ABSTRACT Early and reliable flood forecasting is crucial for mitigating the impacts of floods and ensuring the safe operation of irrigation and hydroelectric facilities. Traditional methods often use a calibrated event-based rainfall-runoff model with a limited number of simulations, making it difficult to measure parameter uncertainties accurately. This paper introduces a new method for estimating the parameters of the HEC-HMS model and evaluating the uncertainties in real-time flood forecasting. First, the Latin Hypercube Sampling (LHS) procedure is used to efficiently sample the parameter values throughout the feasible parameter space. Next, thousands of parameter sets are simulated using a deterministic rainfall-runoff model, generating numerous initial solutions for the Shuffled Complex Evolution (SCE-UA) algorithm to search and evolve. Additional parameter sets are then generated as the search evolves, leading to new simulations until the algorithm reaches the convergence criteria. The optimal solutions are selected based on predefined multiple objective functions. Uncertainty of the forecast results is also computed using the Generalized Likelihood Uncertainty Estimation (GLUE) method and represented as confidence intervals. The method was applied to forecast flood hydrographs at the Krong H’nang hydropower reservoir in Vietnam, using data from 33 flood events from 2016 to 2021. The results demonstrate that the program can effectively forecast the flood hydrograph up to 4 hours in advance (the Kling-Gupta efficiency KGE > 0.8 and the absolute relative volume error |VE| < 10%). The observed values fall within the uncertainty range of Q5%-Q95%. Compared to the conventional method, which uses a fixed parameter set value, this approach is superior and therefore can assist policymakers and operators in more effectively managing reservoir operations.