In the present paper, the process of estimating the important statistical properties of extreme wind loads on structures is investigated by considering the effect of large variability. In fact, for the safety design and operating conditions of structures such as the ones characterizing tall buildings, wind towers, and offshore structures, it is of interest to obtain the best possible estimates of extreme wind loads on structures, the recurrence frequency, the return periods, and other stochastic properties, given the available statistical data. In this paper, a Bayes estimation of extreme load values is investigated in the framework of structural safety analysis. The evaluation of extreme values of the wind loads on the structures is performed via a combined employment of a Poisson process model for the peak-over-threshold characterization and an adequate characterization of the parent distribution which generates the base wind load values. In particular, the present investigation is based upon a key parameter for assessing the safety of structures, i.e., a proper safety index referred to a given extreme value of wind speed. The attention is focused upon the estimation process, for which the presented procedure proposes an adequate Bayesian approach based upon prior assumptions regarding (1) the Weibull probability that wind speed is higher than a prefixed threshold value, and (2) the frequency of the Poisson process of gusts. In the last part of the investigation, a large set of numerical simulations is analyzed to evaluate the feasibility and efficiency of the above estimation method and with the objective to analyze and compare the presented approach with the classical Maximum Likelihood method. Moreover, the robustness of the proposed Bayes estimation is also investigated with successful results, both with respect to the assumed parameter prior distributions and with respect to the Weibull distribution of the wind speed values.