Vegetation net primary productivity (VNPP) is the main factor in ecosystem carbon sink function and regulation of environmental processes. However, NPP data products have data missing in some areas, which affects the availability and overall accuracy level of data. Therefore, we adopted the Factor Analysis Backpropagation neural network model (FA-BP model) to acquire a high-accuracy and high-reliability NPP result without missing or empty areas by using a series of easily accessible datasets, such as meteorological data and remote sensing data. We selected the western Sichuan region as the study area and carried out a VNPP time series estimation from 2000 to 2016. Comparative simulations also verify the accuracy of the time series estimation results: The Pearson correlation r of VNPP prediction results ranged from 0.807 to 0.917, the mean absolute error ranged from 29.1 to 38.9, the root mean square error was between 37.3 and 51.8, and the mean relative error varies from 0.10 to 0.14. Further analysis shows that the spatial pattern of estimated VNPP during the past 17 years in western Sichuan shows a decreasing trend from southeast to northwest. Besides, the VNPP time series is generally on an upward trend in this period. The increasing and decreasing areas of VNPP values in the study area accounted for 81.42% and 18.58%, respectively. Moreover, we find that temperature dominates the change of VNPP in the whole western Sichuan region. The data processing method and experimental results presented in this paper can provide a reference for accurately acquiring VNPP and related studies on natural resources and climate change.