Ethnic Groups In Singapore Research Articles

Total Oxidative Index Is Associated with Glycated Hemoglobin, Low-Grade Inflammation, and Non-HDL Cholesterol in Type 2 Diabetes

Objectives: To study associations of established cardiovascular risk factors, inflammation and carotid artery intima-media thickness (CIMT) with oxidative stress in type 2 diabetes mellitus (T2DM). Methods: We recruited 343 T2DM subjects from the three main ethnic groups in Singapore (Chinese: 196, Indians: 106, Malays: 41; Age: 54.7±10.4 years; Males: 46%). Measurements: Demographics, BMI, blood pressure, HbA1c, glucose and lipids; CIMT and C-reactive protein (hsCRP). Derivatives of reactive oxygen metabolites (dROMS) and total anti-oxidant status (TAC) was estimated by the automated clinical chemistry analyser (Diacron, Italy). The total oxidative index (OXY) was calculated as the difference between standardised dROMS and TAC values. The relationship between OXY, dROMS and TAC as dependent variable and age, gender, ethnicity, BMI, blood pressure, HbA1c, fasting lipids, log CRP and CIMT as co-variates was assessed using multiple regression analysis. Associations with gender and ethnicity were assessed by student’s t test and Kruskal Wallis test respectively. Results: The mean OXY was higher in the females (0.2±1.3) compared to the males (0.2±1.0); p<0.001 and highest in the Indians (0.3±1.2) when compared to Chinese (-0.1±1.2) and Malays (-0.1±1.0); p=0.01. OXY exhibited a linear relationship with HbA1c (β=0.09, p=0.01), Non-HDL cholesterol ((β=0.28, p<0.001) and CRP (β=0.21, p<0.001). dROMS associated with HbA1c (β=5.3, p=0.04) and CRP (β=14.80, p<0.001) and TAC associated inversely with non-HDL-cholesterol (β= -121.4, p<0.001). No association with CIMT was seen. Conclusions: In T2DM, total oxidative stress is a function of HbA1c, non-HDL-Cholesterol and low-grade inflammation. HbA1c and inflammation increase reactive oxygen metabolites, whereas non-HDL cholesterol decreases the anti-oxidant potential. The mechanisms of oxidative stress generation, in particular in various ethnic groups, needs to be studied further. Disclosure R. Dalan: None. L. Goh: None. X. Tang: None. D.E.K. Chew: None. B. Boehm: None.

Does ethnicity matter in risk and protective factors for suicide attempts and suicide lethality?

This study explored ethnic differences in risk and protective factors for suicide attempts, for the major ethnic groups in Singapore, and ethnic differences in prediction of lethality. Three years of medical records related to suicide attempters (N = 666) who were admitted to the emergency department of a large teaching hospital in Singapore were subjected to analysis. Of the sample, 69.2% were female, 30.8% male; 63.8% Chinese, 15.8% Indian, and 15.0% Malay. Indians were over-represented in this sample, as compared with the ethnic distribution in the general population. Ages ranged from 10 to 85 years old (M = 29.7, SD = 16.1). Ethnic differences were found in risk and protective factors, and perceived lethality of suicide attempts. All available variables were subjected to regression analyses for Chinese, Indian and Malay attempters to arrive at parsimonious models for prediction of perceived lethality. The findings were discussed in regards to implications in assessment of suicide risk and primary prevention for the multiethnic society in Singapore.

Differential seroprevalence of epstein-barr virus (EBV) antibodies among three ethnic groups in singapore

Differential seroprevalence of epstein-barr virus (EBV) antibodies among three ethnic groups in singapore

Development of food lists as a first step to develop a food frequency questionnaire for toddlers in a multi-ethnic population.

Toddlerhood is an important stage of growth, thus understanding the food intake of children in this age group is important. In Singapore, there is currently no simple tool, such as Food Frequency Questionnaire (FFQ), to collect dietary information from this ethnically diverse age group. Generating an appropriate food list is a crucial step in the development of a FFQ and this step is not clearly documented in the literature. The purpose of this study is to generate food lists and portion sizes for toddlers from three major ethnic groups in Singapore and document the processes involved in this first stage. A total of 30 mothers (equal number of Malays, Indians and Chinese) of 11-24-month-old children completed three-day food records and participated in the focus group discussion. The reported food items were then categorised into food groups. The food lists varied by ethnic groups with the longest list obtained from Chinese toddlers. There were also other foods that were then classified as common foods for all ethnicities. Commonly used utensils among the three ethnic groups were small-sized bowls, plates, cups and spoons. For portion sizes, these utensils were typically half-filled for the toddlers. As all Singaporeans have access to the same foods, the ethnic-specific food lists generated in this study could be combined into one list. Together with portion sizes, this information can be used for developing a semi-quantitative FFQ.

The impact of ethnicity on luxury perception: the case of Singapore’s Generation Y

PurposeThis study investigates Singaporean millennials’ attitudes toward luxury brands. The research focuses on the financial, functional, individual, and social dimensions of luxury value perception and whether ethnicity influences these dimensions.Design/methodology/approachThe research measures luxury value perception among millennials of the three main ethnic groups in Singapore (Chinese, Indians, and Malays) via more than 200 questionnaires. Data were analyzed through Kruskal-Wallis non-parametric ANOVA and cluster analysis.FindingsLuxury value perception does not vary across ethnicity, with the exception of the financial value dimension. Four market segments of young luxury consumers in Singapore are identified and profiled. These segments do not differ in terms of ethnicity.Research limitations/implicationsMillennials are an evolving and moving population segment, and thus longitudinal analyses would be useful to develop a more comprehensive understanding of this segment.Practical implicationsEthnicity does not affect luxury value perception. The results of the cluster analysis suggest that luxury companies should address the millennials as a global target sharing the same luxury value perception. At the same time, luxury companies can emphasize some different aspects (i.e., the financial dimension) of their value offer.Originality/valueThe research studies the most interesting market for luxury brands—millennials—in a fast-growing luxury market. It adds knowledge to the previous literature on luxury value perception. This research can guide managers to devise suitable marketing strategies addressing the millennials segment as a global market that has the same set of luxury values worldwide.

Prevalence and Correlates of Pain in People Aged 60 Years and above in Singapore: Results from the WiSE Study

Background. Although pain is experienced among people of all ages, there is a need to study its risk factors and impact among older adults. Aims. The study sought to determine the prevalence, sociodemographics, and clinical correlates of pain along with association of pain with disability among older adults in Singapore. Methods. The WiSE study was a comprehensive cross-sectional, single phase, epidemiological survey conducted among the elderly aged 60 years and above and used a nationally representative sample of three main ethnic groups in Singapore: Chinese, Malays, and Indians. The survey administered 10/66 protocol pain questionnaire, sociodemographic questionnaire, health status questionnaire, World Health Organization Disability Assessment Scale (WHODAS 2.0), and Geriatric Mental State (GMS) examination. Results. A total of 2565 respondents completed the study giving a response rate of 65.5%. The prevalence of pain among the elderly aged 60 years and above is 19.5 %. Females, incomplete primary education Indians, and those diagnosed with any chronic health condition were associated with risk of pain and disability. Conclusion. Study findings showed that disability related to pain among the elderly is considerable making it a priority to reduce the morbidity and disability among the elderly with pain.

Glycaemic and insulin responses, glycaemic index and insulinaemic index values of rice between three Asian ethnic groups.

Asians exhibit larger glycaemic response (GR) and insulin response (IR) than Caucasians, predisposing to an increased risk of type 2 diabetes mellitus (T2DM). We aimed to determine the GR and IR as well as the glycaemic index (GI) and insulinaemic index (II) of two rice varieties among three ethnic groups in Singapore. A total of seventy-five healthy males (twenty-five Chinese, twenty-five Malay and twenty-five Asian-Indians) were served the available equivalent carbohydrate amounts (50 g) of test foods (Jasmine rice and Basmati rice) and a reference food (glucose) on separate occasions. Postprandial blood glucose and plasma insulin concentrations were measured at fasting ( -5 and 0 min) and at 15, 30, 45, 60, 90 and 120 min after food consumption. Using the trapezoidal rule, GR, IR, GI and II values were determined. The GR did not differ between ethnic groups for Jasmine rice and Basmati rice. The IR was consistently higher for Jasmine rice (P=0·002) and Basmati rice (P=0·002) among Asian-Indians, probably due to compensatory hyperinsulinaemia to maintain normoglycaemia. The GI and II of both rice varieties did not differ significantly between ethnicities. The overall mean GI for Jasmine rice and Basmati rice were 91 (sd 21) and 59 (sd 15), respectively. The overall mean II for Jasmine rice was 76 (sd 26) and for Basmati rice was 57 (sd 24). We conclude that the GI values presented for Jasmine rice and Basmati rice were applicable to all three ethnic groups in Singapore. Future studies should include deriving the II for greater clinical utility in the prevention and management of T2DM.

Strengths of character, orientations to happiness, life satisfaction and purpose in Singapore

Positive psychology has identified six virtues comprising 24 character strengths of humans. This study examines the relationships among these character strengths, including Happiness, Life Purpose and Life Satisfaction as valued by Singapore Chinese, Malays, Indians and Other Asians and Caucasians. A sample of Singapore adults (N = 304) completed an online survey in English comprising four measures, the Values in Action Inventory of Strengths, the Orientations to Happiness Scale, the Satisfaction with Life Scale and the Life Engagement Test. Results show that Zest, Hope, Curiosity, Capacity to Love and Gratitude are the top five character strengths of the sampled Singaporeans. Happiness orientation through pursuing a Life of Meaning is preferred by all four ethnic groups. Ethnic differences are found for character strengths of Kindness, Humour, Gratitude, and Religiousness and Spirituality. Life of Meaning and Life of Engagement, Happiness orientations and character strengths of Curiosity and Perseverance are direct predictors of Life Purpose. In turn, Life Purpose and character strengths of Capacity to Love and Gratitude are found to be direct predictors of Life Satisfaction. Despite its other limitations, this study lays the groundwork for future studies using more robust sampling strategies and greater participation from the major ethnic groups in Singapore.

Ethnic variation of the histological subtypes of renal cell carcinoma in Singapore

IntroductionThe purpose of this study is to determine how the histological subtypes of renal cell carcinoma (RCC) vary among the heterogeneous Singaporean population and how this affects the survival rate. Patients and methodsThe data analyzed in this retrospective study of the histological subtypes of RCC cases treated in Singapore General Hospital over a ten year period (2001–2010) were obtained from the Cancer Registry of the hospital's department of urology. Statistical analysis was done using the Statistical Package Service Solution (SPSS) version 17.0 software. Chi Square and z-tests were used where appropriate; a p value <0.05 was considered significant. ResultsThe records of 676 patients studied showed that 80.8% of the patients were Chinese, while Malays, Indians and other minor groups accounted for 6.5%, 4.6% and 8.1%, respectively. The mean age (SD) at presentation was 58.1 (12.1), 57.6 (10) and 55.1 (9.6) years for the Chinese, Indians and Malays, respectively. The commonest histological variant in each of the ethnic groups, irrespective of sex, was clear cell carcinoma which accounted for 79.7% of all the histological subtypes found in Chinese, for 70.5% in Malaysian and 77.4% in Indian patients. The sarcomatoid histological subtype was found in 4.3% of the studied population with a high prevalence in the Indian ethnicity (9.7%). The worst survival rate (33.3%) was recorded among Malays with the papillary cell subtype, and also in the Chinese population the highest mortality rate was found in cases with the papillary cell subtype (16.9%). ConclusionThe commonest histological subtype of RCC in each of the studied ethnic groups in Singapore is clear cell carcinoma. However, most of the cancer deaths in Chinese (16.9%) and Malays (66.7%) were associated with the papillary cell type, while in Indians the sarcomatoid component prevailed (9.7%). Thus, the usual prognostic trend for RCC subtypes cannot be applied to all Singaporean ethnicities, necessitating individualization of prognosis for each group.

Gaps in educational outcomes: analysing national examination performance of Singaporean Malay and non-Malay students in the past 20 years

Singaporean students generally perform very well in international tests of mathematics and science. Nonetheless, in multi-cultural Singapore, there exist gaps with the Malays, a minority group in Singapore, systematically lagging behind the other ethnic groups of the Chinese and Indians in many educational performance indicators. While there have been previous qualitative assessments of this issue, rigorous statistical analyses are lacking. In this article, I analyse data from 1991 to 2011 of aggregate percentage passes in national examinations for the different ethnic groups in Singapore. Using time series techniques and regression, I uncovered two major findings. First, the Malay trends in percentage passes for the last two decades were strongly correlated with the non-Malay, national trends. Second, despite the correlation, there remained fluctuations around the national trend by Malay cohorts in the past two decades. Malay cohorts tended to perform better during an upward national trend, but also performed worse during a downward national trend, indicating systematic volatility in performance. The implications of these findings are discussed in the light of current research on educational gaps and three decades of community self-help to improve the educational achievement of the minority Malays in Singapore.

Systematic Study on Genetic and Epimutational Profile of a Cohort of Amsterdam Criteria-Defined Lynch Syndrome in Singapore

BackgroundGermline defects of mismatch repair (MMR) genes underlie Lynch Syndrome (LS). We aimed to gain comprehensive genetic and epigenetic profiles of LS families in Singapore, which will facilitate efficient molecular diagnosis of LS in Singapore and the region.MethodsFifty nine unrelated families were studied. Mutations in exons, splice-site junctions and promoters of five MMR genes were scanned by high resolution melting assay followed by DNA sequencing, large fragment deletions/duplications and promoter methylation in MLH1, MSH2, MSH6 and PMS2 were evaluated by multiplex ligation-dependent probe amplification. Tumor microsatellite instability (MSI) was assessed with five mononucleotide markers and immunohistochemical staining (IHC) was also performed.ResultsPathogenic defects, all confined to MLH1 and MSH2, were identified in 17 out of 59 (28.8%) families. The mutational spectrum was highly heterogeneous and 28 novel variants were identified. One recurrent mutation in MLH1 (c.793C>T) was also observed. 92.9% sensitivity for indication of germline mutations conferred by IHC surpassed 64.3% sensitivity by MSI. Furthermore, 15.6% patients with MSS tumors harbored pathogenic mutations.ConclusionsAmong major ethnic groups in Singapore, all pathogenic germline defects were confined to MLH1 and MSH2. Caution should be applied when the Amsterdam criteria and consensus microsatellite marker panel recommended in the revised Bethesda guidelines are applied to the local context. We recommend a screening strategy for the local LS by starting with tumor IHC and the hotspot mutation testing at MLH1 c.793C>T followed by comprehensive mutation scanning in MLH1 and MSH2 prior to proceeding to other MMR genes.

Cross-Cultural Studies of Implicit Theories of Creativity: A Comparative Analysis Between the United States and the Main Ethnic Groups in Singapore

This article explores the extent of influence of culture on implicit theories of creativity among laypeople from the United States and Singapore, as well as the ethnic groups in Singapore. Adaptive and innovative styles of creativity were examined, as well as their own conceptions of creativity. Laypersons from the United States and Singapore were asked to rate the creativity level for the descriptors of the adaptor and innovator explicit theory of creativity. The laypersons were also asked to give words they believed associated with creativity. Data indicated that there was an implicit belief that high creativity was associated with the innovative style of creativity. Further, the words that were associated with creativity seemed to have an innovator bias.

Ethnic Variation in Central Corneal Refractive Power and Steep Cornea in Asians

Purpose: To describe ethnic differences in the distribution of central corneal refractive power and steep cornea in a multiethnic Asian population.Methods: A total of 2968 Chinese, 2957 Indian and 2928 Malay participants aged over 40 years were included in this study. Each subject underwent standardized systematic and ocular examinations, interviewer-administered questionnaires, and blood investigations for risk factor assessment. Central corneal refractive power was measured using an autorefractor. Steep cornea was defined as central corneal refractive power exceeding 48 diopters (D) measured by keratometry.Results: Mean keratometry readings were 43.9 ± 1.5 D in Malays, 44.2 ± 1.5 D in Indians and 43.9 ± 1.5 D in Chinese. The prevalence of steep cornea was 0.6% (95% confidence interval, CI, 0.3–0.9%) in Malays, 1.0% (95% CI 0.7–1.4%) in Indians and 0.5% (95% CI 0.3–0.8%) in Chinese. In multivariate analysis, increasing central corneal refractive power was associated with Indian race, shorter body height, non-smokers, absence of pterygium, shorter axial length, thinner corneas and greater anterior chamber depth, while the presence of steep cornea was significantly associated with Indian race, shorter axial length and thinner corneas.Conclusions: Indian participants had the steepest corneas among the three major ethnic groups in Singapore. Central corneal refractive power was related to several ocular parameters including anterior chamber depth, axial length and central corneal thickness. These data have important clinical implications for understanding the risk of keratoconus.

Ming Wong’s Imitations

Author(s): Mennel, Barbara | Abstract: The article Wong's Imitations analyzes the installation Life of Imitation, created by visual artist Ming Wong for the Singapore Pavilion at the 53rd Venice Biennale in 2009. Life of Imitation restages a key scene from Douglas Sirk's 1959 melodrama Imitation of Life, in which the African American character Annie visits her daughter Sarah Jane who is passing as white. In Wong's restaging three male actors from different ethnic groups in Singapore reenact the scene, but switch roles at every cut. The article traces the shifts from the original literary source, Fannie Hurst's 1933 Imitation of Life to John M. Stahl's 1934 film of the same title to Sirk's version. Emphasizing melodrama's organizing structure of too late, I show how Sirk shifted the melodramatic emphasis from the white mother/daughter pair's romantic conflict to the African American mother/daughter pair's racial conflict. Addressing the question whether such a shift implies a progressive politics, I turn to the contentious discussion of Sirk's earlier film work in Weimar and Nazi Germany, pointing to ideological and formal continuities.In contrast to these significant shifts in the different instantiations of the text, I propose that the different versions share the subordination and disavowal of ethnic difference in order to construct a racial binary, which then becomes the setting of the passing narrative organized around the 'tragic mulatta'. I illustrate my argument with the instances of ethnic passing of the writers, directors, and actors involved in the different versions of the text. However, I also show the appeal of racial passing narratives can have for a gay camp imagination, identification, and appropriation. I conclude the article with a discussion of Wong's double move in Life of Imitation of returning ethnic bodies that have been excised from the original diegesis to their significance and appropriating the gendered melodrama through cross-dressing. After a survey of the term remediation as it emerged from the discussion of new media, I show that Wong's piece belongs to a group of works by visual artists who remake film in digital media in the environment of the art space. I conclude with reading the effect of rotating the actors at each cut, which does not subvert spatial and temporal continuity, but challenges spectators' perception of ethnicity and gender, and produces unstable identities.

Weak Ties in the Singaporean Labour Market

According to Granovetter, weak ties link individuals to other social circles that place them in strategic positions to gain access to job information and opportunities otherwise not available in their innate networks. This paper affirms that weak ties, as a form of social capital, matter and that they assist in explaining variations in status attainment between ethnic groups in Singapore. I show that access to weak ties affects status attainment differently across ethnic groups and that the Malay’s weaker performance in the labour market is partly due to their lower access to weak ties. This paper would be of interest to scholars concerned with the intertwining of social stratification with social capital and ethnicity.

Simultaneous determination of probe drugs, metabolites, inhibitors and inducer in human plasma by liquid chromatography/tandem mass spectrometry and its application to pharmacokinetic study

Cytochrome P450 3A4 (CYP3A4) and UDP-glucuronosyltransferase 1A1 (UGT1A1) are important enzymes responsible for the metabolism of many xenobiotics. To investigate their induction and inhibition properties, administering probe drugs and monitoring their concentration in plasma under the effects of inducers/inhibitors is the gold standard method. A rapid and sensitive liquid chromatography–tandem mass spectrometry method was developed for simultaneous quantification of midazolam, raltegravir (probe drugs for CYP3A4 and UGT1A1), their major metabolites, 1′-hydroxymidazolam, 1′-hydroxymidazolam glucuronide and raltegravir glucuronide, rifampicin (inducer), ritonavir and ketoconazole (inhibitors). Analytes were extracted from 100μl of plasma using solid-phase extraction followed by chromatographic separation on a reversed-phase C18 column (50mm×2.1mm, particle size 1.8μm). The mass spectrometer was operated under positive ionization mode. Excellent linearity (r2≥0.995) was achieved for all. The method was validated and found to be accurate (88–111%), precise (CV%<13) and selective. Matrix effect was acceptable (88–118%) and analytes recovery was reproducible (60–95%). Analytes in plasma were also found to be stable in the autosampler (6°C for 48h) and after two freeze-thaw cycles. We have developed a robust analytical method to simultaneously quantify probes, inducer and inhibitor of important drug metabolism enzymes. The method was successfully applied in a clinical study to investigate the degree of induction and inhibition of CYP3A4 and UGT1A1 among ethnic groups in Singapore.

Coronary Artery Calcification Across Ethnic Groups in Singapore

Introduction: In Singapore, the age-standardised event rates of myocardial infarction (MI) are 2- and 3-fold higher for Malays and Indians respectively compared to the Chinese. The objectives of this study were to determine the prevalence and quantity of coronary artery calcification (CAC) and non-calcified plaques across these 3 ethnic groups. Materials and Methods: This was a retrospective descriptive study. We identified 1041 patients (810 Chinese, 139 Malays, 92 Indians) without previous history of cardiovascular disease who underwent cardiac computed tomography for atypical chest pain evaluation. A cardiologist, who was blinded to the patients’ clinical demographics, reviewed all scans. We retrospectively analysed all their case records. Results: Overall, Malays were most likely to be active smokers (P = 0.02), Indians had the highest prevalence of diabetes mellitus (P = 0.01) and Chinese had the highest mean age (P &lt;0.0001). The overall prevalence of patients with non-calcified plaques as the only manifestation of sub-clinical coronary artery disease was 2.1%. There was no significant difference in the prevalence of CAC, mean CAC score or prevalence of non-calcified plaques among the 3 ethnic groups. Active smoking, age and hypertension were independent predictors of CAC. Non-calcified plaques were positively associated with male gender, age, dyslipidaemia and diabetes mellitus. Conclusion: The higher MI rates in Malays and Indians in Singapore cannot be explained by any difference in CAC or non-calcified plaque. More research with prospective follow-up of larger patient populations is necessary to establish if ethnic-specific calibration of CAC measures is needed to adjust for differences among ethnic groups. Key words: Coronary artery disease, Myocardial infarction, Race

Cardio-metabolic risk factors and prehypertension in persons without diabetes, hypertension, and cardiovascular disease

BackgroundPrehypertension has been shown to be an early risk factor of cardiovascular disease (CVD). We investigated the prevalence and pattern of cardiometabolic risk factors in prehypertension in three ethnic Asian populations in Singapore.MethodsWe examined data from Chinese (n = 1177), Malay (n = 774), and Indian (n = 985) adults aged 40–80 years who participated in three independent population based studies conducted from 2004–2011 in Singapore who were free of diabetes, hypertension and previous CVD. Prehypertension was defined as systolic blood pressure (BP) 120–139 mm Hg or diastolic BP 80–89 mm Hg. Random blood glucose, glycated haemoglobin (HbA1c), body mass index (BMI), triglycerides, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol were examined as indicators of adverse cardiometabolic profile. The association between metabolic variables and prehypertension was examined using logistic regression models adjusting for potential confounders.ResultsThe prevalence of prehypertension was 59.8% (Chinese), 68.9% (Malays) and 57.7% Indians. Higher levels of blood glucose, HbA1c and BMI were significantly associated with prehypertension in all three ethnic groups, odds ratio (95% confidence interval) of prehypertension in Chinese, Malays and Indians were: 1.42 (1.10, 1.83), 1.53 (1.05, 2.24), 1.49 (1.13, 1.98) for high-glucose; 3.50 (1.01, 12.18), 3.72 (1.29, 10.75), 2.79 (1.31, 5.94) for high-HbA1c; 1.86 (1.34, 2.56), 2.96 (2.10, 4.18), 1.68 (1.28, 2.20) for high-BMI. In addition, higher levels of LDL cholesterol in Chinese and higher levels of triglycerides were significantly associated with prehypertension. These associations persisted when metabolic variables were analysed as continuous variables.ConclusionsHigher levels of blood glucose, HbA1c and BMI were associated with prehypertension in all three ethnic groups in Singapore. Screening for prehypertension and lifestyle modifications could potentially reduce the burden of CVD in otherwise healthy Asian adults living in Singapore.

Paradoxical effects of adiponectin level on plaque vulnerability and clinical outcomes after coronary revascularization

plaque content signifies vulnerability and is predictive of subsequent cardiovascular events, our findings were in line with the hypothesis that serum adiponectin level is elevated in a counter-regulatory fashion in advanced coronary artery disease. Yet, in the same study, we found that serum adiponectin levels differed between the three ethnic groups in Singapore [6] .I t was significantly lower in the Indian patients than in the Chinese and Malay patients. Although this explains the known augmented risk of adverse events after coronary revascularization among Indian patients, it argues against the aforementioned necrotic core content theory. In view of the conflicting data on the role of adiponectin and vascular outcomes, we perceived it to be necessary to

Evidence of differential selection for the −α3.7 and −α4.2 single‐α‐globin gene deletions within the same population

Since the 1950s, a strong correlation between high carrier rates for β-thalassemia mutations and selective survival advantage in tropical and subtropical 'malarial belt' regions has been established. Due to the relatively more complex genetics of α-thalassemia, a similar relationship was demonstrated for α-globin gene mutations only from the 1980s, with both single- and double-α-globin gene deletions prevalent in the malarial belt. Mechanistically, the single-α-globin gene deletions arise from non-allelic recombination between the homologous α1 (HBA1) and α2 (HBA2) globin genes. Compared to the -α(3.7) and ααα(anti3.7) rightward crossover alleles, much less is known about the -α(4.2) and ααα(anti4.2) leftward crossover alleles. We performed a survey of 1,285 unselected cord blood samples from the 3 major ethnic groups in Singapore. Overall, the frequency of the -α(3.7) deletion was significantly higher than its reciprocal ααα(anti3.7) triplication, consistent with positive selection for the -α(3.7) single-gene deletion. In marked contrast, there was no significant difference in frequency between the -α(4.2) and reciprocal ααα(anti4.2) alleles, suggesting the absence of positive selection for the -α(4.2) single-gene deletion. The similar ααα(anti3.7) and ααα(anti4.2) allele frequencies also suggested that the crossover rates at X and Z homology boxes are similar. Taken together, these observations suggest a differential positive selection for the -α(3.7) and -α(4.2) alleles within the same population. Further population and biological studies may be required to explain these current observations.