Artificial Intelligence (AI) promises to revolutionise how healthcare organisations serve patients but harnessing this technology to design better services is fraught with unknowns and confounders. This is particularly true at academic medical centres, where orchestrating care is complex. To help leaders and clinicians at academic medical centres consider, develop and roll out AI-enabled services, we are proposing a blueprint called ‘Care- Centred AI’ (CCAI). This framework reimagines technology’s place in the delivery of complex care and reprioritises the patient-caregiver relationship in care delivery. Furthermore, the CCAI framework takes into account the strategic importance of leveraging data in an ethical way to further enable innovation and care across clinical pathways and operational value chains.