The creation of livestock complexes with the introduction of new methods of organization and technologies has led to a wide manifestation of technological stresses in cattle. Stress reduces the natural resistance and the level of humoral immunity, as a result of which conditions are created for the activation of conditionally pathogenic microflora, which leads to digestive disorders, respiratory diseases, decreased productivity, increased morbidity and mortality of animals. Therefore, the analysis of adaptive reactions of blood in cows under technological stress will allow us to assess the state of the body and timely develop measures to prevent emerging disorders. The marker of the general adaptation process is the blood system. The study of the content of leukocytes, erythrocytes, ATP in erythrocytes, electrophoretic mobility of erythrocytes (EFPE) of cattle blood under technological stress.It was shown that in animals after technological stress there was a significant increase in the number of leukocytes on the 3rd- 14th day of the study compared with the control group of animals, the development of neutrophilosis, monocytosis and lymphopenia was noted. The number of red blood cells, hemoglobin concentration, EFPE and ATP content after technological stress were lower compared to the control group for 3 days. Thus, to correct technological stress in cows, means are needed that increase the overall adaptive capabilities of the animal organism.