In order to solve the problem that the traditional artificial heart pump has poor dynamic bionic performance and cannot respond to blood perfusion in real time according to the patient’s state, this paper proposes a new physiological control method based on adaptive adjustment of heart rate. Firstly, a coupled model of the cardiovascular circulatory system and artificial heart pump was established, and the correctness of the model is verified by hemodynamic simulation. Secondly, according to the model-free adaptive control theory, the artificial heart pump physiological control strategy for adaptive regulation of heart rate is designed, including pseudo partial derivative estimation algorithm and adaptive control law. Then, the parameters of the adaptive controller are optimized by the improved beetle antennae search algorithm. Finally, the auxiliary effect and dynamic performance of the adaptive control strategy are studied by numerical methods. The results show that the physiological control method based on adaptive regulation of heart rate realizes the adaptive modulation of heart rate and blood flow, which can meet the needs of blood perfusion in different states and help to promote the recovery of damaged heart.