Ti-HMS, MCM-41 and FSM-16, which are typical hexagonal mesoporous silicas, were attempted to use as a promoter for organic synthesis. Ti-HMS, which possesses Lewis acid sites due to Ti-atom, was found to accelerate deprotection of benzyl groups, which is a typical protective group of hydroxyl group, selectively under hydrogenolytic conditions with palladium catalyst even in the presence of acid-sensitive functional groups such as silyl ether and acetal moieties in the molecule. MCM-41 proved to deprotect triethylsilyl (TES) group, which is another typical protective group of hydroxyl group, selectively and easily in the presence of t-butyldimethylsilyl (TBS) group. FSM-16 was found to accelerate several photo-reaction such as oxidative photodecarboxylation of α-hydroxy carboxylic acid, oxidation of arylmethylhalides and arylmethylalcohols, and oxidative cleavage of styrenes. Efficiency of these reactions was investigated concerning the solvent effect and activities of the promoters including common zeolites and ion-exchange resins.