<p>Bio-liquid fuel is one of the effective ways to alleviate energy shortages and reduce greenhouse gas emissions. Sweet sorghum, as an energy crop used in fuel ethanol production, has enormous potential for development. However, due to seasonality, vulnerability, and logistical scheduling costs during transportation, the sweet sorghum ethanol supply chain faces significant difficulties and challenges in its development. To address the research gap, this paper proposes a multi-objective sustainable supply chain optimization model for Chinese sweet sorghum bioenergy based on mixed-integer linear programming. In this framework, the crop growth process model is first spatially extended to obtain the feedstock sources of the sweet sorghum ethanol supply chain. Then a site selection model for the feedstock collection stations and ethanol processing plants is constructed based on the geographic information system (GIS) to determine the candidate locations of the basic units of the sweet sorghum ethanol supply chain. Finally, a multi-objective supply chain optimization model based on the mixed-integer linear programming methodology is created to achieve the sweet sorghum ethanol supply chain layout and optimization at the national level. This framework takes into account the fuel ethanol market demand in China and the current state of the sweet sorghum ethanol supply chain industry, achieving national-level layout and optimization of the sweet sorghum ethanol supply chain. The total aboveground biomass (dry weight) of sweet sorghum on marginal land in China can be converted into approximately 37.212 million tons of fuel ethanol production, meeting the requirement to promote a nationwide 10% substitution rate for automotive ethanol gasoline. The lowest-cost supply chain layout scheme suggests establishing large ethanol processing plants near the Hu Huanyong Line, as this area benefits from abundant sweet sorghum yield on marginal lands and lower east-west direction transportation costs. However, the lowest carbon emission supply chain layout scheme recommends reducing the raw material supply area and increasing the ethanol transportation route to lower carbon emissions. The results of the sensitivity analyses indicate that lowering feedstock production and increasing ethanol demand increases the overall cost and carbon emissions of the sweet sorghum ethanol supply chain, while using rail transportation methods, increasing feedstock production, and decreasing ethanol demand reduces costs and carbon emissions.</p>
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