Penetration Test Research Articles

Data Monetization Service Development Using Iterative Lifecycle Framework, Quality Assurance, and Open Web Application Security Project: A Case Study of a Utility Company in Indonesia

The research aims to provide Data Monetization (DM) services for an Indonesian utility company as a pilot to generate additional revenue beyond the primary operation. The service is built using an iterative development lifecycle framework and evaluated based on five Quality Goals (QGs), including application and security testing activities. The framework includes methods for processing and modeling electricity usage data, testing application quality, checking infrastructure quality, and ensuring access security for front-end and back-end applications using the Open Web Application Security Project (OWASP). For data modeling, Support Vector Regression (SVR) is used, and it outperforms Polynomial Regression (PR) and Multi-Layer Perception (MLP) Neural Networks. Furthermore, QG shows strong performance with an Relative Root Mean Squared Error (RRMSE) value < 10%, high forecasting ability with Mean Average Probability Error (MAPE) < 10%, and a near-zero average error rate (Mean Squared Error (MSE)) square using minimal data from four months. The services go through functional and integration test to ensure product quality and application performance, which results in a minimum of 95% service response in throughput, 0.128 seconds for processing 2,000 requests, stability at 300–500 in one second per hour, and 7–21 seconds during peak hours. Additionally, the service passes nine penetration tests and ten vulnerability assessments using the OWASP top 10:2021 category. Based on the comprehensive testing and evaluation results, both the application and the service are considered ready and secured for deployment.

A simple model incorporating foam rheology to quantify foam penetration behaviour in EPB shield tunnelling

Fulfilling the role of a soil conditioner, foam plays a pivotal role in Earth Pressure Balance (EPB) shield tunnelling by enhancing soil properties such as lowering permeability and increasing flowability. This study introduces a macro-model designed to quantify foam penetration behaviour in saturated sand, utilising rheological properties. To validate this model, experiments were conducted to replicate the foam penetration behaviour. Six sand beds characterised by varying particle sizes, along with foam having an expansion ratio of fifteen, were employed for penetration tests under different hydraulic conditions utilising a sand column device. The rheological profile of the foam is described by the power-law model, as also found by rheometer tests, although with different parameters. The flow behaviour of foam within the sand column conforms to the flow equation that governs power-law fluids in porous media. The developed model effectively predicts the foam penetration process under varying hydraulic conditions compared with the experimental results. Furthermore, the fitting results of the experimental data indicate that the flow behaviour index of the foam remains approximately 0.09 across all tests, regardless of the type of sand used. In contrast, the model-derived generalised permeability coefficient strongly correlates with the effective particle size (d10) of the sand bed. Overall, the model effectively quantifies the foam penetration behaviour, accounting for changes in infiltration velocity and pore water pressure, which is essential for understanding the transfer of support pressure in EPB shield tunnelling.

Computerized Penetrometry Methodology Assisted by Advanced Algorithms Applied in the Multi-Dimensional Analysis of the Rheology of Mold-Ripened Cheeses

The main objective of this study is to understand the rheological behavior of various types of cheeses with mold subjected to multiple stresses during processing/handling, transport, or storage, aiming to maintain or even improve product quality, using computer-assisted penetration methods and advanced regression algorithms. Uniaxial penetration tests with a cone at a constant speed were conducted using a universal Hounsfield testing equipment connected to a computer to analyze the texture behavior (tangential stress, flow index, apparent viscosity) of four of the most common types of cheese with mold depending on the cone’s tip angle (9, 19, and 90 degrees) and penetration speed (12, 30, and 60 mm/min). From the results obtained for the four categories of mold cheeses (Brie, Camembert, Dorblue, and Roquefort), the amplitude of the speed and angle of penetration were considered as the main influencing factors for the shear deformation (τc), flow index (Kf), and apparent viscosity (ηa). The moisture and firmness of mold cheeses are closely linked and depend on the type of mold, the maturation process, or storage conditions. Careful control of these factors is essential to achieve the desired texture and taste characteristics in cheeses with mold.

A Survey on Penetration Path Planning in Automated Penetration Testing

Penetration Testing (PT) is an effective proactive security technique that simulates hacker attacks to identify vulnerabilities in networks or systems. However, traditional PT relies on specialized experience and costs extraordinary time and effort. With the advancement of artificial intelligence technologies, automated PT has emerged as a promising solution, attracting attention from researchers increasingly. In automated PT, penetration path planning is a core task that involves selecting the optimal attack paths to maximize the overall efficiency and success rate of the testing process. Recent years have seen significant progress in the field of penetration path planning, with diverse methods being proposed. This survey aims to comprehensively examine and summarize the research findings in this domain. Our work first outlines the background and challenges of penetration path planning and establishes the framework for research methods. It then provides a detailed analysis of existing studies from three key aspects: penetration path planning models, penetration path planning methods, and simulation environments. Finally, this survey offers insights into the future development trends of penetration path planning in PT. This paper aims to provide comprehensive references for academia and industry, promoting further research and application of automated PT path planning methods.

Chloro-aluminum phthalocyanine encapsulation into liquid crystalline nanodispersions enhance skin penetration and phototoxicity in skin cancer cells

Non-melanoma skin cancer is one of the most common tumors in the world. Photodynamic therapy (PDT) is currently a non-invasive therapeutic option for the treatment of skin cancer and actinic keratosis. Chloro-aluminum phthalocyanine (AlClPc) is a second-generation photosensitizer that has been studied for application in PDT. However, it has the disadvantage of self-aggregating in a biological environment, which impairs its therapeutic action, making it a candidate for nanocarrier delivery. Among the nanocarriers, liquid crystalline nanodispersions (LCN) are biocompatible and present unique organizational characteristics that make them suitable for skin delivery of drugs. Herein, a new LCN based on oleic acid (OA), Phosal 75SA® containing or not D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) was developed and characterized aiming its application for skin cancer. The selected LCN with AlClPc showed nanometric size (152.3 ± 1.93 nm), adequate PDI (0.231 ± 0.009) and encapsulation efficiency (70.26 ± 3.87 %) and stability for 30 days. Also, LCN were characterized by polarized light microscopy and small angle X-ray diffraction (SAXS) resulting in hexagonal liquid crystalline nanodispersions. In the in vitro skin penetration test, LCN-AlClPc showed better penetration into the deeper skin layers than the control. LCN-AlClPc showed greater phototoxicity in the A431 tumor cell line than the control in the same cell line and also greater phototoxicity in A431 when compared to L929 fibroblast cells. Thus, LCN developed could improve the phototoxicity and skin penetration in vitro and are potential drug delivery systems for the treatment of non-melanoma skin cancer.

A comparative study into the effect of spent coffee powder and ash on improving the mechanical properties of bitumen

Nowadays, waste and renewable materials are used to modify bitumen and asphalt, reduce costs, decrease the use of natural resources, and maintain ecological balance, and have thus received much attention. This study aimed to improve the rheological properties of bitumen and reduce spent coffee grounds' (SCG) waste by partially replacing it with SCG powder and ash. SCG powder and ash were added in percentages of 0, 1, 3, 5, and 8 wt percent of bitumen to check the properties of control and modified bitumens. Microstructural properties were evaluated by Fourier transform infrared spectroscopy, thermal gravimetric analysis, X-ray fluorescence spectroscopy (XRF), and scanning electron microscopy (SEM). Penetration, softening point, and ductility tests were performed to check the physical properties of bitumens, along with the storage stability test. Rheological tests (viscosity, bending beam rheometer (BBR), dynamic shear rheometer (DSR), multiple stress creep and recovery (MSCR), and linear amplitude sweep (LAS) were also carried out. According to the BBR results, adding SCG powder up to −12 °C and adding SCG ash up to −6 °C increased the resistance to low temperatures. Based on DSR and MSCR results, SCG, either in the form of ash or powder, increased the resistance to rutting, and adding SCG ash improved the high temperature performance of bitumen by 1 grade. At 64 °C, adding 8 % of SCG powder increased the rutting resistance by 43 %, and adding SCG ash raised the rutting resistance by about 113 %. LAS results also showed that SCG ash outperforms SCG powder in fatigue. Although both SCG powder and ash performed well in high, moderate, and low temperatures, SCG powder performed better in cold regions, and SCG ash performed better in regions with temperate and tropical climates.

Effect of high-density-polyethylene (HDPE) and waste tire rubber (WTR) on laboratory performance of styrene butadiene styrene (SBS) modified asphalt

To reduce the cost of SBS modified asphalt, we incorporated waste high-density polyethylene (HDPE) and waste tire rubber (WTR) as partial substitutes for SBS modifier. The performance parameters for HDPE, WTR, and SBS synergistic modified asphalt were designed using the response surface method. Specifically, modified asphalt groups with excellent conventional properties were identified through penetration, softening point, and ductility tests. The high/low-temperature rheological properties and anti-aging properties of the selected modified asphalt were investigated. The modification mechanism of the composite modified asphalt was studied using fluorescence microscopy (FM). Subsequently, a cost analysis of the modified asphalt was conducted. Based on the aforementioned studies, we recommend a composition of 1.5% SBS, 3% HDPE, and 10% WTR, which demonstrated superior performance compared to 4% SBS modified asphalt. Furthermore, the cost of the modified asphalt was found to be 13.3% lower than that of SBS modified asphalt.

The role of liquefaction in the evolution of shallow submarine canyon heads from a geotechnical perspective: A case study of the Garrucha Canyon (SE Mediterranean)

This work aims to establish the role of liquefaction in a shallow submarine environment defined by a canyon head reaching the coast. The study area is the Garrucha submarine canyon head, which is located in the western Mediterranean Sea.The potential of liquefaction is approached empirically by two methods in parallel, undrained cyclic direct simple shear (UCDSS) test and piezocone penetration test (CPTu) analyses. For both approaches, considering the regional earthquake records, a cyclic load linked to Mw ≤ 6.5 earthquake events or a maximum ground surface acceleration amax of 0.25 g is considered.The sediment samples analysed are nonplastic sands with low silt/clay contents and can be defined as liquefiable. Geotechnical analysis reveals a high probability of triggering liquefaction in this kind of sediment at depths greater than 3 m below the seafloor. CPTu records are used to assess and improve the liquefaction model for the study area by defining 3 different stratigraphic configurations or liquefiable conditions: uniformly liquefiable, interbedded liquifiable and nonliquefiable.This work highlights the importance of liquefaction—a process normally underestimated in submarine environments—in the downslope transport of sediment from the upper part of a canyon and, more generally, in canyon head evolution with different potential morphosedimentary consequences.

Large-scale agile security practices in software engineering

Purpose Security in large-scale agile is a crucial aspect that should be carefully addressed to ensure the protection of sensitive data, systems and user privacy. This study aims to identify and characterize the security practices that can be applied in managing large-scale agile projects. Design/methodology/approach A qualitative study is carried out through 18 interviews with 6 software development companies based in Portugal. Professionals who play the roles of Product Owner, Scrum Master and Scrum Member were interviewed. A thematic analysis was applied to identify deductive and inductive security practices. Findings The findings identified a total of 15 security practices, of which 8 are deductive themes and 7 are inductive. Most common security practices in large-scale agile include penetration testing, sensitive data management, automated testing, threat modeling and the implementation of a DevSecOps approach. Originality/value The results of this study extend the knowledge about large-scale security practices and offer relevant practical contributions for organizations that are migrating to large-scale agile environments. By incorporating security practices at every stage of the agile development lifecycle and fostering a security-conscious culture, organizations can effectively address security challenges in large-scale agile environments.

Mechanical Performance of a Hot Mix Asphalt Modified with Biochar Obtained from Oil Palm Mesocarp Fiber

A recently used material that shows environmental and technical advantages for use as an asphalt binder modifier is biochar (BC). Different biomasses can be converted into BC by pyrolysis. One agro-industrial biomass that is abundant in copious quantities is oil palm mesocarp fiber (OPMF) obtained from African palm cultivation. In the present study, the use of a BC obtained from OPMF (BC-OPMF) as a modifier of asphalt binder (AC type) to produce a hot mix asphalt (HMA) was evaluated. This type of BC has not been investigated or reported in the reference literature as a binder and/or asphalt mix modifier. Initially, AC was modified with BC in three ratios (BC/AC = 5, 10, and 15%, with respect to mass) to perform penetration, softening point, and rotational viscosity tests; rheological characterization at high and intermediate temperatures; and scanning electron microscope (SEM) visualization. Based on this experimental phase, BC/AC = 10% was chosen to manufacture the modified HMA. Resistance parameters under monotonic loading (stability—S, flow—F, S/F ratio of the Marshall test, and indirect tensile strength in dry—ITSD and wet—ITSC conditions) and cyclic loading (resilient modulus, permanent deformation, and fatigue resistance under stress-controlled conditions) were evaluated on the control HMA (AC unmodified) and the modified HMA. Additionally, the tensile strength ratio (TSR) was calculated to evaluate the resistance to moisture damage. Abrasion and raveling resistance were evaluated by performing Cantabro tests. BC-OPMF is shown to be a sustainable and promising material for modifying asphalt binders for those seeking to increase stiffness and rutting resistance in high-temperature climates, resistance to moisture damage, raveling, and fatigue without increasing the optimum asphalt binder content (OAC), changing the volumetric composition of the HMA or increasing the manufacturing and construction temperatures.

A lightweight carbon-incorporated polymer current collector for improving the performance and safety of lithium-ion batteries

The current collector plays a crucial role in transporting electrons and mechanical support of electrodes for lithium-ion batteries (LIBs). Commercial Cu and Al foil with high density deliver no capacity, so decreasing the weight of the metallic current collector is an effective method for enhancing the energy density of batteries. In this study, we prepared a carbon-incorporated polyimide (CIPI) current collector with a lightweight areal density of 1.41 mg cm−2 and voltage window of 0–5 V. CIPI can suppress the current collector corrosion and improve the long-term cycling performance of high-voltage cathode. Besides, CIPI decreases polarization resistance and relieves the volume expansion of SiOx particles, demonstrating a high capacity retention after 200 cycles. In nail penetration tests, the maximum temperature of the pouch battery with CIPI is only 46.73 % of the battery using Cu and Al foil. In addition, the mechanical flexibility makes CIPI suitable for flexible batteries, delivering ultra-stable voltage even when repeatedly folded in half. The CIPI opens a new pathway to develop high energy density and high safety LIBs and promotes the development of flexible and wearable storage devices.

Development of a Enhanced System Review for Public Agency Multi-Sectoral Integrated Data Systems

While traditional security assessments (such as mandated external security reviews which include a penetration test tied to a security framework) are a critical component to securing your data infrastructure, the complexities and governance structures around integrated data systems that involve multiple public sector agencies require a more comprehensive framework to address comprehensive risk, regulatory, and governance considerations that are critical to the confidentiality of the data within these systems. In January of 2024, the Data Integration Support Center (DISC) created and piloted an enhanced system review that includes components that are often overlooked or oversimplified when working with today's technologies such as cloud-based secure enclaves. By following up on a mandated security review, an enhanced system review can help a maturing Integrated Data System (IDS) address both security and privacy risks as it moves forward. An enhanced system review looks primarily, though not necessarily exclusively, at the following aspects of an IDS, principally in the interest of ensuring privacy: IDS alignment with its legal framework and other structuring documents (e.g., policies, procedures, interagency agreements) Training to support privacy and security Use of technology to prevent or mitigate human error The results of the review are provided directly to the IDS leadership and generally include a list of recommendations in the areas of improved legal agreements, leveraging privacy enhancing technologies to mitigate or reduce errors, procedural/policy gap identification and/or architectural recommendations to improve the security.

Impact of antiaging additives on the conventional properties of bituminous binder

Aging of binders is a complex phenomenon which reduces the longevity of flexible pavements. Aging involves change in physical, chemical, and morphological properties of binder which makes the binder brittle and highly susceptible to fatigue and thermal cracking. Antiaging additives enhance the service life of flexible pavements by reducing the impact of aging on the performance of binders. An iterative approach is essential to identify the optimal dosage of antiaging additive necessary to counteract the aging effects on binder. The present study aims to evaluate the mixing conditions for uniform dispersion of carbon black and hydrated lime within the binder matrix and thereby evaluate the impact of incorporating these antiaging additives on the conventional properties of binder. For this purpose, varying proportions of carbon black and hydrated lime are added to VG 30 binder and is subjected to softening point, ductility, and penetration tests. The optimal dosage of carbon black and hydrated lime is found to be 6 and 12% respectively based on their significant effects on the conventional properties of the binder. An optimal mixing duration of 60 and 75 min ensures uniform dispersion of carbon black and hydrated lime within the binder matrix at a mixing temperature of 120 °C and a speed of 1000 rpm thereby producing a homogenous binder mastic. Incorporation of antiaging additives up to the optimal dosage enhances the softening point whereas decreases the penetration and ductility of binder. The increase in softening point of binder with incorporation of carbon black and hydrated lime signifies enhanced resistance to rutting and permanent deformation of binder, whereas the reduction in ductility and penetration of binder with incorporation of carbon black and hydrated lime signifies the reduced susceptibility of binder to environmental factors such as temperature fluctuations, UV radiation, and oxidation. The surface texture of the additive influences the ability of binder adsorption, which subsequently affects the rheological properties of binder mastics. Significant improvement in conventional properties of binder with incorporation of carbon black and hydrated lime paves a viable and cost-effective solution for engineering application as it has a subsequent effect on the rheological properties of binder.

Multistep procedure for estimating non-linear soil response in low seismicity areas—a case study of Lucerne, Switzerland

SUMMARY The impact of non-linear soil behaviour on seismic hazard in low-to-moderate seismicity areas is often neglected; however, it may become relevant for long return periods. In this study, we used fully non-linear 1-D simulations to estimate the site-specific non-linear soil response in the low seismicity area, using the city of Lucerne in Switzerland as an example. The constitutive model considers the development of pore pressure excess and requires calibration of complex soil models, including the soil dilatancy parameters. In the absence of laboratory measurements, we mainly used the cone penetration test data to estimate the model variables and perform inversion for the dilatancy parameters. Our findings, using Swiss building code-compatible input ground motions, suggest a high probability of strong non-linear behaviour and the possibility of liquefaction at high ground motion levels in the case study area. While the non-linearity observations from strong-motion recordings are not available in Lucerne, the comparison with empirical data from other sites and other methods shows similarity with our predictions. Moreover, we show that the site response modelled is largely influenced by the strong pore pressure effects produced in thin sandy water-saturated layers. In addition, we demonstrate that the variability of the results due to the input motion and the soil parameters is significant, but within reasonable bounds.

Seismic site characterization baseline data for microzonation and site response analysis of Otuasega Town, Bayelsa State, Niger Delta region of Nigeria

This study presents the findings of a comprehensive geotechnical and seismic site investigation conducted at Otuasega Town located in Bayelsa State within the Niger Delta region of Nigeria. Subsurface exploration involved advancing 10 boreholes to 30 m depth using hollow stem auger drilling. Continuous disturbed and undisturbed soil sampling was performed at 1.5 m intervals for detailed geotechnical testing. Laboratory tests on the recovered soil samples established the index properties, classification, densities and consistency limits of the stratified deposits. The subsurface profile comprised alternating layers of clay, silt and sand typical of deltaic sediments, with the clay fractions exhibiting medium to high plasticity. Shear wave velocity (Vs) profiling using Multichannel Analysis of Surface Waves (WASW) techniques categorised the site predominantly as Site Class C and D based on international standards. The Standard Penetration Test (SPT) N-values ranged from 5 to 10, indicating soft normally consolidated clay conditions typical of the Niger Delta region. Predictive empirical models developed from the field and lab data showed strong correlations for estimating key geotechnical parameters such as SPT blow count, Vs and liquefaction resistance. Ground response analyses using the Vs and SPT data indicated significant site amplification potential, with peak ground accelerations up to 1.5 times the bedrock motion. Liquefaction analysis based on the empirical SPT-based methods revealed a high potential for liquefaction in the sandy layers, especially under strong earthquake shaking. The study characterized the complex sedimentology and provided baseline information for seismic microzonation and site-specific ground response analyses to advance understanding of geohazards in this delta environment.

Improving erosion resistance of calcareous sand slope with zinc sulfate solution

Loose and uncemented calcareous sand slopes are prone to collapse under rainstorm erosion. In order to improve the erosion resistance stability of slopes, it is crucial to enhance the erosion resistance of calcareous sand. In this study, a new method of cementing calcareous sand with zinc sulfate solution (ZSS) is proposed. The ZSS reinforcement technique can effectively cement calcareous sand, enhance the mechanical properties and help reduce erosion on calcareous sand slopes. A series of laboratory experiments were conducted, including uniaxial compression tests, Brazilian splitting tests, surface penetration tests, microscopic tests, and rainfall scouring tests. The test results show that the uniaxial compressive strength of calcareous sand achieved 8.3 MPa reinforced with ZSS. Microscopic analyses revealed the mechanism of reinforcement, discovering the formation of environmentally friendly compounds such as ZnCO3 and CaSO4·2 H2O between calcareous sand particles, which enhanced the soil mechanical properties. The calcareous sand slope reinforced with ZSS forms a hard shell on the slope surface, which effectively improves the erosion resistance of the slope. After being reinforced with a ZSS concentration of 1.0 mol/L, the slope remained stable after 20 min of scouring at a rainfall intensity of 80 mm/h. This method provides a quick solution for reinforcing calcareous sand slopes and holds promising potential for practical engineering applications.

AHT-QCN: Adaptive Hunt Tuner Algorithm Optimized Q-learning Based Deep Convolutional Neural Network for the Penetration Testing

Abstract Penetration Testing (PT), which mimics actual cyber attacks, has become an essential procedure for assessing the security posture of network infrastructures in recent years. Automated PT reduces human labor, increases scalability, and allows for more frequent evaluations. Real-world exploitation still challenges RL-based penetration testing because the agent’s many possible actions make it hard for the algorithm to converge. To resolve these shortcomings, a deep learning- model named Adaptive Hunt Tuner algorithm optimized Q-learning based deep Convolutional neural Network (AHT-QCN) is developed for efficient PT. Specifically, the Q-learning employed in this model improves its efficiency by enabling optimal policy learning for decision-making. In addition, the Adaptive Hunt Tuner (AHT) algorithm enhances the model’s performance by tuning its parameters with reduced computational time. The experimental outcomes demonstrate that the developed model attains 95.25% accuracy, 97.66% precision, and 93.81% F1 score.

Effect of adding sodium fluoride and nano-hydroxyapatite nanoparticles to the universal adhesive on bond strength and microleakage on caries-affected primary molars.

Evaluation of micro tensile bond strength (μTBS) and marginal leakage of sodium fluoride (NaF) and nano-hydroxyapatite (n-HA) modified universal adhesives (UAs) bonded using etch-and-rinse (ER) and self-etch (SE) bonding technique to the carious affected dentin (CAD). One hundred and twenty primary molars were prepared for CAD on the occlusal surface. The occlusal CAD surface was flattened and underwent a polishing procedure. The specimens were divided into six groups using a random allocation method based on the UAs applied and the mode of etching used (n = 20) Group A1: UAs (ER), Group B1: UAs (SE), Group A2: UAs (NaF) + ER, Group B2: UAs (NaF) + SE, Group A3: UA (n-HA) + ER and Group B3: UAs (n-HA) + SE. Composite restoration was placed and samples were thermocycled. Microleakage, μTBS, and failure mode assessment were performed using a dye penetration test, universal testing equipment, and stereomicroscope respectively. The μTBS and microleakage results (mean ± SD) were examined using analysis of the variance (ANOVA) and Tukey post hoc tests. Group B1 (UAs + SE) demonstrated the maximum scores of microleakage (25.14 ± 9.12 nm) and minimum recorded value of μTBS (14.16 ± 0.55 MPa). In contrast, Group A3 (UAs (n-HA) + ER) displayed a minimum value of marginal leakage (12.32 ± 6.33 nm) and maximum μTBS scores (19.22 ± 0.92 MPa). The outcomes of the intergroup comparison analysis showed that Group A2 (UAs (NaF) + ER), Group B2 (UAs (NaF) + SE), Group A3 (UA (n-HA) + ER) and Group B3 (UAs (n-HA) + SE) presented comparable outcomes of marginal seal outcomes and μTBS scores (p > 0.05). NaF and n-HA-modified UAs displayed favorable bond strength and minimum marginal leakage to the deciduous affected dentin surface.

Leveraging Bayesian methods for addressing multi-uncertainty in data-driven seismic liquefaction assessment

When assessing seismic liquefaction potential with data-driven models, addressing the uncertainties of establishing models, interpreting cone penetration tests (CPT) data and decision threshold is crucial for avoiding biased data selection, ameliorating overconfident models, and being flexible to varying practical objectives, especially when the training and testing data are not identically distributed. A workflow characterized by leveraging Bayesian methodology was proposed to address these issues. Employing a Multi-Layer Perceptron (MLP) as the foundational model, this approach was benchmarked against empirical methods and advanced algorithms for its efficacy in simplicity, accuracy, and resistance to overfitting. The analysis revealed that, while MLP models optimized via maximum a posteriori algorithm suffices for straightforward scenarios, Bayesian neural networks showed great potential for preventing overfitting. Additionally, integrating decision thresholds through various evaluative principles offers insights for challenging decisions. Two case studies demonstrate the framework's capacity for nuanced interpretation of in situ data, employing a model committee for a detailed evaluation of liquefaction potential via Monte Carlo simulations and basic statistics. Overall, the proposed step-by-step workflow for analyzing seismic liquefaction incorporates multifold testing and real-world data validation, showing improved robustness against overfitting and greater versatility in addressing practical challenges. This research contributes to the seismic liquefaction assessment field by providing a structured, adaptable methodology for accurate and reliable analysis.

Expert consensus on the technical specifications of the in vitro skin penetration test of cosmetic product by Franz diffusion cell

BackgroundDiffusion cell test is one of the most commonly used in vitro model to detect the percutaneous absorption of cosmetic ingredients. Although PRC State Administration of Quality Supervision and Quarantine has issued the guideline for the in vitro test method for the percutaneous absorption of drug molecules, there is still a lack of guideline for the percutaneous absorption test of cosmetic components. ObjectiveIn order to improve the standardized level and make the in vitro percutaneous absorption test of cosmetic ingredients more comparable, based on the international and domestic experience, Transdermal Drug Delivery Committee of the World Federation of Chinese Medicine Societies organized the experts to discuss and formed this consensus as reference for the percutaneous absorption test of cosmetic components. Materials and MethodsTo standardize the in vitro diffusion cell test technique for transdermal penetration of functional cosmetic ingredients, the Transdermal Drug Delivery Professional Committee of the World Federation of Societies of Traditional Chinese Medicine has organized many discussions among experts. ResultsThe expert group established this expert consensus by integrating international requirements, domestic practice, and the experience of experts. ConclusionThis consensus provides technical operation recommendations for the detection of cosmetic percutaneous permeation in in vitro diffusion cells to reduce the differences between studies. Cosmetic formulations with different compositions and types may show different release kinetics, and this consensus does not cover all possible situations.