AR-NMDs). We selected 268 AR-NMD genes and analyzed their genetic variants sourced from the gnomAD database. After identifying the pathogenic variants using an algorithm, we calculated the carrier frequency and predicted the genetic prevalence of AR-NMDs. In total, 10,887 pathogenic variants were identified, including 3848 literature verified and 7039 manually verified variants. In the global population, the carrier frequency of AR-NMDs is 32.9%, with variations across subpopulations ranging from 22.4% in the Finnish population to 36.2% in the non-Finnish European population. The predicted genetic prevalence of AR-NMDs was estimated to be 24.3 cases per 100,000 individuals worldwide, with variations across subpopulations ranging from 26.5 to 41.4 cases per 100,000 individuals in the Latino/Admixed American and the Ashkenazi Jewish populations, respectively. The AR-NMD gene with the highest carrier frequency was GAA (1.3%) and the variant with the highest allele frequency was c.-32-13 T>G in GAA with 0.0033 in the global population. Our study revealed a higher-than-expected frequency of AR-NMD carriers, constituting approximately one-third of the global population, highlighting ethnic heterogeneity in genetic susceptibility.

Trapped in Place? Ethnic and Educational Heterogeneity in Residential Mobility and Integration of Young Adults in Brussels

Spatial assimilation theory asserts that immigrants’ socioeconomic progress leads to residential adaptation and integration. This association has proven robust in USA and European urban areas through much of the twentieth century, but drastic change of ethnic and class compositions yet persistent (neighbourhood) inequality in the urban landscape urge us to reconsider the dynamic interaction between stability and change. In this study, we investigate to what extent education shapes residential mobility differently for young adults with varying ethnic and social origins. Focussing on Brussels, we use multinomial logistic regressions on linked longitudinal population-based censuses from 1991 and 2001 and register data for the period 2001–2006. Analyses show that dispersal away from poor inner-city neighbourhoods appears least likely for the offspring of poor low-educated non-Western households, regardless of their own educational attainment. While our approach roughly confirms traditional arguments of socio-spatial integration, it also reveals how educational success generates opportunities to escape poor neighbourhoods for some but not for others. With this, it points at the subtle ways in which factors and mechanisms in traditional spatial assimilation theory affect residential behaviour of young adults over their life course, at the intersection of specific locales, ethnic groups, social classes and generations.