Eruption Of Pregnancy Research Articles

What's in a name? Prurigo versus atopic eruption of pregnancy without atopic history.

What's in a name? Prurigo versus atopic eruption of pregnancy without atopic history.

Post-partum Polymorphic Eruption of Pregnancy

Post-partum Polymorphic Eruption of Pregnancy

Polymorphic eruption of pregnancy – new therapeutic approach

Polymorphic eruption of pregnancy – new therapeutic approach

Pruritic urticarial papules and plaques of gestation in perinatal depression

IntroductionThe cutaneous polymorphic eruption of pregnancy (PEP) is presented by skin lesions usually in the third trimester of gestation and about 13% of women also suffer from perinatal depression.ObjectiveTo determine the frequency of pruritic urticarial papules of gestation with and without perinatal depression.AimTo assess the maternal causes for polymorphic eruption of pregnancy (PEP) in patients with and without perinatal depression.MethodsCases and controls were matched on the grounds of maternal weight gain in gestation, hormonal changes, deficit in iron and zinc, dysregulation of hypothalamic pituitary axis, pre-maturity, pre-eclampsia, pre-term labour. Univariate and multivariate analysis, adjusting for important demographic factors and comorbodities was conducted to assess the relationship of PEP with and without perinatal depression in reduced and full models of ANOVA in regression analysis. (Reduced model Y = β0 + β1X1 + … and the full model Y = β0 + β1X1 + β2X2 + β3X3 + β4X4 + β5X5 + β6X6 + …)ResultsPolymorphic eruption of pregnancy with perinatal depression was statistically significant in maternal weight gain in gestation [odds ratio (OR) 1.20; 95% (CI): 1.15–1.30], hormonal changes [(OR) 2.78; 95% (CI): 2.52–2.82], deficit in iron and zinc [(OR) 2.18; 95% (CI): 2.04–2.38], dysregulation of hypothalamic pituitary axis [(OR) 1.37; 95% (CI): 1.18–1.49] and was not statistically significant in pre-maturity, pre-eclampsia and pre-term labour in cases and controls.ConclusionPruritic urticarial papules and plaques of gestation are commonly associated in patients with perinatal derpession.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Study of Cutaneous manifestation of pregnancy in a Tertiary Care Hospital, South India

Background: Pregnancy is a period of profound immunologic, endocrine, metabolic and vascular changes, which makes them venerable for physiological and pathological changes in skin and its appendages. Dermatoses unique to pregnancy are important to recognize for the clinician as they carry considerable morbidity for pregnant mothers and in some instances constitute a risk to the fetus. Objectives: To determine the frequency and pattern of dermatoses in pregnancy. Methods: A total of 600 pregnant women attending out- patient department of dermatology and obstetrics at tertiary care hospital having symptoms related to skin, nail and its appendages between June 2014 and July 2015 were studied. Detailed history, clinical examination and relevant investigations were performed. The data was analyzed by using SPSS software version 16. Results: Age of patients ranged from 18 years to 44 years. Primigravida group accounted for about 396 (66%). Commonest physiological changes noted was Striae distensae 288 (48%) followed by Linea nigra 270 (45%), Gingival hyperemia/ gingivitis was seen 20 (3.33%), Pigmentary changes 198 (33%), Melasma 192 (32%). Polymorphic eruption of pregnancy (PEP) 31 (5.6%) was the commonest specific dermatosis followed by Atopic eruption of pregnancy (AEP) 12(2%) Pemphigoid Gestations (PG) 1 (0.16%) and Intrahepatic Cholestasis Pregnancy (ICP) 1 (0.16%) Fungal infection 40 (6.6%) was the commonest infection, followed by bacterial infections 12(2%). 4 patients showed skin scraping positive for Scabies mite. Conclusion: Physiological dematoses are common in Primigravida compared to multigravida. Specific dermatoses of pregnancy are also not uncommon, can be a source of significant distress to the patients which warrants specific care in turn influences the maternal and fetal outcome. The awareness, recognition of these skin conditions, familiarity with their treatment, antepartum surveillance, early diagnosis and prompt treatment is essential for improv

“One year clinical study of dermatoses in pregnancy”

Objectives: To study frequency and pattern of physiological skin changes and skin disease effected by pregnancy and factors affecting them. Methods: A total of 300 pregnant women were randomly selected from outpatient antenatal clinic and antenatal ward in ASRAM, Eluru appropriate investigations were done to confirm the diagnosis if required. Results: Majority of the pregnant women were multipara, belonging to age group 21-25 years and most changes were observed in the third trimester of pregnancy. Pigmentation was the commonest physiological change. Striae were more common in multigravida, more on abdomen but the onset of striae was early on breast. Among specific dermatoses, atopic eruption of pregnancy was observed to be the most common. Infections and infestations constituted a major part of affected dermatoses. Conclusions: In this study various pregnancy dermatoses were studied. It is imperative to recognize these changes to differentiate benign conditions from those associated with potential fetal and maternal risks and to know when the treatment should be initiated. Keywords: Pregnancy, physiological changes, specific dermatoses

Polymorphic eruption of pregnancy with palmoplantar involvement that developed after delivery

Polymorphic eruption of pregnancy is the most common specific dermatosis of pregnancy. It usually develops in the third trimester and rapidly resolves in the first weeks postpartum. Intensely pruritic urticarial papules and plaques initially occur on the abdomen and/or proximal thighs, particularly within or adjacent to striae distensae with periumbilical sparing, and usually tend to spread to affect the peripheral limbs, buttocks, chest and back. The face, palmoplantar regions and mucosal surfaces are generally spared. Here, we report a case of polymorphic eruption of pregnancy associated with palmoplantar involvement that developed in the postpartum period.

Atopic eruption of pregnancy

Atopic eruption of pregnancy

Dramatic Regression of Dermatoses after Delivery

ABSTRACT Atopic eruptions of pregnancy may be sometimes very distressing to mother because of intense itching and aggressive appearing and difficult to manage due to nonresponding to symptomatic treatment but usually regress very well after delivery without any adverse maternal and fetal out come. We are presenting a case which appeared very virulent antenatally but resolved dramatically after delivery.

Specific pruritic dermatoses of pregnancy

The nomenclature and classification of specific pruritic dermatoses of pregnancy have remained confused and disputed all along. It is not until 2006 that a rationalized classification system was proposed and they were classified into pemphigoid gestationis, polymorphic eruption of pregnancy, atopic eruption of pregnancy and intrahepatie cholestasis of pregnancy. This article addresses the advances in classification, characterization of clinical manifestations (including the time of onset during pregnancy), laboratory examination, pathology, differential diagnosis, impact on fetus and management of specific pruritic dermatoses of pregnancy. Key words: Pregnancy complications; Skin manifestations; Skin diseases; Prurigo

Köebner phenomenon occurring in polymorphic eruption of pregnancy

Köebner phenomenon occurring in polymorphic eruption of pregnancy

A case-control study of polymorphic eruption of pregnancy

A case-control study of polymorphic eruption of pregnancy

At a glance - Polymorphic light eruption vs eruption of pregnancy

Polymorphic light eruption vs eruption of pregnancy

Abstracts

Fetal cells enter the maternal circulation during all human and murine pregnancy. The presence of fetal microchimeric cells has been demonstrated in lesional skin of pregnant women affected with polymorphic eruptions of pregnancy. We aimed at determining in a mouse model the role of maternal inflammation in attracting microchimeric cells. Wild type female mice were mated to transgenic males for various reporter genes or wild type male controls. We used males transgenic for the luciferase gene under the control of an ubiquitous (CMV)(C-Luc) or the VEGFR2 (V-Luc) promoter. Alternatively we used males transgenic for the EGFP under the control of the beta-actin promoter. Female pregnant mice were sensitized on day 10 of pregnancy with 2% Oxazolone. On day 16 we revealed a contact hypersensitivity reaction (CHR) by painting the right ear with oxazolone while the left ear received only the vehicle. The presence of fetal cells was then monitored using one of the following: in vivo imaging to detect luciferase expressing fetal cell real time quantitative amplification of the egfp transgene or Y chromosome in situ hybridization to detect male microchimeric cells. On femalemice bearing V-Luc fetuses, a fetal signal could be detected only on the right ear that was significantly higher when compared to controls (3362 versus 1507 photons/s/cm2, p=0.02). Wealso detected fetal cells by real time quantitative PCR in the right as well as the left ear at similar frequencies. Finally, we demonstrated the presence of fetal cells in maternal inflamed ears. Fetal cells were either among the inflammatory cells or were part of the vascular wall. We demonstrate that maternal inflamed skin can recruit fetal microchimeric cells. The fetal cells adopt an endothelial phenotype in the inflamed maternal skin. Fetal cells may therefore participate in maternal angiogenesis and inflammation.

Polymorphic Eruption of Pregnancy

Pruritic urticarial papules and plaques of pregnancy (PUPPP) were first reported in 1979 by Lawley and colleagues (JAMA 1979; 241:1696). Subsequently,

Microchimerism in Human Health and Disease

During pregnancy some cells traffic between the fetus and the mother. Recent investigative work indicates a low level of fetal cells commonly persists in the maternal circulation for years, or even indefinitely, after pregnancy has been completed. The term microchimerism refers to one individual harboring DNA or cells at a low level that derive from another individual. Chronic graft-versus-host disease (cGvHD) shares similarities with some autoimmune diseases and is an iatrogenic form of chimerism, occurring as a complication of hematopoietic stem cell transplantation. The HLA genes of the donor and the host are known to be of central importance to the development of cGvHD. When also considered in light of the female predilection to autoimmunity, these series of observations led to the hypothesis that microchimerism and HLA genes of host and non-host cells are involved in some autoimmune diseases. The hypothesis can also apply to men, children, and women who have not been pregnant because there are other sources of microchimerism. Persistent microchimerism can follow a blood transfusion, or can occur from transfer between twins in utereo. Additionally, maternal cells have recently been found to persist in her immune competent progeny. A number of studies have investigated a potential role of microchimerism in human diseases including systemic sclerosis (SSc), primary biliary cirrhosis (PBC), Sjögren's syndrome, polymorphic eruption of pregnancy, myositis, and thyroid disease. While some studies lend support to the concept that microchimerism is involved in the pathogenesis of selected autoimmune diseases, studies also indicate microchimerism is not uncommon in other human conditions and in healthy individuals.

Maternal and Fetal Microchimerism: Implications for Human Diseases

After completing this article, readers should be able to: 1. Explain when fetal cells pass into a pregnant woman and maternal cells pass into the fetus. 2. Explain findings of fetal cells in women who have systemic sclerosis. 3. List autoimmune diseases in which fetal cells have been found in target tissues. 4. Describe the prevalence of maternal cells in blood and muscle of patients who have juvenile idiopathic inflammatory myositis. 5. Characterize the influence of human leukocyte antigen compatibility with her children on a woman’s risk for developing systemic sclerosis. It is now recognized that cells traffic between fetus and mother during pregnancy. Fetal cells have been found to persist for years, probably for a lifetime, in the circulation of normal women. The term chimerism is used when one individual harbors cells from another individual, and the term microchimerism refers to low levels of chimerism. Chronic graft-versus-host disease (GVHD) is a condition of human chimerism that has similarities to some autoimmune diseases. Women have a predilection to autoimmune disease, and human leukocyte antigen (HLA) class II genes are known to be important both in autoimmune disease and in GVHD. Considered together, these observations led to the hypothesis that microchimerism and HLA genes of host and nonhost cells are involved in autoimmune disease. Alternative sources of microchimerism could affect men and women who have never been pregnant, including from a twin, from a blood transfusion, or long-term persistence of maternal cells that have trafficked to the fetal circulation during pregnancy. Studies of systemic sclerosis (SSc), primary biliary cirrhosis (PBC), Sjogren syndrome, pruritic eruption of pregnancy, myositis, and thyroid disease have both lent support and raised doubts about the role of microchimerism in autoimmune disease. Fetal cells pass into the maternal circulation during normal human pregnancy. Fetal microchimerism during pregnancy is detected most readily in plasma …

WS053 PUPPP or polymorphic eruption of pregnancy

WS053 PUPPP or polymorphic eruption of pregnancy

Pustular Eruption of Pregnancy Treated With Locally Administered PUVA

A 32-year-old woman in the third trimester of her fourth pregnancy had a 3-week history of pruritic eruption. The patient first developed a similar eruption 12 years previously, immediately after delivery with her first pregnancy, and had had subsequent episodes in the third trimester every time when pregnant. In the second pregnancy, topical corticosteriods provided limited relief of symptoms. During the third pregnancy the eruption was successfully treated with the local administration of methoxsalen plus UV light (PUVA). No other family member had psoriasis. On examination, the patient had erythematous patches studded with superficial pustules, particularly at the margins, in the groin area, lower abdomen, upper thighs, and neck. The centers of the lesions were impetiginized and crusted (Fig 1). The mucous membranes and nails were normal. Results of a complete blood cell count and chemistry panel were normal. A biopsy specimen taken from an active edge of the lesion

The eruptions of pregnancy: Review and new classification

The eruptions of pregnancy: Review and new classification