Essential Connections Research Articles

DATA DISTRIBUTION METHOD WITH TEXT EXTRACTION FROM BIG DATA

Right now, Enormous information extraction strategies incorporate the recognition of examples and secured connections between factors numbering and acquire the necessary data. A quick examination of monstrous information can prompt the development and ideas of the hypothetical worth. Contrasted and comes about because of mining between customary informational indexes and the immense measure of huge heterogeneous information associated it can extend the information and thoughts regarding the objective space. Data isolating in immense data examination is creating as a helpful resource for outfitting the force of unstructured scholarly data by separating it to expel new data and to perceive essential models and connections concealed in the data. At present, we isolated the information on gigantic measures of the pages and examined the pages of the site using Java code, and we incorporated the removed information into a remarkable database for the site page. We utilized the information arrange capacity to get precise consequences of assessing and classifying the information pages discovered, which recognizes the believed web or unsafe site pages, and imported the information onto a CSV expansion. Large information emerges new difficulties for IE methods with the quick development of multifaceted likewise called multidimensional unstructured information. Conventional IE frameworks are wasteful to manage this tremendous downpour of unstructured large information. The volume and assortment of huge information request to improve the computational capacities of these IE frameworks. It is imperative to grasp the competency and limitations of the present IE methods related to data pre-taking care of, data extraction and change, and depictions for gigantic volumes of multidimensional unstructured data. Different assessments have been driven on IE, watching out for the challenges and issues for different data types, for instance, content, picture, sound, and video.

Inhabiting (CC.) ‘Religion’ in Hegel’s Phenomenology of Spirit to Develop an Ambedkarite Critique of the Blasphemous Nucleus of Upanishadic Wisdom

This paper begins with several opening passages from the most esoteric writings in Hinduism’s vast, ancient religious-philosophical heritage, namely the Upanishads. The aim is to reveal certain essential connections between the primordial relation between self and sacrifice while exploring uncanny paradoxes of eternity and time, immortals and mortals and their secret linkages. The work is entirely philosophical in its intent and does not aspire to defend a faith-perspective. The horizon for this exposition follows the spirit of Ambedkar’s critique of Brahmanic superiority inherent in this entire system of religious thought: we must expose what lies in the heart of modern Hinduism to reveal its inner-contradictory entanglements, which are not exactly innocuous. A phenomenological-deconstructive inspiration motivates our own critical theoretical-philosophical conceptualizations beyond Ambedkar’s basic attestation to liberate India from Hinduism. The enterprise derives from a speculative appropriation and extension of the depths of (CC.) ‘Religion,’ the penultimate chapter of Hegel’s indomitable Phenomenology of Spirit (1807). The aim of the paper is to advance new philosophical theses in an unrelenting metaphysical critique of Hinduism– beyond Ambedkar’s writings–but also in a manner that is irreducible to the Western philosophical cosmos within which the nineteenth-century Hegel inhabited. The paper argues that the internal contradictions and aporias of mortality, immortality, self, bodyhood, time, and eternity in the Hindu Upanishads can be contrasted with Hegel’s speculative Western-Christological propositions to expose a greater metaphysical complexity that escapes Eastern and Western religious and philosophical traditions alike. Therefore, the paper falls within the scope of comparative philosophies of religion.

Offer, consumption and freedom of information in the context of assisted reproduction in the digital age: problematizing contractual guiding principles

ABSTRACT In this paper we focus on the offer of assisted reproduction (AR) services in Brazil, and in this context we focus on important regulatory instruments that guide contractual relationships in the consumption of medical procedures and rights to information, considering their wide popularization through social media. The methodological discussion seeks to collate legal reflections and sociocultural studies of offers of AR, consumption and access to information on AR. Bio-rights, a recent field of knowledge that embraces life and human reproduction, is a rich source for rising debates on AR that allows us to establish essential connections between fields of knowledge that can improve situations of non-access to information. A renewed reading of contractual relations is sought, as well as a critical outlook on the diffusion of AR technical knowledge. For this, we carefully consider the principles of new contractual theory, constitutional parameters, principalism, and basic consumer rights. This is an incipient regulation where contractual relationships touch complex topics that involve procedural success/failure rates, genetic material exchange and confidentiality. The validity of such principles as an aid to legal interpretations of concrete cases must be reconsidered in a situation characterized by legal precarity and reckless dissemination of information.

Modeling essential connections in obsessive–compulsive disorder patients using functional MRI

ObjectObsessive–compulsive disorder (OCD) is a mental disease in which people experience uncontrollable and repetitive thoughts or behaviors. Clinical diagnosis of OCD is achieved by using neuropsychological assessment metrics, which are often subjectively affected by psychologists and patients. In this study, we propose a classification model for OCD diagnosis using functional MR images.MethodsUsing functional connectivity (FC) matrices calculated from brain region of interest (ROI) pairs, a novel Riemann Kernel principal component analysis (PCA) model is employed for feature extraction, which preserves the topological information in the FC matrices. Hierarchical features are then fed into an ensemble classifier based on the XGBoost algorithm. Finally, decisive features extracted during classification are used to investigate the brain FC variations between patients with OCD and healthy controls.ResultsThe proposed algorithm yielded a classification accuracy of 91.8%. Additionally, the well‐known cortico–striatal–thalamic–cortical (CSTC) circuit and cerebellum were found as highly related regions with OCD. To further analyze the cerebellar‐related function in OCD, we demarcated cerebellum into three subregions according to their anatomical and functional property. Using these three functional cerebellum regions as seeds for brain connectivity computation, statistical results showed that patients with OCD have decreased posterior cerebellar connections.ConclusionsThis study provides a new and efficient method to characterize patients with OCD using resting‐state functional MRI. We also provide a new perspective to analyze disease‐related features. Despite of CSTC circuit, our model‐driven feature analysis reported cerebellum as an OCD‐related region. This paper may provide novel insight to the understanding of genetic etiology of OCD.

Perineuronal net expression in the brain of a hibernating mammal.

During hibernation, mammals like the 13-lined ground squirrel cycle between physiological extremes. Most of the hibernation season is spent in bouts of torpor, where body temperature, heart rate, and cerebral blood flow are all very low. However, the ground squirrels periodically enter into interbout arousals (IBAs), where physiological parameters return to non-hibernating levels. During torpor, neurons in many brain regions shrink and become electrically quiescent, but reconnect and regain activity during IBA. Previous work showed evidence of extracellular matrix (ECM) changes occurring in the hypothalamus during hibernation that could be associated with this plasticity. Here, we examined expression of a specialized ECM structure, the perineuronal net (PNN), in the forebrain of ground squirrels in torpor, IBA, and summer (non-hibernating). PNNs are known to restrict plasticity, and could be important for retaining essential connections in the brain during hibernation. We found PNNs in three regions of the hypothalamus: ventrolateral hypothalamus, paraventricular nucleus (PVN), and anterior hypothalamic area. We also found PNNs throughout the cerebral cortex, amygdala, and lateral septum. The total area covered by PNNs within the PVN was significantly higher during IBA compared to non-hibernating and torpor (P < 0.01). Additionally, the amount of PNN coverage area per Nissl-stained neuron in the PVN was significantly higher in hibernation compared to non-hibernating (P < 0.05). No other significant differences were found across seasons. The PVN is involved in food intake and homeostasis, and PNNs found here could be essential for retaining vital life functions during hibernation.

The sound world of the alienated film character

Alienation is a concept interpreted from different angles and used in various areas of human thought: in philosophy, psychology, sociology, law, and economics. Some theoretical works and those works of art which center on the phenomenon of alienation, emphasize three main aspects of this phenomenon: alienation as the loss of essential connections (identification) with the outside world (society, social group, nature); with close people (the loved one, family, friends) and, ultimately, with oneself, the true self. It is these aspects of the understanding of alienation that can also be seen in cinema an art form which, perhaps, responds to the problems and events of contemporary reality in the quickest and most vivid way. Most frequently, the theme of alienation in the film is based on the development of the artistic image of one as a rule, the main character. Despite the fact that alienation a priori implies the alienation of the actors performance and the minimization of expressive means, the ideas and deep meanings that are very important for the director, the directors aesthetic and ethical principles and his or her interpretation of contemporary problems are often conveyed through the image of the alienated character. The essay deals with the visual and sound techniques and the semantics of word and music employed in the process of creating the inner and the outer worlds of an alienated film character.

Fuzzifying interval operators, fuzzifying convex structures and fuzzy pre-orders

The paper presents essential connections between fuzzifying convexities, fuzzifying interval operators and fuzzy pre-orders. Firstly, we study the relationship between fuzzifying convex structures and fuzzifying interval operators on a universal set. Secondly, we show that there exists a connection between based-point fuzzy orders and geometric fuzzifying interval operators on fuzzy partially ordered sets. Finally, we establish a connection between fuzzifying convexities and fuzzy pre-orders.

Analytical model of hypervelocity penetration into rock

The results of dynamic compression tests of the rock revealed that the actual working pressure ranged from 5 GPa to 20 GPa when the penetration velocity ranged from 1000 m/s to 4000 m/s. The region is exactly the transition area where the compression state changes from elastoplasticity to hydrodynamics, and the rock is subject to restricted internal friction. Also the region lacks accurate representation in existing penetration theories. A study of the hydrodynamic was performed by using the internal friction theory. Equations were systematically presented which covered and linked up the elastoplasticity-semifluid with internal friction and hydrodynamic pressure. And the essential connections and differences between the penetration of hypervelocity kinetic energy bombs and common penetrating bombs were illuminated. Furthermore the velocity region of hypervelocity was demarcated theoretically, illuminating the transformation of the target medium with the increased penetration velocity from elastoplasticity to semifluid with internal friction and hydrodynamics. The calculations revealed the characteristic phenomenon that the decrease of penetration depth in that the abrasion of the bomb mass and the existence of a limitation depth. In conclusion the formulas to calculate the depth and diameter of the crater were presented.

Media portrayal of sportswomen in East Asia: A systematic review

It has been widely recognized that women in Western countries are marginalized in the sports field, and sports media is one of the institutions that strengthens such trivialization. However, there are very few studies investigating women in sports in countries outside of Europe and the USA. The aim of this study is to review how sportswomen are portrayed in sports media in China, Japan, South Korea and North Korea. East Asian media is congruous in its disparities regarding quantity of coverage between domestic athletes and abroad athletes, between sportsmen and sportswomen, and between international events and local events. Narratives and commentary focus on nationalism, appropriate femininity, non-sports related aspects of sportswomen’s lives, and the dual identities of sportswomen. Some slight differences regarding quantity, narratives and commentary exist between the four countries. In its current state, scholarly research on media images of sportswomen is contradictory and too limited. Overall, more studies regarding how sportswomen are represented in East Asian media are needed, with further considerations of social media and media autonomy while making essential connections to social and cultural contexts.

Afropolitanism, celebrity politics, and iconic imaginations of North–South relations

‘Afropolitanism’ has become a disputed term referring to diverse engagements by Africans who are typically members of the cultural elite and participate in diaspora politics, online activism, fashion and literature debates. Simultaneously, in discussions of development aid, celebrity has become a way of mediating between proximity and distance in imagining relationships between South and North. Afropolitanism can be usefully considered as an Africa-specific, post-colonial form of cosmopolitanism that spans discourses of elite pan-African culture to theories of elite global aid culture. We argue that there are essential connections between the rise of Afropolitanism and the celebritization of North–South relations. In this realm, ‘Afropolitanism’ is an idea combining cosmopolitanism’s notions of kindness to strangers in a world where the ‘kindness’ is aid and the ‘strangers’ are Africans. We analyse two archetypical Afropolitan performances by Danish aid celebrities to argue that their representations of Africa’s external relations are theoretically more interesting, and politically more dangerous, than is currently understood. In doing so, we expand the debates around Afropolitanism and celebritization from the realm of cultural politics to one of International Relations.

646 - Coordinating an Immunotherapy Trial for High Risk Pediatric Patients

Over the past decade, chimeric antigen receptor T-cell therapy, CAR T-cell therapy, has virtually transformed the fight against pediatric leukemia and lymphoma. An increasing number of institutions both large and small have begun to show interest in conducting their own CAR T-cell therapy trials. Sharing the knowledge and best practices gained over years of successful clinical research at Children's Hospital of Philadelphia (CHOP) offers the opportunity to promote safe, effective, and efficient therapy programs across the country. The evolution of immunotherapy at CHOP from a single clinical trial to a successful clinical research program necessitated a systematic approach to conducting research from patient referral through completion of the study and long-term follow-up. In order to build and maintain a program of this complexity, the clinical research coordinators (CRCs) developed a robust infrastructure, including effective personnel training and resource utilization. Well-organized communication ensured the safe and accurate management of the most critical time-sensitive intricacies of immunotherapy: on- or off-site apheresis, manufacturing and infusion of cells, and acute follow-up. In addition, the CHOP CRCs grew healthy long-standing relationships with outside hospitals, which created essential connections throughout the trials. Lastly, the success of these studies relied on the CRCs' role in meticulous regulatory compliance and safety reporting. Collaboration and structure are the foundation of any successful clinical research program, and the demanding high-risk nature of immunotherapy research increases that exponentially. As such, the expertise CHOP CRCs gained through hands-on coordination of these complex trials can act as a template for institutions looking to build their own immunotherapy programs.

Dysregulation of AKT3 along with a small panel of mRNAs stratifies high-grade serous ovarian cancer from both normal epithelia and benign tumor tissues.

Screening methods of High-Grade Serous Ovarian Cancer (HGSOC) lack specificity and sensitivity, partly due to benign tumors producing false-positive findings. We utilized a differential expression analysis pipeline on malignant tumor (MT) and normal epithelial (NE) samples, and also filtered the results to discriminate between MT and benign tumor (BT). We report that a panel of 26 dysregulated genes stratifies MT from both BT and NE. We further validated our findings by utilizing unsupervised clustering methods on two independent datasets. We show that the 26-genes panel completely distinguishes HGSOC from NE, and produces a more accurate classification between HGSOC and BT. Pathway analysis reveals that AKT3 is of particular significance, because of its high fold change and appearance in the majority of the dysregulated pathways. mRNA patterns of AKT3 suggest essential connections with tumor growth and metastasis, as well as a strong biomarker potential when used with 3 other genes (PTTG1, MND1, CENPF). Our results show that dysregulation of the 26-mRNA signature panel provides an evidence of malignancy and contribute to the design of a high specificity biomarker panel for detection of HGSOC, potentially in an early more curable stage.

Data-Driven Topological Filtering Based on Orthogonal Minimal Spanning Trees: Application to Multigroup Magnetoencephalography Resting-State Connectivity.

In the present study, a novel data-driven topological filtering technique is introduced to derive the backbone of functional brain networks relying on orthogonal minimal spanning trees (OMSTs). The method aims to identify the essential functional connections to ensure optimal information flow via the objective criterion of global efficiency minus the cost of surviving connections. The OMST technique was applied to multichannel, resting-state neuromagnetic recordings from four groups of participants: healthy adults (n = 50), adults who have suffered mild traumatic brain injury (n = 30), typically developing children (n = 27), and reading-disabled children (n = 25). Weighted interactions between network nodes (sensors) were computed using an integrated approach of dominant intrinsic coupling modes based on two alternative metrics (symbolic mutual information and phase lag index), resulting in excellent discrimination of individual cases according to their group membership. Classification results using OMST-derived functional networks were clearly superior to results using either relative power spectrum features or functional networks derived through the conventional minimal spanning tree algorithm.

The use of high-throughput screening techniques to evaluate mitochondrial toxicity

Toxicologists and chemical regulators depend on accurate and effective methods to evaluate and predict the toxicity of thousands of current and future compounds. Robust high-throughput screening (HTS) experiments have the potential to efficiently test large numbers of chemical compounds for effects on biological pathways. HTS assays can be utilized to examine chemical toxicity across multiple mechanisms of action, experimental models, concentrations, and lengths of exposure. Many agricultural, industrial, and pharmaceutical chemicals classified as harmful to human and environmental health exert their effects through the mechanism of mitochondrial toxicity. Mitochondrial toxicants are compounds that cause a decrease in the number of mitochondria within a cell, and/or decrease the ability of mitochondria to perform normal functions including producing adenosine triphosphate (ATP) and maintaining cellular homeostasis. Mitochondrial dysfunction can lead to apoptosis, necrosis, altered metabolism, muscle weakness, neurodegeneration, decreased organ function, and eventually disease or death of the whole organism. The development of HTS techniques to identify mitochondrial toxicants will provide extensive databases with essential connections between mechanistic mitochondrial toxicity and chemical structure. Computational and bioinformatics approaches can be used to evaluate compound databases for specific chemical structures associated with toxicity, with the goal of developing quantitative structure-activity relationship (QSAR) models and mitochondrial toxicophores. Ultimately these predictive models will facilitate the identification of mitochondrial liabilities in consumer products, industrial compounds, pharmaceuticals and environmental hazards.

The research potential of educational theory: On the specific characteristics of the issues of education

In this article, I present the argument that educational theory has specific character, which distinguishes it from most scientific disciplines. It requires the application of not only strictly scientific methods, which essentially consist of descriptions and explanations, but also normative ones, which indicate how it is related to philosophy and ethics. Its essential connections with philosophy and ethics cause that clear and final thesis (e.g. about educational aims) are actually impossible to claim, but from the other hand, it is the only discipline (excluding normative ethics) which, according to its definition, tries to answer practical-moral questions.The crucial elements of this analysis are (1) the presentation of the justification of a thesis on the specific character of educational theory, which will be accomplished with the concept of “research potential”, formulated for its purposes, and (2) showing the consequences of this particular characteristic of the discipline being discussed.

HEALTH RELATED FITNESS (H-RF) OF OBESE AND OVERWEIGHT CHILDREN FROM MALOPOLSKA REGION – PART I. girls

Aim of research. Basing on the results of the researches conducted on 3221 girls from Małopolska in years 1996-2005 some hypothesis were verified about ontogenetic period ap-pearance of: the negative influence of too low and too high fatness level on the positive health measures level, and the similar structure of the physical efficiency analyzed referring to health and the similar strength of the correlation connection between its elements and the height-weight index (Quetelet II) sorted in groups according to BMI level. Methods. The results of the positive health indexes were analyzed such as: the basic somat-ic features, antropometric indexes, the oxygen efficiency (VO2 max), motor ability tested on Eurofit and MTSF tests. Basing on the average value and the standard aberration of BMI all tested girls were divided into 3 groups: 8-10, 13-14, 17-18. In every group the range and the trend of the considering features differentiations were discerned and only in two groups (above and below the range of 1 SD BMI) the concentration analysis was conducted where the strength of the correlation connection between the elements of the physical efficiency structure, tested according to the relation of health and BMI level, were estimated. Results. The researches confirmed the accepted hypothesis about the negative influence of low and high fatness level, tested by BMI indexes, on the selected indexes of the positive health. The results of the concentration analysis and the Pearson’s correlation between BMI index and the physical efficiency’s elements tested referring to health show the reason to claim there are similar connections between the elements of the physical efficiency and the hierarchic structure in the group of individuals of low and high fatness. The statistically es-sential correlations only between efficiency’s morphologic components and BMI were found. Conclusion. The conducted researches confirmed: 1. The negative influence of too low and too high level of fatness on the level of the health positive indexes, 2. The statistically essen-tial correlation connections only between BMI and the somatic features which measure a body’s fatness, 3. The poor relations between BMI level and the positive health measures such as: physical efficiency, motor ability, 4. The similar structure of the physical efficiency tested referring to health in groups of lower and higher level of fatness.

Super Tall Timber: design research for the next generation of natural structure

This research project aspires to make truly tall timber buildings a reality. Through a combination of theoretical design and physical testing this research demonstrates the viability of timber buildings at much greater heights than has previously been possible. By pushing the limits of theoretical designs into the realms of the supertall, sometimes beyond that which is feasible using current materials and construction technologies, this research also sets out the requirements for the next generation of engineered plant-based materials.The research is a collaboration between academics, practising architects and practising structural engineers. The approach is research through design, and design through research. Timber towers are designed well beyond existing heights, and analysed to understand how they stand up and which areas are most critical for further research. By bringing highly regarded architectural and structural designers together with the research capabilities of a leading university, this project creates a precedent-setting model for interdisciplinary engagement within and between the design and research communities. By coupling exemplary design in timber with a university’s research capacity, the project represents a real opportunity for transformational change in the design of tall timber buildings. Essential details and connections are determined and ‘unknowns’ with respect to material and structural performance are identified. A programme of testing to investigate these unknowns and validate the design approaches is carried out at the university. Outcomes of the test programme and new insights are fed back into the design process.The results show that tall timber towers are feasible, with substantial but surmountable questions outstanding. By providing thought provoking yet credible solutions for the design of tall timber buildings and exceeding current limits, the project can inspire the design community to think beyond the status quo and embrace the possibilities offered by timber construction.

A study on the effectiveness of inventory management and control system in a milk producer organisation

Inventory management is mainly concerned about identifying the amount and the position of the goods that a firm has in their inventory. Inventory management is imperative as it helps to defend the intended course of production against the chance of running out of important materials or goods. Inventory management also includes making essential connections between the replenishment lead time of goods, asset management, and the carrying costs of inventory, future inventory price forecasting, physical inventory, and available space for inventory, demand forecasting and much more. The major objective of the study is to examine to the techniques used by the company to control the inventory. It also includes studying the effectiveness of the technique adopted. In this report we can come to know the background information and the objective of the industry as a whole and also develop the project procedures and various method performed in order to get a detailed report on the industry.

Diversity management strategies for the adaptation of educational systems to the challenges of social marginalization

Marginalization in the classical interpretation refers to the development in a traditional sustainable society of groups and individuals, positioned in a borderline, precarious state with respect to their social and cultural identity. Marginalization, thus, is a multifaceted process, reinforcing the internal diversity of a society. Today, the traditional society itself exists as an unstable network of disparate social groups. &lt;The latter are in fact closed systems, which are connected by more discrete, formal communicative contacts rather than essential connections. Identifications currently are not woven into a strong social structure, and this structure itself is a transient, flexible mass. Therefore, we do not deal with individual marginal groups arising in a society, but with solid marginalized masses, among which there are “islands” of the traditional population groups. Processes of globalization and integration in the society, strengthening of social dynamics, migration, etc. are the objective reasons for this. In the context of strong ethnic and cultural diversity, military and political tensions, environmental and economic crises, rise in property stratification, social exclusion and inequality – processes of individual self-realization become more complicated. To create conditions for each individual’s development in order to meet urgent needs and improve life quality, becomes first of all the task of an educational system. All this requires more flexibility and adaptability of educational systems, which they unfortunately do not have. Under these challenges it is necessary to focus on finding ways of educational humanization in order to overcome the negative effects of marginalization processes and to use their innovation potential.

Online Learning in a South African Higher Education Institution: Determining the Right Connections for the Student

&lt;p class="3"&gt;Online learning is a means of reaching marginalised and disadvantaged students within South Africa. Nevertheless, these students encounter obstacles in online learning. This research investigates South African students’ opinions regarding online learning, culminating in a model of important connections (facets that connect students to their learning and the institution). Most participants had no prior experience with online learning. Their perceptions and barriers to learning may apply to other developing countries as well.&lt;/p&gt;&lt;p class="3"&gt;A cross-sequential research design was employed using a survey among 58 fourth-year students who were studying a traditional paper-based module via open distance learning. The findings indicated certain essential connections: first, a &lt;em&gt;strong s&lt;/em&gt;&lt;em&gt;ocial presence &lt;/em&gt;(through timely feedback, interaction with facilitators, peer-to-peer contact, discussion forums, and collaborative activities); second, &lt;em&gt;technological aspects&lt;/em&gt;&lt;strong&gt; &lt;/strong&gt;(technology access, online learning self-efficacy, and computer self-efficacy); and third, &lt;em&gt;tools&lt;/em&gt;&lt;strong&gt; &lt;/strong&gt;(web sites, video clips). The study revealed low levels of computer/internet access at home, which is of concern in an ODL milieu heading online. Institutions moving to online learning in developing countries should pay close attention to their students’ situations and perceptions, and develop a path that would accommodate both the disadvantaged and techno-savvy students without compromising quality of education and learning. The article culminates in practical recommendations that encompass the main findings to help guide institutions in developing countries as they move towards online teaching and learning.&lt;/p&gt;